Abstract: Provided is an optical modulator including a substrate, and a plurality of meta units provided on the substrate and spaced apart from each other, wherein at least one of the plurality of meta units includes a metal layer provided on the substrate, a dielectric layer provided an upper surface and side surfaces of the metal layer, and an antenna provided on an upper surface of the dielectric layer, the antenna including phase change material, wherein a refractive index of the phase change material changes based on a voltage applied to the metal layer to modulate incident light.
Type:
Grant
Filed:
August 4, 2021
Date of Patent:
May 7, 2024
Assignees:
SAMSUNG ELECTRONICS CO., LTD., The Board of Trustees of the Leland Stanford Junior University
Inventors:
Junghyun Park, Mark L. Brongersma, Yifei Wang
Abstract: Methods and compositions are provided for treating endometriosis in an individual, and the pain associated with endometriosis. Aspects of the methods include administering to the individual an agent that promotes ALDH activity.
Type:
Grant
Filed:
February 25, 2022
Date of Patent:
May 7, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Eric Gross, Daria Mochly-Rosen, Stacy Lynn McAllister
Abstract: An audio signal encoding/decoding method and an apparatus for performing the same are disclosed. The audio signal encoding method includes obtaining a full-band input signal, extracting a first feature vector corresponding to a first sub-band signal and a second feature vector corresponding to a second sub-band signal using an encoder neural network including a plurality of encoding layers, generating a first code vector corresponding to the first feature vector and a second code vector corresponding to the second feature vector by compressing the first feature vector and the second feature vector, and generating a bitstream by quantizing the first code vector and the second code vector.
Type:
Application
Filed:
September 25, 2023
Publication date:
May 2, 2024
Applicants:
Electronics and Telecommunications Research Institute, The Trustees of Indiana University
Inventors:
Woo-taek LIM, Seung Kwon BEACK, Inseon JANG, Jongmo SUNG, Tae Jin LEE, Byeongho CHO, Minje KIM, Darius Petermann
Abstract: A soft pressure sensing apparatus is provided. In one aspect of the present pressure sensing apparatus, a polymeric member, including conductive particles therein, is located between offset angled and crossing sets of electrodes. A further aspect includes a controller configured to calculate at least one regularized least-squares algorithm, to reduce cross-talk between the resistive members. In another aspect, a pressure sensor apparatus includes a piezoresistive film encapsulated between layers of substantially perpendicular electrodes to create a resistor network circuit where the ability to reconstruct cell resistance from measured two-point resistance. A method of manufacturing a pressure sensor includes using a mechanical vinyl cutter for the electrodes and/or piezoelectric resistive members.
Type:
Application
Filed:
October 10, 2023
Publication date:
May 2, 2024
Applicant:
Board of Trustees of Michigan State University
Inventors:
Xiaobo TAN, Hongyang SHI, Nelson SEPULVEDA, Claudia CHEN, Yu MEI
Abstract: A system is disclosed that includes a computer that includes a processor and a memory, the memory including instructions executable by the processor to input an image acquired by a sensor to a neural network to output a prediction regarding an object included in the image. The neural network can be trained, based on (a) a distributed robust optimization that minimizes an expectation applied to probability distributions of loss functions to select training images that yield a solution with a selected uncertainty level and (b) generating additional input images based on adversarial images.
Type:
Application
Filed:
November 1, 2022
Publication date:
May 2, 2024
Applicants:
Ford Global Technologies, LLC, The Board of Trustees of the Leland Stanford Junior University
Inventors:
Xinru Hua, Huanzhong Xu, Jose Blanchet, Viet Anh Nguyen, Marcos Paul Gerardo Castro
Abstract: A method for the electrochemical remediation of a metal species comprises flowing a contaminated solution comprising a metal species to be removed through an electrochemical cell that includes a working electrode and a counter electrode spaced apart from the working electrode. The working electrode comprises a conductive substrate or current collector with a polymeric coating thereon, where the polymeric coating comprises a semiconducting or redox-active polymer. A reducing potential is applied to the electrochemical cell, thereby inducing the metal species from the contaminated solution to deposit onto the working electrode. After depositing the metal species, a recovery solution is flowed through the electrochemical cell. An oxidizing potential is applied to the electrochemical cell, thereby stripping the metal species from the working electrode and recovering the metal species in the recovery solution.
Type:
Application
Filed:
October 6, 2023
Publication date:
May 2, 2024
Applicant:
The Board of Trustees of the University of Illinois
Abstract: A method of training a neural network model to generate a three-dimensional (3D) model of a scene includes: generating the 3D model based on a latent code; based on the 3D model, sampling a camera view including a camera position and a camera angle corresponding to the 3D model of the scene; generating a two-dimensional (2D) image based on the 3D model and the sampled camera view; and training the neural network model to, using the 3D model, generate a scene corresponding to the sampled camera view based on the generated 2D image and a real 2D image.
Type:
Application
Filed:
July 24, 2023
Publication date:
May 2, 2024
Applicants:
Samsung Electronics Co., Ltd., The Board of Trustees of the Leland Stanford Junior University
Inventors:
Minjung SON, Jeong Joon PARK, Gordon WETZSTEIN
Abstract: Described are systems, methods, and devices relating to normothermic extracorporeal support of an organ, tissue, or bioengineered graft comprising cross-circulation (XC) perfusion for prolonged periods (days to weeks) via an XC perfusion circuit in connection with an extracorporeal host (e.g., animal, patient, organ transplant recipient) are disclosed. The XC perfusion circuit comprises auto-regulation of blood flow based on the trans-organ blood pressure difference between arterial and venous pressure. Recipient support enabled 36 h of normothermic perfusion that maintained healthy lungs with no significant changes in physiologic parameters and allowed for the recovery of injured lungs. Extended support enabled multiscale therapeutic interventions in all extracorporeal lungs. Lungs exceeded transplantation criteria.
Type:
Grant
Filed:
January 10, 2019
Date of Patent:
April 30, 2024
Assignee:
The Trustees of Columbia University in the City of New York
Inventors:
Matthew Bacchetta, Scott Chicotka, Kenmond Fung, Brandon Guenthart, John O'Neill, Gordana Vunjak-Novakovic
Abstract: Provided herein are compositions, methods, and kits for proliferating muscle cells by exposing the muscle cells to a prostaglandin E2 (PGE2) compound or compound that activates PGE2 signaling. Also provided are methods for regenerating muscle in a subject suffering from muscular atrophy, dystrophy, and/or injury by administering a PGE2 compound alone or in combination with isolated muscle cells. The PGE2 compound in combination with the isolated muscle cells can be administered prophylactically to prevent a muscle disease or condition.
Type:
Grant
Filed:
August 22, 2019
Date of Patent:
April 30, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Helen M. Blau, Andrew Tri Van Ho, Adelaida R. Palla
Abstract: The present invention provides compositions and methods for selectively treating a cancer or tumor utilizing an effective amount of a vegetable oil-derived polyol or hydrogel particles comprising a vegetable oil-derived polyol. In some embodiments, the cancer is a gynecologic cancer, specifically an ovarian cancer. In other aspects, the present invention provides a method of targeting and imaging various tumors and/or tumor associated macrophages (TAMs).
Type:
Grant
Filed:
July 7, 2023
Date of Patent:
April 30, 2024
Assignee:
The Florida International University Board of Trustees
Inventors:
Arti Vashist, Andrea D. Raymond, Prem Chapagain, Madhavan P. Nair, Carolyn D. Runowicz
Abstract: Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3? or C4? modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.
Type:
Grant
Filed:
September 2, 2021
Date of Patent:
April 30, 2024
Assignee:
The Board of Trustees of the University of Illinois
Inventors:
Martin D. Burke, Stephen Davis, Brice E. Uno, Justin Struble, Ian Dailey, Kaitlyn C. Gray, David M. Knapp, Pulin Wang, Nagarjuna Palyam
Abstract: A catalyst structure includes: (1) a substrate; (2) a catalyst layer on the substrate; and (3) an adhesion layer disposed between the substrate and the catalyst layer. In some implementations, an average thickness of the adhesion layer is about 1 nm or less. In some implementations, a material of the catalyst layer at least partially extends into a region of the adhesion layer. In some implementations, the catalyst layer is characterized by a lattice strain imparted by the adhesion layer.
Type:
Grant
Filed:
December 11, 2020
Date of Patent:
April 30, 2024
Assignees:
The Board of Trustees of the Leland Stanford Junior University, Volkswagen Aktiengesellschaft
Inventors:
Friedrich B. Prinz, Shicheng Xu, Yongmin Kim, Thomas Jaramillo, Drew C. Higgins, Maha Yusuf, Zhaoxuan Wang, Kyung Min Lee, Marat Orazov, Dong Un Lee, Tanja Graf, Thomas Schladt, Gerold Huebner, Hanna-Lena Wittern, Jonathan Edward Mueller
Abstract: Disclosed are electrochemical devices, such as lithium ion battery electrodes, lithium ion conducting solid-state electrolytes, and solid-state lithium ion batteries including these electrodes and solid-state electrolytes. Also disclosed are methods for making such electrochemical devices.
Type:
Grant
Filed:
June 29, 2020
Date of Patent:
April 30, 2024
Assignees:
The Regents of the University of Michigan, Board of Trustees of Michigan State University
Inventors:
Jeffrey Sakamoto, Travis Thompson, Isabel N. Boona
Abstract: The present invention relates to compositions and methods for treating diseases, disorders or conditions associated with the expression of the Glycosyl-phosphatidylinositol (GPI)-linked GDNF family ?-receptor 4 (GFR?4).
Type:
Grant
Filed:
October 23, 2020
Date of Patent:
April 30, 2024
Assignees:
The Trustees of the University of Pennsylvania, Novartis AG, The Scripps Research Institute
Inventors:
Donald L. Siegel, Michael C. Milone, Vijay Bhoj, Christoph Rader
Abstract: The disclosure relates to immune cells comprising one or more vectors comprising a nucleic acid sequence encoding a chimeric antigen receptor specific for CD19 and a nucleic acid sequence encoding an enhancer of T cell priming (e.g., IL-18), compositions comprising the T cells, and methods of generating and/or using the T cells to treat diseases associated with the expression of CD19.
Type:
Application
Filed:
October 17, 2023
Publication date:
April 25, 2024
Applicants:
Kite Pharma, Inc., The Trustees of the University of Pennsylvania
Inventors:
Neil C. Sheppard, Yanping Luo, David Barrett, Regina Young
Abstract: Provided herein are novel heterocyclic compounds, for example, compounds having Formula I, I-P, II, II-P, III, or IV. Also provided herein are pharmaceutical compositions comprising the compounds and methods of using the same, for example, in inhibiting aldehyde dehydrogenases, retinoid pathway activation, and/or for treating various cancers, cancer metastasis, type 2 diabetes, pulmonary arterial hypertension (PAH) or neointimal hyperplasia (NIH) or as a male contraceptive.
Type:
Application
Filed:
October 17, 2023
Publication date:
April 25, 2024
Applicants:
KayoThera Inc., The Trustees of Princeton University
Inventors:
Mark ESPOSITO, John PROUDFOOT, Yibin KANG, John PIWINSKI
Abstract: Embodiments herein describe systems and methods to enhance RNA stability and uses thereof. Many embodiments alter the sequence of an RNA therapeutic molecule (e.g., vaccines) to encode for a variant peptide while maintaining and/or increasing stability of the RNA therapeutic.
Type:
Application
Filed:
June 30, 2021
Publication date:
April 25, 2024
Applicant:
The Board of Trustees of the Leland Stanford Junior University
Abstract: Aspects of the present disclosure include methods of producing modified polypeptides and modified polypeptide-ribosome or polypeptide-mRNA complexes, and methods of screening polynucleotide and polypeptide libraries. The present disclosure also provides polypeptide libraries useful in screening for single molecule phenotypes. Also provided are kits useful for producing polypeptides capable of being modified using methods disclosed herein.
Type:
Application
Filed:
April 11, 2023
Publication date:
April 25, 2024
Applicant:
The Trustees of the California State University
Abstract: A method and a system for managing power resources. One or more measurements received from one or more sensors communicatively coupled to at least one processor are processed. The sensors monitor and measure at least one of: one or more operational parameters associated with operation of at least one equipment, one or more external parameters associated with an environment of the equipment, and one or more power parameters associated with a power consumption by the equipment. Based on the processed one or more measurements, one or more future operational parameters associated with an operation of the are determined. The operation of the equipment is controlled using the determined future operational parameters.
Type:
Grant
Filed:
March 24, 2022
Date of Patent:
April 23, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Ram Rajagopal, Gustavo Vianna Cezar, Thomas Navidi, Elizabeth Buechler, Abbas El Gamal