Patents Assigned to Trustee
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Patent number: 12377077Abstract: Methods of treatment and pharmaceutical formulations configured to treat primary and secondary mitochondrial dysfunction are provided. The methods and treatments use an agonist of AMPK. The agonist activates AMPK to activate ATP-producing pathways and inhibiting ATP-consuming pathways, thus allowing for the alleviation of symptoms associated with mitochondrial dysfunctions.Type: GrantFiled: December 31, 2019Date of Patent: August 5, 2025Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Tereza Moore, Tina M. Cowan, Gregory M. Enns, Mehrdad Shamloo, Michael J. Green, Alam Jahangir, Rolando E. Yanes
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Patent number: 12379331Abstract: In accordance with the invention, an X-ray amplitude analyzer grating adapted for use in an interferometric imaging system, the interferometric imaging system comprising an X-ray source and an X-ray detector with an X-ray fringe plane between the X-ray source and the X-ray detector, wherein an X-ray fringe pattern is formed at the X-ray fringe plane, wherein the X-ray amplitude analyzer grating is provided. The X-ray amplitude analyzer grating comprises a plurality of grating pixels across two dimensions of the X-ray amplitude analyzer grating, wherein each grating pixels of the plurality of grating pixels has a different pattern with respect to all adjacent grating pixels to the grating pixel so that all adjacent grating pixels do not have a same pattern as the grating pixel.Type: GrantFiled: September 4, 2020Date of Patent: August 5, 2025Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Max Yuen, Yao-Te Cheng, Paul Christopher Hansen, Lambertus Hesselink
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Patent number: 12377415Abstract: Provided is photoactivated selective release (or PHASR) of droplets from a microwell array enabled by a photoresponsive polymer layer integrated into the microfluidic device. This photoresponsive layer is placed in between a microwell array that traps a large number of droplets and a monolithic flow chamber that can be used for recovery. By using focused light, the photoresponsive layer can either be punctured or induced to create local heating to selectively release droplets. The type of photoacoustic dye and the physical properties of the photoresponsive layer can be engineered to induce either puncture of the membrane or pushing of droplets out of the microwells with low thermal impact on the droplets. This approach has broad application in the field of soft lithography-based microfluidic devices for various applications including photoresponsive valves as well as high throughput single cell sequencing.Type: GrantFiled: December 27, 2021Date of Patent: August 5, 2025Assignee: The Trustees of the University of PennsylvaniaInventors: Yongwon Choi, Daeyeon Lee, Junhyong Kim, Syung Hun Han
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Patent number: 12378577Abstract: The present disclosure relates to CRISPR-Cas10 systems and methods for phage genome editing.Type: GrantFiled: September 16, 2022Date of Patent: August 5, 2025Assignee: The Board of Trustees of The University of AlabamaInventor: Asma Hatoum
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Patent number: 12381418Abstract: An integrated circuit on a chip may include a plurality of capacitors that are connected in series and generate an AC noise signal. A selected bandwidth of the AC noise signal transmits through the series of capacitors as a first AC power signal. Respective rectifiers are positioned for receiving a positive cycle of the first AC power signal and a negative cycle of the first AC power signal. Output terminals are connected to the respective rectifiers and configured for connection to an off chip circuit. The capacitors may be fixed or variable gap capacitors.Type: GrantFiled: July 11, 2023Date of Patent: August 5, 2025Assignee: Board of Trustees of The University of ArkansasInventor: Paul Thibado
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Patent number: 12377396Abstract: Provided are systems and methods that can combine T cell receptor sequencing (TCRseq) and Assay for Transposase Accessible Chromatin using sequencing (ATAC-seq), and/or respective aspects thereof. Further provided are systems and methods that can combine ATAC-seq and perturbation sequencing (Perturb-seq), and/or respective aspects thereof.Type: GrantFiled: December 19, 2018Date of Patent: August 5, 2025Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Naresha Saligrama, Ansuman Satpathy, Howard Y. Chang, Mark M. Davis
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Patent number: 12378290Abstract: Methods for synthesizing nanowires are provided. Modified PilA peptides are used as peptide building blocks for synthesizing the nanowires. The method places the peptide building blocks in an assembly buffer with a hydrophobe. Addition of a hydrophobe and molecular crowding by evaporation of the assembly buffer triggers the self-assembly of the peptide building blocks into fibers. Multiple elongation cycles of addition of peptide building blocks, mixing and evaporation are conducted to promote elongation of the fibers and synthesis of nanowires. Electronic characterization of the synthesized nanowires is provided.Type: GrantFiled: October 9, 2023Date of Patent: August 5, 2025Assignee: Board of Trustees of Michigan State UniversityInventors: Gemma Reguera, Krista Marie Cosert
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Patent number: 12378305Abstract: The present disclosure relates to compositions and methods for treating or preventing neonatal herpes simplex virus (HSV) infection and/or the neurological and/or non-neurological sequelae thereof.Type: GrantFiled: October 10, 2019Date of Patent: August 5, 2025Assignees: Trustees of Dartmouth College, Duke UniversityInventors: Margaret E. Ackerman, Iara M. Backes, David A. Leib, Chaya D. Patel, Michael Anthony Moody
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Patent number: 12380139Abstract: Disclosed embodiments include computer-implemented methods and systems that can efficiently generate highly relevant recommended search terms to clinicians. A hybrid collaborative filtering model recommends search terms for a specific patient to the clinician. The model draws on information from patients' clinical encounters and the searches that were performed during the clinical encounters. To generate recommendations, the model uses search terms which are (1) frequently co-occurring with the ICD codes recorded for the patient and (2) highly relevant to the most recent search terms. One variation of the model uses only the most recent ICD codes assigned to the patient. Another variation uses all ICD codes. Comprehensive experiments of embodiments of the methods and systems have demonstrate high levels of performance.Type: GrantFiled: December 8, 2022Date of Patent: August 5, 2025Assignees: Ohio State Innovation Foundation, The Trustees of Indiana UniversityInventors: Xia Ning, Zhiyun Ren, Bo Peng, Titus K. Schleyer
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Patent number: 12379326Abstract: An apparatus includes a main body, circuit assembly, lens, and clamping assembly. The main body includes an aperture that receives a wafer configured to receive a sample under study. The main body is configured to support the circuit assembly, which includes illumination sources that emit light of different colors such that total internal reflection is generated in the wafer. The main body is configured to provide support for the lens, and the clamping assembly mechanically coupled to the main body such that the lens is selectively positionable with respect to a camera lens. A microscopy imaging apparatus includes an illumination source, wafer, and charge-coupled device. The illumination source is configured to emit white light such that total internal reflection is generated in the wafer.Type: GrantFiled: May 16, 2022Date of Patent: August 5, 2025Assignees: The Trustees of Columbia University in the City of New York, United States Department of EnergyInventors: Mingzhao Liu, Justine E. Haupt, Connie-Rose Mai Deane, Oleg Gang
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Patent number: 12378278Abstract: The present disclosure relates to disaccharides with defined sulfation patterns, and oligosaccharide mimetics comprising the disaccharides as repeating units linked in a head to tail fashion. The present disclosure further relates to methods of making the same, and to methods of using the same to mediate cell proliferation, cell differentiation, amyloid plaque formation, anti-coagulation, and neuronal growth.Type: GrantFiled: September 21, 2020Date of Patent: August 5, 2025Assignee: Board of Trustees of Michigan State UniversityInventors: Xuefei Huang, Jicheng Zhang
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Patent number: 12379251Abstract: A self-calibrating hybrid spectrophotometer comprises a receptacle for receiving the cuvette, first and second optodes that are configured to permit light to enter the cuvette, third and fourth optodes that are configured to permit light to leave the cuvette, and a controller that is configured to control delivery of light to one of the first and second optodes. Light entering one of the first and second optodes is received at the third and fourth optodes after having interacted with the turbid sample along different paths having different lengths. Measurements made at the third and fourth optodes in response to having illuminated both the first and second source optodes provide two slopes of optical transmittance as a function of path length. The spectrophotometer uses these slopes to identify a slope that is indicative of the absorption coefficient and the reduced scattering coefficient of the sample.Type: GrantFiled: February 7, 2022Date of Patent: August 5, 2025Assignee: Trustees of Tufts CollegeInventors: Sergio Fantini, Giles Blaney, Angelo Sassaroli
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Patent number: 12377407Abstract: The present disclosure provides compositions and methods for metathesizing a first alkenyl or alkynyl group with a second alkenyl or alkynyl group, the composition comprising a ruthenium metathesis catalyst and a photoredox catalyst that is activated by visible light.Type: GrantFiled: March 10, 2022Date of Patent: August 5, 2025Assignee: The Trustees of Columbia University in the City of New YorkInventors: Tomislav Rovis, Cedric Theunissen
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Patent number: 12380728Abstract: A method and system for fingerprint recognition includes generating a first set of feature embeddings for a first image at a feature extractor, generating a second set of feature embeddings for a second image at the feature extractor, generating a third set of embeddings at a first classification head from the first set of feature embeddings, generating a fourth set of embeddings at a second classification head from the first set of feature embeddings, generating a fifth set of embeddings at the first classification head from the second, set of feature embeddings, generating a sixth set of embeddings at the second classification head from the second set of feature embeddings, generating a first similarity score based on the third and fourth sets of embeddings and the fifth and sixth set of embeddings and generating a similarity indicator based on the first similarity score.Type: GrantFiled: January 31, 2024Date of Patent: August 5, 2025Assignee: Board of Trustees of Michigan State UniversityInventors: Anil K. Jain, Steven Grosz
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Portable bioreactors and portable bioreactor systems for analyzing biofilm formation and degradation
Patent number: 12378511Abstract: The present disclosure is directed to portable bioreactors that allow the custom production of microbial cultures, and in some embodiments, the production of custom microbial biofilms. Also disclosed are portable bioreactor systems that are networked and capable of cooperative work in parallel.Type: GrantFiled: October 9, 2019Date of Patent: August 5, 2025Assignees: The Trustees of the University of Pennsylvania, Biorealize, Inc.Inventors: Orkan Telhan, Karen Hogan -
Patent number: 12378530Abstract: Functional in vitro assays are provided for determining patient specific responsiveness to immunotherapy agents within a clinically actionable time frame.Type: GrantFiled: October 22, 2021Date of Patent: August 5, 2025Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: James Neal, Calvin Jay Kuo
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Patent number: 12380337Abstract: The present disclosure provides systems and methods that relate to storing encoded information in, and reading the encoded information from, nucleotide sequences. An example method includes receiving, at a DNA readout system, a nucleotide sequence. The method also includes reading the nucleotide sequence based on an alphabet consisting of {adenine (A), cytosine (C), guanine (G), and thymine (T)}. The method further includes determining positions of unique markers between a plurality of encoded blocks in the nucleotide sequence. The method yet further includes decoding each encoded block of the plurality of encoded blocks according to an inner code, so as to form a plurality of decoded blocks. The method also includes appending the decoded blocks to one another to provide a decoded message with message length n bits.Type: GrantFiled: October 13, 2020Date of Patent: August 5, 2025Assignees: the Board of Trustees of the University of Illinois, Imperial College Innovations LimitedInventors: Olgica Milenkovic, Ryan Gabrys, João Ribeiro, Mahdi Cheraghchi Bashi Astaneh
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Patent number: 12379343Abstract: Provided are devices and methods for detecting a target molecule, based on using a graphene electrode. The devices exhibit high sensitivity to target molecules such as DNA that may be present at comparatively low concentrations.Type: GrantFiled: September 22, 2022Date of Patent: August 5, 2025Assignee: The Trustees of the University of PennsylvaniaInventors: Alan T. Johnson, Jr., Jinglei Ping, Ramya Vishnubhotla
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Publication number: 20250247658Abstract: A method for personalized sound modification, with a personal sound system having a microphone; a user device which includes a processor, computer readable medium, and optionally the microphone; and a sound output device; is provided. The method includes: providing a user hearing profile including lower and upper limits of the user's auditory dynamic range at a plurality of sound frequencies, prepared with the personal sound system; receiving a sound signal from the microphone; optionally separating the sound signal into a plurality of frequency channels; amplifying or attenuating sound frequencies in the sound signal which have a volume level outside the lower or upper limits of the user's auditory dynamic range, respectively, and forming a modified sound signal with which the sound output device will produce sounds within the user's auditory dynamic range; and providing the modified sound signal to the sound output device.Type: ApplicationFiled: January 14, 2025Publication date: July 31, 2025Applicant: Board of Trustees of Northern Illinois UniversityInventor: King Chung
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Publication number: 20250243357Abstract: The present disclosure pertains to a rotaxane composition that includes a plurality of macrocyclic rings, a plurality of macrocycle-binding moieties, and a plurality of first polymers and second polymers. The macrocyclic rings and macrocycle-binding moieties are reversibly threaded onto the first polymers. At least some of the macrocyclic rings are operational to unthread from one first polymer and rethread onto another first polymer or a second polymer. The present disclosure also pertains to methods of manufacturing a three-dimensional structure by applying a rotaxane composition onto a surface. The present disclosure also pertains to methods of forming the rotaxane compositions.Type: ApplicationFiled: January 30, 2025Publication date: July 31, 2025Applicant: Trustees of Dartmouth CollegeInventors: Chenfeng Ke, Dan Zheng, Zhuoran Zhong