Patents Assigned to Trustee
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Publication number: 20250255638Abstract: A system for creating an endoluminal valve from a blood vessel wall, includes: a tubular assembly having a longitudinal axis, a proximal end, a distal portion with a distal end, and a first lumen extending from the proximal end to a distal port located proximate the distal portion, the distal port located along the longitudinal axis, the distal portion having a supporting surface on a same side of the tubular assembly as the distal port, the supporting surface extending in a longitudinal direction and offset from a surface of the tubular assembly proximal the distal port and configured to contact the blood vessel wall; and a tissue dissection probe disposed within the first lumen, the tissue dissection probe having a fluid delivery lumen extending to a fluid delivery port located at a distal end of the tissue dissection probe, the tissue dissection probe configured to be inserted into the blood vessel wall.Type: ApplicationFiled: March 3, 2025Publication date: August 14, 2025Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Fletcher T. Wilson, Rhunjay J. Yu
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Patent number: 12385010Abstract: Methods are provided for the cell-based delivery of collagen VII for the treatment of Epidermolysis Bullosa and corneal erosion. The disclosure also provides a composition and a pharmaceutical composition comprises, comprise, or alternatively consist essentially of, or yet further consist of a keratinocyte sheet or a corneal cell sheet.Type: GrantFiled: October 31, 2024Date of Patent: August 12, 2025Assignees: The Board of Trustees of the Leland Stanford Junior University, The United States Government as represented by the Department of Veterans AffairsInventors: Zurab Siprashvili, Ngon T. Nguyen, M. Peter Marinkovich, Jean Tang, Alfred T. Lane, Paul A. Khavari
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Patent number: 12389052Abstract: New systems and methods allow for transmission of multiple types of content protocols over a unidirectional content delivery network, such as a television broadcast. Hardware and/or software used at the network transmission location (such as a television broadcast station) and hardware and/or software located at an endpoint (such as a home television, car infotainment system, or first responder location) allow for a native ATSC 1.0 signal to have embedded within it additional content that is not encoded as ATSC 1.0 content. The non-ATSC 1.0 content can be detected and segregated from ATSC 1.0 content so that the endpoint devices (such as a television receiver) will not attempt to render the non-ATSC 1.0 content (such as, e.g., ATSC 3.0 content or application specific content) as normal ATSC 1.0 programming. Instead, the non-ATSC 1.Type: GrantFiled: June 6, 2023Date of Patent: August 12, 2025Assignee: Board of Trustees of Michigan State UniversityInventors: Chandra Kotaru, Prabu David, Susanne Elkins
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Patent number: 12383581Abstract: The present invention includes compositions and methods for treating AML utilizing bispecific CARs. In certain aspects, the invention includes a bispecific split CAR which binds CD13 and TIM-3 on AML cells.Type: GrantFiled: October 9, 2020Date of Patent: August 12, 2025Assignee: The Trustees of the University of PennsylvaniaInventors: Xianxin Hua, Xin He, Xuyao Zhang
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Patent number: 12385838Abstract: A spectroscopy and microscopy system and method include a source of pulsed infrared light generating pulsed infrared excitation light for exciting a sample, such that the pulsed infrared light selectively heats the sample by absorption of the pulsed infrared light and allows the sample to cool. A source of probe light generates probe light for illuminating the sample. A detection element detects a signal indicative of selective heating of the sample by the excitation light. A processor receives the signal indicative of the selective heating of the sample, computes a time rate of local temperature rise in the sample to obtain instantaneous absorption in the sample, and, using the instantaneous absorption, generates a spectrum related to the sample.Type: GrantFiled: January 24, 2025Date of Patent: August 12, 2025Assignee: Trustees of Boston UniversityInventors: Ji-Xin Cheng, Jiaze Yin
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Patent number: 12385874Abstract: A sensor includes a bio-recognition module and a transducer module having a dock sized and shaped to receive the bio-recognition module. The bio-recognition modules comprise a hydrogel matrix having bio-recognition elements embedded therein. The bio-recognition elements cause a particular biochemical input to engage in an interaction that generates a perturbation in an electric field within the bio-recognition module. The transducer module transduces this perturbation into an electrical signal that is provided at an output of the transducer module. This electrical signal indicates occurrence of the interaction.Type: GrantFiled: August 11, 2020Date of Patent: August 12, 2025Assignee: Trustees of Tufts CollegeInventors: Xiaocheng Jiang, Xiaochuan Dai, Richard Vo, Huan-Hsuan Hsu, Zhiming Mo, Hamed Hosseini Bay
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Patent number: 12384875Abstract: Disclosed herein are ladder polymers comprising fused aromatic and non-aromatic rings. Also disclosed are the manufacture and use of these ladder polymers, e.g., in separation membranes, such as membrane for gas separation.Type: GrantFiled: October 23, 2020Date of Patent: August 12, 2025Assignees: The Board of Trustees of the Leland Stanford Junior University, Massachusetts Institute of TechnologyInventors: Holden Wan Hong Lai, Jun Myun Ahn, Yan Xia, Zachary P. Smith, Francesco M. Benedetti
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Patent number: 12384993Abstract: A bioreactor comprising a housing defining a perfusion chamber, the housing including at least one port, wherein the at least one port is coupled to the housing, and a sample holder positioned within the perfusion chamber. A bioreactor and spheroid-based biofabrication method for making perfusible tissue constructs and perfusing them.Type: GrantFiled: August 9, 2021Date of Patent: August 12, 2025Assignee: The Trustees of Indiana UniversityInventors: Lester Jeshua Smith, Brian Paul McCarthy, Mark Robert Holland, Paul Richard Territo
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Patent number: 12385837Abstract: A photon peak event detection system accepts an analog output from a photon sensor, directly digitizes the analogy output and includes a graphics processing unit (GPU) programmed to conduct a photon peak event detection in real-time via a photon count program that analyzes the digitized photon sensor output in sampling periods each having at least three consecutive data points to determine a local maximum among the consecutive data points and compare the local maximum to one or more predetermined thresholds to determine whether or not a photon was received in each sampling period, the algorithm providing photon counts to a phasor analysis program in the GPU. The phasor analysis program calculates pixelwise fluorescence lifetime phasor data in real-time and sends the data to a central processing unit.Type: GrantFiled: June 9, 2022Date of Patent: August 12, 2025Assignee: The Board of Trustees of the University of IllinoisInventors: Stephen Boppart, Janet Sorrells, Rishyashring Raman Iyer
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Patent number: 12385841Abstract: Systems and methods implement of high-speed delay scanning for spectroscopic SRS imaging characterized by scanning a first pulsed beam across a stepwise reflective surface (such as a stepwise mirror or a reflective blazed grating) in a Littrow configuration to generate near continuous temporal delays relative to a second pulsed beam. Systems and methods also implement deep learning techniques for image restoration of spectroscopic SRS images using a trained encoder-decoder convolution neural network (CNN) which in some embodiments may be designed as a spatial-spectral residual net (SS-ResNet) characterized by two parallel filters including a first convolution filter on the spatial domain and a second convolution filter on the spectral domain.Type: GrantFiled: August 17, 2023Date of Patent: August 12, 2025Assignee: Trustees of Boston UniversityInventors: Ji-Xin Cheng, Haonan Lin
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Patent number: 12383196Abstract: Provided herein are, inter alia, methods for identifying subjects suffering from depression that will respond to treatment with an antidepressant.Type: GrantFiled: October 15, 2019Date of Patent: August 12, 2025Assignees: The Board of Trustees of the Leland Stanford Junior University, Board of Regents, The University of Texas System, The United States Government as represented by the Department of Veterans AffairsInventors: Amit Etkin, Madhukar Trivedi, Wei Wu
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Patent number: 12384023Abstract: Various implementations include a modular soft robot including a base, an arm coupled to the base, and an actuator. The arm includes a first surface and a second surface opposite and spaced apart from the first surface. The first surface defines a plurality of channels, each channel comprising a proximal end at the first surface and a distal end spaced apart from the proximal end. Each channel has a longitudinal axis extending therethrough. The actuator is configured to deform the arm.Type: GrantFiled: April 20, 2023Date of Patent: August 12, 2025Assignee: The Board of Trustees of The University of AlabamaInventors: Vishesh Vikas, Caitlin Freeman, Michael Maynard
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Patent number: 12387816Abstract: Processes to identify a subset of trait-related genes and classify individuals are described. Generally, systems generate classification models which are used to identify the subset of trait-related genes and classify individuals. The classification models are also used in various applications, including developing research tools, performing diagnostics, and treating individuals.Type: GrantFiled: January 9, 2019Date of Patent: August 12, 2025Assignees: The Board of Trustees of the Leland Stanford Junior University, The United States Government as represented by the Department of Veterans AffairsInventors: Jingjing Li, Sai Zhang, Michael P. Snyder, Cuiping Pan, Philip S. Tsao
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Patent number: 12386807Abstract: Various disclosed embodiments pertain to a distributed audit trail system for use in a connected system including: a master unit to control a first aspect of the connected system and to create a blockchain light client and a distributed hash table (DHT); a first node to control a second aspect of the connected system; a second node to control a third aspect of the connected system; and one or more remote servers to form a blockchain full node, where the master unit, the first node, and the second node electronically communicate with each other through the DHT in order to form a combined audit trail, where the master unit creates a meta-hash of the software version of the software in the master unit, the first node, and the second node, system identification data, system sensor data, and system hardware configuration.Type: GrantFiled: October 5, 2021Date of Patent: August 12, 2025Assignees: The Board of Trustees of the Leland Stanford Junior University, Board of Trustees of Michigan State UniversityInventors: Gregory Falco, Joshua Siegel
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Patent number: 12385065Abstract: Compositions and regimens useful in treating type I citrullenemia are provided. The compositions include recombinant adeno-associated virus (rAAV) with a transthyretin enhancer and promoter driving expression of a human Argininosuccinate Synthase 1 (ASS1).Type: GrantFiled: November 21, 2022Date of Patent: August 12, 2025Assignee: The Trustees of the University of PennsylvaniaInventors: James M. Wilson, Jenny Agnes Sidrane, Lili Wang
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Publication number: 20250250582Abstract: Plant cells, plants, seeds and portions of plants modified or genetically engineered to have increased expression or activity of at least one protein selected from the group consisting of trehalose phosphate synthetase (TPS), trehalose phosphate phosphatase (TPP), Protein ALP1-like (At3g55350 or ALPL1), Glycosyltransferase 75D1 (UGT75D1), Cytochrome P450 709B2 (CYP709B2), Cytochrome P450 709B1 (CYP709B1) and Cytochrome P450 72A15 (CYP72A15) are provided herein. Also provided are methods of increasing plant resistance to herbicides and/or abiotic stress by increasing expression of at least one of trehalose phosphate synthetase (TPS), trehalose phosphate phosphatase (TPP), Protein ALP1-like (At3g55350 or ALPL1), Glycosyltransferase 75D1 (UGT75D1), Cytochrome P450 709B2 (CYP709B2), Cytochrome P450 709B1 (CYP709B1) or Cytochrome P450 72A15 (CYP72A15).Type: ApplicationFiled: January 3, 2025Publication date: August 7, 2025Applicant: The Board of Trustees of the University of ArkansasInventors: Christopher E. Rouse, Nilda Roma-Burgos, Gulabben Rangani
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Publication number: 20250252263Abstract: Disclosed are systems, methods, and other implementations, including a method for detecting machine-generated content that includes receiving written source input at a machine learning system configured to transform written content into resultant transformed content, and generating by the machine learning system one or more rewritten versions of the written source input, with the one or more rewritten versions being semantically similar to the written source input. The method further includes deriving one or more rewriting change measurements, for the one or more rewritten versions, representing extent of differences between the one or more rewritten versions and the written source input, and determining likelihood that the written source input was machine generated based at least on the derived one or more rewriting change measurements.Type: ApplicationFiled: January 28, 2025Publication date: August 7, 2025Applicant: The Trustees of Columbia University in the City of New YorkInventors: Junfeng YANG, Chengzhi MAO, Carl VONDRICK, Wei HAO
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Publication number: 20250250616Abstract: Provided are methods of analyzing target nucleic acids, the methods comprising, using the target nucleic acids as reagents and reporters as substrates, assaying enzyme kinetic parameters of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) endonucleases comprising guide RNAs (gRNAs) that hybridize with reference nucleic acids. In certain aspects, certain such methods comprise comparing a sequence of a target nucleic acid with a sequence of a reference nucleic acid. In some embodiments, such comparison is based on the rates of cleavage of the reporters at plurality of concentrations of the reporters. The kinetic parameters can also be the Michaelis-Menten constant (KM), the apparent turnover rate (K*cat), and/or the apparent catalytic efficiency (K*cat/KM). Kits for performing the methods of the disclosure are also provided.Type: ApplicationFiled: April 12, 2023Publication date: August 7, 2025Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Juan Santiago, Alexandre Avaro, Ashwin Ramachandran, Diego Huyke, Charles Blanluet
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Publication number: 20250249454Abstract: Disclosed is a method to control and manipulate floating water droplets. More particularly, disclosed are the self-assembly and pattern formation of electrically charged water droplets that are floating at an oil-gas interface. Also shown is that the assembly occurs because of electrostatic interactions between the drops. It is shown that the depth of the oil bath plays a significant role in the distance between the drops assembled at the interface. The relevance of the type of the boundary containing the entire system is highlighted by showing that even drops with a net zero electric charge can self-assemble under certain conditions. Furthermore, disclosed are ways to control the motion and the assembly of the drops at an interface.Type: ApplicationFiled: February 7, 2025Publication date: August 7, 2025Applicant: The Trustees of Princeton UniversityInventors: Paul R. Kaneelil, Howard A. Stone, Amir A. Pahlavan, J. Pedro de Souza, Günther Turk
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Patent number: RE50514Abstract: A method for treating a subject having a diseased or atrophic state of fibrotic tissue, kidney disease and associated nerve endings, or for promoting tissue regeneration in muscle tissue is accomplished through exposing the tissue with a laser light having a wavelength of about 400 nm to about 700 nm, or more preferably having a wavelength of about 405 nm, about 532 nm, about 635 nm, or a combination thereof. Subsequent to exposure, mesenchymal stem cells can be administered to the subject. After the administration of mesenchymal stem cells, the tissue is further exposed to laser light having a wavelength of about 400 nm to about 700 nm, or a laser light having a single wavelength of about 400 nm to about 700 nm. The mesenchymal cells can be interferon gamma activated.Type: GrantFiled: December 15, 2022Date of Patent: August 5, 2025Assignee: The Board of Trustees of the University of IllinoisInventors: Amelia Bartholomew, Megan O'Connor, Rachana Patil