Abstract: The present invention relates to methods for predicting T cell epitopes useful for vaccination. In particular, the present invention relates to methods for predicting whether modifications in peptides or polypeptides such as tumor-associated neoantigens are immunogenic and, in particular, useful for vaccination, or for predicting which of such modifications are most immunogenic and, in particular, most useful for vaccination. The methods of the invention may be used, in particular, for the provision of vaccines which are specific for a patient's tumor and thus, in the context of personalized cancer vaccines.

Abstract: A zone controller system that includes global communication of inputs, outputs and controller states from all zone controllers allowing each zone controller to operate based on inputs, outputs and controller states from all other zones. The zone controller system may also include direct one-to-one communication connections that allow additional communications. The system may include a user interface to configure operation of the zone controllers utilizing programmable logic equations that may use as variables the inputs, outputs and controller states of any zone controller. The user interface may be implemented in an off board configuration tool that is run on a computer connected to the global network. The system may also utilize one-to-one communications connections to provide self-repair and auto-configuration features. Each zone controller may store its ID(s) and configuration parameters on two other zone controllers, where they can be recovered for self-repair and auto-configuration.

Abstract: The present invention relates to cytokine fusion proteins and to nucleic acid molecules encoding such cytokine fusion proteins. The present invention further relates to cells, non-human organisms. pharmaceutical compositions and kits comprising the cytokine fusion proteins or the nucleic acid molecules encoding them, as well as to their use as medicaments.

Abstract: The invention relates to a vibratory feeder comprising a support arrangement (8), for carrying out a vibrational movement when in operation, for a feeder element in which material (12) which is to be fed is fed, also comprising a drive arrangement (5) for the support arrangement (8) and a bearing arrangement (3) which initiates vibrational oscillations of the vibratory feeder (1, 30, 40, 60, 90, 100) reducing in the base (2). Means which suppress a movement of the vertical components due to the vibratory movement of the front end (10a) of the feeder element from that of the rear end (10b) when the vibratory feeder (30, 40, 60, 90, 100) is in operation are provided. The mass flow emitted by the vibratory feeder (30, 40, 60, 90, 100) can be easily changed without a time delay which can therefore improve the control of the vibratory feeder.

Abstract: The present invention relates to a patient-specific tumor treatment targeting individual expression patterns of tumor antigens, in particular shared tumor antigens, and individual tumor mutations. In one aspect, the present invention relates to a method for preventing or treating cancer in a patient comprising the steps of: (i) inducing a first immune response against one or more tumor antigens in the patient, and (ii) inducing a second immune response against one or more tumor antigens in the patient wherein the second immune response is specific for cancer specific somatic mutations present in cancer cells of the patient.

Abstract: An optical fingerprint recognition sensor package, which comprises a carrier, at least one image sensor, at least one light emitting diode, a first molding compound and at least one second molding compound is provided. The image sensor is disposed on the carrier and being electrically connected thereto. The at least one light emitting diode is peripherally surrounding the image sensor for providing at least one light source. The first molding compound made of infrared material is configured to be adjacent to the image sensor to hinder ambient lights from interfering with the image sensor. The second molding compound made of colored silicone is disposed over the light emitting diode to provide lighting path for the light source. By employing the proposed present invention, interferences from the ambient lights with the image sensor can be effectively avoided, thus increasing the accuracy and precision of the sensing results.

Abstract: The present invention relates to expressing RNA in cells and, in particular, enhancing viability of cells in which RNA is to be expressed. Specifically, the present invention provides methods for expressing RNA in cells comprising the steps of preventing engagement of IFN receptor by extracellular IFN and inhibiting intracellular IFN signalling in the cells. Thus, preventing engagement of IFN receptor by extracellular IFN and inhibiting intracellular IFN signalling in the cells allows repetitive transfer of RNA into the cells.

Abstract: A pulsating high pressure air and water nozzle is disclosed. The nozzle includes an impeller adapted to rotate about an axis, a housing adapted to secure the impeller therein, and a supply conduit secured to the housing. The supply conduit is orientated to direct a stream of pressurized fluid to impact the impeller to cause the impeller to rotate. The nozzle also includes a discharge port secured to the housing and is adapted to discharge a pulsating stream of fluid directly from the housing. The impeller includes a plurality of radial spaced vanes secured to a hub, where a cavity is disposed between each vane of the plurality of vanes. The plurality of vanes is adapted to intermittently block the discharge port as the impeller rotates. In addition, the nozzle includes a cover adapted to be removably secured to the housing to access an inside of the housing.

Abstract: The invention relates to a device for detecting the three-dimensional geometry of objects, in particular teeth, comprising a handpiece which is provided with at least one position sensor for detecting the change of the spatial position of the handpiece, and an optical device having at least one camera for capturing images and at least one light source for at least one projector. The position sensor in the handpiece initially determines the size of the change of the spatial position of the device. It is determined therefrom, how many pictures the camera can take in a defined time unit.

Abstract: The present invention relates to a patient-specific tumor treatment targeting individual expression patterns of tumor antigens, in particular shared tumor antigens, and individual tumor mutations. In one aspect, the present invention relates to a method for preventing or treating cancer in a patient comprising the steps of: (i) inducing a first immune response against one or more tumor antigens in the patient, and (ii) inducing a second immune response against one or more tumor antigens in the patient wherein the second immune response is specific for cancer specific somatic mutations present in cancer cells of the patient.

Abstract: A rotatable hydro excavation suction wand includes an upper section having an upper end configured to be connected to a suction hose, an angled lower section secured to a lower end of the upper portion and the angled lower section having an open end, and a rotary manifold connecting the upper section to the angled lower section and configured to rotate the angled lower section as the upper section remains fixed. The suction wand also includes a pressurized line coupled to the rotary manifold, where the angled lower section is adapted to rotate causing the open end to track in a circular motion covering an area larger than a diameter of the suction wand.

Abstract: An event data and location-linked spherical imaging system including a spherical imager configured for capturing a spherical image with an action; a localization device collocated with the spherical imager, the localization device configured for providing a location of the spherical imager; a level collocated with the spherical imager, the level configured for indicating an imaging level of the spherical imager; an event data receiver configured for receiving event data from a user, the event data is associated with one or more points of interest on the spherical image; and a compass configured for providing an orientation of the spherical imager in capturing the spherical image, wherein the orientation and location-linked event data is accessible within the context of the spherical image. In one embodiment, the spherical imager includes no more than two imagers. In one embodiment, the action is a single capture.

Abstract: The present invention provides binding agents that contain a binding domain that is specific for CD3 allowing binding to T cells and a binding domain that is specific for a tumor-associated claudin molecule and methods of using these binding agents or nucleic acids encoding therefor for treating cancer.

Abstract: A door locking device for hydro excavation equipment. The door locking device includes a grapple support housing secured to a door of a debris tank, a lower gripping jaw having a lower pin defining a lower axis about which the lower gripping jaw is configured to rotate, and an upper gripping jaw having an upper pin defining an upper axis about which the upper gripping jaw is configured to rotate. The locking device also includes a yoke having a first end coupled to proximate ends of the lower and upper gripping jaw, and an actuator coupled to a second end of the yoke and configured to extend and retract the yoke to cause the lower and upper gripping jaws to rotate in response thereto about the lower axis and the upper axis, respectively.

Abstract: A method to manufacture a native soil flowable fill includes hydro excavating native soil to form a hole at a first excavation, transferring the native soil from the first excavation to a debris tank, and adding a pozzolan component, cement and water to the debris tank. The method also includes mixing the native soil in the debris tank using a mixing apparatus to form the native soil flowable fill, and transferring the native soil flowable fill back to the first excavation into the hole. The native soil flowable fill comprises 30-90% by weight of native soil, 0-50% by weight of the added pozzolan component, 0-50% by weight of the cement, and 10-45% by weight of the water.

Abstract: A system to manufacture a native soil flowable fill onsite includes hydro excavation equipment having a suction hose. In addition, the system includes a plurality of onsite debris tanks, where each onsite debris tank is configured to be coupled separately to the suction hose and to store native soil vacuumed from an adjacent hole at an onsite excavation. The system also includes a mixing apparatus inside each of the onsite debris tanks configured to mix the native soil from the adjacent hole with additional components to form a native soil flowable fill for the respective adjacent hole.

Abstract: A system to excavate and remove underground noxious vapors includes a suction wand in fluid communication with a debris tank. A collar is fitted around the suction wand and is configured to seal noxious vapors within a hole around the suction wand. A primary valve is used to control whether the suction wand is being used to excavate material to send to the debris tank, or whether the suction wand is being used to remove noxious vapors from the hole to send to a filtration unit. A monitor is configured to detect explosive concentrates in the noxious vapors to determine whether the explosive concentrates exceed an acceptable level. In addition, the system is configured to dilute and filter the noxious vapors before discharging to the atmosphere.

Abstract: A strongarm device for use with a hydro excavation hose includes a support frame configured to carry hydro excavation equipment, a support post having first and second ends, the first end being secured to the support frame, and a boom having a first end and a second end, where the first end is pivotally connected to the second end of the support post and configured for the second end of the boom to rotate relative thereto. In addition, the strongarm device includes a bracket secured to and suspended from the second end of the boom, and a roller secured to the bracket and configured for the hydro excavation hose to roll back and forth over an upper surface of the roller.

Abstract: A fingerprint identification optical imaging package structure is applied in the field of the fingerprint identification optical system. An isolating base is arranged under a light source device and a height of the isolating base is higher than a height of a sensing base to achieve the effects of light shielding and preventing from being influenced by the heat of the light source. And then, the sensitivity and precision of fingerprint reading and identifying may be increased and improved. At the same time, the volume may be reduced to make the applicability of the structure much broader.

Abstract: A rotating high pressure air and water nozzle is disclosed. The nozzle includes a head adapted to rotate, a housing adapted to secure the head therein, and a plurality of passageways disposed through the head. In addition, the nozzle includes a supply port disposed at a first end of each of the passageways, where each supply port has a funnel shape adapted to direct fluid into each passageway to reduce hydraulic losses, and a discharge port disposed at an opposing end of each of the passageways adapted to discharge a jet of fluid. Each discharge port is offset from the respective supply port to cause the head to rotate when fluid flows through the passageways.