Abstract: A climate control circuit for a transport climate control system is provided. The circuit includes a compressor, a plurality of evaporators, a suction flow control device, and a controller. The suction flow control device is downstream of the plurality of evaporators and directs the working fluid from each of the evaporators to one of a main suction port and an auxiliary port of the compressor. The controller determines whether each of the evaporators is operating in a fresh temperature range or in a frozen temperature range. For each of the evaporators operating in the fresh temperature range, the controller instructs the suction flow control device to direct the working fluid from the corresponding evaporator to the auxiliary suction port. For each of the plurality of evaporators operating in the frozen temperature range, the controller instructs the suction flow control device to direct the working fluid to the main suction port.

Abstract: A voltage supply and a method for calibrating the voltage supply are provided. The voltage supply is for providing a reference voltage to supply a voltage to at least one electrode. The voltage supply comprises: an ultra-stable DC voltage source, an accurate DC voltage source, a tuning unit, a comparator, and a control unit. An ultra-stable voltage is applied to the tuning unit, which is provided based on a supplied voltage of the ultra-stable DC voltage source. The tuning unit provides an output voltage. A voltage based on the output voltage of the tuning unit is compared by the comparator with an accurate voltage. The accurate voltage is provided based on a supplied voltage of the accurate DC voltage source.

Abstract: An optimization control system may receive mass spectra of ions emitted from an ionization emitter toward an inlet of a mass spectrometer and control, based on the mass spectra, an automated motion system to adjust a position of the emitter relative to the inlet.

Abstract: An embodiment of a support structure for adjusting the position of a plurality of optical elements is described that comprises a base plate comprising a centering pin, a first translation slot, and a second translation slot; and a translatable plate configured to operatively couple with a plurality of the optical elements and move relative to the base plate, wherein the translatable plate comprises a centering slot configured to engage with the centering pin, a first cam configured to engage with the first translation slot and control movement of the translatable plate along a first axis, and a second cam configured to engage with the second translation slot and control movement of the translatable plate along a second axis.

Abstract: There is disclosed an environmental control system for heating at least one enclosed space. The system comprises a heat-pump circuit that includes a compressor, a heat-output stage, an expansion device and an evaporator arranged in series along a flow path for a refrigerant. The heat-output stage comprises a primary heat exchanger and a secondary heat exchanger that are both configured to transfer heat from the refrigerant to one or more external mediums in thermal communication with the at least one enclosed space. The primary heat exchanger and the secondary heat exchanger are connected in series along the flow path, such that the secondary heat exchanger will transfer excess heat energy remaining within the refrigerant after passing through the primary heat exchanger to the one or more external mediums.

Abstract: A transport power system is provided. The transport power system includes a prime mover separate from another prime mover used for operating a vehicle, an absolute pressure sensor configured to sense an absolute pressure, and a controller. The controller is configured to determine an altitude of the transport power system based on a first absolute pressure sensed during a start-up sequence of the transport power system prior to running of the prime mover, adjust a power output upper limit for the prime mover based on the determined altitude, and control an operation of the prime mover of the transport power system not to exceed the adjusted power output upper limit.

Abstract: A system for analyzing a sample includes a source configured to generate ions from constituent components of the sample; a mobility separator configured to separate ions received from the source based on the mobility in a gas; a ion storage array configured to store ions from the mobility separator as a plurality of mobility fractions; a mass filter configured to select ions within a mass-to-charge window; a mass analyzer configured to determine the mass-to-charge ratio of the ions; and a controller. The controller is configured to identify an ion mobility fraction and a mass-to-charge window to select for a charge state or ion class; utilize the mass filter to select ions from the ion storage array within the mass-to-charge window corresponding to a charge state or ion class; and analyze the selected ions with the mass analyzer.

Abstract: An electrospray emitter assembly for interfacing a separation column to a mass spectrometer is disclosed. An emitter capillary includes an inlet end and an outlet end. A fitting is coupled to the inlet end of the emitter, configured to be removably connected to the separation column. A stop with a defined through hole is integrated proximate the inlet end of the emitter to produce a path for liquid to flow from the separation column to the emitter via the through hole where a voltage is applied to the liquid entering the emitter.

Abstract: Methods for linearization of photodetector response include establishing one or more static calibration coefficients based on comparison of test photodetector response to a linear reference photodetector. In some examples, dynamic calibration coefficients are determined based on average photodetector signals. In some applications such as FTIR, linearized ratios are obtained with a single calibration coefficient.

Abstract: A method of performing targeted multiplexed mass spectrometry includes performing, at a mass spectrometer, a targeted MS3 analysis of an isobaric tag-labeled target analyte included in a multiplex sample eluting from a column. The targeted MS3 analysis is performed during an acquisition segment scheduled based on an expected retention time of the isobaric tag-labeled target analyte. The method further includes performing, during the acquisition segment, a plurality of MS2 analyses of product ions derived from components included in the multiplex sample and eluting from the column. The method further includes determining, based on MS3 mass spectra acquired by the targeted MS3 analysis and MS2 mass spectra acquired by the plurality of MS2 analyses, a relative quantity of the isobaric tag-labeled target analyte in the multiplex sample.

Abstract: A compression fitting includes a nut with a threaded end for receiving a threaded tube and a receiving end for holding a plunger head; and a plunger with an inner bore for receiving a capillary tube and the plunger head for engaging a ferrule positioned within the receiving end between the plunger head and the threaded tube, the plunger slidingly engaged with the nut to force the ferrule from the nut.

Abstract: An automated laboratory system includes a storage system including a frame and a platform slidably mounted to the frame such that the platform is slidable relative to the frame between a docked position and an undocked position, the platform being configured to carry an instrument. The system also includes a robotic device proximate the storage system and being configured to access the instrument carried by the platform. Another automated laboratory system includes a storage system including a table and a tabletop having a central axis and being rotatably positioned on the table such that the tabletop is rotatable about the central axis between a docked position and an undocked position, the tabletop being configured to carry an instrument. The system also includes a robotic device proximate the storage system and being configured to access the instrument carried by the tabletop.

Abstract: A method comprises: heating a flow of coolant liquid by passing the flow through one or more fluidic tubing lines, channels or conduits that are in thermal contact with a housing of a vacuum pump; apportioning the flow of heated coolant liquid between a bypass fluid tubing line and a channel within a wall of a vacuum chamber; recombining the first and second partial flows of the heated coolant liquid; passing the recombined flow of the coolant liquid through a heat exchanger that cools the coolant liquid; and recirculating the cooled coolant liquid through the one or more fluidic tubing lines, channels or conduits that are in thermal contact with the vacuum pump housing, wherein the apportionment of the flow of the heated coolant liquid is automatically performed under the control of an electronic controller or computer in response to a temperature measurement received by the electronic controller or computer.

Abstract: A first multipole assembly includes a first plurality of rod electrodes arranged about an axis and configured to confine ions radially about the axis. A second multipole assembly disposed adjacent to the first multipole assembly includes a second plurality of rod electrodes arranged about the axis and configured to confine the ions radially about the axis. An orientation of the first multipole assembly about the axis is rotationally offset relative to an orientation of the second multipole assembly about the axis.

Abstract: An ion guide may comprise a set of plate electrodes, each plate electrode having a plurality of apertures formed therethrough. The set of plate electrodes are spatially arranged such that a relative positioning of each plurality of apertures of a respective plate electrode of the set of plate electrodes and respective adjacent plate electrodes of the set of plate electrodes defines a continuous ion flight path through the respective plurality of apertures of each plate electrode of the set of plate electrodes. The continuous ion flight path has a helical-based and/or spiral-based shape.

Abstract: A space-time buffer includes a plurality of discrete trapping regions and a controller. The plurality of discrete trapping regions is configured to trap ions as individual trapping regions or as combinations of trapping regions. The controller is configured to combine at least a portion of the plurality of trapping regions into a larger trap region; fill the larger trap region with a plurality of ions; split the larger trap region into individual trapping regions each containing a portion of the plurality of ions; and eject ions from the trapping regions.

Abstract: The present disclosure describes oligonucleotide-tethered nucleotides, methods of making them, and methods of using them. The oligonucleotide-tethered nucleotides comprise, in some embodiments, a nucleotide linked to an oligonucleotide of from about 3 to about 100 nucleotides in length. These oligonucleotide-tethered nucleotides can be used to label a plurality of different types of nucleic acids in a plurality of different situations with a known oligonucleotide, which can serve as a barcode in some embodiments. The resulting oligonucleotide-labeled nucleic acids oligonucleotides can be used in a variety of nucleic acid sequencing methods.

Abstract: A method of remotely managing a transport climate control system (TCCS) includes a remote management device receiving performance data from the TCCS. The performance data based on one or more detected operating parameters of the climate control circuit. The method also including the remote management device providing the performance data to one or more user devices. A remote management system includes a remote management device configured to receive performance data for a climate control circuit from a climate controller of a TCCS and to provide the performance data to one or more user devices. A TCCS includes a controller configured to: generate performance data based on the one or more detected operating parameters of a climate control circuit, and transmit the performance data to a remote monitoring device. The climate controller also configured to receive an operating instruction from the remote monitoring device.

Abstract: A multipole ion guide includes a plurality of electrodes disposed about a longitudinal axis of the device so as to define an ion transmission volume for transmitting ions along a length of the device between opposite inlet and outlet ends. An electronic controller is operably connected to an RF power source and to at least some of the electrodes and is configured to apply at least an RF potential to the electrodes. During use the electrodes generate an RF-only field along a first portion of the device and an axial DC field along a second portion of the device. Ions are focused radially inward toward the longitudinal axis of the device by the RF-only field within the first portion of the device prior to and/or subsequent to experiencing the axial DC field within the second portion of the device.