Patents Assigned to Trustee
  • Systems and Methods for Detection of Musculoskeletal Anomalies
    Publication number: 20240023809
    Abstract: Systems and methods for the detection of musculoskeletal anomalies are disclosed. Various embodiments are directed to methods to detect and treat anomalies, including fracture (e.g. clavicle), deformity (e.g. scoliosis), and other anomalies. Various embodiments utilize structured white light scanners, while additional embodiments utilize LiDAR to generate 3-dimensional (3D) topographic scans. Various embodiments obtain these scans via a mobile device, such as a mobile phone or tablet. Further embodiments utilize machine learning models to analyze the 3D scans to identify an anomaly and/or a treatment for such anomaly and/or monitor change of that condition over time.
    Type: Application
    Filed: February 1, 2021
    Publication date: January 25, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Malcolm R. DeBaun, Michael J. Gardner
  • METHOD FOR DETECTION AND QUANTITATIVE MONITORING OF INFECTIONS WITH HERPESVIRUSES
    Publication number: 20240027453
    Abstract: Described are systems and assays that monitor presence and/or quantity of herpesviruses viral proteins. Embodiments offer accurate detection and quantification of viral proteins from all temporal classes of viral replication. Three exemplary assays provide specific detection of: herpes simplex vims type 1 (HSV1), human cytomegalovirus (HCMV), and Kaposi's sarcoma-associated herpesvirus (KSHV). These assays can be utilized in combination with drug treatments, genetic modifications, or other perturbations to assess the impact of the intervention on viral protein production.
    Type: Application
    Filed: July 28, 2021
    Publication date: January 25, 2024
    Applicant: The Trustees of Princeton University
    Inventors: Ileana M. Cristea, Joel Federspiel, Michelle A. Kennedy
  • SYSTEM AND METHOD TO MAINTAIN HEALTH USING PERSONAL DIGITAL PHENOTYPES
    Publication number: 20240023888
    Abstract: A system and method for identifying and treating a disease in a patient collects one or more data streams from sensors configured to detect biological signals generated within a patient's tissue over time. Patient data elements including one or more of demographic, clinical, laboratory, pathology, chemical, image, historical, genetic, and activity data for the patient is collected and processed with the data streams to generate a personalized digital phenotype (PDP). The PDP is compared to a digital taxonomy comprising prior data to classify the patient into one or more quantitative disease classifications to guide personalized intervention for treating the patient.
    Type: Application
    Filed: August 17, 2023
    Publication date: January 25, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Sanjiv M. NARAYAN, Mahmood ALHUSSEINI
  • HIGH THROUGHPUT SCREENING SYSTEM FOR ENGINEERED CARDIAC TISSUES
    Publication number: 20240027655
    Abstract: An exemplary imaging system is provided. The imaging system includes a light source configured to illuminate a plurality of spatially separated regions of a material structure producing a first illumination. A lens produces an image of the spatially separated regions. A lens array magnifies the spatially separated regions of the image. The lens array produces a mosaic image comprised of magnified subimages of each region spatially separated region. A camera sensor to record the image.
    Type: Application
    Filed: July 18, 2023
    Publication date: January 25, 2024
    Applicants: Trustees of Boston University, Massachusetts Institute of Technology
    Inventors: Thomas Bifano, Jerome Mertz, Marshall Ma, Devin Beaulieu
  • Systems and Methods of Flexible Electrochemical Stripping to Recover Alkaline Ammonia and Acidic Ammonium from Wastewaters
    Publication number: 20240025776
    Abstract: Most nitrogen recovery techniques recover acidic ammonium fertilizers, and few enable alkaline ammonia recovery. Many embodiments provide multi-chamber electrochemical stripping reactors to recover alkaline ammonia and acidic ammonium from wastewater. The reactor combines electrodialysis and membrane stripping. The acidic and alkaline product portfolio for wastewater-derived ammonia expand implementation opportunities for nitrogen recovery.
    Type: Application
    Filed: August 16, 2021
    Publication date: January 25, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: William A. Tarpeh, Anna Kogler, Brandon D. Clark, Matthew Junjie Liu, William Chow
  • METHOD OF SPONTANEOUSLY PATTERNING A POLYMER DURING FRONTAL POLYMERIZATION
    Publication number: 20240026068
    Abstract: A method of spontaneously patterning a polymer during frontal polymerization includes activating an initiation region of a monomer solution to reaction to initiate a polymerization reaction. A polymerization front is generated and propagates through the monomer solution in a radial or longitudinal direction away from the initiation region. The monomer solution is spontaneously heated downstream of the polymerization front by thermal transport away from the polymerization reaction. Once a localized region of the monomer solution reaches a temperature sufficient for spontaneous initiation of another polymerization reaction, a new polymerization front is generated and propagates through the monomer solution in a circumferential or transverse direction.
    Type: Application
    Filed: December 6, 2021
    Publication date: January 25, 2024
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: Jeffrey S. Moore, Philippe H. Geubelle, Nancy R. Sottos, Elizabeth C. Firestone, Evan M. Lloyd
  • NOVEL COMPOSITIONS WITH TISSUE-SPECIFIC TARGETING MOTIFS AND COMPOSITIONS CONTAINING SAME
    Publication number: 20240024507
    Abstract: Provided herein are compositions including targeting peptides linked thereto or inserted in a targeting protein of a recombinant vector having at least one exogenous peptide comprising an amino acid sequence of N-x-(T/I/V/A)-(K/R) (SEQ ID NO: 47). Compositions providing such conjugates, targeting peptides, or recombinant vectors having a mutant capsid or envelope protein are provided as are uses thereof.
    Type: Application
    Filed: December 1, 2021
    Publication date: January 25, 2024
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: James M. Wilson, Joshua Joyner Sims, Yuan Yuan
  • Methods and Systems for Analyzing Nucleic Acid Molecules
    Publication number: 20240026460
    Abstract: Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed.
    Type: Application
    Filed: February 10, 2023
    Publication date: January 25, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: David M. Kurtz, Maximilian Diehn, Arash Ash Alizadeh
  • Device and method to assess hand flexion tone
    Patent number: 11877849
    Abstract: Survivors of central nervous system injury commonly present with spastic hypertonia. The affected muscles are hyperexcitable and can display involuntary static muscle tone and an exaggerated stretch reflex. These symptoms affect posture and disrupt activities of daily living. Symptoms are typically measured using subjective manual tests such as the Modified Ashworth Scale; however, more quantitative measures are necessary to evaluate potential treatments. The hands are one of the most common targets for intervention, but few investigators attempt to quantify symptoms of spastic hypertonia affecting the fingers. An Isometric Force Pillow (IFP) is provided herein to quantify involuntary grip force. This lightweight, computerized tool provides a holistic measure of finger flexion force and can be used in various orientations for clinical testing and to measure the impact of assistive devices.
    Type: Grant
    Filed: March 4, 2021
    Date of Patent: January 23, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Caitlyn E. Seim, Allison M. Okamura
  • Systems and methods for thermal side-channel analysis and malware detection
    Patent number: 11880463
    Abstract: In some embodiments, the present disclosure provides systems and methods for detecting malware, including receiving thermal images of an integrated circuit, and generating a power density profile using at least one of the thermal images. The present disclosure further includes comparing the power density profile to an expected power density profile of the integrated circuit, and determining, based on the comparison, if the integrated circuit is in an abnormal operating state.
    Type: Grant
    Filed: October 7, 2019
    Date of Patent: January 23, 2024
    Assignees: Trustees of Tufts College, Drexel University
    Inventors: Mark Hempstead, David Werner, Eric Miller, Kyle Juretus, Ioannis Savadis
  • Method for inhibiting Zika virus infection
    Patent number: 11878004
    Abstract: The present invention concerns the use of compounds and compositions for the treatment or prevention of Flavivirus infections, such as dengue virus infections and Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as dengue virus and Zika virus infection, by administering a compound or composition of the invention, to a subject in need thereof; methods for inhibiting Flavivirus infections, such as dengue virus and Zika virus infections, in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits useful for treating or preventing Flavivirus infections, such as dengue virus and Zika virus infections.
    Type: Grant
    Filed: June 28, 2022
    Date of Patent: January 23, 2024
    Assignees: The United States of America, as Represented by the Secretary, Dept. of Health and Human Services, Florida Stte University Research Foundation, Inc., The Trustees of the University of Pensylvania
    Inventors: Hengli Tang, Emily M. Lee, Wei Zheng, Ruili Huang, Miao Xu, Wenwei Huang, Khalida Shamim, Guoli Ming, Hongjun Song
  • Gene therapy for ocular disorders
    Patent number: 11879133
    Abstract: Compositions and methods are provided for treating ocular neuropathy in a subject. In one aspect, a recombinant adeno-associated viral vector is provided which includes a nucleic acid molecule comprising a sequence encoding NRF2. In another aspect, a recombinant adeno-associated viral vector is provided which includes a nucleic acid molecule comprising a sequence encoding SIRT1. In desired embodiments, the subject is human, cat, dog, sheep, or non-human primate.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: January 23, 2024
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Jean Bennett, Junwei Sun, Kenneth Shindler, Devin McDougald, Ahmara Gibbons Ross
  • Microfabricated fractionator for particulate matter monitor
    Patent number: 11879819
    Abstract: Microfabricated particulate matter (PM) monitors and fractionators within the PM monitors are provided. A primary channel of a vertical or out-of-plane fractionator receives air samples, comprising particles of varying sizes, from the external environment. The air samples then pass through a plurality of microfluidic channels, wherein inertial forces are applied within the microfluidic channels to separate the particles by size. The fractionator comprises a horizontal air outlet for particles having a size below a threshold size and a vertical air outlet for particles having a size above a threshold size. Thus, the proportion of PM in the air sample is reduced prior to deposition on a PM monitor. A virtual cyclone may also be provided that comprises a bend positioned at a flow path through a primary channel of the vertical microfabricated fractionator.
    Type: Grant
    Filed: November 9, 2017
    Date of Patent: January 23, 2024
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Igor Paprotny, Dorsa Fahimi, Omid Mahdavipour
  • Cyclopropeneimines for capture and transfer of carbon dioxide
    Patent number: 11878269
    Abstract: A composition, process, and apparatus are disclosed. The composition includes a cyclopropeneimine-carbon dioxide (CPI-CO2) adduct. The process includes forming the CPI-CO2 adduct by reacting a CPI with CO2 gas. The apparatus includes components for providing the CPI and mixing the CPI with CO2 gas. The mixing results in formation of the CPI-CO2 adduct.
    Type: Grant
    Filed: March 17, 2022
    Date of Patent: January 23, 2024
    Assignees: International Business Machines Corporation, The Trustees of Columbia University in the City of New York
    Inventors: James L. Hedrick, Nathaniel H. Park, Luis M. Campos, Dino Wu, Daniel Malinowski
  • COMPOSITIONS AND METHODS FOR TREATING MOTOR NEURON DISEASES
    Publication number: 20240016889
    Abstract: The present disclosure provides compositions and methods of treating motor neuron diseases, including spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS). A modulator of a heat shock protein, such as an Hsp70 family member protein, may be used in the present method. Alternatively, a mutant heat shock protein may be used.
    Type: Application
    Filed: September 22, 2023
    Publication date: January 18, 2024
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Umrao MONANI, Jeong KI-KIM
  • KNOCK-IN OF LARGE DNA FOR LONG-TERM HIGH GENOMIC EXPRESSION
    Publication number: 20240018493
    Abstract: The present disclosure provides compositions, systems, and methods for genome editing, efficient knock-in of large DNA fragments, and long-term, stable, high expression of integrated transgenes. Also provided are modified cells, vaccines comprising modified cells, and methods of using such cells to induce an immune response.
    Type: Application
    Filed: November 10, 2021
    Publication date: January 18, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Michael G. CHAVEZ, Lei S. QI
  • BOND-SELECTIVE INTENSITY DIFFRACTION TOMOGRAPHY AND USES THEREOF
    Publication number: 20240019369
    Abstract: An example microscope includes a pump laser for providing a first illumination to a sample. A laser array provides a second illumination to the sample. The laser array may include a plurality of laser elements, each providing oblique illuminations to the sample. An illumination collecting source collects the first illumination and the second illumination from the sample. The illumination collecting source may capture transient 3D refractive index (RI) variations in the sample due to the first illumination and second illumination.
    Type: Application
    Filed: January 23, 2023
    Publication date: January 18, 2024
    Applicant: Trustees of Boston University
    Inventors: Ji-Xin Cheng, Jian Zhao, Lei Tian, Alex Matlock
  • Systems and Methods for Recognizing Human Actions from Privacy-Preserving Optics
    Publication number: 20240021018
    Abstract: Systems and methods of capturing privacy protected images and performing machine vision tasks are described. An embodiment includes a system that includes an optical component and an image processing application configured to capture distorted video using the optical component, where the optical component includes a set of optimal camera lens parameters ?*o learned using machine learning, performing a machine vision task on the distorted video, where the machine vision task includes a set of optimal action recognition parameters ?*c learned using the machine learning, and generating a classification based on the machine vision task, where the machine learning is jointly trained to optimize the optical element and the machine vision task.
    Type: Application
    Filed: July 13, 2023
    Publication date: January 18, 2024
    Applicants: The Board of Trustees of the Leland Stanford Junior University, Universidad Industrial de Santander
    Inventors: Juan Carlos Niebles, Carlos Hinojosa, Henry Arguello, Miguel Marquez, Ehsan Adeli-Mosabbeb, Fei-Fei Li
  • DEVICES AND METHODS FOR PUMPLESS BLOOD PRESSURE MEASUREMENT
    Publication number: 20240016398
    Abstract: Systems, devices, and methods for measuring blood pressure without the use of a pump are provided. A pumpless blood pressure measuring system or device can be wearable for long periods of time comfortably. The pumpless blood pressure measuring system or device can include a body, at least one tension band connected to the body, at least one pressure sensor configured to be in direct physical contact with the user's body, and a tourniquet mechanism. The tourniquet mechanism can be tightened to lead to artery occlusion such that the at least one pressure plate can determine the blood pressure of the user/wearer.
    Type: Application
    Filed: June 9, 2023
    Publication date: January 18, 2024
    Applicant: The Florida International University Board of Trustees
    Inventors: Jessica Claudia Ramella-Roman, Tananant Boonya-Ananta
  • Probiotic-Guided CAR-T Cells for Tumor Targeting
    Publication number: 20240016847
    Abstract: A system combining programmable bacteria cells that produce one or more antigens and optionally one or more cytokines and CAR-T cells that recognize and respond to at least one of the antigens to elicit an immune response against tumors and treat hyperproliferative disorders.
    Type: Application
    Filed: August 17, 2023
    Publication date: January 18, 2024
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Tal DANINO, Nicholas ARPAIA, Rosa VINCENT, Thomas SAVAGE, Jongwon IM, Candice GURBATRI