Patents Assigned to Trustee
  • Publication number: 20250145993
    Abstract: A method of enhancing the presence of alternatively-spliced UMOD protein by inducing exon-skipping of a AS-UMOD m-RNA to protect TAL cells of kidneys in a patient suffering from acute kidney injury or chronic kidney disease.
    Type: Application
    Filed: November 1, 2024
    Publication date: May 8, 2025
    Applicant: The Trustees of Indiana University
    Inventors: Tarek Maurice Ashkar, Azuma Nanamatsu
  • Patent number: 12291699
    Abstract: The presently disclosed subject matter provides a biomimetic lung disease model, and methods of its production and use. In one exemplary embodiment, the biomimetic lung disease model can include a first and second microchannel with a membrane coated with airway epithelial cells disposed between the microchannels and at least one device coupled to the biomimetic model that delivers an agent to at least one microchannel. In certain embodiments, the agent is cigarette smoke.
    Type: Grant
    Filed: October 11, 2023
    Date of Patent: May 6, 2025
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Dongeun Huh, Mark Mondrinos, Woo Yul Byun
  • Patent number: 12292346
    Abstract: The subject invention is concerned with systems and methods advantageously applying finite element analysis to establish design rules for a highly sensitive piezo-resistive pressure sensor with an output that is high enough to be detectable by simple and inexpensive circuits and therefore ensure wearability. Four frequently reported micro-feature shapes in micro-patterned piezo-resistive sensors are provided, where the micro-dome and micro-pyramid yield the highest sensitivity. Investigations of different conductivity values of micro-patterned elastomers show that coating the elastomer with a conductive material (e.g., a metallic coating) leads to higher current response when compared to composited conductive elastomers. Advantageous geometric parameters and spatial configurations of micro-pyramid design of piezo-resistive sensors are provided.
    Type: Grant
    Filed: August 27, 2024
    Date of Patent: May 6, 2025
    Assignee: The Florida International University Board of Trustees
    Inventors: Chunlei Wang, Borzooye Jafarizadeh, Azmal Chowdhury, Iman Khakpour, Nezih Pala
  • Patent number: 12290575
    Abstract: The present subject matter provides compounds, compositions, and methods for identifying, monitoring, treating, and removing diseased tissue. Compounds, compositions, and methods for identifying, monitoring, and detecting circulating fluids such as blood are also provided.
    Type: Grant
    Filed: July 10, 2023
    Date of Patent: May 6, 2025
    Assignees: University of Rhode Island Board of Trustees, Yale University
    Inventors: Yana K. Reshetnyak, Oleg A. Andreev, Donald M. Engelman
  • Patent number: 12290353
    Abstract: A wearable sensor for monitoring an external bodily fluid includes a sensor thread, a wick, a substrate, and a communication interface all of which are disposed on a substrate. The wick wicks the external bodily fluid to a functionalized region of the thread. The communication interface transmits, to an external device, data indicative of what the sensor thread has measured in said external bodily fluid. The external device can then carry out real-time analysis or storage.
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: May 6, 2025
    Assignee: Trustees of Tufts College
    Inventors: Sameer Sonkusale, Trupti Terse
  • Patent number: 12293152
    Abstract: Systems and methods are provided for enabling users to work with TimeML annotations and perform advanced temporal analysis, offering a comprehensive suite of features. Systems and methods of embodiments allow users to parse TimeML annotations, construct TimeML graphs, and execute the timeline extraction (TLEX) algorithm to effect complete timeline extraction. An algorithm can be incorporated for increasing connectivity in temporal graphs, which identifies graph disconnectivity and recommends links based on temporal reasoning, thereby enhancing the coherence of the graph representation. Also, a built-in validation algorithm can be included, ensuring compliance with TimeML annotation guidelines.
    Type: Grant
    Filed: September 11, 2024
    Date of Patent: May 6, 2025
    Assignee: The Florida International University Board of Trustees
    Inventors: Mustafa Ocal, Mark Finlayson
  • Patent number: 12291725
    Abstract: This disclosure pertains to a non-living biological product. Particularly, exosomes derived from stem cells can help restore heart function. According to certain embodiments, a fluid-induced shear stress mechanical stimulation process of stem cells is used to augmented quantity and quality of exosomes produced from stem cells. These exosomes serve as a therapeutic agent for the regenerative repair of diseases, such as diseased heart tissues. Therefore, compositions comprising the exosomes derived from stem cells and methods of treating a degenerative disease by administering the exosomes isolated from stem cells are also provided.
    Type: Grant
    Filed: July 12, 2023
    Date of Patent: May 6, 2025
    Assignee: The Florida International University Board of Trustees
    Inventors: Sharan Ramaswamy, Manuel Perez, Yih-Mei Lin
  • Patent number: 12291596
    Abstract: Radical cascade reactions enabling sequence-controlled ring-closing polymerization and ring-opening polymerization for the controlled synthesis of polymers with complex main-chain structures are provided. Facile syntheses leading to low-strain macrocyclic monomers consisting of the ring-opening triggers and extended main-chain structures are also provided. The present disclosure further provides methods for excellent control over polymer molecular weights and molecular weight distributions and high chain-end fidelity allows for the preparation of polymeric systems with well-defined architectures. Further provided are the general nature of the radical cascade-triggered transformations in polymer chemistry, and its application to the synthesis of polymers with diverse main-chain structural motifs with tailored functions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
    Type: Grant
    Filed: October 27, 2021
    Date of Patent: May 6, 2025
    Assignee: The Trustees of Boston College
    Inventors: Jia Niu, Hanchu Huang, Wenqi Wang
  • Patent number: 12291707
    Abstract: The present disclosure provides gene edited modified immune cells or precursors thereof (e.g., gene edited modified T cells) comprising an exogenous T cell receptor (TCR) and/or a chimeric antigen receptor (CAR) having specificity for a target antigen, and an insertion and/or deletion in one or more endogenous gene loci, wherein the endogenous gene loci encode regulators of T cell function, thereby resulting in immune cells having enhanced function. Compositions and methods of treatment are also provided. The present invention provides methods of screening for TCR- or CAR-T cells with enhanced immune function (e.g., T cell efficacy, T cell memory, and/or T cell persistence).
    Type: Grant
    Filed: January 29, 2024
    Date of Patent: May 6, 2025
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Yangbing Zhao, Jiangtao Ren
  • Patent number: 12292626
    Abstract: An electro-optic modulation structure 110, a method for fabrication of the electro-optic modulation structure, and a method of optical modulation derived from an electro-optic modulation structure with low voltage of operation are disclosed. The low voltage operation of the electro-optic modulator is realized by designed electro-optic modulation structures that include the light confining waveguide 114, overclad layer 120 and modulating electrode structure 116 for applying modulation voltages that are directed towards a low voltage operation of the electro-optic modulation 110 device upon consideration of optimal optical loss.
    Type: Grant
    Filed: May 6, 2021
    Date of Patent: May 6, 2025
    Assignee: The Trustees of the Stevens Institute of Technology
    Inventors: Yuping Huang, Yong Meng Sua, Mingwei Jin, Jiayang Chen
  • Publication number: 20250139961
    Abstract: A method and system for removing smeared pixels from an image includes obtaining a plurality of training images of a scene from different poses, forming a point cloud of the scene having a plurality of pixels and a depth, and rendering a first pixel in a first reference frame to a second reference frame. The method includes comparing a depth difference of the first depth and the second depth, determining whether the pixel is valid or smeared based on the depth difference, associating a label with the pixel corresponding to valid or smeared, training a classifier with the pixel and the label to form a trained classifier, obtaining an image to be classified at the classifier and classifying the pixels in the image as valid or smeared and removing smeared pixels from the image to form a cleaned image.
    Type: Application
    Filed: October 28, 2024
    Publication date: May 1, 2025
    Applicant: Board of Trustees of Michigan State University
    Inventors: Daniel MORRIS, Miaowei WANG
  • Publication number: 20250134907
    Abstract: Disclosed is a compound of formula (I), in which R1, R2, R3, R4, R5, X1, X2, X3, X4, and X5 are described herein. The small molecule compounds of formula (I) activate the functional activity of relaxin family peptide receptor 2 (RXFP2), thereby providing therapeutic treatments for a variety of disorders, such as a bone disorder, hypogonadism, cryptorchidism, polycystic ovary syndrome, cancer, infertility, or an ocular wound.
    Type: Application
    Filed: January 31, 2023
    Publication date: May 1, 2025
    Applicants: The United States of America,as represented by the Secretary,Department of Health and Human Services, The Florida International University Board of Trustees
    Inventors: Juan J. Marugan, Noel T. Southall, Marc Ferrer, Mark J. Henderson, Kenneth J. Wilson, Alexander I. Agoulnik, Courtney B. Myhr, Maria Esteban-Lopez, Elena Barnaeva, Xin Hu, Wenjuan Ye, Irina Agoulnik
  • Publication number: 20250134737
    Abstract: The invention provides a connector for attaching a first part to a second part in a connection joint, the connector comprising a body attachable to the first part and comprising link element extending from the body, wherein the link comprises substantially opposing surfaces, each surface comprising a curved region configured to nest with a complimentary curved region of a washer of the connection joint, and further comprising an opening located substantially centrally within each curved region of the arm and passing through the arm.
    Type: Application
    Filed: January 31, 2023
    Publication date: May 1, 2025
    Applicant: ROGER THOMAS MASCULL and ELIZABETH JOCELYN MASCULL as Trustees of the RT AND EJ MASCULL FAMILY TRUS
    Inventors: Benjamin Joseph Hunt EAGLE, Paul James EASTWOOD, Hugo Max Treherne JAMES
  • Publication number: 20250135072
    Abstract: Disclosed herein are compositions comprising a polymer and a metabolic inhibitor, as well as a method of using the composition to modulate an immune response. The composition may be produced in the form of a synthetic tissue for provision in a subject. The composition or synthetic tissue may further comprise additional therapeutic agents.
    Type: Application
    Filed: January 27, 2023
    Publication date: May 1, 2025
    Applicant: Board of Trustees of Michigan State University
    Inventors: Chima V. MADUKA, Christopher CONTAG
  • Patent number: 12286539
    Abstract: This disclosure enables the generation and patterning of color centers with nanometer-scale spatial control in a variety of materials in repeatable fashion and without the use of radiation. Embodiments in accordance with the present disclosure employ a layer of vacancy-injection material disposed on a host-material, where the vacancy-injection material forms a compound with host-material atoms at elevated temperatures. During compound formation, lattice vacancies are generated in the host material and diffuse within the substrate lattice to bond with impurity atoms, thereby forming color centers. High-resolution lithographic patterning of the vacancy-injection film and the short diffusion lengths of the lattice vacancies enables nanometer-level spatial control over the lateral positions of the color centers. Furthermore, the depth of the color centers in the substrate can be controlled by controlling the coating material, thickness, anneal time, and anneal temperature.
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: April 29, 2025
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Nicholas Alexander Melosh, Matthew A. Gebbie, Patrick McQuade, Andrew E. Gonzalez
  • Patent number: 12285426
    Abstract: A method of treating and attenuating L-DOPA-induced dyskinesia, comprising administering an effective dose of at least one pharmacological agent, e.g., vilazodone, having serotonin-specific reuptake inhibition (SSRI) and serotonin receptor 1A (5-HT1AR) partial agonism activity, in conjunction with L-DOPA. Other agents, such as an L-DOPA decarboxylase inhibitor, e.g., carbidopa, or other adjunct treatments may also be provided.
    Type: Grant
    Filed: April 26, 2021
    Date of Patent: April 29, 2025
    Assignees: The Research Foundation for The State University of New York, Rosalind Franklin University of Medicine and Science, Board of Trustees of Michigan State University
    Inventors: Christopher Roy Bishop, Anthony West, Fredric Manfredsson
  • Patent number: 12285544
    Abstract: Porous electrically conductive graphene/carbon nanofiber bio-scaffolds can be fabricated having a Youngs modulus and electrical conductivity that both match typical values for brain tissue. Such scaffolds have been tested and found to provide improved differentiation of stem cells into functional neural cells relative to conventional scaffolds. In preferred embodiments, neural cell differentiation in conductive graphene/carbon nanofiber scaffolds is promoted by an applied electrical stimulus.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: April 29, 2025
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Byeongtaek Oh, Vivek Nath Lam, Paul George
  • Patent number: 12285780
    Abstract: Aspects of this disclosure relate to driving a capacitive micromachined ultrasonic transducer (CMUT) with a pulse train of unipolar pulses. The CMUT may be electrically excited with a pulse train of unipolar pulses such that the CMUT operates in a continuous wave mode. In some embodiments, the CMUT may have a contoured electrode.
    Type: Grant
    Filed: July 5, 2023
    Date of Patent: April 29, 2025
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Bo Ma, Kamyar Firouzi, Butrus T. Khuri-Yakub, Jose Joseph
  • Patent number: 12286407
    Abstract: 4-Hydroxyphenyl-2H-indazol-5-ol compounds are estrogen receptor beta ligands that have immunomodulatory properties and increase oligodendrocyte survival, differentiation, and remyelination. The compounds, compositions, and kits are useful in the treatment of multiple sclerosis and endometriosis.
    Type: Grant
    Filed: April 12, 2023
    Date of Patent: April 29, 2025
    Assignees: The Board of Trustees of the University of Illinois, The Regents of the University of California
    Inventors: John A. Katzenellenbogen, Seema K. Tiwari-Woodruff, Sung Hoon Kim, Benita Katzenellenbogen
  • Patent number: RE50413
    Abstract: An insulated heating-unit cover having an opening to permit air to circulate around the heating-source when a vent disposed at the top of the cover is opened, allowing heat into a space. The cover can include a heating-unit temperature sensor disposed within a space covered by the cover and a controller in wireless communication with a space temperature sensor located at a distance away from the heating-unit. The controller can be configured to operate an actuator such that the vent is open when the space temperature sensor indicates that the ambient temperature is below a set point temperature and such that the vent is closed when the ambient temperature is greater than the set point temperature. The controller can communicate with a plurality of other similar controllers and a central server to effect changes in the output of a central heating source coupled to a plurality of individual heating-units.
    Type: Grant
    Filed: January 23, 2020
    Date of Patent: May 6, 2025
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Ioannis Kymissis, Marshall Cox, John Sarik