Abstract: The present invention relates to lipid particles comprising at least one cationic lipid, at least one water-soluble therapeutically effective compound and RNA. Further, the present invention relates to a pharmaceutical composition comprising such particles. Said pharmaceutical composition is useful for inducing an immune response. It is also useful in a prophylactic and/or therapeutic treatment of a disease involving an antigen. Furthermore, the present invention relates to a method for producing the particles.

Abstract: The present invention provides molecules that mimic antigenic determinants of the CD3 (cluster of differentiation 3) T-cell co-receptor epsilon chain (CD3?). These molecules compete with CD3? for binding to a CD3? binding domain. e.g. a CD3? binding domain of an antibody, and are capable of detecting antibodies against CD3?. The mimotopes of the invention may be used to generate or inhibit immune responses in animals and preferably humans. Additionally, they may serve as tools for anti-CD3? antibody purification and the detection of anti-CD3? antibodies in biological samples.

Abstract: A signal converting apparatus includes a comparing device, a first digital-slope quantizer, and a second digital-slope quantizer. The comparing device has a first input terminal and a second input terminal for receiving a received signal and an adjustable reference voltage respectively, and for generating an output signal at an output port. The first digital-slope quantizer is coupled to the output port and the second input terminal for generating a first set of digital signals to monotonically adjust the adjustable reference voltage at the second input terminal during a first phase according to a first quantization unit. The second digital-slope quantizer is coupled to the output port and the second input terminal for generating a second set of digital signals to monotonically adjust the adjustable reference voltage at the second input terminal during a second phase after the first phase according to a second quantization unit.

Abstract: The invention relates to a vibratory feeder comprising a support arrangement (8), for carrying out a vibrational movement when in operation, for a feeder element in which material (12) which is to be fed is fed, also comprising a drive arrangement (5) for the support arrangement (8) and a bearing arrangement (3) which initiates vibrational oscillations of the vibratory feeder (1, 30, 40, 60, 90, 100) reducing in the base (2). Means which suppress a movement of the vertical components due to the vibratory movement of the front end (10a) of the feeder element from that of the rear end (10b) when the vibratory feeder (30, 40, 60, 90, 100) is in operation are provided. The mass flow emitted by the vibratory feeder (30, 40, 60, 90, 100) can be easily changed without a time delay which can therefore improve the control of the vibratory feeder.

Abstract: The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as pancreatic cancer and metastases thereof.

Abstract: A radar system includes: a processing device arranged to generate a plurality of phase shifting digital signals; a plurality of transmitting devices for generating an RF beam according to the plurality of phase shifting digital signals during a first mode; a plurality of first receiving devices for generating a plurality of first digital signals according to a plurality of first incoming signals, respectively, during a second mode; and a plurality of second receiving devices for generating a plurality of second digital signals according to a plurality of second incoming signals, respectively, during the second mode. The processing device is further arranged to distinguish a first object and a second object when the RF beam hits the first object and the second object, and the first object and the second object have a same radial speed and are located at a same range.

Abstract: A signal divider includes: a dividing circuit arranged to generate an output oscillating signal according to a first input oscillating signal; and a signal generating circuit, coupled to the dividing circuit, for generating an injection signal to the dividing circuit. The dividing circuit is arranged to generate the output oscillating signal with a predetermined phase according to the injection signal and the first input oscillating signal.

Abstract: The present invention relates to cytokine fusion proteins and to nucleic acid molecules encoding such cytokine fusion proteins. The present invention further relates to cells, non-human organisms. pharmaceutical compositions and kits comprising the cytokine fusion proteins or the nucleic acid molecules encoding them, as well as to their use as medicaments.

Abstract: Disclosed is a method for registering at least two different 3D models, whereby the models image the same object at least in places, including: detecting and describing features in the 3D models; assigning features of the first 3D model to the features of the second based on descriptions that are as similar, for each feature of the first 3D model, a feature of the second is determined, and notating the first assignments as vectors, then performing the opposite assignment; comparing the vectors of the first and second assignments and determining common, bijective vectors of both, and randomly selecting at least three bijective vectors; applying the selected vectors to the first 3D model and checking whether the vectors essentially image common points of the 3D models; if successful, using the selected vectors to generate a transformation, and if not, discarding all vectors and rerunning of the method with other data.

Abstract: The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.

Abstract: The present invention relates to the provision of vaccines which are specific for a patient's tumor and are potentially useful for immunotherapy of the primary tumor as well as tumor metastases. In one aspect, the present invention relates to a method for providing an individualized cancer vaccine comprising the steps: (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient; and (b) providing a vaccine featuring the cancer mutation signature obtained in step (a). In a further aspect, the present invention relates to vaccines which are obtainable by said method.

Abstract: The present invention relates to expressing RNA in cells and, in particular, enhancing viability of cells in which RNA is to be expressed. Specifically, the present invention provides methods for expressing RNA in cells comprising the steps of preventing engagement of IFN receptor by extracellular IFN and inhibiting intracellular IFN signalling in the cells. Thus, preventing engagement of IFN receptor by extracellular IFN and inhibiting intracellular IFN signalling in the cells allows repetitive transfer of RNA into the cells.

Abstract: A remote debris tank includes a housing having a top and a bottom discharge opening, a pair of discharge doors mounted to opposing lateral sides of the bottom discharge opening and configured for pivotal movement between an open position and a closed position, and an actuating shaft operably coupled to the first and second discharge doors. The remote debris tank also includes a crank lever having a plurality of vertices, where the crank lever is secured to the actuating shaft at a first vertex and configured to rotate with the actuating shaft. A first radial arm has a first end articulately connected to a second vertex of the crank lever and a second end articulately connected to the first discharge door. Similarly, a second radial arm is articulately connected to a third vertex of the crank lever and extending away from the actuating shaft to the second discharge door.

Abstract: The present invention relates to methods and kits for the diagnosis, prognosis and/or monitoring of cancer in a patient. The present invention further relates to isolated peptides, panels of isolated peptides and diagnostic devices.

Abstract: The present invention provides methods for diagnosis or treatment of cancer diseases involving cancer stem cells comprising targeting CLDN6. In particular, the present invention provides a method of determining cancer stem cells comprising detecting cells expressing CLDN6, Furthermore, the present invention provides a method of treating or preventing cancer comprising inhibiting and/or eliminating cancer stem cells by administering an antibody having the ability of binding to CLDN6 to a cancer patient.

Abstract: The present invention is in the field of immunotherapy, in particular tumor immunotherapy. The present invention provides pharmaceutical formulations for delivering RNA to antigen presenting cells such as dendrite cells (DCs) in the spleen after systemic administration. In particular, the formulations described herein enable to induce an immune response after systemic administration of antigen-coding RNA.

Abstract: The present invention relates to RNA decorated particles such as RNA decorated lipid particles, preferably to RNA decorated liposomes. Further, the present invention relates to a pharmaceutical composition comprising RNA decorated particles such as RNA decorated lipid particles, preferably RNA decorated liposomes. Said pharmaceutical composition is useful for inducing an immune response. It is also useful in a prophylactic and/or therapeutic treatment of a disease involving an antigen. Furthermore, the present invention relates to a method for producing the RNA decorated particles such as RNA decorated lipid particles, preferably RNA decorated liposomes.

Abstract: A filter of the present invention creates a cavity filter that can be embedded within the inner layers of a printed circuit board. The embodiment can provide for a tunable microwave filter with lower loss, lower manufacturing cost and higher production yields. In addition, the tunable microwave includes a temperature compensation means to accommodate an electrical characteristic of filter with regard to the temperature variation. Such temperature compensation embodiment can be embedded into the upper layer communicably associated with the processor. For performing intelligent temperature compensation, the processor can include a look-up table of tuning values for controlling can store a set of temperature offset value that can modify the tuning table.

Abstract: A method for clearing unwanted data from optically detected virtual representations of objects includes: a. Defining an extension line of the representation; b. Generating a projection plane at one point of the extension line, which is perpendicular to the generated projection plane; c. Projecting all known points in space of the representation from one region on the projection plane onto the projection plane, the corresponding point in space being stored for each projected point; d. Generating a two-dimensional curve on the projection plane; e. Determining maxima, minima and a center of the curve; f. Identifying projected points of the curve that—viewed from the center of the curve—lie outside of the minima or maxima; g. Removing the points in space that correspond to the projected points that were identified in step f.; and h. Optionally, repeating starting from step b. for one further point of the extension line.