Patents Assigned to Trustee
  • Method for ablating or roughening wafer surfaces
    Patent number: 11958739
    Abstract: The present invention provides a simple method for ablating a protective thin film on a bulk surface and roughening the underlying bulk. In an embodiment, silicon nitride thin films, which are useful as etch-stop masks in micro- and nano-fabrication, is removed from a silicon wafer's surface using a hand-held “flameless” Tesla-coil lighter. Vias created by a spatially localized electron beam from the lighter allow a practitioner to perform micro- and nano-fabrication without the conventional steps of needing a photoresist and photolithography. Patterning could be achieved with a hard mask or rastering of the spatially confined discharge, offering—with low barriers to rapid use—particular capabilities that might otherwise be out of reach to researchers without access to conventional, instrumentation-intensive micro- and nano-fabrication workflows.
    Type: Grant
    Filed: March 1, 2021
    Date of Patent: April 16, 2024
    Assignee: University of Rhode Island Board of Trustees
    Inventors: Jason Rodger Dwyer, Y. M. Nuwan D. Y. Bandara, Brian Sheetz
  • Systems and methods for sleep optimization
    Patent number: 11957480
    Abstract: Computer-implemented systems and methods for sleep optimization are disclosed. In certain embodiments, the system includes one or more peripheral devices, a network, one or more networked computers, and one or more remote servers. The peripheral devices and/or the networked computers collect one or more types of sleep data, calculate one or more sleep parameters, and transmit said sleep parameters to the one or more remote servers. The remote servers then perform calculations to determine optimal sleep recommendations. The sleep recommendations are then output to one or more networked computers and/or one or more peripheral devices as adjustments to sleep time and sleep duration.
    Type: Grant
    Filed: July 8, 2022
    Date of Patent: April 16, 2024
    Assignees: Arizona Board of Regents on Behalf of the University of Arizona, The Trustees of the University of Pennsylvania
    Inventors: Michael Grandner, Michael Perlis
  • Stretchable supercapacitors with vertically-aligned embedded carbon nanotubes
    Patent number: 11961669
    Abstract: Flexible and stretchable supercapacitors are made using carbon nanostructures produced by providing a first composite structure which includes a temporary substrate and an array of carbon nanotubes arranged in a stack on a surface of the temporary substrate such that the stack of carbon nanotubes is oriented generally perpendicular to the surface of the temporary substrate, which may include silicon dioxide. The stack of carbon nanotubes is transferred from the temporary substrate to another substrate, which includes a curable polymer, thereby forming another composite structure comprising the stack of carbon nanotubes and the cured polymer.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: April 16, 2024
    Assignee: The Trustees of the Stevens Institute of Technology
    Inventors: Runzhi Zhang, Junjun Ding, Eui-Hyeok Yang
  • Biomimetic chemocatalytic cascades of degradable polymers
    Patent number: 11958031
    Abstract: A method of simultaneously modifying degradation rates of at least two compounds including a first compound having a first unmodified degradation rate constant k1 and a second compound having a second unmodified degradation rate k2 is provided. The method includes combining a first composition including the first compound with a second composition including the second compound, degrading the first compound and forming a first degradation product; and degrading the second compound and forming a second degradation product. The second degradation product modifies the first unmodified degradation rate constant k1 of the first compound to a first modified degradation rate k1? and the first degradation product modifies the second unmodified degradation rate k2 of the second compound to a second modified degradation rate k2?. Compositions resulting from the method are also provided.
    Type: Grant
    Filed: May 19, 2021
    Date of Patent: April 16, 2024
    Assignee: Board of Trustees of Michigan State University
    Inventors: John R. Dorgan, Bin Tan
  • Use of ICOS-based cars to enhance antitumor activity and car persistence
    Patent number: 11958892
    Abstract: The present invention provides compositions and methods for treating cancer in a human. The invention includes administering a genetically modified Th17 cell to express a CAR having an antigen binding domain, a transmembrane domain, and an ICOS intracellular signaling domain.
    Type: Grant
    Filed: February 17, 2020
    Date of Patent: April 16, 2024
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Carl H. June, Sonia Guedan Carrio, Yangbing Zhao, John Scholler
  • Methods of treating Prader-Willi syndrome
    Patent number: 11957656
    Abstract: The present invention relates to methods for regulating prohormone convertase (PC1) and compounds and treatments which increase PC1 levels, for treating Prader-Willi Syndrome (PWS).
    Type: Grant
    Filed: October 26, 2020
    Date of Patent: April 16, 2024
    Assignees: The Trustees of Columbia University in the City of New York, Levo Therapeutics, Inc.
    Inventors: Lisa Cole Burnett, Dieter Egli, Rudolph L Leibel, Sara Cotter
  • Laser induced collagen crosslinking in tissue
    Patent number: 11957622
    Abstract: The presently disclosed subject matter provides techniques for inducing collagen cross-linking in human tissue, such as cartilage, by inducing ionization of the water contained in the tissue to produce free radicals that induce chemical cross-linking in the human tissue. In an embodiment, a femtosecond laser operates at sufficiently low laser pulse energy to avoid optical breakdown of the tissue being treated. In an embodiment, the femtosecond laser operates in the infrared frequency range.
    Type: Grant
    Filed: January 12, 2023
    Date of Patent: April 16, 2024
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Sinisa Vukelic, Gerard A. Ateshian
  • Electrically controllable surgical tools
    Patent number: 11957366
    Abstract: The present disclosure relates to electrically controllable surgical tools. In general, surgical devices are provided having an electrically controllable, fingered operating end for use in angiography, endovascular and/or neurological surgery. The finger(s) at the operating end can be made from ionic polymer metal composite (IPMC) material to facilitate control of the finger(s).
    Type: Grant
    Filed: January 19, 2022
    Date of Patent: April 16, 2024
    Assignees: MaineHealth, Board of Trustees of the University of Maine System
    Inventors: Robert D. Ecker, Mohsen Shahinpoor
  • Combination therapies using immuno-dash inhibitors and PGE2 antagonists
    Patent number: 11957657
    Abstract: Disclosed are combination therapies including administration of I-DASH inhibitors and PGE2 antagonists, and the use of such therapies in the treatment of cell proliferative diseases.
    Type: Grant
    Filed: July 6, 2021
    Date of Patent: April 16, 2024
    Assignee: Trustees of Tufts College
    Inventors: William W. Bachovchin, Hung-sen Lai, Wengen Wu
  • SHIGELLA MULTI-EPITOPE FUSION ANTIGEN PROTEINS AND METHODS OF USE
    Publication number: 20240115686
    Abstract: Compositions and methods for eliciting an immune response in a subject (such as against Shigella) are provided. In examples, the compositions can include fusion proteins including one or more epitopes from Shigella or E. coli. In examples, the methods can include administering a disclosed fusion protein to a subject.
    Type: Application
    Filed: October 14, 2020
    Publication date: April 11, 2024
    Applicant: The Board of Trustees of the University of Illinois
    Inventor: Weiping Zhang
  • COMPOSITIONS AND METHODS FOR PREVENTING OR TREATING MUSCLE CONDITIONS
    Publication number: 20240115583
    Abstract: Provided herein are compositions for preventing or treating muscle conditions such as muscle damage, injury, or atrophy. In some embodiments, the compositions comprise a prostaglandin E2 (PGE2) compound and a myotoxin. In some embodiments, the muscle damage, injury, or atrophy is the result of a nerve injury, a surgical procedure, or a traumatic injury. Methods of promoting muscle regeneration and methods of increasing muscle mass are also provided herein.
    Type: Application
    Filed: May 15, 2023
    Publication date: April 11, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Helen M. Blau, Adelaida R. Palla, Andrew Tri Van Ho
  • Human Therapeutic Targets and Modulators Thereof
    Publication number: 20240120023
    Abstract: Methods for identifying biosynthetic gene clusters that include genes for producing compounds that interact with specific target proteins are disclosed. Some methods relate to bioinformatics methods for identifying and/or prioritizing biosynthetic gene clusters. Related systems, components, and tools for the identification and expression of such gene clusters are also disclosed.
    Type: Application
    Filed: July 7, 2023
    Publication date: April 11, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Brian Thomas Naughton, Colin Harvey, Ulrich Schlecht, Maureen Elizabeth Hillenmeyer, Joe Horecka
  • METHOD AND SYSTEM FOR GROWING A LATTICE MATCHED, MULTILAYER, ORGANIC CRYSTAL HETEROSTRUCTURE
    Publication number: 20240117521
    Abstract: Disclosed are criteria for a lattice matched, multilayer, organic crystal heterostructure. Current organic devices (e.g., photovoltaics, light emitting diodes, or transistors) rely on amorphous material despite superior charge transport properties of crystalline organic semiconductors. Achieving a fully crystalline device architecture requires growth of a molecular crystal atop a different one, or heteroepitaxy, and is particularly relevant in organic semiconductor devices that demand multiple layers of different molecules. This challenge is complicated when attempting to stack highly ordered layers needed for crystalline devices because strategies are needed to ensure that each layer grows crystalline. It is shown herein that lattice matching alone is not sufficient for successful organic heteroepitaxy deposited via physical vapor deposition.
    Type: Application
    Filed: September 29, 2023
    Publication date: April 11, 2024
    Applicant: The Trustees of Princeton University
    Inventors: Barry Rand, Jordan Dull
  • Method of Increasing the Function of an AAV Vector
    Publication number: 20240117378
    Abstract: A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid sequences.
    Type: Application
    Filed: June 30, 2023
    Publication date: April 11, 2024
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Luk VANDENBERGHE, Guangping GAO, James M. WILSON
  • NOVEL ADENO-ASSOCIATED VIRUS (AAV) CLADE F VECTOR AND USES THEREFOR
    Publication number: 20240117322
    Abstract: A recombinant adeno-associated virus (rAAV) vector comprising an AAVhu68 capsid produced in a production system comprising a nucleotide sequence of SEQ ID NO: 1, or a sequence at least 75% identical thereto which encodes SEQ ID NO:2. The AAVhu68 capsid comprises subpopulations of highly deamidated asparagine residues in asparagine-glycine pairs in the amino acid sequence of SEQ ID NO: 2. Also provided are compositions containing the rAAV and uses thereof. Additionally, rAAV having an engineered AAV capsid comprising at least one subpopulation of vp1 or vp2 proteins having a Val at amino acid position 157 with reference to the AAVhu68 vp1 numbering are provided.
    Type: Application
    Filed: October 11, 2023
    Publication date: April 11, 2024
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: James M. Wilson, Qiang Wang, April Tepe, Kevin Turner
  • Systems and methods for providing a control solution for an actuator
    Patent number: 11951630
    Abstract: Systems and methods of the present disclosure provide a control solution for a robotic actuator. The actuator can have one or two degrees of freedom of control, and can connect with a platform using an arm. The arm can have at least two degrees of freedom of control, and the platform can have at least two degrees of freedom of control. The platform can be subjected to unpredictable forces requiring a control response. The control solution can be generated using operational space control, using the degrees of freedom of the arm, platform and actuator.
    Type: Grant
    Filed: April 23, 2021
    Date of Patent: April 9, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventor: Oussama Khatib
  • Ultrathin electrochemical catalysts on catalyst support for proton exchange membrane fuel cells
    Patent number: 11955646
    Abstract: A supported catalyst includes: (1) a catalyst support; and (2) deposits of a catalyst covering the catalyst support, wherein the deposits have an average thickness of about 2 nm or less, and the deposits are spaced apart from one another.
    Type: Grant
    Filed: November 7, 2018
    Date of Patent: April 9, 2024
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Volkswagen Aktiengesellschaft
    Inventors: Friedrich B. Prinz, Thomas Jaramillo, Drew C. Higgins, Yongmin Kim, Shicheng Xu, Thomas Schladt, Tanja Graf
  • Anti-annexin A1 antibodies
    Patent number: 11952416
    Abstract: Anti-annexin A1 antibodies are provided and methods of treating FAP and cancer using Anti-annexin A1 antibodies, antibody fragments or fusion proteins, including bispecific antibodies targeting two different annexin A1 epitopes, are also provided.
    Type: Grant
    Filed: September 14, 2023
    Date of Patent: April 9, 2024
    Assignee: The Trustees of Columbia University in the City of New York
    Inventor: Yiping Han
  • Artificial cornea with double-side microtextured pHEMA hydrogel
    Patent number: 11950997
    Abstract: An artificial cornea and an associated manufacturing method are disclosed. The artificial cornea has two sides, each of which has an associated microstructure. In an embodiment, microlines can be provided on an anterior side, and a posterior side can have micropores. Both the geometry of the microstructures and their dimensions can be customized for an individual patient. The geometry of the artificial cornea itself and its dimensions can also be customized as such. In addition, the lifetime of the artificial cornea can be significantly enhanced by adding co-polymer(s) into the hydrogel to strengthen its mechanical properties. Patient recovery can be aided by adding peptides into the artificial cornea surfaces to improve cell growth post-operation.
    Type: Grant
    Filed: May 20, 2020
    Date of Patent: April 9, 2024
    Assignee: The Trustees of the Stevens Institute of Technology
    Inventors: Yiwen Xi, Chang-Hwan Choi, Xiaojun Yu, Junfeng Liang
  • Sharp turning steerable needle
    Patent number: 11950805
    Abstract: Disclosed are steerable needles having a shaft that can be controllably buckled, a steering head positioned at a distal end of the shaft, a transmission for controlling the orientation of the steering head, and a base at the end of the shaft, the base optionally comprising a controller for controlling the transmission. Also disclosed are methods of using the disclosed steerable needles.
    Type: Grant
    Filed: March 28, 2023
    Date of Patent: April 9, 2024
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: Mark Yim