Patents Assigned to Tohoku University
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Publication number: 20230154851Abstract: Provided is a semiconductor device, which has a wiring structure including a single-layer diffusion barrier layer having both a diffusion barrier function and a liner function. The semiconductor device has a wiring structure including an insulating layer, a conductive wiring, and a diffusion barrier layer disposed between the insulating layer and the conductive wiring in a manner of being in contact with both the insulating layer and the conductive wiring. The diffusion barrier layer is made of an alloy having an amorphous structure containing a first metal and a second element in an amount of 90% by mass or more in total. The first metal is any one selected from Co, Ru, and Mo. The second element is one or two or more selected from Zr, Al, and Nb when the first metal is Co, the second element is Zr when the first metal is Ru, and the second element is one or two selected from Y and B when the first metal is Mo.Type: ApplicationFiled: June 4, 2020Publication date: May 18, 2023Applicant: Tohoku UniversityInventors: Junichi KOIKE, Masataka YAHAGI, Yuki YAMADA
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Patent number: 11644430Abstract: A high-sensitive phase imaging is achieved using a grating section without upsizing the imaging device or narrowing the period of the gratings. A radiation source generates radiation on a radiation path toward the grating section. The grating section comprises a G1 grating and a refraction-enhancing grating. The G1 grating has a G1 periodic structure that forms radiation converging points where an intensity of the radiation is increased between the G1 grating and a detector. The refraction-enhancing grating is located at the position of the radiation converging points and has enhancement planes and that increase the refraction angle of the radiation. The detector detects the radiation that has passed through the grating section.Type: GrantFiled: January 24, 2020Date of Patent: May 9, 2023Assignee: Tohoku UniversityInventor: Atsushi Momose
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Patent number: 11608545Abstract: A conductive supporting member includes an outer portion that includes a Cu matrix phase and a second phase dispersed in the Cu matrix phase and containing a Cu—Zr compound and that has an alloy composition represented by Cu-xZr (x is atomic % of Zr and 0.5?x?16.7 is satisfied) and an inner portion that is present on an inner side of the outer portion, is formed of a metal containing Cu, and has higher conductivity than the outer portion.Type: GrantFiled: April 25, 2019Date of Patent: March 21, 2023Assignees: NGK Insulators, Ltd., Tohoku UniversityInventors: Takashi Goto, Hirokazu Katsui, Naokuni Muramatsu, Takanari Nakajima
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Patent number: 11608313Abstract: The present invention provides a pharmaceutical composition for treating or preventing a cognitive disease or disorder, comprising a compound represented by Formula (I), an enantiomer thereof a diastereomer thereof, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: August 2, 2018Date of Patent: March 21, 2023Assignee: Tohoku UniversityInventors: Shigeki Moriguchi, Kohji Fukunaga, Yoshiharu Iwabuchi
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Publication number: 20220363987Abstract: An object of the present invention is to provide a scintillator having a high radiation stopping power, and having a shorter fluorescence decay time compared to conventional scintillators. The above object is achieved by setting the composition of a scintillator to a composition represented by General Formula (1). QxMyO3z??(1) (wherein in General Formula (1), Q includes at least two or more divalent metallic elements; M includes at least Hf; and x, y, and z independently satisfy 0.5?x?1.5, 0.5?y?1.5, and 0.7?z?1.5, respectively).Type: ApplicationFiled: July 19, 2022Publication date: November 17, 2022Applicants: Mitsubishi Chemical Corporation, Tohoku UniversityInventors: Koji Hazu, Kentaro Horibe, Keiji Yamahara, Sunsuke Kurosawa, Akira Yoshikawa
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Publication number: 20220326400Abstract: The present invention aims to provide a scintillator which has a short fluorescence decay time, whose fluorescence intensity after a period of time following radiation irradiation is low, and which shows largely improved light-transmittance. A scintillator represented by the following General Formula (1), the scintillator including Zr, having a Zr content of not less than 1500 ppm by mass therein, and being a block of a sintered body. QxMyO3z:A . . . (1) (wherein in General Formula (1), Q includes at least one or more kinds of divalent metallic elements; M includes at least Hf; and x, y, and z independently satisfy 0.5?x?1.5, 0.5?y?1.5, and 0.7?z?1.5, respectively).Type: ApplicationFiled: June 23, 2022Publication date: October 13, 2022Applicants: Mitsubishi Chemical Corporation, Tohoku UniversityInventors: Koji Hazu, Kentaro Horibe, Tetsuya Kawano, Keiji Yamahara, Shunsuke Kurosawa, Akira Yoshikawa
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Patent number: 11448563Abstract: One aspect of the present invention is a force measurement method including a first acquisition step in which, among data included in time course data indicating a movement trajectory of cargo acquired in a non-invasive manner, first data indicating a temporal change of a position of the cargo during a period in which the displacement of the cargo per unit time is substantially constant is acquired, a fluctuation value calculation step in which, based on a first probability distribution indicating a distribution of a probability that the amount of change at a predetermined position of the cargo per unit time is a predetermined amount, which is a probability distribution based on the first data, a fluctuation value proportional to a force applied to the cargo by motor proteins that transport the cargo is calculated, and a force calculation step in which the force is calculated based on the calculated fluctuation value.Type: GrantFiled: October 30, 2018Date of Patent: September 20, 2022Assignee: Tohoku UniversityInventors: Kumiko Hayashi, Yasushi Okada
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Patent number: 11407772Abstract: The present invention provides: industrially desirable and novel optically-active cyclopentenone derivatives; and a novel industrial manufacturing method. The novel optically-active cyclopentenone derivatives and method for manufacturing the same are, respectively: an intermediate for industrially desirable and novel prostaglandin derivatives and the like; and a method for manufacturing the same. It is expected that the present invention will be commercialized and industrialized.Type: GrantFiled: September 13, 2019Date of Patent: August 9, 2022Assignees: Tohoku University, Genesis Research Institute, Inc., Ouchi Shinko Chemical Industrial Co., Ltd.Inventors: Hitoshi Kasai, Yoshitaka Koseki, Takaaki Kamishima, Shigenobu Aoyagi
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Patent number: 11306152Abstract: The present invention provides a cancer cell-specific anti-podoplanin antibody or an antigen-binding fragment thereof having an epitope in a Thr85-containing region of an amino acid sequence of human podoplanin represented by SEQ ID NO: 1, the Thr85 having a sialylated O-glycan added thereto.Type: GrantFiled: March 30, 2017Date of Patent: April 19, 2022Assignees: Tohoku University, Zenogen Pharma Co., Ltd.Inventors: Yukinari Kato, Mika Kato, Shinji Yamada, Satoshi Ogasawara, Takuro Nakamura
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Patent number: 11133743Abstract: To provide an individual boost circuit capable of boosting a minute power voltage to a target voltage more reliably. An individual boost circuit includes a first PMOS transistor that has a gate to which a first clock voltage is applied and performs on- and off-operations; a second PMOS transistor that has a gate to which a second clock voltage that has a reciprocal relation with the first clock voltage is applied and performs the on- and off-operations; an auxiliary capacitor; a boost capacitor; an auxiliary charging circuit 211 that charges an auxiliary capacitor via the second PMOS transistor with a power voltage from an external power when the first PMOS translator enters an off-state and the second PMOS transistor enters an on-state; and a boost charging circuit 212 that charges the boost capacitor via the first PMOS transistor with the second clock voltage through the auxiliary capacitor when the first PMOS transistor enters the on-state and the second switching transistor enters the off-state.Type: GrantFiled: August 26, 2019Date of Patent: September 28, 2021Assignee: Tohoku UniversityInventors: Shinya Yoshida, Tsutomu Nakamura
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Patent number: 11045425Abstract: The present invention provides a method for preparing a graft material containing organ or tissue cells, the cells including cells having inhibited PHLDA3 expression.Type: GrantFiled: May 22, 2015Date of Patent: June 29, 2021Assignees: Kyoto University, Tohoku University, Kuraray Co., Ltd.Inventors: Shoichiro Sumi, Rieko Ohki, Naoaki Sakata
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Patent number: 11014865Abstract: [Problem] The present invention provides an industrially-preferable, cost-efficient, low-cost production method for 4-hydroxy-2-hydroxymethyl-2-cyclopenten-1-one (a compound represented by formula (I)) useful as a medicine, an agricultural chemical, or a raw material or intermediate of a medicine, an agricultural chemical, or the like. [Solution] According to the present invention, this compound represented by formula (I) is produced by subjecting an easily available compound represented by formula (II) (tri-O-acetyl-D-glucal) to a heating reaction in pressurized water.Type: GrantFiled: February 12, 2019Date of Patent: May 25, 2021Assignees: Tohoku University, Genesis Research Institute, Inc.Inventors: Yoshitaka Koseki, Hitoshi Kasai, Takaaki Kamishima
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Patent number: 11000552Abstract: The purpose of the present invention is to provide a novel medicinal use in regeneration medicine, said medicinal use comprising using pluripotent stem cells (Muse cells). Provided is a cell preparation for treating skin ulcer, said cell preparation comprising SSEA-3 positive pluripotent stem cells isolated from a mesenchymal tissue of a living organism or cultured mesenchymal cells. The cell preparation according to the present invention is based on such mechanism of skin tissue regeneration that, when the Muse cells are administered to a skin ulcer site of a subject suffering from the aforesaid disease, the Muse cells differentiate into skin-constituting cells.Type: GrantFiled: February 28, 2019Date of Patent: May 11, 2021Assignees: The University of Tokyo, Tohoku UniversityInventors: Kotaro Yoshimura, Kahori Kinoshita, Mari Dezawa
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Patent number: 10944018Abstract: The present invention relates to an application liquid for forming a semiconductor film, the application liquid comprising: an inorganic semiconductor particle; and a compound having a relative permittivity of 2 or more or a compound having reducing power against the inorganic semiconductor particle; a method for producing a semiconductor film comprising a step of applying the application liquid; a semiconductor film and a semiconductor element comprising the semiconductor film; and a method for producing the semiconductor element.Type: GrantFiled: July 18, 2013Date of Patent: March 9, 2021Assignees: Asahi Kasei Kabushiki Kaisha, Tohoku UniversityInventors: Akira Watanabe, Toru Yumoto
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Publication number: 20210055542Abstract: A mirror device includes a frame body, a shaft member provided inside the frame body and connected to the frame body at both end portions, and a reflection member fixed to the shaft member and provided so as to be capable of swinging around an axis of the shaft member. The reflection member has a base portion provided along an axial direction of the shaft member and a reflection portion provided on the base portion. The base portion has a three-dimensional uneven structure including a bottom wall portion having a main surface provided along the axial direction of the shaft member and a plurality of side wall portions extending from the bottom wall portion on the side opposite to the reflection portion.Type: ApplicationFiled: August 21, 2020Publication date: February 25, 2021Applicant: Tohoku UniversityInventors: Takashi SASAKI, Kazuhiro Hane, Tung Thanh Nguyen
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Patent number: 10927454Abstract: A method of forming a nitride film wherein (a) a silane-based gas is supplied to a processing chamber through a gas supply port; (b) a nitrogen radical gas from a radical generator is supplied to the processing chamber through a radical gas pass-through port; and (c) the silane-based gas supplied in (a) is reacted with the nitrogen radical gas supplied in (b), without causing a plasma phenomenon in the processing chamber, to form a nitride film on a wafer.Type: GrantFiled: February 14, 2017Date of Patent: February 23, 2021Assignees: Toshiba Mitsubishi-Electric Industrial Systems Corporation, Tohoku UniversityInventors: Shinichi Nishimura, Kensuke Watanabe, Yoshihito Yamada, Akinobu Teramoto, Tomoyuki Suwa, Yoshinobu Shiba
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Patent number: 10906972Abstract: The present invention provides a method for producing an antibody against podocalyxin expressed specifically in cancer cells. The method includes a step of introducing a nucleic acid encoding all or a portion of podocalyxin into cells expressing a cancer cell-specific sugar chain structure to cause cancer cell-specific podocalyxin or a portion thereof to be expressed therein, a step of immunizing a non-human mammal with the cancer cell-specific podocalyxin or portion thereof to obtain antibodies, and a step of purifying the antibodies by primary screening using purified cancer cell-specific podocalyxin or a portion thereof.Type: GrantFiled: February 12, 2016Date of Patent: February 2, 2021Assignees: Tohoku University, ZENOAQ RESOURCE CO., LTD.Inventors: Yukinari Kato, Mika Kaneko, Satoshi Ogasawara
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Patent number: 10900854Abstract: Provided are a pressure sensor which exhibits exceptional performance and a method of producing the same. The pressure sensor includes: a silicon substrate having a cavity; a diaphragm which is formed of a metallic glass and has a tensile stress in a range in which a resonant frequency is higher than an audible range; and a counter electrode which is insulated from the diaphragm and has a plurality of holes. The diaphragm and the counter electrode are disposed on the silicon substrate to face each other with a gap therebetween, the diaphragm and the counter electrode being released from the silicon substrate by the cavity.Type: GrantFiled: March 27, 2017Date of Patent: January 26, 2021Assignee: Tohoku UniversityInventors: Shuji Tanaka, Joerg Froemel
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Patent number: 10894067Abstract: Disclosed is a genome stability enhancer comprising, as an active ingredient, at least one member selected from the group consisting of enzyme-treated royal jelly, gnetum or its extract, and gnetin C.Type: GrantFiled: March 6, 2018Date of Patent: January 19, 2021Assignees: Yamada Bee Company, Inc., National Cancer Center, Tohoku UniversityInventors: Tomoki Ikuta, Shinobu Fukushima, Tomoki Tatefuji, Kenichi Yoshioka, Hitoshi Shirakawa
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Patent number: RE49518Abstract: [Problem] To provide a fluorescent probe that detects calpain activity in cells at high sensitivity. [Solution] A compound represented by the following general formula (I) or a salt thereof.Type: GrantFiled: May 21, 2021Date of Patent: May 2, 2023Assignees: The University of Tokyo, Tohoku UniversityInventors: Yasuteru Urano, Yuri Nagayo, Mako Kamiya, Toru Nakazawa