Abstract: Methods and systems are described for implementing a photodynamic therapy. An example method may comprise determining, during photodynamic therapy and using a plurality of optical probes spatially distributed within a patient, data indicative of one or more of a photodynamic therapy dosage, a fluence rate of a photodynamic therapy treatment light, or a reactive oxygen species concentration associated with corresponding locations of the plurality of optical probes. The example method may comprise changing, based on the data, one or more treatment parameters associated with providing a photodynamic therapy.
Type:
Grant
Filed:
November 6, 2019
Date of Patent:
June 10, 2025
Assignee:
The Trustees of the University of Pennsylvania
Abstract: Various embodiments of the disclosure are directed to methods for identifying a subject responsive to treatment of a psychiatric illness, diagnosing and treating a psychiatric illness in a subject, determining the efficacy of a medicament for treating a psychiatric illness in a subject, a panel of biomarkers for use in the methods thereof, and compositions for treating a psychiatric illness in a subject. The biomarkers and methods using such biomarkers described here can identify subsets or populations of patients having impaired endogenous neurosteroidogenesis, where the biomarkers serve as predictive biomarkers for identifying patients having a psychiatric illness who are responsive to neuroactive steroid (NAS)-based treatments.
Abstract: Aspects of the disclosure are directed toward fluidic devices that allow lateral and/or vertical transport of a fluid comprising cells, and possibly at least a portion of the cells disposed in the fluid, through one or more layers therein. For example, some fluidic devices comprise a layer comprising a channel that allows for lateral transport of a fluid comprising cells and/or cells disposed in such a fluid. As another example, some fluidic devices comprise a layer comprising a vertical transport region that allows for vertical transport of a fluid comprising cells and/or cells disposed in such a fluid. The fluidic devices described herein may also comprise one or more layers that filter cells and/or do not allow for transport of cells therethrough. The use of such layers in combination with layers allowing for lateral and/or vertical cell transport may advantageously allow cells to be transported through one or more portions of a device and retained at another portion of the device.
Abstract: Methods are disclosed for predicting a likelihood of developing a severe immune-related adverse event (irAE) associated with the administration of an immunotherapy in a melanoma patient based on abundances of activated CD4 memory T cells and/or diversities of T cell receptors (TCR) within a peripheral blood sample obtained from the patient.
Type:
Application
Filed:
January 12, 2023
Publication date:
June 5, 2025
Applicants:
Washington University, The Board of Trustees of the Leland Stanford Junior University
Inventors:
Aadel Chaudhuri, Aaron M. Newman, Alexander Lozano
Abstract: There are provided herein, inter alia, complexes, compositions and methods for the delivery of nucleic acid into a cell in vivo. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides and polyanionic cargos into target cells, tissues, and organs both in vitro and in vivo.
Type:
Application
Filed:
March 7, 2023
Publication date:
June 5, 2025
Applicant:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Harrison P. Rahn, Jiuzhi Sun, Zhijian Li, Ronald Levy, Robert M. Waymouth, Paul A. Wender
Abstract: This disclosure provides recombinant DNA mol-encoding fusion proteins that are able to regulate expression of alpha-synuclein. Also provided are various compositions comprising the recombinant DNA molecules, as well as associated methods of use. The recombinant DNA molecules and associated methods are useful for the treatment of subjects having disorders caused by excess expression or intracellular accumulation of alpha-synuclein, including Parkinson's disease.
Type:
Application
Filed:
March 16, 2023
Publication date:
June 5, 2025
Applicant:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
C. Alejandra Morato Torres, Faria Zafar, Lei S. Qi, Birgitt Schüle, Deniz Kirik
Abstract: Kirigami mixing systems and related methods are generally described. In some embodiments, a mixing system includes one or more grippers configured to deform a portion of a flexible container containing fluid when undergoing axial deformation. The grippers may include features including slots, hinges, and spines to aid in the transition of the grippers between a closed and retracted configuration when the one or more grippers are deformed. The compression of the container subsequently result in fluid flow within the container which may mix or agitate the fluid. In some embodiments, the described grippers may be formed integrally with the flexible containers. In some embodiments, the mixing system may include a plurality of grippers arranged around the flexible container.
Type:
Application
Filed:
March 1, 2023
Publication date:
June 5, 2025
Applicants:
Sartorius Stedim Biotech GmbH, Trustees of Boston University
Inventors:
Samin Akbari, Douglas Holmes, Yi Yang, David James Pollard
Abstract: Processes that determine transcriptional regulation from genetic sequence data are described. Generally, computational models are trained to predict transcriptional regulatory effects, which can be used in several downstream applications. Various methods further develop research tools, develop and perform diagnostics, and treat individuals based on identified variants.
Type:
Application
Filed:
June 21, 2022
Publication date:
June 5, 2025
Applicants:
The Trustees of Princeton University, The Simons Foundation, Inc., The Board of Regents of The University of Texas System
Inventors:
Olga G. Troyanskaya, Kathleen Chen, Jian Zhou
Abstract: Provided is a recombinant adeno-associated virus (rAAV) having an AAVhu68 capsid and a vector genome which comprises a nucleic acid sequence encoding a functional human arylsulfatase A (ARSA). Also provided are a production system useful for producing the rAAV, a pharmaceutical composition comprising the rAAV, and a method of treating a subject having metachromatic leukodystrophy, or ameliorating symptoms of metachromatic leukodystrophy, or delaying progression of metachromatic leukodystrophy via administrating an effective amount of the rAAV to a subject in need thereof.
Type:
Application
Filed:
January 10, 2023
Publication date:
June 5, 2025
Applicant:
The Trustees of the University of Pennsylvania
Abstract: Disclosed is a platform for fluorescence imaging of bulk RNA dynamics in living cells. The platform utilizes a technique including exposing a plurality of live cells configured to overexpress a WT or mutant ribonucleoside kinase UCK2 under control of an inducible promoter, a constitutively active promoter, or both, to a first quantity of a fluorescent nucleoside (such as fluorescent bicyclic and tricyclic cytidine analogues) for a first period of time.
Type:
Application
Filed:
February 28, 2023
Publication date:
June 5, 2025
Applicants:
The Trustees of Princeton University, San Diego State University Research Foundation
Inventors:
Ralph KLEINER, Danyang WANG, Byron PURSE, Ana SHALAMBERIDZE
Abstract: Antenna arrays, systems and methods using an algorithm-based array synthesis approach of designing and manufacturing an antenna array with non-uniform element distribution which fundamentally enables low side lobe beamforming capability over desired broadband/multiband frequency range across large scanning angles.
Abstract: Differential methylation profiles of a panel of genes are identified from colorectal carcinoma tissues of colorectal cancer patients compared to normal colon mucosal tissue or to white blood cells from healthy subjects. A high methylation level of cytosines at CpG dinucleotide sites (in CpG-rich regions) of the panel of genetic loci are further validated in plasma cell-free DNA as signature markers indicative of colorectal cancer, which is useful for early stage detection of colorectal cancer and monitoring of disease progression. This panel of genetic loci include genes MAP3K14-AS1, DNM1P46, EMBP1, GATM, VSV2, LAYN, and SFMBT2, which individually or in combination can complement SEPT9-based assays in improving sensitivity and/or specificity in the detection of colorectal cancer. Assay methods and reagents for detection of the presence and levels of methylation of the marker genetic loci are also provided.
Type:
Application
Filed:
March 2, 2023
Publication date:
June 5, 2025
Applicants:
Cedars-Sinai Medical Center, The Board of Trustees of the Leland Stanford Junior University
Inventors:
Megan P. Hitchins, Robert W. Haile, Jun Gong, Andrew Hendifar, Michael Snyder, Hayan Lee
Abstract: A capacitor may include a substrate may include a cavity. The capacitor may include a plurality of particles disposed within the cavity. The capacitor may include a first metal layer, deposited on the substrate, within the cavity, and on the plurality of particles. The capacitor may include a dielectric layer, deposited on the first metal layer. The capacitor may include a second metal layer, deposited on the dielectric layer. The capacitor may include a third metal layer, deposited on the second metal layer such that the cavity is substantially filled.
Type:
Application
Filed:
November 30, 2023
Publication date:
June 5, 2025
Applicants:
Applied Materials, Inc., The Florida International University Board of Trustees
Abstract: Systems and methods for expression and delivery of proteinaceous species are described. Generally, a system can comprise biological cells within a porous membrane. The biological cells can be utilized to produce proteinaceous species. The biological cells can further store proteinaceous species within secretory granules such that the species can be controllably released upon depolarization of the cell. A secondary force can be provided to release proteinaceous species out of the porous membrane. Proteinaceous species can be expressed from an expression cassette configured to provide controllable release.
Type:
Application
Filed:
December 5, 2024
Publication date:
June 5, 2025
Applicant:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Ada Poon, Justin Annes, Rayhan Lal, Ella A. Thomson
Abstract: A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid sequences.
Type:
Application
Filed:
February 12, 2025
Publication date:
June 5, 2025
Applicant:
The Trustees of the University of Pennsylvania
Inventors:
Luk Vandenberghe, Guangping Gao, James M. Wilson
Abstract: A stimulated Raman photothermal (SRP) microscope for imaging a sample. A first optical source omits an intensity-modulated pump beam. A second optical source omits an intensity-modulated Stokes beam. The Stokes beam is combined with the pump beam to form a combined beam. The combined beam is directed to the sample to induce a thermal effect caused by the stimulated Raman process. A third optical source emits a probe beam, the probe beam is directed to the sample. An optical detector detects modulation of the probe beam after modulation by the sample to measure an SRP signal.
Abstract: Methods, compositions and kits for producing functional antigen-specific regulatory T cells (Tr1 cells) by reprogramming non-Tr1 target cells with suitable transcription factors.
Type:
Grant
Filed:
February 10, 2020
Date of Patent:
June 3, 2025
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Molly Kathryn Javier Uyeda, Maria Grazia Roncarolo
Abstract: Various aspects as described herein are directed to a radiative cooling device and method for cooling an object. As consistent with one or more embodiments, a radiative cooling device includes a solar spectrum reflecting structure configured and arranged to suppress light modes, and a thermally-emissive structure configured and arranged to facilitate thermally-generated electromagnetic emissions from the object and in mid-infrared (IR) wavelengths.
Type:
Grant
Filed:
December 29, 2023
Date of Patent:
June 3, 2025
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Aaswath Pattabhi Raman, Shanhui Fan, Eden Rephaeli
Abstract: Therapeutic and diagnostic methods are provided, which methods relate to the induction of expression of calreticulin on phagocytic cells. Specifically, the methods relate to macrophage-mediated programmed cell removal (PrCR), the methods comprising increasing PrCR by contacting a phagocytic cell with a toll-like receptor (TLR) agonist; or down-regulating PrCR by contacting a phagocytic cell with an inhibitor of Bruton's tyrosine kinase (BTK). In some embodiments, an activator of TLR signaling or a BTK agonist is provided in combination with CD47 blockade.
Type:
Grant
Filed:
August 29, 2023
Date of Patent:
June 3, 2025
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Irving L. Weissman, Mingye Feng, Jens-Peter Volkmer
Abstract: A composition of matter defined by the general formula of M2+vL1?vX2, wherein: X is carbon; M represents a transition metal selected from the group consisting of Ti, Ta, Sc, Cr, Zr, Mo, V, and Nb; and L represents a lanthanide element selected from the group consisting of Ce, Pr, Nd, Sm, Gd, Tb, Dy, Ho, Er, Tm, Yb, and Lu.