Abstract: The present invention provides a useful medicament for the treatment and/or prophylaxis of a disease associated with the enhancement of OPN production including cancer, which comprises a compound of formula: wherein R1, R2, R3, R4, R5, R6, R7, m, n, p, X, and Y are as defined in the specification, a pharmaceutically acceptable salt thereof.

Abstract: An ultrasonic transverse wave is transmitted or ultrasonic longitudinal wave and transverse wave are transmitted in a perpendicular direction to a bonding interface between materials by transmission such as a probe. A reflection signal of the transmitted transverse wave reflected by the bonding interface and/or a transmission signal of the transmitted transverse wave transmitted through the bonding interface and the longitudinal wave, a reflection signal of the transmitted longitudinal wave reflected by the bonding interface and/or a transmission signal of the transmitted longitudinal wave transmitted through the bonding interface are received by reception such as the probe.

Abstract: An optical connector ferrule, an optical connector, and a composite fiber connecting assembly are provided. The optical connector ferrule includes a stationary ferrule having a first through-hole, a composite fiber, and a connecting ferrule having a second through-hole. The composite fiber includes a first optical fiber and a signal wire, and is placed in the first through-hole in the stationary ferrule. The connecting ferrule includes a conductive path. The stationary ferrule has a second end face abutting a third end face of the connecting ferrule. The first optical fiber has an end connected to an end of the second through-hole. The signal wire and the conductive path are connected to each other.

Abstract: An energy converter is formed by bonding a solid soft magnetic material and a solid magnetostrictive material. A vibration power generator is configured to generate power by means of the inverse magnetostriction effect of the magnetostrictive material produced by the vibration of a vibration unit configured using the energy converter. A force sensor device includes a force detection unit that detects magnetization change resulting from the inverse magnetostriction effect of the magnetostrictive material produced when a sensor unit configured using the energy converter deforms, and determines force acting on the sensor unit on the basis of the detected magnetization change. An actuator is configured to vibrate the vibration unit configured using the energy converter by means of the magnetostriction effect of the magnetostrictive material.

Abstract: To provide a vibrator made of a piezoelectric crystal having a larger electromechanical coupling coefficient and a more satisfactory frequency-temperature characteristic than those of quartz, a vibrating piece (101) is made of a Ca3Ta(Ga1-xAlx)3Si2O14 single crystal (0<x?1). In the single crystal, letting ? be a rotation angle from an X-Z plane about an X-axis serving as a rotation axis, 18x+17.5???24x+24.5 is set. In addition, the vibrating piece (101) is made of a Ca3Nb(Ga1-xAlx)3Si2O14 single crystal (0<x?1). In the single crystal of this arrangement, letting ? be a rotation angle from an X-Z plane about an X-axis serving as a rotation axis, 25x+23.083???32x+26.167 is set.

Abstract: Conventional ozone water is still insufficient in the removal rate and cleaning ability of resist required in today's semiconductor manufacturing field, and it does not fully meet the expectation of further improvement in the effects of sterilization, deodorization, and cleaning in the fields such as cleaning of foodstuffs, cleaning of process equipment and tools, and cleaning of fingers, as well as in the fields such as deodorization, sterilization, and preservation of freshness of foodstuffs. The above-problem can be solved by defining the values of a plurality of specific production parameters in the production of ozone water into specific ranges.

Abstract: A method for producing a cinnamic acid ester derivative includes reacting a cinnamic acid derivative compound represented by the formula (1), wherein the symbols are as defined in the description, with an alcohol compound represented by the formula: R6OH, wherein the symbol is as defined in the description, in the presence of a strong acid resin catalyst without using a solvent. As the cinnamic acid derivative compound, cinnamic acid, ferulic acid, and caffeic acid are preferred, and as the alcohol compound, methanol, ethanol, propanol, butanol, pentanol, hexanol, ethylene glycol, glycerol, phenethyl alcohol, and a monosaccharide are preferred.

Abstract: Provided is a mutant filamentous fungus, which lacks expression of ?-1,3-glucan, and is deficient in at least part of a GAG biosynthetic cluster. Also provided is a method of producing a substance, including the steps of: culturing the filamentous fungus to allow the filamentous fungus to produce a substance; and collecting the resulting substance.

Abstract: An object to be achieved by the present invention is to culture a filamentous fungus at a high density, thereby enabling mass production of a useful substance. The present invention provides a method of producing a substance, including the steps of: culturing a mutant filamentous fungus with no expression of ?-1,3-glucan to allow the filamentous fungus to produce a substance; and collecting the resulting substance.

Abstract: An electrochemical measurement method is provided in which a working electrode that causes an oxidation-reduction reaction with a measurement target and a counter electrode connected to the working electrode are provided in an electrolytic solution containing the measurement target, and a measuring voltage is applied between the working electrode and the counter electrode to measure a current that flows between the working electrode and the counter electrode in proportion to the amount of the measurement target, wherein an eliminating electrode is provided in the electrolytic solution, and the method performs: eliminating the measurement target by applying an eliminating voltage, which has the same polarity as the measuring voltage, between the eliminating electrode and the counter electrode to oxidize or reduce the measurement target; diffusing a new measurement target; and measuring the current by applying the measuring voltage between the working electrode and the counter electrode.

Abstract: [Problem] The present invention provides an industrially-preferable, cost-efficient, low-cost production method for 4-hydroxy-2-hydroxymethyl-2-cyclopenten-1-one (a compound represented by formula (I)) useful as a medicine, an agricultural chemical, or a raw material or intermediate of a medicine, an agricultural chemical, or the like. [Solution] According to the present invention, this compound represented by formula (I) is produced by subjecting an easily available compound represented by formula (II) (tri-O-acetyl-D-glucal) to a heating reaction in pressurized water.

Abstract: Provided is a method of culturing mesenchymal stem cells as a cell construct while maintaining undifferentiation thereof, the method including subjecting mesenchymal stem cells to shaking culture.

Abstract: The present invention provides an apparatus for applying electrical stimulation to cells in a liquid culture medium without using electrodes immersed in the liquid culture medium. This apparatus is an electrical stimulation apparatus A for electrically stimulating cells in a liquid culture medium (2). A liquid culture medium vessel (3) includes: a ring-shaped recess (7) for holding the liquid culture medium (2); and a through hole (6) formed within the ring-shaped recess (7). A magnetic core (1) is made of a magnetic material and disposed such that a portion thereof is inserted through the through hole (6) of the liquid culture medium vessel (3). An excitation coil (5) is wound around the magnetic core (1). A coil power supply (8) supplies a varying current to the excitation coil (5).

Abstract: An object of the present invention is to provide a novel medical application to regenerative medicine that uses pluripotent stem cells (Muse cells). The present invention provides a cell preparation for treating cerebral infarction and sequelae associated therewith that contains SSEA-3-positive pluripotent stem cells isolated from mesenchymal tissue in the body or cultured mesenchymal cells. The cell preparation of the present invention is based on a brain tissue regeneration mechanism by which Muse cells differentiate into nerve cells and the like in damaged brain tissue by administering Muse cells into cerebral parenchyma.

Abstract: A magnetoresistance effect element is provided, which can, even in a region where the element size of the magnetoresistance effect element is small, implement stable record holding at higher temperatures, and moreover which has higher thermal stability. The magnetoresistance effect element has a configuration including reference layer (B1)/first non-magnetic layer (1)/first magnetic layer (21)/first non-magnetic insertion layer (31)/second magnetic layer (22). A magnetostatic coupling is established between the first magnetic layer (21) and the second magnetic layer (22) due to magnetostatic interaction becoming dominant.

Abstract: The present invention relates to a food composition comprising an alkalinizing agent, particularly an alkali metal salt of citric acid. Ingestion of the food composition maintains kidney function.

Abstract: A random number generator according to one embodiment includes a write circuit, a read circuit, and a signal output circuit. The write circuit inverts magnetization of a magnetic layer of a magnetic tunnel junction element stochastically by supplying current to the magnetic layer. The read circuit reads the magnetization. The signal output circuit generates a random number on the basis of the magnetization read by the read circuit. The random number generator includes a sequence control circuit that controls the write circuit and the read circuit. The sequence control circuit regulates the write circuit to supply the current to the write circuit in a first period, and causes the read circuit to read the magnetization after the first period is finished and then a second period longer than the first period is elapsed.

Abstract: An amorphous soft magnetic alloy of the formula (Fe1-?TM?)100-w-x-y-zPwBxLySiz TipCqMnrCus, wherein TM is Co or Ni; L is Al, Cr, Zr, Mo or Nb; 0???0.3, 2?w?18 at %, 2?x?18 at %, 15?w+x?23 at %, 1<y?5 at %, 0?z?4 at %; p, q, r, and s represents an addition ratio such that the total mass of Fe, TM, P, B, L and Si is 100, and 0?p?0.3, 0?q?0.5, 0?r?2, 0?s?1 and r+s>0; the composition fulfills one of the following conditions: L is Cr, Zr, Mo or Nb; or L is a combination of Al and Cr, Zr, Mo or Nb, wherein 0<Al?5 at %, 1?Cr?4 at %, 0<Zr?5 at %, 2?Mo?5 at %, and 2?Nb?5 at %; the alloy has a crystallization start temperature (Tx) which is 550° C. or less, a glass transition temperature (Tg) which is 520° C. or less, and a supercooled liquid region represented by ?Tx=Tx?Tg, which is 20° C. or more.

Abstract: A process for producing a molded material that can form metallic glass material in a state of lower viscosity, and can manufacture a small structure of several 10 ?m or less in a comparatively short time while precisely controlling shape thereof, by the process comprising a heating step of heating supercooled state metallic glass material or a solid metallic glass material at a temperature increase rate of 0.5 K/s to a temperature at or higher than a temperature at which a crystallization process for a supercooled liquid of the metallic glass material begins, and a molding step of transfer molding the metallic glass material until the crystallization process for the supercooled liquid of the metallic glass material has been completed. In addition, the purpose is also to provide the molded material that has been formed by this process, a wavefront control element, and a diffraction grating.

Abstract: A sputtering target for magnetic recording media capable of producing a magnetic thin film in which the magnetic crystal grains are micronized and the distance between the centers of the grains is reduced while good magnetic properties are maintained. The target including metallic Pt and an oxide, with the balance being metallic Co and inevitable impurities, wherein the Co is contained in a range of 70 at % to 90 at % and the Pt is contained in a range of 10 at % to 30 at % relative to a total of metallic components in the sputtering target for magnetic recording media, the oxide is contained in a range of 26 vol % to 40 vol % relative to a total volume of the sputtering target for magnetic recording media, and the oxide is composed of B2O3 and one or more high-melting-point oxides having a melting point of 1470° C. or higher and 2800° C. or lower.