Abstract: The present invention addresses the issue of providing a norovirus component vaccine for subcutaneous, intradermal, percutaneous, or intramuscular administration which vaccine can readily immunize the target cells, an associated product of a molecular needle serving as an active ingredient of the vaccine, and a production method for the associated product. The invention provides a norovirus component vaccine containing, as an active ingredient, an associated product including a hexamer formed through bonding of two molecules of a trimer of a molecular needle represented by the following formula (1). W-L1-Xn—Y (1) [wherein W represents an amino acid sequence of P domain of the capsid protein of norovirus as an immunogen; L1 represents a first linker sequence having 0 to 100 amino acids; X represents an amino acid sequence represented by SEQ ID NO: 1; Y represents an amino acid sequence of a cell introduction domain; n is an integer of 1 to 3].

Abstract: An actuator capable of attaining high output. The actuator includes a frame structure part that forms a frame structure surrounding a housing part, and a volume change part housed in the housing part. The volume change part increases a volume thereof by input of external energy. The frame structure part has a higher Young's modulus than a Young's modulus of the volume change part. The housing part has an anisotropic shape, with a maximum width in first direction of the housing part longer than a maximum width in second direction different from the first direction of the housing part.

Abstract: Provided are a terahertz wave detection device and a terahertz wave detection system to execute checking at high speed with high sensitivity and accuracy and to execute omnidirectional inspection without requiring a large checking system. A flexible array sensor (30) includes: a terahertz wave detection element (10) having a flexible single-walled carbon nanotube film (11), and a first electrode (12) and a second electrode (13) disposed to face each other on a two-dimensional plane of the single-walled carbon nanotube film (11); and a flexible substrate (20) having flexibility to support the terahertz wave detection element (10) so as to be freely curved. The flexible substrate (20) is preferably formed in a curved or cylindrical shape, so that the terahertz wave detection elements (10) are arrayed on the flexible substrate 20 formed in a curved or cylindrical shape.

Abstract: Provided is a method for measuring tyrosine phosphatase and tyrosine kinase activity, as a high-sensitivity measuring method, which is suitable for high throughput and which uses a compound represented by general formula (I) (in the formula, A represents a conjugated ring; L represents a linker or the like having a labeling substance at an end; R1 represents a hydrogen atom or the like; and R2 and R3 each represent a hydrogen atom, an alkyl group or the like).

Abstract: A method for producing a cellooligosaccharide that enables the formation of a cellooligosaccharide having a high degree of polymerization to be suppressed in enzymatic synthesis of a cellooligosaccharide, the method comprising reacting ?-glucose-1-phosphate and at least one primer selected from the group consisting of glucose, cellobiose, and alkylated glucose with cellodextrin phosphorylase in a mixed solvent containing water and a water-soluble organic solvent.

Abstract: A rotaxane compound comprising one or more cyclic molecules and an axial molecule penetrating through inner holes of the cyclic molecules and having cap structures disposed lest the cyclic molecules should be detached, where one of the cyclic molecule and the axial molecule has one of a functional group being capable of reacting with silica and a functional group being capable of reacting with a carbon-carbon unsaturated bond, and the other of the cyclic molecule and the axial molecule has the other of the functional group being capable of reacting with silica and the functional group being capable of reacting with a carbon-carbon unsaturated bond.

Abstract: A sulfide solid electrolyte is capable of suppressing a decrease in Li ion conductivity due to moisture. A sulfide solid electrolyte includes a Li element, a P element, a S element and an O element, and having a granular shape, and including a crystal portion oriented along the granular shape, on an inner surface of the sulfide solid electrolyte.

Abstract: An object is to provide a technology for enabling prevention of deterioration of characteristics of an oxide semiconductor device. The oxide semiconductor device includes an n-type gallium oxide epitaxial layer, a p-type oxide semiconductor layer, and an oxide layer. The p-type oxide semiconductor layer is disposed above the n-type gallium oxide epitaxial layer, contains an element different from gallium as a main component, and has p-type conductivity. The oxide layer is disposed between the n-type gallium oxide epitaxial layer and the p-type oxide semiconductor layer, and is made of a material different from gallium oxide and different at least partly from a material of the p-type oxide semiconductor layer.

Abstract: Provided is a cold atomic beam generation technology that causes a cold atomic beam to travel in a direction different from the traveling direction of a pushing laser beam. The pushing laser beam is used to generate a cold atomic beam from atoms trapped in a space. Next, the cold atomic beam is deflected by using a zero magnetic field line of a quadrupole magnetic field in a two-dimensional magneto-optical trap mechanism or by using a drift direction of a standing light wave in a moving molasses mechanism.

Abstract: An oxide semiconductor compound includes gallium; and oxygen. An optical band gap is 3.4 eV or more. An electron Hall mobility obtained by performing a Hall measurement at a temperature of 300 K is 3 cm2/Vs or more.

Abstract: Provide is a deformation testing apparatus in which a sign of breakage of a specimen under a deformation test can be detected before an actual breakage. The deformation testing apparatus carrying out a plurality of deformation cycles includes an image capturing means; reference data storing means storing the reference data showing the deformation state calculated based on the reference image data shot by the image capturing means; reference cycle number deformation data calculating means to calculate the reference data; detection cycle number deformation data calculating means to calculate detection cycle number deformation data showing the deformation state based on the detection image data shot at the detection cycle number being larger than the reference cycle number; and change detection means to detect that the deformation caused in the specimen is changed based on the reference cycle number deformation data and the detection cycle number deformation data.

Abstract: The present invention provides, in order to prepare matured hepatocytes analogous in various points to primary hepatocytes, a method for preparing hepatocytes or cells that can be differentiated into hepatocytes from pluripotent stem cells, comprising the steps of: (1) culturing the pluripotent stem cells in a medium containing an activator of an activin receptor-like kinase-4,7; (2) culturing the cells obtained in the step (1) in a medium containing a bone morphogenetic factor and a fibroblast growth factor; (3) culturing the cells obtained in the step (2) in a medium containing an activator of a hepatocyte growth factor receptor and an activator of an oncostatin M receptor; and (4) culturing the cells obtained in the step (3) to obtain hepatocytes or cells that can be differentiated into hepatocytes, wherein in at least one of the steps (2), (3) and (4), cells are cultured on a high-density collagen gel membrane.

Abstract: An object of the present invention is to provide a novel rotaxane and a production method of the same. The present invention provides a rotaxane polyurea having a cyclic molecule and a polyurea chain piercing through the cyclic molecule.

Abstract: A change in geoid height is measured easily. A geoid measurement method of the present invention executes an inertial measurement data acquiring step, a comparison data acquiring step, a state variable estimating step, and a geoid calculating step. In the inertial measurement data acquiring step, data related to velocity, position, and attitude angle is acquired as inertially-derived data based on the output of an inertial measurement part having a three-axis gyro and a three-axis accelerometer attached to a moving body. In the comparison data acquiring step, data related to velocity is acquired as comparison data from a source other than the inertial measurement part. In the state variable estimating step, state variables including a plumb line deviation are estimated by using the inertially-derived data and the comparison data to apply a Kalman filter in which the plumb line deviation is included in the state variables.

Abstract: Provided is an artificial nucleoside or artificial nucleotide capable of composing an artificial oligonucleotide having superior nuclease resistance. The artificial nucleoside or artificial nucleotide is a compound represented by formula (I) or a salt thereof (wherein, Bx represents a pyrimidine base or purine base, R1, R2, R3 and R4 represent hydrogen atoms, C1-6 alkyl groups or the like, Y represents NR5R6 (wherein, R5 and R6, independently of each other, represent a hydrogen atom, C1-6 alkyl group or the like, or R5 and R6, together with a nitrogen atom bound thereto, form a 3- to 11-membered nitrogen-containing non-aromatic heterocyclic group) or an optionally substituted C2-9 aromatic heterocyclic group, Z1 and Z2 represent hydrogen atoms, hydroxyl group-protecting groups, phosphorous-containing groups or the like, and n represents an integer of 1 to 3).

Abstract: A branched type hetero monodispersed polyethylene glycol represented by formula (1) (X1 and Y1 each represents an atomic group containing at least a functional group capable of reacting with a functional group present in a biofunctional molecule to form a covalent bond, provided that the functional group contained in the atomic group X1 and the functional group contained in the atomic group Y1 are different from each other, n represents a number of repeating units of a monodispersed polyethylene glycol and is an integer of 6 to 30, E is a branch site having a divalent bond valence number to L2 and a monovalent bond valence number to L3 and represents a glycerol site, L1 and L2 each independently represents a single bond or a divalent organic group, and L3 represents a single bond, -L4-(CH2)m1— or -L4-(CH2)m2-L5-(CH2)m3—, L4 represents any of an ether bond, an amide bond and a urethane bond, L5 represents an amide bond or a urethane bond, and m1, m2 and m3 each independently represents an integer or 1 to 5.

Abstract: An object of the present invention is to provide a low height type actuator capable of performing a two-dimensional motion. An actuator includes a magnet structure 20 that includes a first array Lx in which the first and second magnets 21 and 22 are alternately arranged in x-direction and a second array Ly in which the first and second magnets 21 and 22 are alternately arranged in y-direction, and first and second wirings 30 and 40. The first wiring 30 crosses the first magnets 21 and 22 included in the first array Lx in y-direction, and the second wiring 40 crosses the first magnets 21 and 22 included in the second array Lx in x-direction. According to the present invention, by making current flow in the first and second wirings 30 and 40, a two-dimensional motion can be achieved. Further, since the first and second wirings 30 and 40 are each a planar wiring that crosses the magnets, height reduction can be achieved.

Abstract: Provided is a terminal apparatus including: a receiver configured to detect a transmission direction of a signal used for communication with at least one base station apparatus; and a transmitter configured to transmit, to a location server, base station direction information for indicating the transmission direction detected.

Abstract: A co-culture device includes: a first body including a first membrane having a first main surface for culturing cells and a second main surface opposite to the first main surface, a first flow path partially defined by the first main surface, the first flow path configured for a first culture medium to flow therethrough, and a second flow path partially defined by the second main surface, the second flow path configured for a second culture medium having a higher dissolved oxygen concentration than that of the first culture medium to flow therethrough; and an oxygen concentration adjuster for adjusting the dissolved oxygen concentration in the first culture medium to be supplied to the first flow path.

Abstract: The invention provides a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The degradable polyethylene glycol derivative is represented by the following formula (1): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, X is a functional group capable of reacting with a bio-related substance, and L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer.