Patents Assigned to Tohoku University
  • Publication number: 20230154851
    Abstract: Provided is a semiconductor device, which has a wiring structure including a single-layer diffusion barrier layer having both a diffusion barrier function and a liner function. The semiconductor device has a wiring structure including an insulating layer, a conductive wiring, and a diffusion barrier layer disposed between the insulating layer and the conductive wiring in a manner of being in contact with both the insulating layer and the conductive wiring. The diffusion barrier layer is made of an alloy having an amorphous structure containing a first metal and a second element in an amount of 90% by mass or more in total. The first metal is any one selected from Co, Ru, and Mo. The second element is one or two or more selected from Zr, Al, and Nb when the first metal is Co, the second element is Zr when the first metal is Ru, and the second element is one or two selected from Y and B when the first metal is Mo.
    Type: Application
    Filed: June 4, 2020
    Publication date: May 18, 2023
    Applicant: Tohoku University
    Inventors: Junichi KOIKE, Masataka YAHAGI, Yuki YAMADA
  • Patent number: 11644430
    Abstract: A high-sensitive phase imaging is achieved using a grating section without upsizing the imaging device or narrowing the period of the gratings. A radiation source generates radiation on a radiation path toward the grating section. The grating section comprises a G1 grating and a refraction-enhancing grating. The G1 grating has a G1 periodic structure that forms radiation converging points where an intensity of the radiation is increased between the G1 grating and a detector. The refraction-enhancing grating is located at the position of the radiation converging points and has enhancement planes and that increase the refraction angle of the radiation. The detector detects the radiation that has passed through the grating section.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: May 9, 2023
    Assignee: Tohoku University
    Inventor: Atsushi Momose
  • Patent number: 11608545
    Abstract: A conductive supporting member includes an outer portion that includes a Cu matrix phase and a second phase dispersed in the Cu matrix phase and containing a Cu—Zr compound and that has an alloy composition represented by Cu-xZr (x is atomic % of Zr and 0.5?x?16.7 is satisfied) and an inner portion that is present on an inner side of the outer portion, is formed of a metal containing Cu, and has higher conductivity than the outer portion.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: March 21, 2023
    Assignees: NGK Insulators, Ltd., Tohoku University
    Inventors: Takashi Goto, Hirokazu Katsui, Naokuni Muramatsu, Takanari Nakajima
  • Patent number: 11608313
    Abstract: The present invention provides a pharmaceutical composition for treating or preventing a cognitive disease or disorder, comprising a compound represented by Formula (I), an enantiomer thereof a diastereomer thereof, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: March 21, 2023
    Assignee: Tohoku University
    Inventors: Shigeki Moriguchi, Kohji Fukunaga, Yoshiharu Iwabuchi
  • Publication number: 20220363987
    Abstract: An object of the present invention is to provide a scintillator having a high radiation stopping power, and having a shorter fluorescence decay time compared to conventional scintillators. The above object is achieved by setting the composition of a scintillator to a composition represented by General Formula (1). QxMyO3z??(1) (wherein in General Formula (1), Q includes at least two or more divalent metallic elements; M includes at least Hf; and x, y, and z independently satisfy 0.5?x?1.5, 0.5?y?1.5, and 0.7?z?1.5, respectively).
    Type: Application
    Filed: July 19, 2022
    Publication date: November 17, 2022
    Applicants: Mitsubishi Chemical Corporation, Tohoku University
    Inventors: Koji Hazu, Kentaro Horibe, Keiji Yamahara, Sunsuke Kurosawa, Akira Yoshikawa
  • Publication number: 20220326400
    Abstract: The present invention aims to provide a scintillator which has a short fluorescence decay time, whose fluorescence intensity after a period of time following radiation irradiation is low, and which shows largely improved light-transmittance. A scintillator represented by the following General Formula (1), the scintillator including Zr, having a Zr content of not less than 1500 ppm by mass therein, and being a block of a sintered body. QxMyO3z:A . . . (1) (wherein in General Formula (1), Q includes at least one or more kinds of divalent metallic elements; M includes at least Hf; and x, y, and z independently satisfy 0.5?x?1.5, 0.5?y?1.5, and 0.7?z?1.5, respectively).
    Type: Application
    Filed: June 23, 2022
    Publication date: October 13, 2022
    Applicants: Mitsubishi Chemical Corporation, Tohoku University
    Inventors: Koji Hazu, Kentaro Horibe, Tetsuya Kawano, Keiji Yamahara, Shunsuke Kurosawa, Akira Yoshikawa
  • Patent number: 11448563
    Abstract: One aspect of the present invention is a force measurement method including a first acquisition step in which, among data included in time course data indicating a movement trajectory of cargo acquired in a non-invasive manner, first data indicating a temporal change of a position of the cargo during a period in which the displacement of the cargo per unit time is substantially constant is acquired, a fluctuation value calculation step in which, based on a first probability distribution indicating a distribution of a probability that the amount of change at a predetermined position of the cargo per unit time is a predetermined amount, which is a probability distribution based on the first data, a fluctuation value proportional to a force applied to the cargo by motor proteins that transport the cargo is calculated, and a force calculation step in which the force is calculated based on the calculated fluctuation value.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: September 20, 2022
    Assignee: Tohoku University
    Inventors: Kumiko Hayashi, Yasushi Okada
  • Patent number: 11407772
    Abstract: The present invention provides: industrially desirable and novel optically-active cyclopentenone derivatives; and a novel industrial manufacturing method. The novel optically-active cyclopentenone derivatives and method for manufacturing the same are, respectively: an intermediate for industrially desirable and novel prostaglandin derivatives and the like; and a method for manufacturing the same. It is expected that the present invention will be commercialized and industrialized.
    Type: Grant
    Filed: September 13, 2019
    Date of Patent: August 9, 2022
    Assignees: Tohoku University, Genesis Research Institute, Inc., Ouchi Shinko Chemical Industrial Co., Ltd.
    Inventors: Hitoshi Kasai, Yoshitaka Koseki, Takaaki Kamishima, Shigenobu Aoyagi
  • Patent number: 11306152
    Abstract: The present invention provides a cancer cell-specific anti-podoplanin antibody or an antigen-binding fragment thereof having an epitope in a Thr85-containing region of an amino acid sequence of human podoplanin represented by SEQ ID NO: 1, the Thr85 having a sialylated O-glycan added thereto.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: April 19, 2022
    Assignees: Tohoku University, Zenogen Pharma Co., Ltd.
    Inventors: Yukinari Kato, Mika Kato, Shinji Yamada, Satoshi Ogasawara, Takuro Nakamura
  • Patent number: 11133743
    Abstract: To provide an individual boost circuit capable of boosting a minute power voltage to a target voltage more reliably. An individual boost circuit includes a first PMOS transistor that has a gate to which a first clock voltage is applied and performs on- and off-operations; a second PMOS transistor that has a gate to which a second clock voltage that has a reciprocal relation with the first clock voltage is applied and performs the on- and off-operations; an auxiliary capacitor; a boost capacitor; an auxiliary charging circuit 211 that charges an auxiliary capacitor via the second PMOS transistor with a power voltage from an external power when the first PMOS translator enters an off-state and the second PMOS transistor enters an on-state; and a boost charging circuit 212 that charges the boost capacitor via the first PMOS transistor with the second clock voltage through the auxiliary capacitor when the first PMOS transistor enters the on-state and the second switching transistor enters the off-state.
    Type: Grant
    Filed: August 26, 2019
    Date of Patent: September 28, 2021
    Assignee: Tohoku University
    Inventors: Shinya Yoshida, Tsutomu Nakamura
  • Patent number: 11045425
    Abstract: The present invention provides a method for preparing a graft material containing organ or tissue cells, the cells including cells having inhibited PHLDA3 expression.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: June 29, 2021
    Assignees: Kyoto University, Tohoku University, Kuraray Co., Ltd.
    Inventors: Shoichiro Sumi, Rieko Ohki, Naoaki Sakata
  • Patent number: 11014865
    Abstract: [Problem] The present invention provides an industrially-preferable, cost-efficient, low-cost production method for 4-hydroxy-2-hydroxymethyl-2-cyclopenten-1-one (a compound represented by formula (I)) useful as a medicine, an agricultural chemical, or a raw material or intermediate of a medicine, an agricultural chemical, or the like. [Solution] According to the present invention, this compound represented by formula (I) is produced by subjecting an easily available compound represented by formula (II) (tri-O-acetyl-D-glucal) to a heating reaction in pressurized water.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: May 25, 2021
    Assignees: Tohoku University, Genesis Research Institute, Inc.
    Inventors: Yoshitaka Koseki, Hitoshi Kasai, Takaaki Kamishima
  • Patent number: 11000552
    Abstract: The purpose of the present invention is to provide a novel medicinal use in regeneration medicine, said medicinal use comprising using pluripotent stem cells (Muse cells). Provided is a cell preparation for treating skin ulcer, said cell preparation comprising SSEA-3 positive pluripotent stem cells isolated from a mesenchymal tissue of a living organism or cultured mesenchymal cells. The cell preparation according to the present invention is based on such mechanism of skin tissue regeneration that, when the Muse cells are administered to a skin ulcer site of a subject suffering from the aforesaid disease, the Muse cells differentiate into skin-constituting cells.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: May 11, 2021
    Assignees: The University of Tokyo, Tohoku University
    Inventors: Kotaro Yoshimura, Kahori Kinoshita, Mari Dezawa
  • Patent number: 10944018
    Abstract: The present invention relates to an application liquid for forming a semiconductor film, the application liquid comprising: an inorganic semiconductor particle; and a compound having a relative permittivity of 2 or more or a compound having reducing power against the inorganic semiconductor particle; a method for producing a semiconductor film comprising a step of applying the application liquid; a semiconductor film and a semiconductor element comprising the semiconductor film; and a method for producing the semiconductor element.
    Type: Grant
    Filed: July 18, 2013
    Date of Patent: March 9, 2021
    Assignees: Asahi Kasei Kabushiki Kaisha, Tohoku University
    Inventors: Akira Watanabe, Toru Yumoto
  • Publication number: 20210055542
    Abstract: A mirror device includes a frame body, a shaft member provided inside the frame body and connected to the frame body at both end portions, and a reflection member fixed to the shaft member and provided so as to be capable of swinging around an axis of the shaft member. The reflection member has a base portion provided along an axial direction of the shaft member and a reflection portion provided on the base portion. The base portion has a three-dimensional uneven structure including a bottom wall portion having a main surface provided along the axial direction of the shaft member and a plurality of side wall portions extending from the bottom wall portion on the side opposite to the reflection portion.
    Type: Application
    Filed: August 21, 2020
    Publication date: February 25, 2021
    Applicant: Tohoku University
    Inventors: Takashi SASAKI, Kazuhiro Hane, Tung Thanh Nguyen
  • Patent number: 10927454
    Abstract: A method of forming a nitride film wherein (a) a silane-based gas is supplied to a processing chamber through a gas supply port; (b) a nitrogen radical gas from a radical generator is supplied to the processing chamber through a radical gas pass-through port; and (c) the silane-based gas supplied in (a) is reacted with the nitrogen radical gas supplied in (b), without causing a plasma phenomenon in the processing chamber, to form a nitride film on a wafer.
    Type: Grant
    Filed: February 14, 2017
    Date of Patent: February 23, 2021
    Assignees: Toshiba Mitsubishi-Electric Industrial Systems Corporation, Tohoku University
    Inventors: Shinichi Nishimura, Kensuke Watanabe, Yoshihito Yamada, Akinobu Teramoto, Tomoyuki Suwa, Yoshinobu Shiba
  • Patent number: 10906972
    Abstract: The present invention provides a method for producing an antibody against podocalyxin expressed specifically in cancer cells. The method includes a step of introducing a nucleic acid encoding all or a portion of podocalyxin into cells expressing a cancer cell-specific sugar chain structure to cause cancer cell-specific podocalyxin or a portion thereof to be expressed therein, a step of immunizing a non-human mammal with the cancer cell-specific podocalyxin or portion thereof to obtain antibodies, and a step of purifying the antibodies by primary screening using purified cancer cell-specific podocalyxin or a portion thereof.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: February 2, 2021
    Assignees: Tohoku University, ZENOAQ RESOURCE CO., LTD.
    Inventors: Yukinari Kato, Mika Kaneko, Satoshi Ogasawara
  • Patent number: 10900854
    Abstract: Provided are a pressure sensor which exhibits exceptional performance and a method of producing the same. The pressure sensor includes: a silicon substrate having a cavity; a diaphragm which is formed of a metallic glass and has a tensile stress in a range in which a resonant frequency is higher than an audible range; and a counter electrode which is insulated from the diaphragm and has a plurality of holes. The diaphragm and the counter electrode are disposed on the silicon substrate to face each other with a gap therebetween, the diaphragm and the counter electrode being released from the silicon substrate by the cavity.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: January 26, 2021
    Assignee: Tohoku University
    Inventors: Shuji Tanaka, Joerg Froemel
  • Patent number: 10894067
    Abstract: Disclosed is a genome stability enhancer comprising, as an active ingredient, at least one member selected from the group consisting of enzyme-treated royal jelly, gnetum or its extract, and gnetin C.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: January 19, 2021
    Assignees: Yamada Bee Company, Inc., National Cancer Center, Tohoku University
    Inventors: Tomoki Ikuta, Shinobu Fukushima, Tomoki Tatefuji, Kenichi Yoshioka, Hitoshi Shirakawa
  • Patent number: RE49518
    Abstract: [Problem] To provide a fluorescent probe that detects calpain activity in cells at high sensitivity. [Solution] A compound represented by the following general formula (I) or a salt thereof.
    Type: Grant
    Filed: May 21, 2021
    Date of Patent: May 2, 2023
    Assignees: The University of Tokyo, Tohoku University
    Inventors: Yasuteru Urano, Yuri Nagayo, Mako Kamiya, Toru Nakazawa