Abstract: The present invention embraces a RNA replicon that can be replicated by a replicase of alphavirus origin and comprises an open reading frame encoding a reprogramming factor. Such RNA replicons are useful for expressing a reprogramming factor in a cell, in particular a somatic cell. Cells engineered to express such reprogramming factors are useful in cell transplantation therapies.

Abstract: A gravimetric metering unit for bulk material includes a metering device, which has a container for bulk material to be metered and a base unit. The base unit has a screw conveyor, which is operably held in position and driven by means of a holder. The screw conveyor and the holder can be axially plugged together and are designed such that they can be operably fastened to each other by means of a plug-in connection. The plug-in connection is a magnetic connection.

Abstract: A gravimetric metering unit includes a metering device including a container for bulk material to be metered and a base unit with a horizontally arranged conveyor for the bulk material. The container and the base unit can be separated from each other for maintenance purposes. The metering unit also comprises a frame that is equipped with at least one scale on which the metering device is supported during operation via a mounting such that the metering unit is designed for a gravimetric metering process. The mounting is connected to the container of the metering device and supports the metering device via the container. The container is provided with a rail which protrudes away from the container, and the base unit has a supporting structure which runs on the rail such that the supporting structure can be moved back and forth between an operating position and a maintenance position.

Abstract: A near-field testing apparatus for testing a device under test having an array of transmitter antennas is provided. The near-field testing apparatus includes a frame structure and a receiver circuit. The frame structure defines an array of grid sections, and is arranged for receiving the array of transmitter antennas at a first side of the array of grid sections. A periphery of each grid section at the first side surrounds a plurality of transmitter antennas in the array of transmitter antennas. The grid section is arranged to guide respective electromagnetic signals emitted by the transmitter antennas from the first side to a second side of the array of grid sections. The receiver circuit, disposed at the second side of the array of grid sections, is arranged to couple the electromagnetic signals out of the grid section.

Abstract: The invention generally relates to methods and compositions for the prediction of therapeutic efficacy of cancer treatments and the prognosis of cancer. The invention discloses markers that are associated with favorable and unfavorable outcomes, respectively, in certain cancer treatments and are useful as prognostic markers for cancer. Methods involving these markers are disclosed for predicting cancer therapy benefit and prognosing clinical outcome for cancer patients.

Abstract: A method for manufacturing a first radio-frequency (RF) device, including: receiving a substrate having the first RF device, wherein the first RF device has a signal port for receiving or transmitting RF signals with an input impedance greater than ten times an input impedance of a testing tool; causing a probe assembly to connect to the signal port and the testing tool; and causing the probe assembly to connect to a first terminal of a resistive element having a resistance equal to the input impedance.

Abstract: The present invention relates to methods for predicting peptides or polypeptides such as T cell epitopes useful for immunotherapy such as for vaccination. In particular, the present invention relates to methods for predicting whether peptides or polypeptides such as tumor-associated antigens or epitopes, in particular tumor-associated neoantigens or neoepitopes, are immunogenic and, in particular, useful for immunotherapy such as for vaccination. The methods of the invention may be used, in particular, for the provision of vaccines which are specific for a patient's tumor and, thus, in the context of personalized cancer vaccines.

Abstract: The present invention provides a sensor mounted wafer, including: a lower case in which a mounting groove is formed; a circuit board on which a plurality of electronic components having different heights are mounted, and placed in the mounting groove; an upper case in which a plurality of insertion grooves having different depths are formed, and bonded together to the lower case so that the plurality of electronic components are inserted into the plurality of insertion grooves; and an adhesive layer placed between the mounting groove and the plurality of insertion grooves, in which the insertion grooves are formed to have different depths according to the heights of the plurality of the electronic components.

Abstract: A sensor mounted wafer includes a lower case, a circuit board, a metal layer, an upper case and lower case. A mounting groove is formed on a surface of the lower case. An electronic component is mounted on the circuit board, and placed in the mounting groove. The upper case having an insertion groove on a surface of the upper case, wherein the electronic component is inserted into the insertion groove, and the upper case is bonded together to the lower case. The metal layer placed on at least one surface of the lower case and the upper case.

Abstract: An air breathing device includes a casing and an air passage cavity encompassed by the casing. The device includes an air intake port and an air discharge port that connect the air passage cavity to the outside of the casing. The device includes a damper (gravity or motorized) that allows the air to flow into the air passage cavity during inhalation through the air intake port. The device includes a damper (gravity or motorized) that allows the air to exit the air passage cavity during exhalation through the air discharge port. The device includes a retractable display screen to display content to the wearer. The device includes a fixed display screen to display images of the mouth of the wearer captured by a camera lens or simulated based on the wearer's captured voice. The device includes UV lights, filters, network connections, camera lenses, speakers, microphones, ear plugs, and heating coils.

Abstract: The present invention relates to nucleic acid molecules containing poly (dA:dT) regions which are stabilized in E.-coli, methods of propagating such nucleic acid molecules in E. coli, methods of obtaining RNA, peptides or proteins using such nucleic acid molecules and to RNA which is obtained from such nucleic acid molecules and its use. In particular, the poly (dA:dT) regions contain at least one disruption by a sequence not encoding a sequence solely composed of A residues.

Abstract: An air breathing device includes a casing and an air passage cavity encompassed by the casing. The device includes an air intake port and an air discharge port that connect the air passage cavity to the outside of the casing. The device includes a damper (gravity or motorized) that allows the air to flow into the air passage cavity during inhalation through the air intake port. The device includes a damper (gravity or motorized) that allows the air to exit the air passage cavity during exhalation through the air discharge port. The device includes a retractable display screen to display content to the wearer. The device includes a fixed display screen to display images of the mouth of the wearer captured by a camera lens or simulated based on the wearer's captured voice. The device includes UV lights, filters, network connections, camera lenses, speakers, microphones, ear plugs, and heating coils.

Abstract: The method according to the invention provides a way to continue gravimetric weighing of bulk material during refilling of a gravimetric metered dispensing unit, and to determine the mass of the refilled bulk material using a refilling container during the filling operation material and so determine the actual mass flow discharged during refilling in real time or on average in order to adjust it to a target mass flow.

Abstract: The invention relates to antibodies directed against an epitope located within the C-terminal portion of CLDN6 which are useful, for example, in diagnosing cancer and/or in determining whether cancer cells express CLDN6.

Abstract: The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as pancreatic cancer and metastases thereof.

Abstract: The vibration feeder has a drive unit comprising a vibration drive, a carrier arrangement comprising a feeding element for the material to be conveyed and a control for the vibration drive, wherein an acceleration sensor is arranged on the drive unit, which when the vibration feeder is operating, detects the actual acceleration of the drive unit, and wherein the control is configured to use the actual acceleration signal of the acceleration sensor for generating a regulating variable for the vibration drive such that the carrier arrangement vibrates essentially within its resonance frequency (fres). This makes it possible, during operation, to detect the acceleration of a drive unit of the vibration feeder and to generate therefrom a regulating variable for a vibration drive such that a carrier arrangement of the vibration feeder vibrates closer to its resonance frequency (fres) or is brought back again to the same.

Abstract: A radar system includes: a plurality of first receiving devices for generating a plurality of first digital signals according to a plurality of first incoming signals, respectively; and a plurality of second receiving devices for generating a plurality of second digital signals according to a plurality of second incoming signals, respectively. A processing device is arranged to perform a first beamforming operation to generate a plurality of first beamforming signals according to the plurality of first digital signals and a first gain matrix, and to perform a second beamforming operation to generate a plurality of second beamforming signals according to the plurality of second digital signals and a second gain matrix; and to determine an altitude angle of a first object and a second object, and to determine a first azimuth angle of the first object and a second azimuth angle of the second object.

Abstract: The present invention relates to RNA decorated particles such as RNA decorated lipid particles, preferably to RNA decorated liposomes. Further, the present invention relates to a pharmaceutical composition comprising RNA decorated particles such as RNA decorated lipid particles, preferably RNA decorated liposomes. Said pharmaceutical composition is useful for inducing an immune response. It is also useful in a prophylactic and/or therapeutic treatment of a disease involving an antigen. Furthermore, the present invention relates to a method for producing the RNA decorated particles such as RNA decorated lipid particles, preferably RNA decorated liposomes.