Abstract: The present invention relates to the treatment of cancer, in particular breast cancer, particularly triple-negative breast cancer. More particularly, the invention concerns methods and means for cancer treatment involving a specific set of tumor antigens.

Abstract: The present invention is in the field of immunotherapy, in particular tumor immunotherapy. The present invention provides pharmaceutical formulations for delivering RNA to antigen presenting cells such as dendrite cells (DCs) in the spleen after systemic administration. In particular, the formulations described herein enable to induce an immune response after systemic administration of antigen-coding RNA.

Abstract: The present invention relates to a patient-specific tumor treatment targeting individual expression patterns of tumor antigens, in particular shared tumor antigens, and individual tumor mutations. In one aspect, the present invention relates to a method for preventing or treating cancer in a patient comprising the steps of: (i) inducing a first immune response against one or more tumor antigens in the patient, and (ii) inducing a second immune response against one or more tumor antigens in the patient wherein the second immune response is specific for cancer specific somatic mutations present in cancer cells of the patient.

Abstract: A signal converting apparatus includes a comparing device, a first digital-slope quantizer, and a second digital-slope quantizer. The comparing device having a first input terminal and a second input terminal for receiving a first received signal and a second received signal, and for generating an output signal at an output port. The first digital-slope quantizer generates a first set of digital signals to monotonically adjust the first received signal and the second received signal at the first input terminal and the second input terminal during a first phase according to a first quantization unit. The second digital-slope quantizer generates a second set of digital signals to monotonically adjust the first received signal and the second received signal at the first input terminal and the second input terminal during a second phase after the first phase according to a second quantization unit.

Abstract: A radar system includes: a plurality of first receiving devices for generating a plurality of first digital signals according to a plurality of first incoming signals, respectively; and a plurality of second receiving devices for generating a plurality of second digital signals according to a plurality of second incoming signals, respectively. A processing device is arranged to perform a first beamforming operation to generate a plurality of first beamforming signals according to the plurality of first digital signals and a first gain matrix, and to perform a second beamforming operation to generate a plurality of second beamforming signals according to the plurality of second digital signals and a second gain matrix; and to determine an altitude angle of a first object and a second object, and to determine a first azimuth angle of the first object and a second azimuth angle of the second object.

Abstract: A signal distribution system includes: a first signal divider arranged to generate a first output oscillating signal according to a first input oscillating signal; a second signal divider arranged to generate a second output oscillating signal according to the first input oscillating signal; a first transmitting channel coupled to the first signal divider and the second divider for transmitting the first input oscillating signal to the first signal divider and the second signal divider; and a second transmitting channel coupled to the first signal divider and the second divider for transmitting a second input oscillating signal to the first signal divider and the second signal divider; wherein the first input oscillating signal has a first frequency, the second input oscillating signal has a second frequency, and the second frequency is smaller than the first frequency.

Abstract: A radar system includes: a processing device arranged to generate a plurality of phase shifting digital signals; a plurality of transmitting devices for generating an RF beam according to the plurality of phase shifting digital signals during a first mode; a plurality of first receiving devices for generating a plurality of first digital signals according to a plurality of first incoming signals, respectively, during a second mode; and a plurality of second receiving devices for generating a plurality of second digital signals according to a plurality of second incoming signals, respectively, during the second mode. The processing device is further arranged to distinguish a first object and a second object when the RF beam hits the first object and the second object, and the first object and the second object have a same radial speed and are located at a same range.

Abstract: A signal distribution system includes: a first signal divider arranged to generate a first output oscillating signal according to a first input oscillating signal; a second signal divider arranged to generate a second output oscillating signal according to the first input oscillating signal; a first transmitting channel coupled to the first signal divider and the second divider for transmitting the first input oscillating signal to the first signal divider and the second signal divider; and a second transmitting channel coupled to the first signal divider and the second divider for transmitting a second input oscillating signal to the first signal divider and the second signal divider; wherein the first input oscillating signal has a first frequency, the second input oscillating signal has a second frequency, and the second frequency is smaller than the first frequency.

Abstract: A signal divider includes: a dividing circuit arranged to generate an output oscillating signal according to a first input oscillating signal; and a signal generating circuit, coupled to the dividing circuit, for generating an injection signal to the dividing circuit. The dividing circuit is arranged to generate the output oscillating signal with a predetermined phase according to the injection signal and the first input oscillating signal.

Abstract: The present invention provides Claudin-6-specific immunoreceptors (T cell receptors and artificial T cell receptors (chimeric antigen receptors; CARs)) and T cell epitopes which are useful for immunotherapy.

Abstract: The present invention relates to compositions comprising polyplex formulations for delivery of RNA to a target organ or a target cell after parenteral administration, in particular after intramuscular administration. More precisely, the present invention relates to formulations for administration of RNA such as self-replicating RNA, in particular by intramuscular injection. In more detail, the formulations comprise polyplex particles from single stranded RNA and a polyalkyleneimine. The RNA may encode a protein of interest, such as a pharmaceutically active protein. Furthermore, the present invention relates to pharmaceutical products, comprising said RNA polyplex formulations for parenteral application to humans or to animals. The present invention relates as well to manufacturing of such pharmaceutical products, comprising, optionally, steps of sterile filtration, freezing and dehydration.

Abstract: An event data and location-linked spherical imaging system including a spherical imager configured for capturing a spherical image with an action; a localization device collocated with the spherical imager, the localization device configured for providing a location of the spherical imager; a level collocated with the spherical imager, the level configured for indicating an imaging level of the spherical imager; an event data receiver configured for receiving event data from a user, the event data is associated with one or more points of interest on the spherical image; and a compass configured for providing an orientation of the spherical imager in capturing the spherical image, wherein the orientation and location-linked event data is accessible within the context of the spherical image. In one embodiment, the spherical imager includes no more than two imagers. In one embodiment, the action is a single capture.

Abstract: The present invention relates to the provision of vaccines which are specific for a patient's tumor and are potentially useful for immunotherapy of the primary tumor as well as tumor metastases. In one aspect, the present invention relates to a method for providing an individualized cancer vaccine comprising the steps: (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient; and (b) providing a vaccine featuring the cancer mutation signature obtained in step (a). In a further aspect, the present invention relates to vaccines which are obtainable by said method.

Abstract: In a computer-implemented method for detecting three-dimensional surface geometries of real intraoral structures, two-dimensional images of intraoral structures are converted into three-dimensional virtual surface geometries. Pixels of the two-dimensional images are each partitioned into segments and each segment is assigned a label. Each segment of a two-dimensional image corresponds to at least one type of real intraoral structure. There are at least two types of segment; each type of segment has a different label and at least one of the labels represents teeth and tooth-like structures.

Abstract: A signal converting apparatus includes a comparing device, a first digital-slope quantizer, and a second digital-slope quantizer. The comparing device having a first input terminal and a second input terminal for receiving a first received signal and a second received signal, and for generating an output signal at an output port. The first digital-slope quantizer generates a first set of digital signals to monotonically adjust the first received signal and the second received signal at the first input terminal and the second input terminal during a first phase according to a first quantization unit. The second digital-slope quantizer generates a second set of digital signals to monotonically adjust the first received signal and the second received signal at the first input terminal and the second input terminal during a second phase after the first phase according to a second quantization unit.

Abstract: The invention relates to a vibratory conveyor comprising a drive unit that generates a vibration movement during operation, and a conveying element arranged on the drive unit, wherein the drive unit comprises a support arrangement for the conveying element, which is mounted on a rear section on the carrier arrangement and has a freely extending section, and a spring-elastic vibration arrangement is provided on the front section of the conveying element, said vibration arrangement being arranged and designed in such a way that it oscillates with respect to the oscillation of the drive arrangement with phase displacement counter to the phase displacement of the conveying element.

Abstract: A signal converting apparatus includes a comparing device, a first digital-slope quantizer, and a second digital-slope quantizer. The comparing device has a first input terminal and a second input terminal for receiving a received signal and an adjustable reference voltage respectively, and for generating an output signal at an output port. The first digital-slope quantizer is coupled to the output port and the second input terminal for generating a first set of digital signals to monotonically adjust the adjustable reference voltage at the second input terminal during a first phase according to a first quantization unit. The second digital-slope quantizer is coupled to the output port and the second input terminal for generating a second set of digital signals to monotonically adjust the adjustable reference voltage at the second input terminal during a second phase after the first phase according to a second quantization unit.

Abstract: The present invention relates to methods for predicting T cell epitopes useful for vaccination. In particular, the present invention relates to methods for predicting whether modifications in peptides or polypeptides such as tumor-associated neoantigens are immunogenic and, in particular, useful for vaccination, or for predicting which of such modifications are most immunogenic and, in particular, most useful for vaccination. The methods of the invention may be used, in particular, for the provision of vaccines which are specific for a patient's tumor and thus, in the context of personalized cancer vaccines.