Abstract: A stimulated Raman photothermal (SRP) microscope for imaging a sample. A first optical source without an optical resonator emits a pump beam. A second optical source emits an intensity-modulated Stokes beam. The Stokes beam is combined with the pump beam to form a combined beam. The combined beam is directed to the sample to induce a thermal effect caused by the stimulated Raman process. A third optical source emits a probe beam, the probe beam is directed to the sample. An optical detector detects modulation of the probe beam after modulation by the sample to measure an SRP signal. Because noise in the pump and Stokes beam do not significantly effect the measurements from the probe beam, these beams can use a high-powered optical parametric amplifier (OPA) source for improved sensitivity and imaging speed compared to SRP microscopes using an optical parametric oscillator (OPO) source.

Abstract: Disclosed herein are compositions comprising a polymer and a metabolic inhibitor, as well as a method of using the composition to modulate an immune response. The composition may be produced in the form of a synthetic tissue for provision in a subject. The composition or synthetic tissue may further comprise additional therapeutic agents.

Abstract: A spectroscopy and microscopy system and method include a source of pulsed infrared light generating pulsed infrared excitation light for exciting a sample, such that the pulsed infrared light selectively heats the sample by absorption of the pulsed infrared light and allows the sample to cool. A source of probe light generates probe light for illuminating the sample. A detection element detects a signal indicative of selective heating of the sample by the excitation light. A processor receives the signal indicative of the selective heating of the sample, computes a time rate of local temperature rise in the sample to obtain instantaneous absorption in the sample, and, using the instantaneous absorption, generates a spectrum related to the sample.

Abstract: Provided herein are methods using machine learning to predict protein variants that are likely to occur in nature. Such variants can be used (selected) to improve properties of the proteins. Also provided herein are antibodies and antigen binding portions thereof generated using the provided methods that specifically bind several antigens from coronaviruses, ebolaviruses, and influenza A viruses, various compositions of such antibodies or antigen binding portions thereof, recombinant nucleic acids encoding the antibodies and antigen binding portions thereof, and associated methods of use.

Abstract: A system and methods to obfuscate encrypted data packets from traffic analysis attacks are disclosed. At a high level, a processing device: executes an application or protocol for receiving traffic associated with the application or protocol; selects an obfuscation interval duration for a next transmission of a data packet; determines, at the obfuscation interval duration, if a queue for transmission of a next data packet associated with the application or protocol is: i) empty, or ii) has a next data packet associated with an application or protocol; and transmits, based on the determination, at least one of: i) a length-adjusted next encrypted data packet, or ii) an encrypted obfuscation data packet. In The transmitted length-adjusted encrypted next data packet can be generated using the next data packet and is adjusted in length with an obfuscation payload prior to encryption and subsequent transmission.

Abstract: A magnetic separation device has a membrane having a plurality of pores, a magnetically soft material layer disposed on the membrane, and a passivation layer disposed on the magnetically soft material layer. The magnetic separation device may be part of a microfluidic device having a lateral flow channel and a vertical flow magnetic separation filter. The magnetic separation device may be used to separate magnetically tagged particles, such as cells.

Abstract: Various implementations include a device for deposition of conformal coatings. The device includes a powder container, a connecting rod, and a crankshaft. The powder container has a first side configured to contain a powder and a second side. The connecting rod has a first end directly hingedly coupled to the second side of the powder container and a second end. The crankshaft has a longitudinal axis, a main shaft portion extending along the longitudinal axis, and a cam portion radially offset from and rotatable about the longitudinal axis. The second end of the connecting rod is directly rotatably coupled to the cam portion. Rotation of the crankshaft about the longitudinal axis causes the second end of the connecting rod to rotate about the longitudinal axis, causing the powder container to linearly oscillate between a first position and a second position.

Abstract: Articles and methods involving fluidic devices are generally provided. In some embodiments, a fluidic device comprises a first layer comprising a central region in fluidic communication with an environment external to the fluidic device. The first layer may also comprise a first channel and a second channel in fluidic communication with the central region and extending radially outwards therefrom. The first and second channels may comprises first and second sample regions from which first and second samples can be removed from the fluidic device. In some embodiments, a fluidic device comprises a first layer and a second, filtration layer configured to separate blood cells from plasma positioned between the environment external to the fluidic device and the first layer.

Abstract: Systems and methods are provided for detecting vehicle position during electric vehicle charging using machine learning, as well as a control scheme for activating charging coils when the vehicle crosses them. The machine learning can have as inputs the primary current, the vehicle ground clearances, and the speed of the vehicle. As different vehicles with different ground clearances are traveling across the transmitter coils for charging, ground clearance can be defined as a variable for machine learning. Vehicles can move at different speeds, so the speed of the vehicle can be considered in the prediction of the vehicle position.

Abstract: Systems and methods are described for sharing components among intelligent agents, such as robot agents that perform tasks autonomously. The intelligent agents may include functional components implemented in a middleware layer that provides an interface among the functional components. The functional components may include components for sensory information processing, managing goals and tasks, planning tasks, knowledge bases, and effector information processing. The middleware layer of the intelligent agents may include a component sharing layer. The component sharing layer may search for and identify components running on agents of an agent group that satisfy one or more constraints specified by a requesting component. The component sharing layer may establish a connection between the requesting component and the identified component. The requesting component may utilize services of the identified component to complete a goal or task.

Abstract: An approach to control or monitoring of battery operation makes use of a recurrent neural network (RNN), which receives one or more battery attributes for a Lithium ion (Li-ion) battery, and determines, based on the received one or more battery attributes, a state-of-charge (SOC) estimate for the Li-ion battery.

Abstract: A rice cultivar designated ARoma 22 is disclosed herein. The present invention provides seeds, plants, and plant parts derived from rice cultivar ARoma 22. Further, it provides methods for producing a rice plant by crossing ARoma 22 with itself or another rice variety. The invention also encompasses any rice seeds, plants, and plant parts produced by the methods disclosed herein, including those in which additional traits have been transferred into ARoma 22 through the introduction of a transgene or by breeding ARoma 22 with another rice cultivar.

Abstract: Antigen binding domain polypeptides (ABD) specific for human CD93 are provided, which ABD may be formatted as antibodies, as chimeric antigen receptors, and the like. T cells comprising an anti-CD93 CAR are useful in the treatment of cancer, e.g. hematologic malignancies.

Abstract: Batteries having a metal interlayer that acts as an ion conductor are provided, as well as methods of forming the same. The metal interlayer can include, for example, palladium, platinum, iridium, rhodium, ruthenium, osmium, gold, silver, or a combination thereof, and can act as a conductor while also inhibiting the transport of other species that would produce byproduct films and cause capacity degradation in the battery.

Abstract: The present invention provides a clinically applicable method of stem cell transplantation that facilitates engraftment and reconstitutes immunocompetence of the recipient without requiring radiotherapy or chemotherapy, and without development of GVHD or graft rejection.

Abstract: An approach to control or monitoring of battery operation makes use of an artificial neural network (ANN), which receives one or more battery attributes for a Lithium ion (Li-ion) battery, and determines, based on the received one or more battery attributes, a state-of-charge (SOC) and/or a state-of-health (SOH) estimate for the Li-ion battery. The ANN includes at least one of a recurrent neural network (RNN) and a convolutional neural network (CNN), and the series of values of the battery attributes includes at one of battery voltage values, battery current values, and battery temperature values.

Abstract: Disclosed herein are kits, articles, and methods for blood separation, comprising: a support structure comprising an inlet, an outlet, and a channel between the inlet and the outlet; a separation device; and an absorbent layer; wherein the absorbent layer and support structure are configured such that the absorbent layer can be positioned in the support structure and be in fluidic connection with the inlet and the outlet of the support structure; wherein the separation device is removable from the support structure; wherein the outlet is a vessel and/or is configured to be in fluidic connection with a vessel.

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing a nucleic acid.

Abstract: A computing system includes accelerator devices for hardware acceleration of operations of a fully homomorphic encryption (FHE) application, including a hybrid bootstrapping operation that may be parallelized for increased performance. Hybrid bootstrapping includes a first extraction on a first ciphertext (e.g., Ring Learning with Errors or RLWE) to form a plurality of second ciphertexts (e.g., LWE) corresponding to respective elements of the encrypted data, and a plurality of blind-rotate operations performed independently on the respective second ciphertexts to collectively produce a plurality of third ciphertexts (e.g., RLWE). A second extraction of respective elements of the third ciphertexts forms a plurality of fourth ciphertexts (e.g., LWE), and a repacking of respective elements of the fourth ciphertexts recreates the first-ciphertext representation of the encrypted data with restored modulus and reduced noise.

Abstract: Immunogenic compositions and methods of their use in eliciting immune responses to coronaviruses, such as SARS-CoV-2 are provided.