Abstract: The object of the present invention is to provide a method to obtain an antibody for a hydrophobic peptide, which can be used for general purposes easily and with great reliability. Also provided is a method for preparing an antigen characterized in that a hydrophobic peptide, which is unbound to carrier protein, is used as high-molecular-weight aggregates in an aqueous solution containing a nonionic surfactant.

Abstract: This invention provides a TNFR2 expression-inducing composition including as an active ingredient a peptide having TNFR2 expression-inducing activity, and a method for producing cells that express TNFR2 selectively by use of the composition. The cell production method provided by this invention includes: culturing at least one species of cells capable of expressing TNF receptor 2, and supplying the cells with a synthetic peptide consisting of a nuclear localization signal sequence (NLS) or a nucleolar localization signal sequence (NoLS) to enhance TNFR2 expression in the cells.

Abstract: An advantage of some aspects of the invention is to provide an antibody against an amyloid precursor protein signal peptide. The invention provides an amyloid precursor protein signal peptide.

Abstract: The purpose of the present invention is to provide an adhesive composition leading to sufficient adhesive strength when used for bonding to a polyolefin resin molded article that bonds poorly with other members. Another purpose of the present invention is to provide an adhesive composition having excellent heat resistance (heat resistant adhesion) in the bonded part of a composite body obtained by joining a polyolefin resin-formed body and other member. This adhesive composition contains an organic solvent, a carboxyl group-containing polyolefin resin which is dissolved in this organic solvent and which has a melt flow rate of 5 to 40 g/10 min when measured at 130° C., and a polyfunctional isocyanate compound. This adhesive composition may further contain a carboxyl group-containing polyolefin resin having a melting point of 120° C. to 170° C.

Abstract: The present invention is a method for producing solvent-soluble polysiloxanes which includes a condensation process of subjecting a raw material having siloxane-bond-forming groups to hydrolytic copolycondesation in the presence of a catalyst to synthesize a reactive polysiloxane represented by general formula (1), the raw material containing both an organosilicon compound (S1) having a (meth)acryloyl group and siloxane-bond-forming groups and at least one silicon compound (S2) selected from among tetraalkoxysilanes and tetrahalogenosilanes, wherein in the condensation process, the organosilicon compound (S1) and silicon compound (S2) are used at a (S2)/(S1) molar ratio of 1.

Abstract: The present invention is a method for manufacturing a reactive polysiloxane solution, the method comprising: a condensation process for hydrolyzing and copolycondensing a starting compound containing an organosilicon compound having a reactive functional group selected from a (meth)acryloyl group and an oxetanyl group, and also having a siloxane bond-forming group to synthetize a reactive polysiloxane represented by general formula (1); a dissolution process for dissolving the obtained reactive polysiloxane in an organic solvent for water washing; and a washing process for bringing the obtained organic solution and water in contact with each other to remove the water layer from the mixed liquid. The organic solvent for water washing that is used is a compound (e.g., propylene glycol mono butyl ether, 1-pentanol) including a hydroxyl group, having a boiling point at 1 atm of 110° C.-200° C., and a solubility of 10 g or less in 100 g of water at 20° C.

Abstract: A method for transferring a foreign substance includes the steps of: preparing a construct for transferring a foreign substance that contains a carrier peptide fragment including either the amino acid sequence KKRTLRKNDRKKR (SEQ ID NO. 1) or an amino acid sequence formed by the substitution, deletion, and/or addition (insertion) of 1, 2, or 3 amino acid residues in the amino acid sequence, and a foreign substance of interest that is bonded to the N-terminus and/or C-terminus of the carrier peptide fragment; supplying the construct for transferring a foreign substance to a test sample that contains a target eukaryotic cell; and incubating the test sample that has been supplied with the construct for transferring a foreign substance to thereby transfer the construct into the eukaryotic cell in the test sample.

Abstract: Conventional tannic acid and polyphenol anti-allergen agents are known as anti-allergen agents capable of deactivating allergens such as mites and pollen, but these agents have inferior heat resistance and pose problems with coloration, discoloration and elution. The purpose of the present invention is to provide an anti-allergen agent that has excellent heat resistance, shows no coloration, and has excellent water resistance and workability. It was discovered that using an inorganic substance having a high acid site concentration with acid site concentration being defined as the number of acid sites having a pKa of 4.8 or less, it is possible to realize an anti-allergen that manifests strong anti-allergen effects, has excellent heat resistance and water resistance, shows little coloration, and has excellent workability.

Abstract: An adhesive composition is provided particularly excellent in thermal shock resistance for adhesive strength as well as high shear adhesive strength, peel adhesive strength and impact adhesive strength. The adhesive composition of the present invention contains (a) a 2-cyanoacrylate such as 2-ethoxyethyl 2-cyanoacrylate and (b) a polyfunctional cyanoacrylate having two or more 2-cyanoacryloyl groups, the number average molecular weight of the polyfunctional cyanoacrylate (b) is in the range from 1,000 to 50,000, and preferably from 2,000 to 30,000, and the content of the polyfunctional cyanoacrylate (b) is in the range from 1 to 400 parts by weight, and preferably from 1 to 200 parts by weight based on 100 parts by weight of the 2-cyanoacrylate (a).

Abstract: This invention is drawn to a curable composition that has excellent smoothness when a plastic substrate is coated therewith. Also disclosed are active energy beam curable compositions, such as actinically curable compositions, that can be cured without using a photopolymerization initiator, or with the use of a small amount thereof. This object is achieved by the presence of surface treated inorganic oxide microparticles. Such particles are obtained by reacting an alkoxysilane compound (a1) represented by the Formula (1) below and inorganic oxide microparticles (a2) in the presence of water and an organic solvent: (P—SiO3/2)1-a(P—Si(R0)O2/2)a(O1/2R3)z (1) in which P denotes a maleimide containing group, R3 denotes a hydrogen atom or a monovalent organic group, R0 denotes a monovalent organic group, a is 0 or a positive number and satisfies 0?a <1, and z is a positive number and satisfies 0.1 ?z ?2.

Abstract: The present invention relates to an additive for use in the molding of a ceramic material, which exhibits satisfactory water absorption performance in a ceramic green ceramic clay, can highly achieve both high fluidability and low loading performance during extrusion molding and high shape-retaining performance after extrusion at the same time, and comprises polymer microparticles. This additive for use in the molding of a ceramic material comprises polymer microparticles, is characterized in that the polymer microparticles have an average particle size between 10 and 150 ?m when the polymer microparticles are swollen with ion exchange water until the swollen polymer microparticles reach a saturated state and can absorb 10-60 mL/g of ion exchange water under ordinary pressure, and is also characterized in that an aqueous dispersion prepared by dispersing 1 part by mass of the polymer microparticles in 110 parts by mass of ion exchange water has an electrical conductivity of 1500 ?S/cm or less at 25° C.

Abstract: [Object] The object of the invention is to provide a granular antimicrobial agent for water processing which has sufficient water permeability and antimicrobial effect, and the effective duration of which can be readily ascertained when used as a water-processing antimicrobial agent in the home. [Means for Solving the Problems] A granular antimicrobial agent for water processing which has a solubility at 25° C. of preferably 0.1 mg/g·L·hour to 1 mg/g·L·hour, comprises 0.5 wt % to 4 wt % of Ag2O, 2 wt % to 10 wt % of K2O, 35 wt % to 50 wt % of SiO2, and 40 wt % to 55 wt % of B2O3, and has a semispherical or conical shape in part was found. In addition, the inventors found that the antimicrobial agent is highly suitable for use in various kinds of water processing, particularly, the antimicrobial treatment of water used for washing, and completed the invention.

Abstract: The present curable composition comprises an organosilicon compound produced by hydrolysis copolycondensation of (A) a silicon compound R0Si(R1)nX13-n [wherein R0 represents a (meth)acryloyl group; and X1 represents a hydrolyzable group] and (B) a silicon compound SiY14 [wherein Y1 represents a siloxane-bond forming group] under an alkaline condition at a ratio of compound (A) to compound (B) of 1:(0.3 to 1.8) by mol. The present process for producing an organosilicon compound comprises a reaction process of conducting alcohol exchange reaction of a silicon compound SiY24 [wherein Y2 represents a siloxane-bond forming group] in 1-propanol to produce a composition; and a condensation process of adding a silicon compound R0Si(R1)nX23-n [wherein R0 represents a (meth)acryloyl group; and X2 represents a hydrolyzable group] to the composition to perform the hydrolysis copolycondensation of the silicon compounds under alkaline conditions.

Abstract: A cell growth inhibitor that includes, as an antibody component, an artificially produced anti-EGFR antibody having specific binding capacity to EGFR which is characterized in that an epitope therefor is in a cysteine-rich subdomain 2 (C2 domain) and/or in a ligand-binding domain 1 (L1 domain) among four subdomains contained in the extracellular domain of EGFR.

Abstract: An adhesive composition for medical use of the present invention includes an acrylic copolymer, a medicament having a carboxyl group, and a base, the acrylic copolymer is prepared by copolymerization of a monomer mixture containing 0.1 to 2 mass % of an ethylenically unsaturated carboxylic acid monomer as a monomer A, 58 to 99.9 mass % of an alkyl(meth)acrylate ester having an alkyl group of 4 to 12 carbon atoms as a monomer B, 30 mass % or less of an alkyl(meth)acrylate ester having 1 to 3 carbon atoms as a monomer C, and 30 mass % or less of a monomer having an ethylenically unsaturated group other than those of the monomers A to C (the total of monomers A to D is taken as 100 mass %) as a monomer D, and the content of sulfuric acid in the acrylic copolymer is 700 ppm by mass or less.

Abstract: A process for producing polymer microparticles by suspension polymerization of a vinyl-based monomer in which, when polymer microparticles are produced by suspension polymerization of a vinyl-based monomer, a macromonomer having a radically polymerizable unsaturated group at a terminus of a vinyl-based monomer-derived polymer is used as a dispersion stabilizer.

Abstract: The pharmaceutical composition includes at least one pharmaceutically acceptable carrier, and an active ingredient including an artificially synthesized peptide includes: (A) an amino acid sequence constituting a cell-penetrating peptide and (B) an amino acid sequence constituting the signal peptide in amyloid precursor protein (APP) or an N-terminal partial amino acid sequence or C-terminal partial amino acid sequence from the amino acid sequence constituting that signal peptide.

Abstract: A curing-type coating-agent composition according to the present invention contains: Component (A) including a urethane adduct compound exhibiting weatherability in an amount of from 99 to 65 parts by mass; Component (B) comprising a reaction product between a colloidal silica and an alkoxysilane compound having a maleimide group in an amount of from 1 to 35 parts by mass; a radical-polymerization initiator serving as Component (C) in an amount of from 0.1 to 10 parts by mass; an ultraviolet absorber serving as Component (D) in an amount of from 1 to 12 parts by mass; and an organic solvent serving as Component (E) in an amount of from 10 to 1,000 parts by mass; with respect to a sum of Component (A) and Component (B) being taken as 100 parts by mass. The composition according to the present invention demonstrates excellent wear resistance and weatherability as a coating agent for plastic substrate, or the like, which is employed outside.

Abstract: The object of the present invention is to provide a process for producing a high-quality polymer microparticle having uniform particle size of the order of several micrometers to tens of micrometers by inverse suspension polymerization at high productivity while keeping excellent dispersion stability without causing aggregation among particles. The process is one for the production of polymer microparticles by inverse polymerization of a vinyl monomer and is characterized in that the inverse suspension polymerization is conducted dividing at least two steps, an oil-soluble oxidizing agent and a water-soluble reducing agent are used as a polymerization initiator, and the oil-soluble oxidizing agent is fed after the water-soluble reducing agent is fed.