Abstract: Methods for encapsulating water-soluble biologic and small molecule active pharmaceutical ingredients (APIs) into nanoparticles by applying nanoprecipitation techniques and ion-pairing the nanoparticles with hydrophobic counterions to produce new API salts that exhibit altered solubilities are presented.

Abstract: Disclosed are methods, systems, devices, circuits. and other implementations, including a method for error identification and correction that includes obtaining from a memory device coded input data, the coded input data previously encoded by multiplying a source data element by a pre-determined multiplier, and stored in the memory device, and performing a decoding operation on the coded input data obtained from the memory device, with the decoding operation including at least a modulo operation, to derive a resultant decoded data element and a remainder portion. The method further includes determining whether the coded input data includes a corrupted portion based on a value of the remainder portion.

Abstract: Systems and methods for predictive glucose in accordance with embodiments of the invention are illustrated. One embodiment includes glucose management device, including a brain signal recorder, and a controller, including a processor, and a memory, the memory containing a glucose monitoring application configured to direct the processor to record a brain activity signal of a user's brain using the brain signal recorder, and decode the brain activity signal to predict future glucose levels of the patient.

Abstract: An ink may be provided that includes a two-dimensional WS2 nanosheet and an organic solvent, such as water, and may be free of protective molecules and surfactants. Circuits may be provided that include this ink disposed onto a surface of a substrate (such as a flexible substrate) in various patterns, including, e.g., a superconducting qubit. The ink may be formed by sonicating, then centrifuging at a first speed, a sulfuric acid-KxWS2 solution, where x=0.3˜0.7, removing any supernatant from the centrifuged first suspension and replacing with water and sonicating the resulting WS2-water suspension, then centrifuging the result at a speed slower than the first speed, and using an upper portion of the resulting suspension.

Abstract: A method of producing ethanol by electrocatalytic reduction of carbon dioxide, comprises reducing carbon dioxide in an aqueous electrolyte on an electrocatalyst with electricity. The electrocatalyst is exposed to a magnetic field of at least 400 Gauss, the electrocatalyst comprises at least one paramagnetic material, and an amount of ethanol produced by the reducing is greater than an amount of ethanol produced without the magnetic field. Also described is a system for electrocatalytic reduction of carbon dioxide, which comprises (a) and electrocatalyst, containing (i) copper and (ii) copper oxide, C60 and/or neodymium; (b) an aqueous electrolyte, in contact with the electrocatalyst; (c) a counter electrode, in ion-conductive contact with the electrocatalyst; (d) a magnet, for providing a magnetic field of at least 400 Gauss to the electrocatalyst; and (e) a power source, electronically connected to the electrocatalyst and the counter electrode.

Abstract: Systems, frameworks, and methods for reinforcement learning (RL)-based real-time path planning for unmanned aerial vehicles (UAVs) are provided. The learning capabilities of federated learning (FL) can be integrated with an improved deep RL framework, including using a significant reply memory buffer (SRMB) to accelerate the intelligent behavior. The framework can train a UAV to intelligently dodge static and dynamic defense systems and achieve assigned goals (e.g., in a hostile area). The FL can enable collaborative learning through a swarm of UAV agents.

Abstract: Antenna arrays with three-dimensional (3D) conformal radiating elements are provided, as well as methods of manufacturing and methods of using the same. An array can include a ground plane and a plurality of unit cells disposed thereon. Each unit cell can include a 3D conformal radiating element. The 3D conformal radiating elements can be, for example, patches (e.g., circular 3D patches), dipoles, or loops, and each radiating element is conformal on a hemispherical shape.

Abstract: The present invention provides compositions and methods for generating a genetically modified T cells comprising a chimeric antigen receptor (CAR) having an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain, wherein the T cell exhibits prolonged exponential expansion in culture that is ligand independent and independent of the addition of exogenous cytokines or feeder cells.

Abstract: A system, apparatus, and method for demodulation of a fiber optic sensor is provided. An aspect of the system provides an optical fiber, a laser, a phase modulator configured to be coupled to the optical fiber, and a sensor. The laser emits a laser beam into the optical fiber. The phase modulator receives the laser beam from the laser and directs the laser beam to the sensor. The sensor includes a coiled portion of the optical fiber, uncoiled segments adjacent the coiled portion, and at least two fiber Bragg gratings configured to be coupled to opposite uncoiled segments adjacent the coiled portion of the optical fiber. The sensor system may further include a photodetector configured to receive a reflected portion of the laser beam from the sensor. The reflected portion is divided into at least two paths where at least two sub-outputs are generated for demodulation and sensing.

Abstract: Therapeutic antibodies specific for osteopontin and methods of using them for treating osteopontin-associated disorders are provided. In particular, antibodies, or antigen-binding fragments thereof, that inhibit thrombin-cleavage of osteopontin or block the activity of thrombin cleavage fragments of osteopontin are provided. Additionally, antibody conjugates and pharmaceutical compositions or formulations comprising the antibodies or antibody conjugates as well as kits including the antibodies, conjugates, or formulations are also provided.

Abstract: Temperature sensors particularly suitable for high temperature heat flux measurements across the thickness of a component, for example a turbine blade. The sensors comprise one or more conductive traces that wrap around an edge of the component, thereby connecting one or more hot junctions on the hot side of the component to the cold junction contacts on the colder side of the component. In some embodiments the traces comprise two dissimilar materials, such as indium tin oxide (ITO) and platinum. Alternatively, if the component is electrically conductive, the component itself can form one thermoelement of the sensor.

Abstract: An end-to-end trainable grouped mathematically differentiable non-maximal suppression (NMS) technique is presented for monocular 3D object detection. First, formulate NMS as a matrix operation and then group and mask the boxes in an unsupervised manner to obtain a simple closed-form expression of the NMS. This technique addresses the mismatch between training and inference pipelines and, therefore, forces the network to select the best 3D box in a differentiable manner. As a result, the proposed technique achieves state-of-the-art monocular 3D object detection results on the KITTI benchmark dataset performing comparably to monocular video-based methods.

Abstract: A method of making a bijel includes dispersing surface-active nanoparticles in a ternary liquid mixture. The ternary liquid mixture includes a hydrophilic liquid, a hydrophobic liquid, and a solvent. The ternary liquid mixture is contacted with water. A bijel includes a stable mixture of two immiscible liquids separated by an interfacial layer of colloidal particles. The bijel has temperature-independent stability, and the domain sizes are below one micrometer.

Abstract: Multiparametric analysis is performed at the single cell level of biological samples obtained from an individual during pregnancy to obtain a determination of changes in immune cell subsets, which changes include, without limitation, altered activation states of proteins involved in signaling pathways. Changes occur in signaling pathways of these immune cells that are predictive of propensity to develop preeclampsia in the pregnancy.

Abstract: The disclosure includes non-naturally occurring or engineered CRISPR systems and proteins, associated with a delivery system comprising a virus component and a lipid component. The disclosure includes CRISPR proteins associated with capsid proteins, e.g., AAV VP1VP2, and/or VP3, on the surface of or internal to the AAV, along with compositions, systems and complexes involving the AAV-CRISPR protein, nucleic acid molecules and vectors encoding the same, deliver}-systems, and uses therefor.

Abstract: A large-scale harmful algae bloom mitigation system that is environmentally safe, cost-effective, and scalable utilizing a hyperoxic nanobubble treatment and remote brevetoxin screening, without relying on heavy laboratory equipment. The hyperoxic nanobubble treatment and remote brevetoxin screening system is configured for installation within a narrow cross-section of an area of a body of water. The system is a stationary, high oxygen concentration, gas flow system that injects a large amount of oxygen enriched nanobubbles underwater at a small cross-section of a body of water, thereby controlling a large amount of water rapidly and in an environmentally-safe manner.

Abstract: Methods are provided for the isolation and analysis of circular DNA from complex samples, based on the topology of the DNA molecule. A sample comprising DNA species is combined with a chaotropic dense salt solution. A fraction containing the circular DNA of interest is isolated and dialyzed to remove excess salt. In some embodiments salt gradients are generated by ultracentrifugation in the absence of intercalating dyes, e.g. ethidium bromide; and in the absence of protease digestion. The circular DNA thus isolated is substantially pure, e.g. greater than about 75%, greater than about 80%, greater than about 90%, greater than about 95% of DNA in the isolated fraction is comprised of circular DNA.

Abstract: The present disclosure provides, inter alia, a recombinant engineered deubiquitinase (DUB) and methods for treating or ameliorating an inherited ion channelopathy, such as long QT syndrome, Brugada syndrome, or cystic fibrosis, in a subject. Further provided are methods for screening mutations causing such inherited ion channelopathies for a trafficking-deficient mutation that is treatable by the recombinant engineered DUB disclosed herein.

Abstract: A short-wave infrared photothermal (SWIP) microscopy system and method for vibrational imaging of a sample generates shortwave infrared excitation light probe light. The excitation light and the probe light are combined to generate a combined beam, which is focused to generate a focused combined beam, which is directed onto the sample to obtain a SWIP signal generated by absorption-induced thermo-optic selective heating of the sample. The SWIP signal is collected through an aperture in a condenser and detected.

Abstract: The present disclosure provides, inter alia, a recombinant engineered deubiquitinase (DUB) and methods for treating or ameliorating an inherited ion channelopathy, such as long QT syndrome, Brugada syndrome, or cystic fibrosis, in a subject. Further provided are methods for screening mutations causing such inherited ion channelopathies for a trafficking-deficient mutation that is treatable by the recombinant engineered DUB disclosed herein.