Abstract: A laser system and method include a self-referencing shaper. A self-referencing pulse shaper is provided in an embodiment. Another aspect of a laser system includes at least one beam splitter splitting a reference beam from a working beam and a test beam, a delay optic delaying a reference laser beam, an active shaper, an interferometer, and a programmable controller. In another aspect, a method includes splitting an input laser pulse into a reference pulse and a shaping pulse, controlling phase and amplitude of the shaping pulse with an adjustable pulse shaper, creating an optical delay of the reference pulse, comparing a test pulse and the reference pulse after the controlling and delay, the laser system characterizing the input laser pulse and monitoring the laser system's own dispersion in a self-referenced manner, and correcting an output working laser pulse by adjusting the pulse shaper based on the comparing step.

Abstract: The methods and assays described herein relate to detection, diagnosis, and treatment of lung cancer, e.g., by detecting the level of expression of certain miRNAs described herein and/or by therapeutically increasing the level of those miRNAs.

Abstract: In certain embodiments, the present systems and methods use Tn7-like transposons that encode CRISPR-Cas systems for programmable, RNA-guided DNA integration. For example, the CRISPR-Cas machinery directs the Tn7 transposon-associated proteins to integrate DNA downstream of a target site (e.g., a genomic target site) recognized by a guide RNA (gRNA).

Abstract: The present disclosure relates to an apparatus and method for synthetically making an ultra-wide imaging bandwidth in millimeter-wave frequencies, resulting in improved image resolutions to values previously unattained. The synthetic approach sums up a number of available sub-bands to build an unavailable ultra-wideband system. Each sub-band contains a transceiver unit which is optimized for operation within that specific sub-band. The number and position of the sub-bands can be adjusted to cover any frequency range as required for the specific application.

Abstract: A method for treating a subject with cancer by administering to the subject a therapeutically effective amount of a recombinant Herpes Simplex Virus-1 (HSV-1) that expresses only a C-terminal portion of ?134.5 protein (e.g., amino acid residues 147-263) with no wild-type or intact ?134.5 protein expression is provided. The recombinant HSV-1 of this invention instigates immune activation, selectively replicates in cancer cells, and resists clearance by interferon.

Abstract: The present disclosure describes a unique, two-part, water-soluble polymer matrix material and a method of application that immobilizes a wide variety of loose powder or crystalline hazardous materials and renders them “safe” or at least “safer” for handling and transport. The polymer matrix material is a two-part polymer material comprising a liquid cross-linking polymer and a cross-linking agent, initiator, or biocide contained in a solution. The cross-linking agent functions to cross-link the polymer and cause it to harden in place.

Abstract: Saccharide-substituted silk fibroin compositions as well as methods for making and using the same are provided. The compositions can include at least one saccharide coupled to silk fibroin. The coupling can be via various residues on the silk fibroin.

Abstract: A tunable shielding system may include a substrate with a dielectric layer disposed on a surface of the substrate. The system may include a tunable metal patch including a metal plate attached to the substrate and encompassed in a magnetic layer, the tunable metal patch configured to be geometrically shifted. The system may include a direct current coil adjacent to the metal plate, and a current source. The system may include one or more processors and a computer readable medium including instructions that cause the system to perform operations to determine that an electromagnetic interference signal is incident on the system, the electromagnetic interference signal characterized by a frequency. The system may also determine a current amount associated with the frequency. The system may provide the current amount to the direct current coil such that a magnetic field is generated such that the tunable metal patch geometrically shifts.

Abstract: A system and methods are disclosed for detecting logical fallacies and other forms of spurious reasoning. Artificial Intelligence methods allow for direct processing of input data in the form of text, an image and/or video. The system can be trained and refined through machine learning algorithms. The invention can be standalone or integrated as part of a larger platform (e.g., as part of a social media platform). Feedback can be provided to allow a user to write more effectively, refine their thinking process, and/or construct sounder, more persuasive arguments. The model can be trained through databases and/or with the help of human annotations of training data.

Abstract: Small molecules compounds and methods of their synthesis are provided. Small molecules identified can inhibit histone acetyltransferase 1 activity. Formulations and medicaments are also provided that are directed to the treatment of human disorders and conditions, such as, for example, neoplasms, cancers, viral, fungal, and parasitic infections, and aging. Therapeutics are also provided containing a therapeutically effective dose of one or more small molecule compounds, present either as pharmaceutically effective salt or in pure form, including, but not limited to, formulations for oral, intravenous, or intramuscular administration.

Abstract: Compositions and methods for treating short bowel syndrome in a subject are provided. A viral vector is provided which includes a nucleic acid molecule comprising a sequence encoding a GLP-2 receptor agonist fusion protein and regulatory sequences which direct expression thereof.

Abstract: In one embodiment, a micro-cooler assembly includes a manifold having at least one inlet for receiving a liquid, a plurality of fins, wherein each fin of the plurality of fins includes a micro-channel, and a plurality of vapor gaps interlaced with the plurality of fins. A width of the micro-channels is graded, and/or a width of the vapor gaps is graded. The micro-cooler assembly further includes a cold plate that includes a surface and a wick region disposed on the surface. The manifold is coupled to the surface of the cold plate. The at least one inlet is operable to provide the liquid proximate the wick region. The liquid is operable to be wicked into the wick region through the micro-channels of the plurality of fins, and heating of the liquid changes phase to a vapor that exits the manifold through the plurality of vapor gaps.

Abstract: Compositions and methods for treating hypoparathyroidism in a subject are provided. A viral vector is provided which includes a nucleic acid molecule comprising a sequence encoding a PTH fusion protein and regulatory sequences which direct expression thereof.

Abstract: One aspect of the invention provides a method of treating a cornea. The method includes controlling a light source to apply light energy pulses to a single corneal layer selected from the group consisting of: an anterior corneal layer and a posterior corneal layer. The light energy pulses are below an optical breakdown threshold for the cornea and ionize water molecules within the treated corneal layer to generate reactive oxygen species that cross-link collagen within the single corneal layer. Another aspect of the invention provides a method of treating a cornea. The method includes controlling a light source to apply light energy pulses to at least a corneal stroma layer of a cornea. The light energy pulses are below an optical breakdown threshold for the cornea and ionize water molecules within the treated corneal stromal layer to generate reactive oxygen species that cross-link collagen within the cornea.

Abstract: Systems and methods for clinical neuronavigation in accordance with embodiments of the invention are illustrated. One embodiment includes a method for generating a brain stimulation target, including obtaining functional magnetic resonance imaging (fMRI) image data of a patient's brain, where brain imaging data describes neuronal activations within the patient's brain, determining a brain stimulation target by mapping at least one region of interest to the patient's brain, locating functional subregions within the at least one region of interest based on the fMRI image data, determining functional relationships between at least two brain regions of interest, generating parameters for each functional subregion, generating a target quality score for each functional subregion based on the parameters and selecting a brain stimulation target based on its target quality score and the patient's neurological condition.

Abstract: Devices and methods are provided for closing an incision through fascia or other tissue of a subject. A first closure element is positioned against tissue on a first side of the incision, a second closure element is positioned against tissue on a second side of the incision, and a fastener from or through the first closure element is directed through the tissue and the second closure element to secure the closure elements against the tissue to close the incision.

Abstract: The present invention provides compositions and methods for inducing a CAR mediated trans-signal in a T cell. The trans-signaling CAR T cells comprise a first CAR having a first signaling module and a second CAR having a distinct second signaling module. The present invention also provides cells comprising a plurality of types of CARs, wherein the plurality of types of CARs participate in trans-signaling to induce T cell activation.

Abstract: Provided are devices that have a distal portion configured to be implanted in a brain of a subject. The distal portion includes one or more emitters configured to emit light in the visible spectrum. The device includes a proximal portion configured to be external to the brain of the subject while the distal portion is implanted, wherein the proximal portion includes at least one waveguide in optical communication with the one or more emitters. The at least one waveguide defines a cross-sectional width less than 500 nm. The at least one waveguide is optionally coupled to a heating element that is optionally configured to adjust a phase of light within the at least one waveguide.

Abstract: Computer-executed methods for training users to discern electronic phishing messages to reduce risk of threats to the integrity of computing systems and/or computing resources. In some embodiments, the methods involve gamifying the training to motivate users to participate in the training. In some embodiments, gamification includes instructing electronic-messaging-system users to forward suspected phishing messages for analysis. The analysis may include automatically determining one or more of a variety of factors for each forwarded suspected phishing message, such as whether or not the suspected phishing message is an actual phishing message, whether or not the reporting is an original reporting, and how quickly the user made the report. In some embodiments, points are awarded based on the analyzed factors. In some embodiments, the methods involve building phishing knowledgebases for automatic electronic-message filtering. Software for performing disclosed methods or one or more portions thereof.

Abstract: Described herein are compositions and methods for treating a disease or disorder associated with PI3K signaling. For example, such compositions can include use of modulators of glucose metabolism, use of at least one kinase in the insulin-receptor/PI3K/AKT/mTOR pathway, and/or use of diet that influences the subject's metabolic state.