Patents Assigned to Trustee
  • Fifth-generation (5G)-focused piezoelectric resonators and filters
    Patent number: 11996820
    Abstract: A piezoelectric thin film suspended above a carrier substrate is adapted to propagate an acoustic wave in a Lamb mode excited by a component of an electric field that is oriented in a longitudinal direction along a length of the piezoelectric thin film. A first signal electrode is located on the piezoelectric thin film and oriented in a transverse direction perpendicular to the longitudinal direction. A first ground electrode is located on the piezoelectric thin film and oriented in the transverse direction. The first ground electrode is separated from the first signal electrode by a gap in which the acoustic wave resonates. A first release window and a second release window are located at a first end and a second end of the piezoelectric thin film, respectively. Intermittent release windows are located beyond distal ends of the first signal electrode and the first ground electrode.
    Type: Grant
    Filed: January 22, 2021
    Date of Patent: May 28, 2024
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Yansong Yang, Ruochen Lu, Liuqing Gao, Songbin Gong
  • Sub-wavelength Raman imaging with combined optical and electron excitation
    Patent number: 11994472
    Abstract: Improved stimulated Raman spectroscopy is provided by replacing the Stokes (or anti-Stokes) optical source with a localized electromagnetic emitter that is excited with a non-electromagnetic excitation. Such a localized emitter can be an efficient Stokes (or anti-Stokes) source for stimulated Raman spectroscopy, and can also provide deep sub-wavelength spatial resolution. In a preferred embodiment, an electron beam from an electron microscope is used to excite the localized emitter. This provides combined Raman imaging and electron microscopy that has the two imaging modalities inherently registered with each other.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: May 28, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jennifer A. Dionne, Amr Ahmed Essawi Saleh, Daniel K. Angell
  • Devices for assisting self-catheterization and methods for using such devices
    Patent number: 11992630
    Abstract: Devices and methods are provided to facilitate self-catheterization of a urethra. In an exemplary embodiment, the device includes an elongate anchor member comprising a proximal end and a rounded distal end to facilitate insertion into a user's vagina, a bridge extending laterally from an intermediate location of the anchor member, a guide on the bridge spaced apart from the anchor member such that the guide is aligned with the user's urethra, the guide including a passage therethrough sized to receive a urinary catheter therethrough, and a handle on the proximal end of the anchor member to facilitate manipulation by the user and consistent, accurate alignment of the guide.
    Type: Grant
    Filed: August 24, 2020
    Date of Patent: May 28, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Craig Comiter, Gabe Ho, Maria Iglesias, Isaac Justice, Amanda Urke
  • Zwitterionic biocompatible polymers, methods, and uses thereof
    Patent number: 11993670
    Abstract: Provided herein are biocompatible polymers having a polymer backbone and one or more repeating units, and methods of making and using the same. The repeating units can each be individually selected from a zwitterionic precursor repeating unit of Formula (1). Also provided are systems for nucleic acid delivery including the biocompatible polymers, the systems having a cationic core and a polysaccharide-anionic peptide conjugate adsorbed to the cationic core.
    Type: Grant
    Filed: June 6, 2019
    Date of Patent: May 28, 2024
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Gang Cheng, Huifeng Wang
  • Therapeutic IL-13 polypeptides
    Patent number: 11993639
    Abstract: Variant IL-13 polypeptides are provided, which are engineered to have one or more of the following properties: (a) altered affinity for IL-13R?2, relative to the native human IL-13 protein; (b) altered affinity for IL-13R?1 relative to the native human IL-13 protein; (c) a disruption in the binding site for IL-4R? relative to the native human IL-13 protein.
    Type: Grant
    Filed: July 29, 2021
    Date of Patent: May 28, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Kenan Christopher Garcia, Ignacio Moraga Gonzalez
  • Peptoid-based inhibitors of the protein arginine methyltransferase (PRMT) family
    Patent number: 11993556
    Abstract: Novel peptoid compounds, compositions and methods of using the compounds and compositions to inhibit protein arginine methyltransferase (PRMT) and induce apoptosis in cancer cells are presented.
    Type: Grant
    Filed: November 16, 2021
    Date of Patent: May 28, 2024
    Assignee: University of North Florida Board of Trustees
    Inventors: Bryan Knuckley, Corey P. Causey, Fatima Khwaja Rehman
  • Compositions comprising R-Spondin (RSPO) surrogate molecules
    Patent number: 11993645
    Abstract: R-spondin (RSPO) surrogate compositions and methods for their use are provided. RSPO surrogates of the invention comprise (i) a specific binding domain for Ring Finger Protein 43 (RNF43) or Zinc and Ring Finger Protein 3 (ZNRF3) and (ii) a cell targeting domain More specifically, wherein the specific binding domain for RNF43 or ZNRF3 is an antibody fragment, and wherein the cell targeting domain is a cytokine.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: May 28, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Vincent Christopher Luca, Kenan Christopher Garcia
  • Monitoring treatment of peripheral artery disease (PAD) using diffuse optical imaging
    Patent number: 11992301
    Abstract: A plurality of modules are simultaneously positioned at locations that correspond to different angiosomes. Each of these modules has a front surface shaped and dimensioned for contacting a person's skin, a plurality of different-wavelength light sources aimed in a forward direction, and a plurality of light detectors aimed to detect light arriving from in front of the front surface. Each module is supported by a support structure (e.g., a strap or a clip) that is shaped and dimensioned to hold the front surface adjacent to the person's skin at a respective position. Perfusion in each of the angiosomes is monitored using these modules, and the surgeon can rely on this information to guide his or her intervention.
    Type: Grant
    Filed: August 5, 2022
    Date of Patent: May 28, 2024
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Andreas H. Hielscher, Christopher J. Fong, Jennifer Hoi, Hyun K. Kim, Michael Khalil
  • Systems and methods for predicting and treating neurological condition relapses
    Patent number: 11992298
    Abstract: Systems and methods for predicting and treating relapses for neurological conditions in accordance with embodiments of the invention are illustrated. One embodiment includes a method for predicting and treating a clinical neurological condition relapse. The method includes steps for selecting a threshold heart rate variability value for a patient suffering from a clinical neurological condition, monitoring, using a cardiac monitor, the heart rate variability of the patient over time, providing an indicator that a relapse is imminent when the heart rate variability of the patient falls below the threshold heart rate variability value, and treating the patient using a transcranial magnetic stimulation device by applying an accelerated theta burst stimulation protocol where the transcranial magnetic stimulation target is the left prefrontal dorsolateral cortex.
    Type: Grant
    Filed: October 26, 2023
    Date of Patent: May 28, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Nolan Williams, Keith Sudheimer
  • Structures and methods for mitigating implosion pressure spikes
    Patent number: 11993355
    Abstract: Structures designed to mitigate implosion pressure spikes through the use of an external sacrificial confining structure. Such improved structures can, in some embodiments, completely surround the existing structures that are at a high risk of imploding. The improved structures can slow the rate at which the surrounding fluid media volume is consumed by providing resistance to flow into the enclosure.
    Type: Grant
    Filed: November 1, 2021
    Date of Patent: May 28, 2024
    Assignee: University of Rhode Island Board of Trustees
    Inventors: Dillon Fontaine, Arun Shukla
  • TREATMENT OF HEART DISEASE BY DISRUPTION OF THE ANCHORING OF PP2A
    Publication number: 20240165268
    Abstract: The present invention provides a method of treating heart failure with reduced ejection fraction, by administering to a patient at risk of such damage, a pharmaceutically effective amount of a composition which inhibits the anchoring of PP2A to mAKAP?. This composition is preferably in the form of a viral based gene therapy vector that encodes a fragment of mAKAP? to which PP2A binds.
    Type: Application
    Filed: January 23, 2024
    Publication date: May 23, 2024
    Applicants: University of Miami, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Michael S. KAPILOFF, Jinliang LI
  • Microscopy imaging device with advanced imaging properties
    Patent number: 11986267
    Abstract: Systems, methods and devices are implemented for microscope imaging solutions. One embodiment of the present disclosure is directed toward an epifluorescence microscope. The microscope includes an image capture circuit including an array of optical sensor. An optical arrangement is configured to direct excitation light of less than about 1 mW to a target object in a field of view of that is at least 0.5 mm2 and to direct epi-fluorescence emission caused by the excitation light to the array of optical sensors. The optical arrangement and array of optical sensors are each sufficiently close to the target object to provide at least 2.5 ?m resolution for an image of the field of view.
    Type: Grant
    Filed: August 26, 2022
    Date of Patent: May 21, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Kunal Ghosh, Laurie D. Burns, Abbas El Gamal, Mark J. Schnitzer, Eric Cocker, Tatt Wei Ho
  • Compositions of matter for detection assays
    Patent number: 11987839
    Abstract: The present disclosure describes compositions of matter comprising a ribonucleoprotein complex comprising a nucleic acid-guided nuclease and a guide RNA, and further comprising a blocking nucleic acid molecule represented by Formula IV, wherein Formula IV in the 5?-to-3? direction comprises: T-D-M-A-Lp-C; wherein T is 17-31 nucleotides in length; D is 0-15 nucleotides in length; M is 1-25 nucleotides in length; A is 0-15 nucleotides in length and comprises a sequence complementary to D; and L is 3-25 nucleotides in length; p is 0 or 1; C is 4-15 nucleotides in length and comprises a sequence complementary to T; and wherein the blocking nucleic acid molecule comprises a sequence complementary to a gRNA.
    Type: Grant
    Filed: September 24, 2023
    Date of Patent: May 21, 2024
    Assignees: VedaBio, Inc., The Board of Trustees of The University of Illinois
    Inventors: Anurup Ganguli, Ariana Mostafa, Jacob Berger, Ashish Pandey
  • Multiplicative recurrent neural network for fast and robust intracortical brain machine interface decoders
    Patent number: 11989641
    Abstract: A brain machine interface (BMI) to control a device is provided. The BMI has a neural decoder, which is a neural to kinematic mapping function with neural signals as input to the neural decoder and kinematics to control the device as output of the neural decoder. The neural decoder is based on a continuous-time multiplicative recurrent neural network, which has been trained as a neural to kinematic mapping function. An advantage of the invention is the robustness of the decoder to perturbations in the neural data; its performance degrades less—or not at all in some circumstances—in comparison to the current state decoders. These perturbations make the current use of BMI in a clinical setting extremely challenging. This invention helps to ameliorate this problem. The robustness of the neural decoder does not come at the cost of some performance, in fact an improvement in performance is observed.
    Type: Grant
    Filed: October 3, 2022
    Date of Patent: May 21, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: David Sussillo, Jonathan C. Kao, Sergey Stavisky, Krishna V. Shenoy
  • Polymer glass transition temperature manipulation via z/e hydrazone photoswitching
    Patent number: 11987654
    Abstract: In an embodiment, the present disclosure pertains to a method of changing the glass transition temperature of a polymer. In some embodiments, the polymer includes at least one hydrazone-containing compound. In general, the methods of the present disclosure include one or more of the following steps of: (1) applying light to the polymer; and (2) thereby changing the glass transition temperature of the polymer. In another embodiment, the present disclosure pertains to a polymer having a light-adjustable glass transition temperature. In some embodiments, the polymer includes at least one hydrazone-containing compound.
    Type: Grant
    Filed: December 20, 2022
    Date of Patent: May 21, 2024
    Assignee: Trustees of Dartmouth College
    Inventors: Ivan Abrahamian, Sirun Yang, Laura L. Jeliazkov, Jared D. Harris
  • Battery monitoring system
    Patent number: 11988716
    Abstract: A battery health monitoring system that utilizes adaptive cathode and adaptive anode observers to estimate the ion concentrations at the respective cathode and anode of a battery. Subsequently, the estimated ion concentrations can be used in a battery model to estimate the state of heath and state of charge of the battery. Additionally, the model and ion concentrations can be updated real time as aging components of the battery are evaluated in the output data from the battery.
    Type: Grant
    Filed: March 16, 2020
    Date of Patent: May 21, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Anirudh Allam, Simona Onori
  • SYNTHETIC ENAMEL AND USES THEREOF
    Publication number: 20240156696
    Abstract: The present disclosure relates to compositions and methods for restoring enamel, e.g., on tooth surfaces.
    Type: Application
    Filed: November 16, 2023
    Publication date: May 16, 2024
    Applicant: Trustees of Boston University
    Inventors: Yuwei FAN, Lina Fahad N. MENGARI, Zhi SUN
  • METHODS AND ARRAYS FOR TARGET ANALYTE DETECTION AND DETERMINATION OF TARGET ANALYTE CONCENTRATION IN SOLUTION
    Publication number: 20240159765
    Abstract: Arrays of single molecules and methods of producing an array of single molecules are described. Arrays with defined volumes between 10 attoliters and 50 picoliters enable single molecule detection and quantitation.
    Type: Application
    Filed: November 22, 2023
    Publication date: May 16, 2024
    Applicant: Trustees of Tufts College
    Inventors: David R. Walt, David M. Rissin
  • SELF-REFERENCING ULTRAFAST LASER SYSTEM WITH PULSE SHAPING
    Publication number: 20240162674
    Abstract: A laser system employs a laser, a pulse shaper, and a controller configured to measure phase variations on pre-compressed laser pulses. In another aspect, a laser apparatus and method include programmed software instructions which measure phase variations of ultrafast laser pulses. A further aspect of the present system and method includes a laser, an active pulse shaper, and a controller which measure and/or correct distortions of laser pulses with ?/2 scanning.
    Type: Application
    Filed: March 3, 2022
    Publication date: May 16, 2024
    Applicant: Board of Trustees of Michigan State University
    Inventors: Marcos DANTUS, Jacob Anthony STAMM, Jorge Guillermo BENEL MOGROVEJO
  • Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
    Patent number: 11981731
    Abstract: The present invention provides compositions and methods for regulating the specificity and activity of immune effector cells for use in immunotherapy. In one embodiment, the invention provides a type of chimeric antigen receptor (CAR) wherein the CAR is termed a “NKR-CAR” which is a CAR design comprising a component of a receptor naturally found on natural killer (NK) cells. In one embodiment, the NK receptor includes but is not limited to a naturally occurring activating and inhibitory receptor of NK cells known as a killer cell immunoglobulin-like receptor (KIR).
    Type: Grant
    Filed: January 15, 2020
    Date of Patent: May 14, 2024
    Assignees: The Trustees of the University of Pennsylvania, Novartis AG
    Inventors: Gregory Beatty, Boris Engels, Neeraja Idamakanti, Carl H. June, Andreas Loew, Michael C. Milone, Huijuan Song, Enxiu Wang, Qilong Wu