Patents Assigned to Trustee
-
Patent number: 11906511Abstract: The present invention provides compositions and methods for detecting exhausted T cells in a subject. The present invention also provides methods for treating a subject having a disease characterized by the presence of exhausted T cells or certain subpopulations thereof.Type: GrantFiled: October 26, 2018Date of Patent: February 20, 2024Assignee: The Trustees of the University of PennsylvaniaInventors: E. John Wherry, Bertram Bengsch, Omar Khan, Jennifer Wu, Josephine Giles
-
Patent number: 11905333Abstract: The present invention provides a clinically applicable method of stem cell transplantation that facilitates engraftment and reconstitutes immunocompetence of the recipient without requiring radiotherapy or chemotherapy, and without development of GVHD or graft rejection. Aspects of the present invention are based on the discovery that the depletion of the endogenous stem cell niche facilitates efficient engraftment of stem cells into that niche. In particular, the present invention combines the use of selective ablation of endogenous stem cells, in combination with the administration to the recipient of exogenous stem cells, resulting in efficient, long-term engraftment and tolerance.Type: GrantFiled: December 22, 2022Date of Patent: February 20, 2024Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Irving L. Weissman, Agnieszka Czechowicz, Deepta Bhattacharya, Daniel Kraft
-
Patent number: 11910728Abstract: Methods, devices, and systems are described for performing quantum operations. An example device at least one magnetic field source configured to supply an inhomogeneous magnetic field, at least one semiconducting layer, and one or more conducting layers configured to: define at least two quantum states in the at least one semiconducting layer, and cause, based on an oscillating electrical signal supplied by the one or more conducting layers, an electron to move back and forth between the at least two quantum states in the presence of the inhomogeneous magnetic field. The movement of the electron between the at least two quantum states may generate an oscillating magnetic field to drive a quantum transition between a spin-up state and spin-down state of the electron thereby implementing a qubit gate on a spin state of the electron.Type: GrantFiled: July 23, 2020Date of Patent: February 20, 2024Assignee: The Trustees of Princeton UniversityInventors: Jason Petta, Stefan Putz, Xiao Mi
-
Publication number: 20240050549Abstract: A mammalian expression system comprising an attenuated, recombinant Ranavirus that has at least one foreign expression element using a unique combination of mammalian transcriptional and translational enhancement elements is disclosed. In other contemplated embodiments, a mammalian expression system comprising a virus, wherein the virus is engineered to express at least two vaccine antigens is disclosed. In addition, methods of delivering human antigens to a mammal are disclosed that include: providing a non-mammalian virus, engineering a recombinant virus that can express at least one foreign molecule by modifying the non-mammalian virus, and using the recombinant Ranavirus to express and deliver foreign antigens to a mammal.Type: ApplicationFiled: October 17, 2023Publication date: February 15, 2024Applicant: The Trustees of the California State UniversityInventors: James Jancovich, Nathan Bartlett
-
Publication number: 20240055101Abstract: The disclosure generally relates to the artificial intelligence (AI) automatic methods, computer program product, and systems and methodology for dietary and medical treatment planning, food waste estimation, analyzing three-dimensional food image construction, measurement, nutrient estimation, nutritional assessment, evaluation, prediction and management. More particularly, the embodiments described herein relate to utilizing an AI-based algorithm that can automatically, detect food items from images acquired by cameras for dietary assessment, dietary planning, and for estimating food waste. In one aspect, the method may include food calorie estimation techniques using machine learning and computer vision techniques for dietary assessment. In another aspect, the tools may apply to personalized nutrition. The method may also include the automation of nutrition planning.Type: ApplicationFiled: December 17, 2021Publication date: February 15, 2024Applicants: Trustees of Tufts College, Research Foundation of the City University of New YorkInventors: Karen A. Panetta, Shishir Paramathma Rao, Shreyas Kamath Kalasa Mohandas, Rahul Rajendran, Srijith Rajeev, Erin Hennessy, Christina Economos, Eleanor Tate Shonkoff, Sos S. Agaian
-
Publication number: 20240054841Abstract: A method of using at least one nanoparticle for an anti-counterfeit application including selecting the at least one nanoparticle having a non-spherical configuration; providing the at least one nanoparticle on a substrate; providing a light to the at least one nanoparticle; determining a position of the at least one nanoparticle based on providing the light to the at least one nanoparticle; determining a color of the at least one nanoparticle based on providing the light to the at least one nanoparticle; defining a nanofingerprint based on the position and the color of the at least one nanoparticle; and recognizing the nanofingerprint.Type: ApplicationFiled: October 8, 2020Publication date: February 15, 2024Applicant: The Trustees of Indiana UniversityInventors: Sara E. Skrabalak, Alison F. Smith, Joshua D. Smith
-
Publication number: 20240051995Abstract: There is currently a high demand for new therapeutic antibiotics with new mechanisms of action. Disclosed are two small molecules, tryglysin A and B, with novel chemical structures and potent antibiotic activity against a narrow spectrum of bacteria. This narrow spectrum of activity indicates the tryglysins could be working through a novel antibiotic mechanism of action. Due to this narrow spectrum, the tryglysins could be used as highly targeted therapeutics to treat or prevent disease without disturbing other important, “beneficial” bacteria within the human microbiome, which is a great improvement over virtually all other clinically used antibiotics that are broad-spectrum. The tryglysins are potent against several streptococcal pathogens, including Streptococcus pneumonia, the leading cause of pneumonia, and Streptococcus mutans, the primary causative agent of tooth decay and gum disease.Type: ApplicationFiled: December 8, 2021Publication date: February 15, 2024Applicant: The Trustees of Princeton UniversityInventors: Mohammad R. SEYEDSAYAMDOST, Michael J. FEDERLE, Brett C. COVINGTON, Leah B. BUSHIN, Britta E. RUED, John AMBROSE
-
Publication number: 20240053295Abstract: A method and system for label-free detection of pathogenic and antibiotic resistant bacteria is disclosed. The method includes fabricating a G-FET/peptide device having a synthesized peptide probe capable of recognizing and binding to a bacterial target; performing electric-field assisted binding of at least one bacterial cell of the bacterial target to the G-FET/peptide device; and electrically detecting the binding of the at least one bacterial cell to the G-FET/peptide device.Type: ApplicationFiled: October 13, 2023Publication date: February 15, 2024Applicant: The Trustees of Boston CollegeInventors: Kenneth S. Burch, Tim van Opijnen, Jianmin Gao, Narendra Kumar, Juan C. Ortiz-Marquez, Wenjian Wang, Mason Gray
-
Publication number: 20240053264Abstract: A mid-infrared photothermal microscopy system images a sample. A mid-infrared optical source generates a mid-infrared beam which is directed along a first optical path to reach the substrate on a first side and heat the sample. A probe light source generates a probe light which is directed along a second optical path to reach the substrate on a second side and illuminate the sample. A first laser scanner is positioned along the first optical path and configured to rotate to redirect light and scan the sample with the mid-infrared beam. A second laser scanner is positioned along the second optical path and configured to rotate to redirect light and scan the sample with the probe light. The laser scanners each include at least one mirror driven to rotate such that the mid-infrared beam and the probe light scan the sample synchronously.Type: ApplicationFiled: August 15, 2023Publication date: February 15, 2024Applicant: Trustees of Boston UniversityInventors: Ji-Xin Cheng, Lu Lan, Jiaze Yin
-
Publication number: 20240053291Abstract: The subject invention provides methods for fabricating electrochemical aptamer-based (E-AB) sensors with enhanced sensitivity, signal-to-noise ratios, LOD, and improved stability and reproducibility. The subject invention also provides methods for aptamer immobilization on the surface of the electrode, which favors sufficient spacing between aptamers at the microscale to achieve optimal target recognition, folding, and signal transduction. The E-AB sensors of the subject invention provide superior sensing regardless of the sequence or structure of the bound aptamers or the physiochemical properties of the target.Type: ApplicationFiled: October 23, 2023Publication date: February 15, 2024Applicant: The Florida International University Board of TrusteesInventors: Yi XIAO, Yingzhu LIU, Juan CANOURA
-
Patent number: 11896612Abstract: A method of treating a bacterial infection including bacteria that have become resistant to an antibiotic in a subject in need thereof is provided. The method includes administering to the subject a safe and therapeutically effective amount of the antibiotic and a reviving agent selected from the group consisting of glass-ceramic particles, silver ions, and combinations thereof. The reviving agent restores antibiotic activity to the antibiotic against the bacteria.Type: GrantFiled: March 27, 2020Date of Patent: February 13, 2024Assignee: Board of Trustees of Michigan State UniversityInventors: Xanthippi Chatzistavrou, Neal D. Hammer, Aljoscha Roch
-
Patent number: 11898168Abstract: The current invention provides for methods of promoting differentiation of human pluripotent stem cells into esophageal progenitor cells as well as the cells obtained from the methods, solutions, compositions, and pharmaceutical compositions comprising such cells. The current invention also provides for methods of using the esophageal progenitor cells for treatment and prevention of disease, and kits.Type: GrantFiled: October 10, 2018Date of Patent: February 13, 2024Assignee: The Trustees of Columbia University in the City of New YorkInventors: Jianwen Que, Yongchun Zhang
-
Patent number: 11896654Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody or fragment thereof that targets an immune checkpoint molecule. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.Type: GrantFiled: May 5, 2017Date of Patent: February 13, 2024Assignees: The Trustees of the University of Pennsylvania, The Wistar Institute of Anatomy and Biology, Inovio PharmaceuticalsInventors: David B. Weiner, Kar Muthumani, Niranjan Sardesai
-
Patent number: 11897087Abstract: A polishing apparatus is provided. Another aspect pertains to a self-leveling polishing apparatus for smoothing diamonds. Yet another aspect of the present system uses a ball and swivel joint in a diamond polishing machine. A further aspect employs a polishing apparatus including a diamond-holder, an elongated arm using gravity to apply downward polishing pressure of the diamond workpiece against a polishing wheel, and a sweeping transmission to cause the holder to radially move across the rotating polishing wheel.Type: GrantFiled: March 9, 2022Date of Patent: February 13, 2024Assignees: Board of Trustees of Michigan State University, Fraunhofer USAInventors: Aaron Hardy, Timothy A. Grotjohn, Edward K. Drown, Michael Becker
-
Patent number: 11896407Abstract: Techniques measuring post contrast phase include collecting 3D medical imagery of a subject after injection with a contrast agent. A first set of slices is obtained in which each includes a first anatomical feature selected from a portal vein, aorta, inferior vena cava, liver, spleen or renal cortex. A second set of slices is obtained in which each includes a different second anatomical feature. A first image region is obtained from the first set and a different second image region from the second set. A trained convolutional neural network is configured to input the first image region to a first plurality of convolutional hidden layers and the second image region to a second plurality of convolutional hidden layers and output from both to a fully connected hidden layer that outputs a post contrast phase. Output data is presented based on the post contrast phase.Type: GrantFiled: May 21, 2021Date of Patent: February 13, 2024Assignee: The Trustees of Columbia University in the City of New YorkInventors: Jingchen Ma, Laurent Dercle, Binsheng Zhao, Lin Lu, Lawrence H. Schwartz
-
Patent number: 11896614Abstract: The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), compositions and reaction mixtures comprising the same, and methods of treatment using the same.Type: GrantFiled: April 15, 2016Date of Patent: February 13, 2024Assignees: Novartis AG, The Trustees of the University of PennsylvaniaInventors: David M. Barrett, Felipe Bedoya, Saba Ghassemi, Carl H. June, Bruce L. Levine, Jan J. Melenhorst, Michael C. Milone, Daniel J. Powell, Jr., Nathan Amar Singh, Zoe Zheng
-
Patent number: 11902320Abstract: Systems and methods are provided to implement a moving target defense for a server computer. The server computer can be provided both a permanent IP address and a temporary IP address. The temporary IP address can be used when communicating with client computers connected to the server computer. The temporary IP address can be dynamically changed at a predetermined interval that can be varied based on conditions at the server computer. An intrusion detection system can be used with the moving target defense systems and methods to identify attacks on the server computer based on the temporary IP address(es) provided by the server computer. When an attack is identified, the corresponding client computer is determined based on the temporary IP address and the client computer is placed on a blacklist that is not provided with new temporary IP addresses when the server computer changes temporary IP address.Type: GrantFiled: June 10, 2021Date of Patent: February 13, 2024Assignee: Board of Trustees of the University of Alabama, for and on behalf of the University of Alabama in HuntsvilleInventor: Vahid Heydari
-
Patent number: 11896937Abstract: Disclosed is a method of preparing a filtration membrane. The method includes providing a copolymer solution by dissolving a statistical copolymer in a mixture of a co-solvent and a first organic solvent, coating the copolymer solution onto a porous support layer to form a polymeric layer thereon, coagulating the polymeric layer on top of the support layer to form a thin film composite membrane, and immersing the thin film composite membrane into a water bath to obtain a filtration membrane. Also disclosed are a filtration membrane prepared by the method, and a process of filtering a liquid using the filtration membrane thus prepared.Type: GrantFiled: October 20, 2017Date of Patent: February 13, 2024Assignee: Trustees of Tufts CollegeInventors: Prity Bengani-Lutz, Ayse Asatekin Alexiou
-
Publication number: 20240041349Abstract: A quantitative gait training and/or analysis system employs instrumented footwear and an independent processing module. The instrumented footwear may have sensors that permit the extraction of gait kinematics in real time and provide feedback from it. Embodiments employing calibration-based estimation of kinematic gait parameters are described. An artificial neural network identifies gait stance phases in real-time.Type: ApplicationFiled: October 12, 2023Publication date: February 8, 2024Applicant: The Trustees of Columbia University in the City of New YorkInventors: Sunil K. AGRAWAL, Jesus Antonio PRADO DE LA MORA
-
Publication number: 20240046612Abstract: A method comprising: obtaining a plurality of data sets, each of the plurality of data sets being generated, at least in part, by using by a different one of a plurality of sensors, each of a plurality of sensors including a wearable sensor that is worn by a user or a sensor that is positioned at a same location as the user; combining the plurality of data sets to produce a fused data set; processing the fused data set to identify at least one of a performance of the user in completing a task, a cognitive load of the user, and/or one or more objects that are positioned at the same location as the user; and outputting an indication of a state of the user based on an outcome of the processing.Type: ApplicationFiled: December 17, 2021Publication date: February 8, 2024Applicants: Trustees of Tufts College, Research Foundation of the City University of New YorkInventors: Karen A. Panetta, Sos S. Agaian, Aruna Ramesh, Shishir Paramathma Rao, Shreyas Kamath Kalasa Mohandas, Srijith Rajeev, Rahul Rajendran
