Patents Assigned to Trustee
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Publication number: 20240191258Abstract: Compositions useful for treatment of Spinal and Bulbar Muscular Atrophy (SBMA) comprising administration of a recombinant adeno-associated virus (rAAV) vector having an AAV capsid and a vector genome comprising a sequence encoding at least one hairpin forming miRNA that comprises a targeting sequence which binds a target site on the mRNA of human androgen receptor, wherein the miRNA inhibits expression of human androgen receptor, is provided. Also provided are compositions containing a rAAV vector and methods of treating SBMA in patient comprising administration of a rAAV vector.Type: ApplicationFiled: April 12, 2022Publication date: June 13, 2024Applicant: The Trustees of the University of PennsylvaniaInventors: James M. Wilson, Christian Hinderer, Eileen Workman
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Patent number: 12007354Abstract: A method and system for label-free detection of pathogenic and antibiotic resistant bacteria is disclosed. The method includes fabricating a G-FET/peptide device having a synthesized peptide probe capable of recognizing and binding to a bacterial target; performing electric-field assisted binding of at least one bacterial cell of the bacterial target to the G-FET/peptide device; and electrically detecting the binding of the at least one bacterial cell to the G-FET/peptide device.Type: GrantFiled: November 6, 2020Date of Patent: June 11, 2024Assignee: The Trustees of Boston CollegeInventors: Kenneth S. Burch, Tim van Opijnen, Jianmin Gao, Narendra Kumar, Juan C. Ortiz-Marquez, Wenjian Wang, Mason Gray
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Patent number: 12006503Abstract: The invention discloses oncogenic fusion proteins. The invention provides methods for treating gene-fusion based cancers.Type: GrantFiled: June 11, 2020Date of Patent: June 11, 2024Assignee: The Trustees of Columbia University in the City of New YorkInventors: Antonio Iavarone, Anna Lasorella
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Patent number: 12009785Abstract: In some embodiments, there is provided an apparatus including a common bus and a plurality of oscillatrode circuits coupled to the common bus, the plurality of oscillatrode circuits including a first oscillatrode circuit outputting a first frequency tone when a first input voltage is detected by the first oscillatrode circuit and a second oscillatrode circuit outputting a second frequency tone when a second input voltage is detected by the second oscillatrode circuit, wherein common bus carries the first frequency tone and the second frequency tone at different frequencies in a frequency division multiplex signal. Related systems, methods, and articles of manufacture are also disclosed.Type: GrantFiled: December 13, 2019Date of Patent: June 11, 2024Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Jun-Chau Chien, Mohammad Amin Arbabian
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Patent number: 12006347Abstract: Novel human interleukin-2 (IL-2) muteins or variants thereof, and nucleic acid molecules and variants thereof are provided. Methods for producing these muteins as well as methods for stimulating the immune system of an animal are also disclosed. In addition, the invention provides recombinant expression vectors comprising the nucleic acid molecules of this invention and host cells into which expression vectors have been introduced. Pharmaceutical compositions are included comprising a therapeutically effective amount of a human IL-2 mutein of the invention and a pharmaceutically acceptable carrier. The IL-2 muteins can be used in pharmaceutical compositions for use in treatment of cancer and in stimulating the immune response.Type: GrantFiled: September 9, 2021Date of Patent: June 11, 2024Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Kenan Christopher Garcia, Aron Levin, Aaron Ring
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Patent number: 12005079Abstract: Engineered orthogonal cytokine receptor/ligand pairs, and methods of use thereof, are provided.Type: GrantFiled: November 19, 2020Date of Patent: June 11, 2024Assignees: The Board of Trustees of the Leland Stanford Junior University, University of WashingtonInventors: Kenan Christopher Garcia, Jonathan Sockolosky, Lora Picton
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Patent number: 12009869Abstract: A cryogenic optoelectronic data link, comprising a sending module operating at a cryogenic temperature less than 100 K. An ultrasensitive electro-optic modulator, sensitive to input voltages of less than 10 mV, may include at least one optically active layer of graphene, which may be part of a microscale resonator, which in turn may be integrated with an optical waveguide or an optical fiber. The optoelectronic data link enables optical output of weak electrical signals from superconducting or other cryogenic electronic devices in either digital or analog form. The modulator may be integrated on the same chip as the cryogenic electrical devices. A plurality of cryogenic electrical devices may generate a plurality of electrical signals, each coupled to its own modulator. The plurality of modulators may be resonant at different frequencies, and coupled to a common optical output line to transmit a combined wavelength-division-multiplexed (WDM) optical signal.Type: GrantFiled: April 3, 2023Date of Patent: June 11, 2024Assignees: SeeQC Inc., Center for Technology Licensing at Cornell University, The Trustees of Columbia University in the City of New YorkInventors: Igor V. Vernik, Oleg A. Mukhanov, Alan M. Kadin, Christopher T. Phare, Michal Lipson, Keren Bergman
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Patent number: 12004707Abstract: An airway visualization system is described herein having an elongate delivery sheath and defining at least one lumen therethrough, wherein the length is positionable within an airway of a subject. An isolation component positioned near or at a distal end of the elongate delivery sheath is expandable to at least partially obstruct the airway and a controller is in communication with the delivery sheath. The controller is also configured to manipulate a fluid flow through the at least one lumen whereby a pressure change within the airway of the subject is imparted sufficiently to at least partially expand or collapse the airway to alter the density of the airway.Type: GrantFiled: August 20, 2020Date of Patent: June 11, 2024Assignee: The Board of Trustees of The Leland Stanford Junior UniversityInventors: Bryan I. Hartley, Norbert Pelc, Dimitri Augustin, Racquel Redwood, Zach Wolf, Benjamin Berkowitz, Harmeet Bedi
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Patent number: 12009524Abstract: Flexible air-breathing microscale fuel cells are produced using ion exchange polymer membranes without silicon substrates or other rigid components. The microscale fuel cells provide long-life energy supply sources in portable electronics due to reduced volume, high energy density, and low cost. More particularly, the microscale fuel cell has a direct hydrogen flow-through porous anode electrode with a pair of air-breathing cathodes.Type: GrantFiled: November 20, 2020Date of Patent: June 11, 2024Assignee: The Trustees of the Stevens Institute of TechnologyInventors: Ronald Besser, Seyed Reza Mahmoodi
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Patent number: 12008987Abstract: Systems and methods for decoding indented speech from neuronal activity in accordance with embodiments of the invention are illustrated.Type: GrantFiled: April 30, 2019Date of Patent: June 11, 2024Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Sergey Stavisky, Krishna V. Shenoy, Jaimie M. Henderson
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Patent number: 12005119Abstract: Polyacrylamide-based copolymers act as stabilizing excipients in formulations of antibody biopharmaceutical agents without interacting directly with the antibody or altering its pharmacokinetic properties. The polyacrylamide-based copolymers confer a substantial stability benefit to high concentration compositions of a variety of antibodies by precluding adsorption of the antibody to the interfaces of the composition, preventing undesirable aggregation events and maintaining the binding activity of the antibody. Such antibody compositions are useful in methods of administering the composition to a subject.Type: GrantFiled: May 23, 2023Date of Patent: June 11, 2024Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Eric A. Appel, Joseph L. Mann, John Klich, Catherine M. Kasse
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Patent number: 12007602Abstract: In an integrated optical device, squeezed light is used internally to effectively increase an optical modulation effect. One exemplary device operates by squeezing the light at the input, then sending it through an electro-optic stage where its phase picks up the signal of interest, and finally anti-squeezing it to obtain a displaced coherent state. Thus the displacement is amplified by the level of squeezing that is achieved inside the device and it is thereby less sensitive to loss. Since this device behaves simply as an electro-optic modulator, albeit one with an exponentially enhanced sensitivity, no extra considerations are needed to integrate the modulator into a system. Such devices can be operated as modulators or as sensors, and can make use of optical phase shift effects other than the electro-optic effect.Type: GrantFiled: May 9, 2022Date of Patent: June 11, 2024Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Amir H. Safavi-Naeini, Timothy Patrick McKenna, Hubert S. Stokowski
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Patent number: 12006373Abstract: The present disclosure is directed to anti-CD3? peptides, compounds, and methods of using same. A biopanning technique was used to identify several phage clones displaying unique anti-CD3? peptide sequences. The anti-CD3? peptide sequences bind to human CD3? on T cells, allowing the identification, labeling, and delivery of cargo to these T cells. Applications for the disclosed peptides include the labeling of T cells with magnetic particles for MRI detection and targeting of T cells with cargo-laden anti-CD3? peptides for immunotherapy. Further still, incubation of T cells with anti-CD3? peptides may result in the activation and increase production of T cells, which may in turn be harvested for applications such as CAR-T therapy.Type: GrantFiled: June 16, 2021Date of Patent: June 11, 2024Assignee: Board of Trustees of the University of Alabama, for and on behalf of the University of Alabama in HuntsvilleInventors: Kyung Ho Roh, Armin Ahmadi
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Patent number: 12005049Abstract: A method of preventing metastasis of a cancer in a patient in need thereof includes administering to the patient a therapeutically effective amount of ibudilast, or a pharmaceutical salt thereof.Type: GrantFiled: July 25, 2022Date of Patent: June 11, 2024Assignees: MediciNova, Inc., The Trustees of Columbia University in the City of New YorkInventors: Kazuko Matsuda, Grazia Ambrosini, Gary K. Schwartz, Alex J. Rai
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Patent number: 12006583Abstract: A process includes means for depositing an anti-corrosion coating filled with liquid oil on an aluminum substrate. Aluminum is anodized and then treated with a thin hydrophobic sub-coating. The pores created through anodization are then impregnated with liquid oil. Oil penetration is maximized and residual air is minimized by first filling the pores with a filling solution, replacing the filling solution with an exchange fluid, and then replacing the exchange fluid with perfluorinated oil. The oil gives the surface coating anti-wetting properties and self-healing properties, thereby protecting the aluminum substrate underneath from corrosion.Type: GrantFiled: January 25, 2022Date of Patent: June 11, 2024Assignee: The Trustees of the Stevens Institute of TechnologyInventors: Chang-Hwan Choi, Junghoon Lee
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Patent number: 12004882Abstract: An adaptive real-time radial k-space sampling trajectory (ARKS) can respond to a physiologic feedback signal to reduce motion effects and ensure sampling uniformity. In this adaptive k-space sampling strategy, the most recent signals from an ECG waveform can be continuously matched to the previous signal history, new radial k-space locations were determined, and these MR signals combined using multi-shot or single-shot radial acquisition schemes. The disclosed methods allow for improved MRI imaging.Type: GrantFiled: October 27, 2015Date of Patent: June 11, 2024Assignee: The Trustees of the University of PennsylvaniaInventors: Walter R. T. Witschey, Francisco Contijoch, Mark A. Elliott, Eugene E. Gualtieri
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Publication number: 20240182331Abstract: An electrode deionizer and method remove polarized molecules of an ionic cluster in a fluid. In another aspect, electrophoresis and dielectrophoresis forces are used between electrodes to move a polarized molecular cluster in an electric field, which are then trapped in an activated-carbon on an anode. A further aspect uses dielectrophoresis to reduce the size of polarized molecules of an ionic cluster in a fluid. Yet another aspect of the present apparatus and method employ RF power in addition to DC power.Type: ApplicationFiled: January 4, 2024Publication date: June 6, 2024Applicants: Board of Trustees of Michigan State University, Fraunhofer USAInventors: Qi Hua FAN, Keliang WANG
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Publication number: 20240183787Abstract: Disclosed herein are fusion peptides comprising a fluorescent domain and a rare earth element detection domain capable of binding to a rare earth element and fluorescing when exposed to light when a rare earth element is bound and compositions thereof. The fusion peptide may further comprise a leader domain and a tail domain. The fusion peptide acts as a biosensor to detect and quantify rare earth elements. Methods for imaging internal body structures, detecting rare earth elements in a biosample or environmental sample, and cleaning an environmental site are also presented.Type: ApplicationFiled: January 12, 2024Publication date: June 6, 2024Applicant: Board of Trustees of Michigan State UniversityInventors: Harvey LEE, Connor GRADY, Assaf GILAD
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Publication number: 20240184738Abstract: A densely integrated and chiplet/dielet based networked memory pool with very high intra-pool bandwidth is provided. Chiplets are used to provide a common interface to the network. This means all memories (even those built with different process technologies) look the same from the network's perspective and vice versa: memory can be assembled in many different configurations while only changing the configuration at a high level of abstraction. The memory pool can easily be scaled in capacity and custom configurations that were previously impossible to achieve because of incompatibility of different technologies or level of integration are made possible.Type: ApplicationFiled: April 13, 2022Publication date: June 6, 2024Applicants: The Regents of the University of California, The Board of Trustees of the University of IllinoisInventors: Saptadeep PAL, Matthew TOMEI, Puneet GUPTA, Rakesh KUMAR
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Patent number: 12000740Abstract: A sensor apparatus is provided. Multiple opposite and self-powered sensors are provided in another aspect of the present apparatus. A further aspect employs a sensor apparatus including a first pair of flexible piezoelectric sensors attached to opposite sides of an exterior surface of a workpiece and at least a second pair of flexible piezoelectric sensors attached to opposite sides of the exterior surface of the workpiece. Another aspect of the present apparatus uses pairs of thin film piezoelectric sensors which are configured to detect bending curvature of a workpiece in at least two dimensions by sending voltage output signals from both of the sensors of a first pair and/or both of the sensors of at least a second pair to a controller and/or electrical circuit.Type: GrantFiled: November 16, 2021Date of Patent: June 4, 2024Assignee: Board of Trustees of Michigan State UniversityInventors: Yunqi Cao, Nelson Sepulveda-Alancastro, Henry D'Souza