Abstract: A shielding structure for a semiconductor device may include a first segment formed from a first set of layers including a first metal and a second metal. The structure may include a second segment formed from a second set of layers. The second set of layers may include the first metal and the second metal, the second segment orthogonal to the first segment, where the second segment is configured to be inserted into a trench in a substrate of the semiconductor device.

Abstract: A dual vector system for treating ornithine transcarbamylase deficiency is provided. The system includes ((a) a gene editing AAV comprising a first AAV rh79 capsid and a first vector genome comprising a 5? ITR, a sequence encoding a meganuclease that targets PCSK9 under control of regulatory sequences that direct expression of the meganuclease in a target cell comprising a PCSK9 gene, and a 3? ITR; and (b) a donor AAV vector comprising a second AAV capsid and a second AAV rh79 vector genome comprising: a 5?ITR, a 5? homology directed recombination (HDR) arm, a transgene encoding ornithine transcarbamylase (OTC) and regulatory sequences that direct expression of the transgene in the target cell, a 3? HDR arm, and a 3? ITR.

Abstract: Biological cells can be identified and recovered from a sample by pumping the sample through a flow channel so that the sample flows through the flow channel with a non-turbulent flow (e.g., a laminar flow). A plurality of images of the sample are captured as the sample passes through the flow channel. These images are analyzed to determine which portions of the sample include a target biological cell. Portions of the sample that were determined to include a target biological cell are routed into at least one first container, and portions of the sample that were not determined to include a target biological cell are routed to at least one second destination (e.g., one or more second containers).

Abstract: An inductor may include a flexible polyimide flexible core may including one or more cavities. The inductor may include a magnetic film, formed on two sides of the flexible polyimide flexible core and on a respective sidewall of each of the one or more cavities. The inductor may include a dielectric layer formed on the magnetic film. The inductor may also include a metal layer formed on the dielectric layer and within the cavities, such that vias are formed on one or more sides of the inductor and extend through the one or more cavities.

Abstract: Embodiments of the present disclosure pertain to microfluidic devices that include at least one channel with a surface and a plurality of magnetic materials positioned on the surface. The plurality of magnetic materials include a metallic component and an adhesive component. The adhesive component is directly positioned on the surface. Further embodiments of the present disclosure pertain to methods of using the microfluidic devices to capture one or more analytes from a sample. Such methods generally include flowing the sample and a plurality of magnetic analyte binding agents through at least one channel of a microfluidic device of the present disclosure. Additional embodiments of the present disclosure pertain to methods of making the microfluidic devices of the present disclosure by forming a plurality of magnetic materials within a cast and transferring the formed magnetic materials from the cast onto a surface to form a channel.

Abstract: Provided is a method of treating a disorder mediated by claudin-2 and/or claudin-15, particularly an intestinal disorder, such as colitis or enteritis. The method comprises administering to the subject an effective amount of a compound of formula (I), formula (II), or otherwise as described herein or a pharmaceutically acceptable salt thereof. In another aspect, also provided are compounds of formula (Ia) and pharmaceutically acceptable salts thereof.

Abstract: In one aspect, the disclosure relates to relates to substituted benzothiophene analogs which are useful as selective degraders of estrogen receptor, methods of making same, pharmaceutical compositions comprising same, and methods of treating one or more clinical conditions associated with estrogen receptor, such as a cancer, including breast cancer, or osteoporosis. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: A system and method for installation of a k-wire through a scaphoid or other fractured bone can include a guide block for accurate trajectory of a k-wire. A support frame for a guide block can be casted and/or secured into place, and a CT scan is obtained, so the fractured bone and the location of the window can be known in the same three-dimensional space. An ideal k-wire trajectory can be plotted through the fractured bone, and a guide block with a lumen can be designed and printed using a three-dimensional printer. The guide block can be inserted into the frame so the lumen aligns with the ideal k-wire trajectory, and a k-wire can be inserted through the lumen into the fractured bone. The net effect would be ideal placement of the k-wire that would facilitate the ultimate insertion of a percutaneous screw to provide fixation of the fractured bone.

Abstract: Example implementations include a textile apparatus for transporting perspiration and heat, the textile apparatus including a substantially planar and heat-conducting substrate including at least one recess, and a textile film including one or more fibers disposed in contact with at least one substantially planar surface of the substrate and at least one surface of the recess. Example implementations also include a method of manufacturing a textile apparatus for transporting perspiration and heat, the method including forming a nanofiber solution, extruding one or more nanofibers from the nanofiber solution, forming one or more recesses in a substantially planar surface of a substrate, and integrating one or more of the nanofibers with the substantially planar surface of the substrate and at least one surface of the recesses.

Abstract: Provided is a method for predicting a location of a fast-moving object. The method includes receiving event information from an event camera, the event information corresponding to an event detected by the event camera, generating a Binary Event History Image (BEHI) based on the event information, providing the BEHI as an input to an event-based neural network, obtaining, as an output of the event-based neural network, a first predicted location of the fast-moving object, a normal distribution indicating prediction uncertainty of the predicted location, and a predicted time-to-collision (TTC). The method further includes estimating a second predicted location of the fast-moving object based on the first predicted location, the normal distribution, and the predicted TTC output by the event-based neural network, and actuating a mechanical catching device to be at the second predicted location.

Abstract: Systems and methods may ethically evaluate intelligent systems operating in a real-world environment. The systems and methods may generate a clone of the intelligent system, and test the clone in a simulation environment. If the clone passes the testing, the systems and methods may permit the intelligent system to continue operating in the real-world environment. If the clone fails the testing, the systems and methods may override the intelligent system, such as disabling the intelligent system and assuming control in the real-world environment. The systems and methods may be implemented at a hardware level of a data processing device to prevent interference with the systems and methods by the intelligent system.

Abstract: An energy harvesting system is provided. The energy harvesting system includes a waveguide, a luminophore embedded in the waveguide, and a solar photovoltaic array or a solar photovoltaic cell coupled to the waveguide. The energy harvesting system is visibly transparent, having an average visible transmittance of greater than about 50% and a color rendering index of greater than about 80 at normal incidence to the waveguide.

Abstract: A mid-infrared photothermal microscopy system images a sample. A mid-infrared optical source generates a mid-infrared beam which is directed along a first optical path to reach the substrate on a first side and heat the sample. A probe light source generates a probe light which is directed along a second optical path to reach the substrate on a second side and illuminate the sample. A first laser scanner is positioned along the first optical path and configured to rotate to redirect light and scan the sample with the mid-infrared beam. A second laser scanner is positioned along the second optical path and configured to rotate to redirect light and scan the sample with the probe light. The laser scanners each include at least one mirror driven to rotate such that the mid-infrared beam and the probe light scan the sample synchronously.

Abstract: System and method for completing knowledge graph. The system includes a computing device, the computing device has a processer and a storage device storing computer executable code. The computer executable code is configured to: provide an incomplete knowledge graph comprising a plurality of nodes and a plurality of edges, each of the edges connecting two of the plurality of nodes; calculate an attention matrix of the incomplete knowledge graph based on one-hop attention between any two of the plurality of the nodes that are connected by one of the plurality of the edges; calculate multi-head diffusion attention for any two of the plurality of nodes from the attention matrix; obtain updated embedding of the incomplete knowledge graph using the multi-head diffusion attention; and update the incomplete knowledge graph to obtain updated knowledge graph based on the updated embedding.

Abstract: Embodiments of the invention are generally directed to compressing genetic sequencing data. In many embodiments, the genetic sequencing data is reordered and encoded based on sequence homology between individual sequencing reads within the genetic sequencing data. Several embodiments are directed to systems to compress genetic sequencing data, and some embodiments are directed to non-transitory, machine-readable media that direct a processor to compress genetic sequencing data. In further embodiments, the genetic sequencing data represents paired-end sequencing data, and several embodiments transmit the data to a remote device.

Abstract: Ultra-wideband (UWB) arrays that are fully planar are provided. Fully-planar inverted-L element (FILE) arrays that are tightly coupled arrays (TCAs) can realize UWB tightly coupled apertures in the W and higher millimeter wave (mmWave) bands. The unit cell architecture of the FILE array, (which can have any desired size, can be comprised of an inverted-L shaped antenna and a capacitively coupled via-fence.

Abstract: Optical frequency combs and related methods, devices, and systems are described. An example device can comprise a waveguide configured to optically couple to an optical source and at least one optical resonator optically coupled to the waveguide. The one or more of the at least one optical resonator can be tuned such that an optical frequency comb is generated based on mode interaction between two different modes of the at least one optical resonator. The device can comprise an output coupled to the waveguide and configured to output the optical frequency comb.

Abstract: Disclosed is a method for quantitative detection of a small, aberrant viral nucleic acid. The method includes combining a detection mixture with a sample, and allowing a reaction with the test mixture to begin. The sample includes an RNA sample. The detection mixture includes a Cas13 enzyme, a reporter, a sequence-specific CRISPR RNA (crRNA), and a buffer. The method includes determining a quantitative value representative of the reporter in the test mixture, where the quantitative value is a measure of an amount of target RNA present in the RNA sample.

Abstract: Disclosed is a technique for improving the throughput of a neural network, using multiplexing and demultiplexing of information. Specifically, the multiplexing may include receiving a plurality of inputs, generating transformed inputs by performing, via a multiplexing layer, a transformation to each input of the plurality of inputs, and combining the transformed inputs into a single compact representation of the plurality of inputs. The demultiplexing may include receiving an output from a neural network, generating a plurality of values by converting, via a demultiplexing layer, the output back into independent representations, and producing predictions for each input based on the plurality of values. Further improvements may be seen when pretraining of the neural network and/or high-throughput transformers are incorporated.

Abstract: Provided herein are novel AAV capsids and recombinant AAV vectors comprising the same. In certain embodiment, vectors comprising a novel AAV capsid show improved transduction of cardiac tissue and/or reduced targeting of liver tissue compared to a prior art AAV capsid.