Abstract: This invention provides a pharmaceutical composition for treating or preventing synucleinopathy comprising a compound represented by formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: An example system includes a physiological sensor for generating physiological data associated with a user bearing the physiological sensor. The physiological sensor is configured to wirelessly communicate the physiological data. A portable device includes a touch input device; an accelerometer for generating accelerometer data indicative of activity of the user; wireless communication circuitry for receiving the physiological data; memory for storing the accelerometer data and the physiological sensor data; and a vibrator for providing tactile output to the user. The wireless communication circuitry transmits the physiological data and the accelerometer data to a computer device for use in a presentation application.

Abstract: A small and inexpensive plasma actuator is capable of accelerating induced flow and increasing the effect of controlling flow. A plurality of electrode pairs are disposed on a dielectric layer upstream to downstream along a predetermined direction. Each electrode pair includes an upstream electrode disposed on one surface of the dielectric layer and a downstream electrode disposed on another surface of the dielectric layer to sandwich the dielectric layer between the upstream electrode. A lowest electrode is on the one surface of the dielectric layer displaced downstream from the downstream electrode in an the most downstream electrode pair to have the same potential as the downstream electrode. A voltage application device is configured to apply voltage including AC voltage or repeated pulse voltage to each electrode pair such that the potential of the applied voltage inverts at adjacent electrode pairs.

Abstract: A magnetic material includes a structure in which a first magnetic layer 1 and a second magnetic layer 2 are stacked such that each layer is formed at least partially in a stacking direction by substantially one atomic layer. The first magnetic layer contains Co as a principal component. The second magnetic layer includes at least Ni. The magnetic material has magnetic anisotropy in the stacking direction. Preferably, an atomic arrangement within a film surface of the first magnetic layer and the second magnetic layer has six-fold symmetry.

Abstract: A method for producing a three-dimensional structure, a method for producing a vertical transistor, a vertical transistor wafer, and a vertical transistor substrate, capable of suppressing the emission of Si due to a heat treatment and making an interface between an oxide film and a core mainly consisting of Si relatively smooth include: forming a three-dimensional shape by processing (for example, by etching) a surface layer of a monocrystalline silicon substrate, the surface layer having an oxygen concentration of 1×1017 atoms/cm3 or more; and then forming an oxide film on the surface of the three-dimensional shape by performing a heat treatment. The three-dimensional structure has a shape having projections and recesses in a thickness direction of the silicon substrate, and a height in the thickness direction of the silicon substrate is between 1 nm and 1000 nm, and preferably between 1 nm and 100 nm.

Abstract: A dried tissue model includes a dried hydrogel which is a dried product of a hydrogel composition, in which when a solvent with which the dried hydrogel can be impregnated is used as a second solvent and the dried hydrogel is impregnated with the second solvent to form an impregnated hydrogel, the impregnated hydrogel satisfies at least one of the following: the impregnated hydrogel has a modulus of elasticity in shear of 0.9×102 to 2.1×102 kPa; the impregnated hydrogel has a viscosity of 4.8 to 17.6 kPa; and the ratio of a second Young's modulus at a strain of 0.5 of the impregnated hydrogel to a first Young's modulus at a strain of 0.5 of the hydrogel composition is 0.39 to 0.69.

Abstract: A data write device for a resistive memory element, the resistive memory element including: a conductive electrode provided at one end of the memory element; and a reading electrode provided at the other end of the memory element being configured to vary a resistance of the memory element by applying a write current to the conductive electrode, the data write device for the resistive memory element further includes: a writing means, an output means, and a control means. The output means is provided between a power supply and the reading electrode. As output signals, a read signal from the memory element and a monitor signal to monitor a writing status of the memory element written by the writing means are output from the output means. By the monitor signal, a termination of data-writing into the resistive memory element is detected.

Abstract: A perimeter 2 capable of acquiring, as a threshold SV, a value corresponding to a response result of a subject 22 to an optotype presented with various brightness, for measurement points set across an entire measurement field of view of the ocular fundus, displaying the threshold SV as a threshold inspection result SHR and storing the same in a memory 13, comprises: a portion 15 for obtaining a pattern deviation PDV of the threshold SV relating to each measurement point RG, from the threshold inspection result SHR; a portion for 15 for obtaining a P value representing the obtained pattern deviation PDV for each measurement point RG as a probability variable, and generating a probability map image MAP4 indicating the measurement points RG separately for each P value; a portion 16 for selecting, from an abnormal measurement point group RG of points in the probability map image MAP4 in which at least a prescribed number of measurement points having a P value at most equal to 5% are continuous, and, of those, for

Abstract: Provided is an optimal intralymphatic preparation containing agents such as a drug, a cell, or a nucleic acid for use in a lymphatic drug delivery system. A drug-containing liquid preparation for delivering a chemical to a target lymph node by a lymphatic drug delivery system, wherein the liquid has an osmotic pressure of 700 to 2,700 kPa.

Abstract: An artificial shuttlecock feather for implanting in a circular ring shape into a shuttlecock base, including: a vane section and a rachis section having one end in an axial direction of the rachis section fixed to the base and supporting the vane section provided to another end side of the rachis section, a hole being formed in the vane section so as to penetrate the vane section, and a porosity of a first region of the vane section being lower than a porosity of a second region of the vane section, the first region spanning from an edge on the one end side in the axial direction to a predetermined position further toward the one end side than a center of vane section in the axial direction, the second region spanning from the predetermined position to an edge on the other end side in the axial direction.

Abstract: The purpose of the present invention is to provide a novel medical application of pluripotent stem cells (muse cells) in regeneration medicine. The present invention provides a cell preparation and a pharmaceutical composition which are for amelioration and treatment of brain disorders resulting from fetal growth retardation, such as abnormal motor quality or abnormal neurological development, and which contain SSEA-3 positive pluripotent stem cells isolated from a mesenchymal tissue from a live body or cultured mesenchymal cells. It is assumed that this cell preparation is based on a mechanism where muse cells that are administered to objects having the disorders are engrafted on an impaired brain tissue, thereby ameliorating or treating the disorders.

Abstract: An object of the present invention is to provide an improved detection method for a specimen substance in a sample. The present invention provides a multiphase polymer fine particle having two or more polymer phases formed by aggregation of two or more polymers, respectively, at least on a surface thereof, wherein a first polymer phase can bind to a specimen substance or a substance that can specifically bind to the specimen substance, and a second polymer phase has a labeling substance. By utilizing the fine particle, the specimen substance in the sample having a biological origin or the like can be quickly detected with high sensitivity.

Abstract: An electrochemical measurement method for electrochemically measuring a chemical substance generated or consumed in a biological sample in a solution is provided which includes performing measurement by placing the biological sample at a distance away from an electrode surface in the direction perpendicular to the electrode surface. The distance is determined in advance on the basis of simulation in which a current flows through a working electrode.

Abstract: A switching circuit device includes high-side and low-side switching element circuits, and high-side and low-side drive circuits. The high-side switching element circuit includes a high-side switching element connected between an output terminal and a high-voltage terminal of a high voltage source. The low-side switching element circuit includes a low-side switching element connected between the output terminal and a reference potential terminal. The high-side drive circuit turns on the high-side switching element. The low-side drive circuit turns on the low-side switching element. The high-side drive circuit includes a bootstrap capacitor connected to a drive power source. The bootstrap capacitor is charged while the low-side switching element is ON. The high-side drive circuit applies a gate voltage to the high-side switching element while the low-side switching element is OFF. The gate voltage is defined by adding a voltage of the output terminal to a voltage of the bootstrap capacitor.

Abstract: A position detection device is a position detection device installed in an apparatus, and detecting a position of the apparatus, and includes an acceleration sensor configured to detect acceleration information of the apparatus, a static acceleration removing unit configured to remove static acceleration information indicating acceleration information in a static state of the apparatus, from the acceleration information detected by the acceleration sensor, and generate movement acceleration information indicating acceleration information in a moving state of the apparatus, an error deriving unit configured to derive an error component contained in the movement acceleration information, an acceleration correcting unit configured to correct the movement acceleration information by subtracting the error component from the movement acceleration information, and a position information acquiring unit configured to acquire position information of the apparatus based on the corrected movement acceleration information

Abstract: A pathogen and pest exterminating device that can efficiently exterminate pathogens and pests in a shorter time. One electrode includes a part to be inserted into a reaction vessel, and other electrode is arranged in a position that opposes the insertion part. A water supply unit is provided to supply water to the reaction vessel through the insertion part, and a gas supply unit provided of supplying gas, which will become plasma, to the reaction vessel. A power supply unit is provided to be capable of applying voltage between the insertion part and the other electrode such that OH radicals are generated inside the reaction vessel to which the water and the gas are supplied. The insertion part is formed in a shape that restricts, between itself and the other electrode, a flow rate of water from the water supply unit such as a coil, waveform, or mesh shape.

Abstract: Provided is a liquid droplet collection device including: a substrate having a hydrophobic surface; and a hydrophilic channel arranged in the hydrophobic surface, wherein the hydrophilic channel includes: a first-generation channel including a plurality of tapered channel portions radially extending from an origin point and monotonically tapering with increasing distance from the origin point; and a second-generation channel that includes a plurality of tapered channel portions radially extending from an origin point and monotonically tapering with increasing distance from the origin point, and is scaled down in size as compared to the first-generation channel, wherein the second-generation channel is joined to the first-generation channel to face the same direction as the first-generation channel, and wherein one of the tapered channel portions of the second-generation channel overlaps a distal end portion of one of the tapered channel portions of the first-generation channel, and the hydrophilic channel mon

Abstract: The present invention provides a pharmaceutical composition for treating or preventing a cognitive disease or disorder, comprising a compound represented by Formula (I), an enantiomer thereof a diastereomer thereof, or a pharmaceutically acceptable salt thereof.

Abstract: A light-receiving device that achieves both high saturation performance and high sensitivity performance includes a light-receiving pixel including a light-receiving element, a first capacitive element that accumulates a photoelectric charge produced by light received by the light-receiving element, a second capacitive element that accumulates a transferred portion of an amount of the photoelectric charge accumulated in the capacitive element, a switch means for turning on and off a photoelectric charge transfer operation from the capacitive element to the capacitive element, a resetting switch means for resetting the capacitive element and the capacitive element, a pixel selecting switch means, and a source follower switch means. An effective saturation capacity of the capacitive element is 10 to 5,000 times an effective saturation capacity of the capacitive element.

Abstract: The route control method and the route setting device according to the present invention is configured such that a learning unit is prepared for each path, a function form of the learning unit of the path in forwarding a packet is adjusted by having traffic information (packet arrival rate, queue length, and the like) and congestion information (congested or not congested) of this path as teacher data, and when this path is congested, changing to a path with an output of no congestion among the learning units is executed. Thus, since the learning unit optimizes the function form, changing to an alternative path can be immediately executed even when the congestion incidentally occurs on the path.