Patents Assigned to TOKYO UNIVERSITY OF SCIENCE FOUNDATION
  • Publication number: 20240019430
    Abstract: Novel factors which are involved in the mechanism of the onset of IgA nephropathy are explored, and diagnostic, preventive or therapeutic agents for this disease are provided. A method for measuring autoantibodies related to IgA nephropathy, the method comprising measuring the amount of anti-spectrin ? IgA antibodies in a sample derived from a living organism.
    Type: Application
    Filed: December 3, 2021
    Publication date: January 18, 2024
    Applicants: JUNTENDO EDUCATIONAL FOUNDATION, TOKYO UNIVERSITY OF SCIENCE FOUNDATION
    Inventors: Yusuke SUZUKI, Yoshihito NIHEI, Daisuke KITAMURA
  • Patent number: 11873380
    Abstract: A photoreactive composition including a base-reactive compound, a photobase generator that is represented by the following Formula (1) and that generates a base when irradiated with light, and at least one compound selected from the group consisting of a polycyclic aromatic compound having a fused ring structure having two or more rings and a polycyclic aromatic compound having three or more aromatic rings and having a conjugated structure including any two or more of the three or more aromatic rings, in which the base-reactive compound is a compound having two or more groups that will have their polarity converted by the action of a base and that exhibit reactivity, in one molecule, or a compound having two or more groups that will react under the action of a base, in one molecule.
    Type: Grant
    Filed: May 7, 2019
    Date of Patent: January 16, 2024
    Assignee: Tokyo University of Science Foundation
    Inventor: Koji Arimitsu
  • Patent number: 11873354
    Abstract: A photobase generator includes a compound including a first skeleton represented by the following formula (a), and a second skeleton including a nitrogen atom bonding to a bonding position of the first skeleton to form an amide group, wherein the compound generates a base, in which a hydrogen atom is bonding with the nitrogen atom of the second skeleton, by light irradiation, and the pKa of a conjugate acid of the base in water is 12 or more. In formula (a), G is a divalent aromatic group, and * represents the bonding position with the nitrogen atom.
    Type: Grant
    Filed: September 10, 2020
    Date of Patent: January 16, 2024
    Assignee: Tokyo University of Science Foundation
    Inventor: Koji Arimitsu
  • Publication number: 20230407127
    Abstract: A coating agent has: a film-forming component containing an organosilicon compound having a radical polymerizable functional group and an alkoxysilyl group; and a film-curing component composed so that a base and a radical can be generated on irradiation with ultraviolet light. The film-curing component includes a nonionic photobase generator having no ionic bond in the molecular structure. The content of the nonionic photobase generator is 0.1 parts by mass or more and 50 parts by mass or less, based on 100 parts by mass of the organosilicon compound.
    Type: Application
    Filed: November 12, 2021
    Publication date: December 21, 2023
    Applicants: KABUSHIKI KAISHA TOYOTA JIDOSHOKKI, Tokyo University of Science Foundation
    Inventors: Ayano SASAKI, Sayako SATO, Hidenori MUNEKATA, Motoshige ISOBE, Hisashi MURAMATSU, Koji ARIMITSU
  • Patent number: 11817261
    Abstract: An ink includes a boron-doped nanodiamond having a specific surface area of 110 m2/g or greater, and electrical conductivity at 20° C. of 5.0×10?3 S/cm or greater.
    Type: Grant
    Filed: November 18, 2021
    Date of Patent: November 14, 2023
    Assignees: DAICEL CORPORATION, TOKYO UNIVERSITY OF SCIENCE FOUNDATION
    Inventors: Takeshi Kondo, Tatsuo Aikawa, Makoto Yuasa, Kenjo Miyashita, Masahiro Nishikawa, Takahiro Tei
  • Publication number: 20230288238
    Abstract: The sensor of a fluid sensor system includes an outer peripheral sensor unit including three or more sensor pairs to surround and sandwich the heating element. The computing device of the system includes a first identification unit identifies a sensor pair in which an output difference between an output value corresponding to a temperature detected by one temperature sensor of the sensor pair and an output value corresponding to a temperature detected by the other temperature sensor of the sensor pair is largest, a second identification unit identifies other sensor pairs adjacent to the identified sensor pair in the circumferential direction, and a flow direction estimation unit estimates the flow direction of the fluid on the basis of the output difference in the sensor pair having the largest output difference and output differences in the other sensor pairs adjacent to the sensor pair in the circumferential direction.
    Type: Application
    Filed: February 28, 2023
    Publication date: September 14, 2023
    Applicants: MITSUBISHI HEAVY INDUSTRIES, LTD., Tokyo University of Science Foundation
    Inventors: Shunsuke MIZUMI, Naoto OMURA, Masahiro MOTOSUKE, Daiki SHIRAISHI, Koichi MURAKAMI
  • Patent number: 11742153
    Abstract: Provided is an electrode-forming material for an electrochemical capacitor useful for forming an electrode of an electrochemical capacitor having a high storage capacity and a high energy density. The electrode-forming material for an electrochemical capacitor according to an embodiment of the present invention includes boron-doped nanodiamond (A) having a specific surface area of 110 m2/g or greater and an electrical conductivity at 20° C. of 5.0×10?3 S/cm or greater; and a metal oxide (B), and the content of the (B) is from 20 to 95 mass % with respect to the total content of the (A) and (B).
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: August 29, 2023
    Assignees: DAICEL CORPORATION, TOKYO UNIVERSITY OF SCIENCE FOUNDATION
    Inventors: Takeshi Kondo, Toshifumi Tojo, Makoto Yuasa, Kenjo Miyashita, Atori Miki, Masahiro Nishikawa, Takahiro Tei
  • Patent number: 11718590
    Abstract: A compound represented by Chemical formula 1: wherein n is an integer of 2 or more, is provided. Also provided is a derivatization reagent for derivatizing a diene-containing compound, including a compound represented by Chemical formula 1. Further provided is a synthesis method for a compound, including a nucleophilic substitution reaction between an aryl halide and a heterocyclic amine compound being saturated, the compound being represented by Chemical formula 1.
    Type: Grant
    Filed: December 21, 2021
    Date of Patent: August 8, 2023
    Assignees: TOKYO UNIVERSITY OF SCIENCE FOUNDATION, JEOL Ltd.
    Inventors: Tatsuya Higashi, Shoujiro Ogawa, Masaki Takiwaki, Seketsu Fukuzawa
  • Publication number: 20230220022
    Abstract: Disclosed are a novel therapeutic means effective and practical against cancer, and a novel substance useful as such a therapeutic means. Provided are novel peptides derived from a partial region of HMGN1, HMGN2, HMGN4 or HMGN5, and anti-cancer agents and anti-cancer effect enhancers containing the peptide as an active ingredient. The peptide of the present invention has an anti-tumor effect even independently, and exerts a remarkably excellent anti-tumor effect particularly when used in combination with an immune checkpoint regulator, or an anti-CD4 antibody or antigen-binding fragment thereof.
    Type: Application
    Filed: January 3, 2023
    Publication date: July 13, 2023
    Applicants: The University of Tokyo, ONO PHARMACEUTICAL CO., LTD., TOKYO UNIVERSITY OF SCIENCE FOUNDATION
    Inventors: Kouji MATSUSHIMA, Satoshi UEHA, Shungo DESHIMARU, Chang-Yu CHEN, Shoji YOKOCHI, Yoshiro ISHIWATA, Shiro SHIBAYAMA
  • Patent number: 11637230
    Abstract: The purpose of the present invention is to provide a thermoelectric conversion element having a film which not only maintains sufficient adhesion even when exposed to a high temperature but also exhibits excellent oxidation resistance and crack resistance. The problem is solved by a thermoelectric conversion element including a thermoelectric conversion component, in which the thermoelectric conversion component contains magnesium silicide and/or manganese silicide and is covered with a film containing Si and Zr.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: April 25, 2023
    Assignees: Nihon Parkerizing Co., Ltd., Tokyo University of Science Foundation
    Inventors: Junichi Uchida, Yuki Haijima, Yuki Sueuchi, Tsutomu Iida
  • Publication number: 20230124539
    Abstract: The present invention provides a binder for positive electrode of lithium ion battery which is excellent in workability at the time of producing a positive electrode, is excellent in charge and discharge characteristics such as cycle characteristics and rate characteristics, and enables to possible to produce a positive electrode having an extended cycle life, as well as the present invention provides a slurry for forming positive electrode mixture layer of lithium ion battery, a positive electrode for lithium ion battery, and a lithium ion battery, using the same.
    Type: Application
    Filed: February 25, 2021
    Publication date: April 20, 2023
    Applicants: Tokyo University of Science Foundation, TOSOH CORPORATION
    Inventors: Tatsuo HORIBA, Kei KUBOTA, Yoshinari ABE, Asako OISHI, Shinichi KOMABA, Hiroshi INOUE, Eiichi TOUGOU
  • Publication number: 20230115206
    Abstract: A sign detection device is provided with a plurality of sensors, a data acquisition unit, a calculation unit, and a detection unit. The plurality of sensors are respectively disposed at a plurality of positions of a detection target to measure a physical parameter at each positions. The data acquisition unit is configured to acquire time-series change data of the physical parameters from the plurality of sensors. The calculation unit is configured to calculate dynamic network information representing a time change of a complex network structure including a parameter indicating a correlation between the physical parameters at any two positions of the plurality of positions, on the basis of the time-series change data. The detection unit is configured to detect a sign of sudden change vibration of the detection target, on the basis of the dynamic network information.
    Type: Application
    Filed: October 5, 2022
    Publication date: April 13, 2023
    Applicants: MITSUBISHI HEAVY INDUSTRIES, LTD., Tokyo University of Science Foundation
    Inventors: Tomohito NAKAMORI, Keisuke MATSUYAMA, Takuya KUROSAKA, Hiroshi GOTODA, Natsumi KIKUTA
  • Patent number: 11578132
    Abstract: It is an object of the present invention to provide a method for efficiently producing a B cell population comprising B cells that recognize a specific antigen. According to the present invention, provided is a method for producing a B cell population, comprising: a step (c) of culturing a cell population comprising B cells together with a specific antigen in the absence of IL-21, in the absence of IL-4, and in the presence of a cytokine other than IL-21 and IL-4, while giving stimulation mediated by CD40 and a BAFF receptor to the cells; and a step (d) of culturing the cell population comprising B cells, while giving stimulation mediated by has to the cells, so as to obtain a B cell population comprising B cells that recognize the specific antigen.
    Type: Grant
    Filed: January 15, 2018
    Date of Patent: February 14, 2023
    Assignees: KANEKA CORPORATION, TOKYO UNIVERSITY OF SCIENCE FOUNDATION
    Inventors: Tatsuya Moutai, Tomoyuki Nakaishi, Hiroshi Kita, Mitsuaki Kitano, Daisuke Kitamura
  • Patent number: 11572393
    Abstract: Disclosed are a novel therapeutic means effective and practical against cancer, and a novel substance useful as such a therapeutic means. Provided are novel peptides derived from a partial region of HMGN1, HMGN2, HMGN4 or HMGN5, and anti-cancer agents and anti-cancer effect enhancers containing the peptide as an active ingredient. The peptide of the present invention has an anti-tumor effect even independently, and exerts a remarkably excellent anti-tumor effect particularly when used in combination with an immune checkpoint regulator, or an anti-CD4 antibody or antigen-binding fragment thereof.
    Type: Grant
    Filed: March 7, 2019
    Date of Patent: February 7, 2023
    Assignees: THE UNIVERSITY OF TOKYO, ONO PHARMACEUTICAL CO., LTD., TOKYO UNIVERSITY OF SCIENCE FOUNDATION
    Inventors: Kouji Matsushima, Satoshi Ueha, Shungo Deshimaru, Chang-Yu Chen, Shoji Yokochi, Yoshiro Ishiwata, Shiro Shibayama
  • Patent number: 11558694
    Abstract: An electret includes a composite oxide having an ABO3 type perovskite structure containing two different metal elements A and B. The composite oxide is in a polarized state, at least a part of one of the metal elements A and B is substituted with a dopant element having a lower valence than the one of the metal elements A and B, and the composite oxide has a bandgap energy of 4 eV or more.
    Type: Grant
    Filed: December 9, 2020
    Date of Patent: January 17, 2023
    Assignees: DENSO CORPORATION, TOKYO UNIVERSITY OF SCIENCE FOUNDATION
    Inventors: Yoshihiro Kozawa, Noriyuki Matsushita, Kazuhiko Kanoh, Yumi Tanaka, Tomoya Maruyama, Hiroshi Okamoto, Naoya Morioka, Katsuyoshi Saiki
  • Publication number: 20230003813
    Abstract: Proposed is a phase shift introduction method, a structure, and a circuit device for eliminating or minimizing a risk associated with dissimilar materials, solving in principle a problem of mixing of a signal current and a control current that occurs due to DC connection of a phase shifter to a signal line, and stably and reliably providing a phase shift that is desired to be introduced without being adversely effected by noise generated by an ambient magnetic field, which is generated due to use of an external power supply. A structure according to the present invention includes a phase shifter 101 and a closed-loop circuit 103 that is directly used for computation or storage, and a quantum phase shift is generated in the closed-loop circuit 103 by using a fractional flux quantum captured by the phase shifter 101 that is DC-separated from the closed-loop circuit 103.
    Type: Application
    Filed: November 26, 2020
    Publication date: January 5, 2023
    Applicants: National Institute of Advanced Industrial Science and Technology, NATIONAL INSTITUTE FOR MATERIALS SCIENCE, Tokyo University of Science Foundation
    Inventors: Yasumoto TANAKA, Hirotake YAMAMORI, Takashi YANAGISAWA, Shunichi ARISAWA, Taichiro NISHIO
  • Patent number: 11542292
    Abstract: Provided a polymerizable compound represented by the following Formula A-1 or Formula A-2: In Formula A-1 or Formula A-2, R1 represents an electron-donating group; n represents an integer from 1 to 5; R2 represents a hydrogen atom, a halogen atom, or —ORO, wherein RO represents a hydrogen atom, an alkyl group, or a protecting group of a hydroxy group; R3 represents a hydrogen atom or a protecting group of a hydroxy group; and X represents a structure represented by any one of Formula B-1 to Formula B-5.
    Type: Grant
    Filed: November 9, 2017
    Date of Patent: January 3, 2023
    Assignee: TOKYO UNIVERSITY OF SCIENCE FOUNDATION
    Inventors: Takeshi Wada, Tatsuya Saito, Yuka Ishii, Yohei Nukaga
  • Publication number: 20220380763
    Abstract: A novel anti-tumor agent capable of delivering siRNA or shRNA specifically to pancreatic cancer cells and suppressing tumor growth, invasion, and metastasis of pancreatic cancer is provided. The present invention provides a nucleic acid delivery enhancer for delivering siRNA or shRNA into cells, which consists of a folic acid-cationic oligopeptide complex. The present invention also provides an anti-tumor agent having siRNA or shRNA capable of binding to mRNA or snoRNA expressed in pancreatic cancer cells to inhibit its expression and a folic acid-cationic oligopeptide complex. The siRNA is capable of binding to RNA selected from the group consisting of, for example, SNORA18 snoRNA, NUP85 mRNA, WASF2 mRNA, and SNORA22 snoRNA.
    Type: Application
    Filed: October 26, 2020
    Publication date: December 1, 2022
    Applicants: NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY, TOKYO UNIVERSITY OF SCIENCE FOUNDATION
    Inventors: Keisuke TANIUCHI, Takeshi WADA, Rintaro HARA, Kazuki SATO, Kazunori TAKAGI
  • Publication number: 20220356462
    Abstract: A nucleic acid amplification method using a solid-phase carrier according to the present invention comprises: capturing a target nucleic acid comprising mRNA on a solid-phase carrier; carrying out complementary-strand synthesis on the solid phase; carrying out exonuclease treatment to degrade and remove unreacted target- capturing nucleic acid on the solid phase; and then carrying out mRNA degradation and homopolymer addition by TdT reaction in the presence of a chain-terminating nucleotide triphosphate. According to the method of the present invention, cDNA can be stably and highly efficiently amplified even from a small amount of sample even in cases where the ratio of the amount of enzyme to the DNA substrate on the solid phase is excessive, where the reaction time is excessive, and/or where reagents show lot-to-lot variation.
    Type: Application
    Filed: July 10, 2020
    Publication date: November 10, 2022
    Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION
    Inventors: Kouji MATSUSHIMA, Satoshi UEHA, Shigeyuki SHICHINO, Satoru ITO, Hiroyasu AOKI
  • Patent number: 11472109
    Abstract: A three-dimensional printing apparatus (1) allowing a linear filament (F) in which a fiber bundle (C) is impregnated with resin (P) to be continuously ejected includes twisting means (6) for allowing a total amount of twisting of the filament (F) or an amount of twisting of the fiber bundle (C) to be changed.
    Type: Grant
    Filed: February 13, 2018
    Date of Patent: October 18, 2022
    Assignees: NIHON UNIVERSITY, TOKYO UNIVERSITY OF SCIENCE FOUNDATION
    Inventors: Masahito Ueda, Ryosuke Matsuzaki, Yoshiyasu Hirano