Patents Assigned to Tianjin University
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Patent number: 11804029Abstract: The present disclosure relates to a hierarchical constraint (HC) based method and system for classifying fine-grained graptolite images. The method includes: constructing a graptolite fossil dataset; extracting features in graptolite images; calculating the similarity between graptolite images, and performing weighting according to a genetic relationship among species to obtain a weighted HC loss function (HC-Loss) of all graptolite images; calculating cross-entropy loss; taking a weighted sum of HC-Loss and CE-Loss as a total loss function in a training stage; and performing model training. The system of the present disclosure includes a processor and a memory.Type: GrantFiled: December 28, 2022Date of Patent: October 31, 2023Assignees: Nanjing Institute of Geology and Palaeontology, CAS, Tianjin UniversityInventors: Honghe Xu, Yaohua Pan, Zhibin Niu
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Patent number: 11753615Abstract: The present disclosure belongs to the field of bioengineering, and relates to breeding of industrial microorganisms, in particular to a genetically engineered strain of Saccharomyces cerevisiae, method for constructing the same, and its use for brewing, the genetically engineered strain of Saccharomyces cerevisiae heterogeneously overexpresses an acetaldehyde dehydrogenase gene ALD6, an acetyl-CoA synthase gene ACS1 and an alcohol acyltransferase gene AeAT9. The Saccharomyces cerevisiae strain with high yield of ethyl acetate and low yield of higher alcohols provided by the present disclosure not only maintains excellent ethanol fermentation characteristics, but also reducing the production of higher alcohols which adversely affect the comfort after drinking, which is of great significance for a well-maintained and strengthened flavor characteristics of Chinese Baijiu, an improved and stabilized quality thereof, and even a reform in the fermentation process thereof.Type: GrantFiled: August 25, 2021Date of Patent: September 12, 2023Assignee: Tianjin University of Science and TechnologyInventors: Yefu Chen, Wenqi Shi, Guo Zhang, Ruirui Li, Yanfang Chen, Huan Wang, Chunhong Sun, Dongguang Xiao, Xiaole Wu, Xuewu Guo
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Patent number: 11753424Abstract: A crystalline form of phenyl bis (2,4,6-trimethylbenzoyl) phosphine oxide, with a large particle size, which belongs to a triclinic crystal system and space group P-1. A crystallization method for making the crystalline form of phenyl bis (2,4,6-trimethylbenzoyl) phosphine oxide, comprising adding a solid of phenyl bis (2,4,6-trimethylbenzoyl) phosphine oxide to a solvent and mixing; followed by heating to 50 to 70° C. to achieve complete dissolution; cooling the solution to room temperature; and adding an anti-solvent to the resulting solution to cause precipitation of crystals. The crystals are allowed to grow at a constant temperature for 10 to 60 minutes, so as to give a slurry containing the crystals. Said slurry is subjected to filtration and then drying to obtain the crystalline form of phenyl bis (2,4,6-trimethylbenzoyl) phosphine oxide.Type: GrantFiled: January 8, 2021Date of Patent: September 12, 2023Assignee: Tianjin UniversityInventors: Ying Bao, Pei Zhao, Mingshuo Chen, Baohong Hou, Chuang Xie, Lina Zhou
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Patent number: 11746353Abstract: A Saccharomyces cerevisiae strain with high yield of ethyl butyrate and a construction method and an application thereof are provided. The strain is obtained by over-expressing in the starting strain acetyl coenzyme A acyl transferase gene Erg10, 3-hydroxybutyryl coenzyme A dehydrogenase gene Hbd, 3-hydroxybutyryl coenzyme A dehydratase gene Crt, trans-2-enoyl coenzyme A reductase gene Ter, and alcohol acyl transferase gene AAT. Compared to the starting bacteria not producing ethyl butyrate, the yield of ethyl butyrate of the constructed strain reaches 77.33±3.79 mg/L, the yield of the ethyl butyrate of the strain with double copy expression of gene Ter and gene AAT reaches 99.65±7.32 mg/L, increased by 28.9% compared with the EST strain, and 40.93±3.18 mg/L of ethyl crotonate is unexpectedly produced.Type: GrantFiled: December 25, 2020Date of Patent: September 5, 2023Assignee: Tianjin University of Science and TechnologyInventors: Yefu Chen, Yanrui Ma, Yongjing Du, Sen Jiang, Jinying Ren, Guo Zhang, Xinyue Kang, Peng Zheng, Xiaole Wu, Dongguang Xiao, Xuewu Guo
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Publication number: 20230267703Abstract: The present disclosure relates to a hierarchical constraint (HC) based method and system for classifying fine-grained graptolite images. The method includes: constructing a graptolite fossil dataset; extracting features in graptolite images; calculating the similarity between graptolite images, and performing weighting according to a genetic relationship among species to obtain a weighted HC loss function (HC-Loss) of all graptolite images; calculating cross-entropy loss; taking a weighted sum of HC-Loss and CE-Loss as a total loss function in a training stage; and performing model training. The system of the present disclosure includes a processor and a memory.Type: ApplicationFiled: December 28, 2022Publication date: August 24, 2023Applicants: Nanjing Institute of Geology and Palaeontology, CAS, Tianjin UniversityInventors: Honghe XU, Yaohua PAN, Zhibin NIU
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Patent number: 11703497Abstract: The present invention discloses a quantitative evaluation method for sensitivity of welding transverse cold cracks in a typical joint of a jacket, including following steps: S1, performing macroscopic analysis, metallographic analysis, fracture analysis and hardness analysis on cracks of a failed component to obtain main causes of cold crack failure; and S2, designing and processing a dedicated sample, and performing rigid restraint crack tests on the dedicated sample at different preheating temperatures to obtain a cracking/non-cracking critical restraint stress ?1cr of the sample.Type: GrantFiled: September 28, 2022Date of Patent: July 18, 2023Assignee: Tianjin UniversityInventors: Yongdian Han, Shifang Zhong, Lianyong Xu, Hongyang Jing, Lei Zhao, Kangda Hao
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Patent number: 11692178Abstract: A genetically engineered bacterium includes a genome of the Eschericia coli and a mutant encoding gene hisG* of a Corynebacterium glutamicum ATP phosphoribosyl transferase HisG on the genome, and the gene hisG* is strongly expressed to enhance activity of a key enzyme HisG for histidine synthesis. The gene hisG* has a nucleotide sequence as shown in SEQ ID NO: 1; a copy number of histidine operon genes hisDBCHAFI of the Eschericia coli is further increased on the genome to enhance a terminal synthetic route of histidine; an encoding gene lysE from an arginine/lysine transportprotein of the Corynebacterium glutamicum is further integrated to the genome and strongly expressed to promote the intracellular histidine secrete to the extracellular space; and an encoding gene rocG of glutamate dehydrogenase of Bacillus subtilis is further integrated to the genome and strongly expressed to promote generation of histidine.Type: GrantFiled: June 18, 2021Date of Patent: July 4, 2023Assignees: ZHEJIANG ZHENYUAN BIOTECH CO., LTD., Tianjin University of Science and TechnologyInventors: Xixian Xie, Weiming Fan, Heyun Wu, Wei Jiang, Daoguang Tian, Yanna Chen, Yue Zhang, Jianqing Tu
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Publication number: 20230182088Abstract: A method for preparing a high-selectivity lithium-magnesium separation membrane includes: (1) preparing an aqueous phase mixture containing aqueous phase monomer, crown ethers or aza-macrocycles, acid acceptor, surfactant and water; (2) preparing an organic phase mixture containing organic phase monomer, and organic solvent that is incompatible with water; (3) contacting the supporting membrane with the aqueous phase mixture to obtain an aqueous phase monomer-adsorbed supporting membrane; (4) contacting the aqueous phase monomer-adsorbed supporting membrane with an organic phase mixture for an interfacial polymerization reaction; and (5) placing a nascent membrane obtained into a drying oven and heat-treating the membrane to obtain a lithium-magnesium separation membrane. The present method is simple in preparation process, mild in preparation conditions, easy to scale up, and easy to realize industrial production.Type: ApplicationFiled: November 29, 2022Publication date: June 15, 2023Applicant: Tianjin UniversityInventors: Song ZHAO, Zhi WANG, Tingyu LI, Yu ZHANG, Jixiao WANG
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Publication number: 20230186254Abstract: Disclosed is an optimizing method for multi-source municipal solid waste combinations based on machine learning, including obtaining relevant property data, classifying the feature variables and obtaining a raw materials pre-combination from the classified feature variables according to a classification ratio, followed by cooperative combustion treatment to obtain data after combustion, summarizing the obtained data into a database, constructing a matrix of raw material components, operating conditions and pollutant distribution according to the database, obtaining matrix data; performing principal component analysis on the matrix data, constructing an information processing model, obtaining a data set of samples; carrying out training according to the data set to construct a relational model, obtaining processed parameters; training the obtained processed parameters to construct a regression module, an optimal parameter, and performing regression calculation using the optimal parameter together with the matrType: ApplicationFiled: November 10, 2022Publication date: June 15, 2023Applicant: Tianjin University of CommerceInventors: Guanyi CHEN, Chengming DU, Yunan SUN, Junyu TAO, Xinyi LIU, Lan MU, Xiaohua WANG, Zhenyu WANG, Yanni ZHENG
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Patent number: 11661417Abstract: The present disclosure provides a low-molecular mass organic gellant and a preparation method and use thereof, belonging to the technical field of gelled fuels. The low-molecular mass organic gellant has a cyclopropane structure. The cyclopropane structure belongs to a high-tension structure, which endows the gellant with excellent gel properties; in addition, the high-tension cyclopropane structure is also capable of greatly improving a combustion performance of the gellant, shortening an ignition delay time of the fuel, and promoting combustion. Moreover, multiple hydroxyl groups contained in the low-molecular mass organic gellant is capable of effectively forming a gel through hydrogen bonding; therefore, the gellant has excellent gel and shear thinning properties for high-energy density fuel and energetic nanofluid fuel, with a critical gellant concentration of not greater than 1% when forming a stable gel.Type: GrantFiled: June 30, 2022Date of Patent: May 30, 2023Assignee: Tianjin UniversityInventors: Lun Pan, Jijun Zou, Yang Liu, Xiangwen Zhang
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Patent number: 11655464Abstract: An alkaline protease mutant, and a gene, engineered strain, a preparation method and application thereof are provided. The method comprises the following steps of extracting genome DNA of Bacillus clausii, performing PCR amplification to obtain a wild-type alkaline protease gene sequence, mutating the wild-type alkaline protease gene obtained by the amplification through an error-prone PCR, performing high-throughput screening to obtain a plurality of highly active alkaline protease genes, performing DNA shuffling on the highly active alkaline protease genes, and performing screening to obtain eight alkaline protease mutant genes with higher activity.Type: GrantFiled: July 31, 2022Date of Patent: May 23, 2023Assignees: Tianjin University of Science and Technology, Shandong Lonct Enzymes Co. LTDInventors: Fuping Lu, Yihan Liu, Yu Li, Xingji Wang, Kefen Wang, Wenlong Liu, Fufeng Liu, Huitu Zhang
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Patent number: 11655231Abstract: The disclosure relates to etoricoxib solvates and a preparation method thereof. A solvent is a hydrogen bond donor solvent with a polarity value ?* ranging from 60 to 100 or a hydrogen bond acceptor solvent with a polarity value ?* ranging from 92 to 100. Solvents with a polarity value ?* within the above range all can form corresponding etoricoxib solvates with etoricoxib. The etoricoxib solvate can be prepared by cooling crystallization or suspension crystallization. A 1,2-propanediol solvate of etoricoxib and a dimethyl sulfoxide (DMSO) solvate of etoricoxib provided in the present disclosure have high thermal stability, unique crystal form, large size, concentrated distribution, and prominent flowability and is safe, pharmaceutically acceptable, and not easy to agglomerate. Compared with etoricoxib, the etoricoxib solvates exhibit significantly improved solubility.Type: GrantFiled: March 22, 2021Date of Patent: May 23, 2023Assignee: Tianjin UniversityInventors: Ying Bao, Feng Zhang, Peihua Liang, Baohong Hou, Chuang Xie, Ting Zhang, Yinghui Chai
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Patent number: 11642649Abstract: The disclosure discloses a method for preparing biochar from Enteromorpha prolifera and use of the biochar. The method includes: subjecting Enteromorpha prolifera to lyophilization, then impregnating lyophilized Enteromorpha prolifera with phosphoric acid, and drying to a constant weight; grinding a dried mixture in a mortar, and then subjecting a ground sample to activation treatment in a tube furnace at 400° C. to 1,000° C. under a nitrogen atmosphere; and boiling an obtained solid product with concentrated hydrochloric acid, then washing with ultrapure water, and drying to a constant weight to obtain Enteromorpha prolifera biochar. The biochar is used in adsorption of cadmium. The method for removing cadmium using Enteromorpha prolifera biochar provided by the disclosure exhibits an extremely high adsorption and removal capacity for cadmium, with an adsorption capacity of biochar up to 250 mg/g or more.Type: GrantFiled: September 18, 2020Date of Patent: May 9, 2023Assignees: Tianjin University, BCIG ENVIRONMENTAL REMEDIATION CO., LTD.Inventors: Guanyi Chen, Chuanbin Wang, Chengliang Yang, Xiangping Li, Beibei Yan, Bin Liu, Juping Liu, Zhenping Su, Ding Li, Xinpei Liu, Bo Li
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Patent number: 11630041Abstract: The invention discloses a method for obtaining the geometrical and mechanical parameters of rock samples and a holographic scanning system thereof, wherein the system includes an observation mechanism, a multi-scale penetration mechanism, a grinding mechanism, a rock sample installation mechanism arranged on a three-axis precision motion platform, and an industrial computer controlling the operation mode of each mechanism of the platform Indentation/rotary penetration test, pulse echo signal acquisition, three-dimensional surface topography reconstruction, layer by layer grinding and repeated experiments are carried out. The geometric parameters and corresponding mechanical field parameters are obtained by spatial interpolation of the three-dimensional parameter lattice accumulated by several layers of single-layer rock parameters. The holographic scanning system and method can obtain the real spatial distribution of various media in rock samples.Type: GrantFiled: January 15, 2021Date of Patent: April 18, 2023Assignee: Tianjin UniversityInventors: Gaofeng Zhao, Yiming Li
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Publication number: 20230061028Abstract: The present disclosure provides a low-molecular mass organic gellant and a preparation method and use thereof, belonging to the technical field of gelled fuels. The low-molecular mass organic gellant has a cyclopropane structure. The cyclopropane structure belongs to a high-tension structure, which endows the gellant with excellent gel properties; in addition, the high-tension cyclopropane structure is also capable of greatly improving a combustion performance of the gellant, shortening an ignition delay time of the fuel, and promoting combustion. Moreover, multiple hydroxyl groups contained in the low-molecular mass organic gellant is capable of effectively forming a gel through hydrogen bonding; therefore, the gellant has excellent gel and shear thinning properties for high-energy density fuel and energetic nanofluid fuel, with a critical gellant concentration of not greater than 1% when forming a stable gel.Type: ApplicationFiled: June 30, 2022Publication date: March 2, 2023Applicant: Tianjin UniversityInventors: Lun Pan, Jijun Zou, Yang Liu, Xiangwen Zhang
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Publication number: 20230043026Abstract: A learning-based active surface model for medical image segmentation uses a method including: (a) data generation: obtaining medical images and associated ground truths, and splitting the sample images into a training set and a testing set; (b) raw segmentation: constructing a surface initialization network, parameters of the network trained by images and labels in the training set; (c) surface initialization: segmenting the images by the surface initialization network, and generating the point cloud data as the initial surface from the segmentation; (d) fine segmentation: constructing the surface evolution network, the parameters of the network trained by the initial surface obtained in step (c); (e) surface evolution: deforming the initial surface points along the offsets to obtain the predicted surface, the offsets presenting the prediction of the surface evolution network; (f) surface reconstruction: reconstructing the 3D volumes from the set of predicted surface points set to obtain the final segmentatioType: ApplicationFiled: September 30, 2021Publication date: February 9, 2023Applicant: Tianjin UniversityInventors: Yuping Duan, Yueyun Liu, Wen Xu
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Patent number: 11569031Abstract: A method for planar transformer with an odd turn ratio includes: determining a turn ratio and winding parameters of a transformer to be manufactured; if the turn ratio is odd, determining that there is respectively one winding turn on a first middle layer and a second middle layer and two winding turns on a top layer and a bottom layer; determining widths of winding wires on marginal layers as well as widths of winding wires on middle layers; winding and parallelly connecting an inner winding wire on the top layer to an inner winding wire on the bottom layer, and then serially connecting the parallel-connected inner winding wires to an outer winding wire to form a primary winding; and parallelly connecting the winding wire on the first middle layer to the winding wire on the second middle layer to form a secondary winding, so as to obtain the transformer.Type: GrantFiled: March 11, 2021Date of Patent: January 31, 2023Assignee: Tianjin UniversityInventors: Yifeng Wang, Bo Chen, Xiaoyong Ma, Mengying Chen, Zhongjie Wang, Chen Chen
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Publication number: 20230016224Abstract: An alkaline protease mutant, and a gene, engineered strain, a preparation method and application thereof are provided. The method comprises the following steps of extracting genome DNA of Bacillus clausii, performing PCR amplification to obtain a wild-type alkaline protease gene sequence, mutating the wild-type alkaline protease gene obtained by the amplification through an error-prone PCR, performing high-throughput screening to obtain a plurality of highly active alkaline protease genes, performing DNA shuffling on the highly active alkaline protease genes, and performing screening to obtain eight alkaline protease mutant genes with higher activity.Type: ApplicationFiled: July 31, 2022Publication date: January 19, 2023Applicants: Tianjin University of Science and Technology, Shandong Lonct Enzymes Co. LTDInventors: Fuping LU, Yihan LIU, Yu LI, Xingji WANG, Kefen WANG, Wenlong LIU, Fufeng LIU, Huitu ZHANG
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Patent number: 11554665Abstract: Disclosed are a drinking under influence (DUI) detection system and a DUI detection method based on an MQ3 sensor and an ultra wide band (UWB) radar. The system includes an alcohol detection module, a respiratory detection module, a signal matching module and a drunk driving alarm module, and each module cooperates to complete a detection. The MQ3 sensor-based alcohol detection module is used for alcohol signal capture, alcohol sequence processing and DUI threshold detection; the UWB radar-based respiratory detection module is used for respiratory signal capture, respiratory signal processing and passenger separation and positioning; the signal matching module is used for periodic signal alignment, sequence feature matching and drinker identity confirmation; and the DUI alarm module is used for a system alarm prompt, a data visualization interface and a DUI information uploading.Type: GrantFiled: August 29, 2022Date of Patent: January 17, 2023Assignee: Tianjin UniversityInventors: Xiulong Liu, Keqiu Li, Liyuan Ma, Jiuwu Zhang
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Patent number: 11547130Abstract: The present invention discloses a novel nano-composite antibacterial material and a preparation method and an application thereof, and belongs to the technical field of preservative materials. The novel nano-composite antibacterial material disclosed by the present invention is prepared by mixing a dimethylimidazole solution, deionized water and a zinc nitrate solution to prepare a metal-organic framework carrier, compositing with nisin to form a nano antibacterial composite material, separating out from a solution in a precipitate form, centrifuging, removing a supernatant, cleaning and re-suspending with the deionized water. The novel nano-composite antibacterial material prepared by the present invention has an antibacterial effect superior to nisin having a same concentration.Type: GrantFiled: March 12, 2020Date of Patent: January 10, 2023Assignee: Tianjin University of Science and TechnologyInventors: Shiru Jia, Jiandong Cui, Zhilei Tan, Cheng Zhong, Yang Liu, Qiaozhen Luo, Xiaona Li, Yuxiao Feng, Baoting Sun, Le Zhong