Patents Assigned to Trustee
  • Ultra-high specific energy cathode materials for lithium-ion batteries and methods for producing the same
    Patent number: 11888146
    Abstract: Cathode active materials for lithium-ion batteries comprise a hybrid nanocomposite of graphene and copper fluoride. Such cathode active materials are used, together with a polymeric binder material and optionally a conductive additive to form a cathode for a lithium-ion battery. Methods of producing hybrid nanocomposites of graphene and copper fluoride include hydrothermally reacting functionalized graphene, such as graphene oxide, and precursors of copper fluoride, such as aqueous fluorosilicic acid. Such hydrothermal reactions include sequential heating and freeze drying steps to produce a CuF2-graphene nanocomposite.
    Type: Grant
    Filed: November 5, 2021
    Date of Patent: January 30, 2024
    Assignee: The Trustees of Indiana University
    Inventor: Jian Xie
  • Method and systems for laser-based cooking
    Patent number: 11882859
    Abstract: An apparatus includes a first laser, a second laser, and a controller. The first and second lasers output different wavelengths of light. The controller controls the first and second lasers so as to cook food.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: January 30, 2024
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Jonathan Blutinger, Hod Lipson, Yorán Meijers
  • Neural stimulation in vitro and in vivo by photoacoustic nanotransducers
    Patent number: 11883344
    Abstract: An example photoacoustic system for neurostimulation includes a light producing device for producing light of a specific wavelength. At least one nanotransducer is binded on a surface of a neuron. The nanotransducer converts the light with the specific wavelength into at least one acoustic wave at or near the neuron.
    Type: Grant
    Filed: January 30, 2023
    Date of Patent: January 30, 2024
    Assignee: Trustees of Boston University
    Inventors: Chen Yang, Ji-Xin Cheng
  • Activation of innate immunity for enhanced nuclear reprogramming of somatic cells with mRNA
    Patent number: 11884937
    Abstract: The nuclear reprogramming of somatic cells with mRNA encoding reprogramming factors is shown to be greatly accelerated by activation of innate immune responses in the somatic cell. Methods of activating innate immunity include activation of PKR, of toll-like receptors, e.g. TLR3, etc. In some embodiments the mRNA provides the activator of innate immunity.
    Type: Grant
    Filed: August 5, 2020
    Date of Patent: January 30, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: John P. Cooke, Eduard Yakubov
  • Tactile blood pressure imager
    Patent number: 11883140
    Abstract: A method is directed to continuously, non-invasively, and directly measuring blood pressure, and includes providing a calibrated measurement device having a blood-flow control balloon and a sensor array. The method further includes placing the sensor array in a non-invasive manner over the surface of a patch of skin connected to an artery by adjoining soft tissues and inflating the blood-flow control balloon with a controlled amount of pressure. In response to the inflating of the blood-flow control balloon, changes in the artery geometry and forces are detected, via the sensor array, during a heartbeat cycle. The changes correspond to spatio-temporal signals from the artery or in the adjoining soft tissues. The spatio-temporal signals are measured and processed, via a controller, to determine blood-pressure parameters.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: January 30, 2024
    Assignees: Trustees of Tufts College, Massachusetts Institute of Technology
    Inventors: Mandayam A. Srinivasan, Mohan Thanikachalam, Edward Howard Adelson, Abhijit Biswas
  • Compositions comprising a lecithin cholesterol acyltransferase variant and uses thereof
    Patent number: 11883470
    Abstract: A synthetic or recombinant human lecithin cholesterol acyltransferase (LCAT) variant is provided which comprises an LCAT enzyme having a substitution at position 114 based on the residue numbering of wild-type (WT) human LCAT [SEQ ID NO:1], wherein said variant is characterized by one or more of: (i) an esterification rate higher than the esterification rate of WT human LCAT; and/or (ii) an association with higher density lipoprotein levels as compared to subjects having WT LCAT. Also provided are vectors encoding the variant, compositions containing same, and methods of using the variant proteins and vectors for treatment of a variety of disorders associated with defective wt LCAT.
    Type: Grant
    Filed: July 24, 2017
    Date of Patent: January 30, 2024
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Daniel Rader, Devin Christopher, Anna P. Tretiakova
  • PI-kinase inhibitors with anti-infective activity
    Patent number: 11884657
    Abstract: Compounds and methods are provided for the treatment of pathogen infections. In some embodiments, the anti-infective compounds have broad spectrum activity against a variety of infective diseases, where the diseases are caused by pathogens containing a basic amino acid PIP-2 pincer (BAAPP) domain that interacts with phosphatidylinositol 4,5-bisphosphate (PIP-2) to mediate pathogen replication. Also provided are methods of inhibiting a PI4-kinase and methods of inhibiting viral infection. In some embodiments, the compound is a PI4-kinase inhibiting compound that is a 5-aryl-thiazole or a 5-heteroaryl-thiazole. The subject compounds may be formulated or provided to a subject in combination with a second anti-infective agent, e.g. interferon, ribavirin, and the like.
    Type: Grant
    Filed: July 9, 2021
    Date of Patent: January 30, 2024
    Assignees: The Board of Trustees of the Leland Stanford Junior University, The Regents of the University of California
    Inventors: Jeffrey S. Glenn, Michael A. Gelman, Brandon Tavshanjian, Kevan Shokat, Ingrid Choong, Mark Smith
  • Compstatin analogs with increased solubility and improved pharmacokinetic properties
    Patent number: 11884747
    Abstract: Compounds comprising peptides capable of binding C3 protein and inhibiting complement activation are disclosed. The compounds comprise compstatin analogs in which the N-terminus and/or C-terminus contains an added component that improves (1) the peptide's solubility at physiological pH; (2) the peptide's plasma half-life; (3) the peptide's intraocular retention; and/or (4) the peptide's binding affinity to C3 or its fragments as compared to an unmodified compstatin peptide under equivalent conditions. Pharmaceutical compositions and methods of using the compounds are also disclosed.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: January 30, 2024
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: John D. Lambris
  • Object trajectory forecasting
    Patent number: 11887317
    Abstract: A plurality of agent locations can be determined at a plurality of time steps by inputting a plurality of images to a perception algorithm that inputs the plurality of images and outputs agent labels and the agent locations. A plurality of first uncertainties corresponding to the agent locations can be determined at the plurality of time steps by inputting the plurality of agent locations to a filter algorithm that inputs the agent locations and outputs the plurality of first uncertainties corresponding to the plurality of agent locations. A plurality of predicted agent trajectories and potential trajectories corresponding to the predicted agent trajectories can be determined by inputting the plurality of agent locations at the plurality of time steps and the first uncertainties corresponding to the agent locations at the plurality of time steps to a variational autoencoder.
    Type: Grant
    Filed: August 30, 2021
    Date of Patent: January 30, 2024
    Assignees: Ford Global Technologies, LLC, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Boris Ivanovic, Yifeng Lin, Shubham Shrivastava, Punarjay Chakravarty, Marco Pavone
  • Compositions and methods of phospholipase A2 receptor chimeric autoantibody receptor T cells
    Patent number: 11884716
    Abstract: The invention includes compositions comprising at least one chimeric autoantibody receptor (CAAR) specific for an anti-phospholipase A2 receptor (PLA2R) autoantibody-based B cell receptor, polynucleotides encoding the CAAR, vectors comprising a polynucleotide encoding the CAAR, and recombinant T cells comprising the CAAR. The invention also includes methods of making a genetically modified cell, e.g., a genetically modified T cell, expressing a PLA2R-CAAR wherein the expressed CAAR comprises a PLA2R extracellular domain.
    Type: Grant
    Filed: December 6, 2021
    Date of Patent: January 30, 2024
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Saar Gill, Jonathan Hogan, Aimee S. Payne, Baomei Wang
  • Systems and methods for reconstructing a scene in three dimensions from a two-dimensional image
    Patent number: 11887248
    Abstract: Systems and methods described herein relate to reconstructing a scene in three dimensions from a two-dimensional image. One embodiment processes an image using a detection transformer to detect an object in the scene and to generate a NOCS map of the object and a background depth map; uses MLPs to relate the object to a differentiable database of object priors (PriorDB); recovers, from the NOCS map, a partial 3D object shape; estimates an initial object pose; fits a PriorDB object prior to align in geometry and appearance with the partial 3D shape to produce a complete shape and refines the initial pose estimate; generates an editable and re-renderable 3D scene reconstruction based, at least in part, on the complete shape, the refined pose estimate, and the depth map; and controls the operation of a robot based, at least in part, on the editable and re-renderable 3D scene reconstruction.
    Type: Grant
    Filed: March 16, 2022
    Date of Patent: January 30, 2024
    Assignees: Toyota Research Institute, Inc., Massachusetts Institute of Technology, The Board of Trustees of the Leland Standford Junior Univeristy
    Inventors: Sergey Zakharov, Wadim Kehl, Vitor Guizilini, Adrien David Gaidon, Rares A. Ambrus, Dennis Park, Joshua Tenenbaum, Jiajun Wu, Fredo Durand, Vincent Sitzmann
  • Hierarchical photonic crystals and methods of making the same
    Patent number: 11885929
    Abstract: The present disclosure provides a composition comprising a hierarchical opal that exhibits structural color when exposed to incident electromagnetic radiation. The hierarchical opal comprises nanoscale periodic cavities separated by a lattice constant, and includes a surface having grooves. The grooves may form a diffractive optical element on the surface of the hierarchical opal, such as a diffuser, a diffraction grating, a beamsplitter, a beam displacement opic, a Fresnel lens, and a micro lens, among others.
    Type: Grant
    Filed: November 18, 2019
    Date of Patent: January 30, 2024
    Assignee: Trustees of Tufts College
    Inventor: Fiorenzo G. Omenetto
  • Extreme polyvalency induces potent cross-clade cellular and humoral responses in rabbits and non-human primates
    Patent number: 11883484
    Abstract: The present invention relates to compositions comprising two or more DNA plasmids encoding consensus and transmitted founder HIV envelope glycoproteins which expressed and induce a potent immune response.
    Type: Grant
    Filed: November 10, 2020
    Date of Patent: January 30, 2024
    Assignees: The Trustees of the University of Pennsylvania, The Wistar Institute of Anatomy and Biology
    Inventors: David Weiner, Megan Wise
  • Focal spot shape for computed tomography
    Patent number: 11883226
    Abstract: An x-ray apparatus includes an x-ray source capable of producing an x-ray beam with a focal spot having a spatial shape that is selected to pre-amplify predetermined spatial frequencies exceeding half a cutoff frequency as compared to spatial frequencies below half the cutoff frequency; an x-ray detector capable of detecting the x-ray beam; and a processor adapted to reconstruct an image from the detected x-ray beam using a filter that compensates the pre-amplified predetermined spatial frequencies. The spatial shape comprises two or more disconnected regions that preferably have widths less than that of a nominal focal spot, combined widths greater than or equal to that of a nominal focal spot, and are separated by less than three times a width of a nominal focal spot.
    Type: Grant
    Filed: October 12, 2021
    Date of Patent: January 30, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Norbert J. Pelc, Adam S. Wang
  • ACCELERATED MIXING AND REACTION KINETICS USING AN ELASTIC INSTABILITY
    Publication number: 20240024829
    Abstract: Disclosed are techniques to mimic turbulent-enhanced reactivity under confinement by the addition of dilute high molecular weight polymers. Micro-scale imaging within a transparent porous medium reveals an elastic instability (EI), which drives chaotic fluctuations that stretch and fold solute blobs exponentially in time analogous to turbulent Batchelor mixing, despite the low Re. A reduction in the required mixing length can be observed, suggesting a cooperation between the elastic instability and the dispersion inherent to the disordered 3D porous media—which can be modeled as additive independent mixing rates, representing a dramatic conceptual simplification. The disclosed enhanced transport of solutes circumvents the traditional trade-off between throughput and reactor length, allowing a simultaneous large reduction in length and increases in throughput.
    Type: Application
    Filed: July 12, 2023
    Publication date: January 25, 2024
    Applicant: The Trustees of Princeton University
    Inventors: Sujit Datta, Christopher Browne, Richard Huang, Callie Zheng
  • SYNTHETIC CELLULAR SIGNALING PATHWAYS AND USES THEREOF
    Publication number: 20240024505
    Abstract: The disclosure relates generally to methods and compositions for generation or enhancement of partial or complete cellular signaling pathways
    Type: Application
    Filed: July 12, 2023
    Publication date: January 25, 2024
    Applicant: Trustees of Boston University
    Inventors: Mark W. Grinstaff, Jack R. Kirsch, Amanda K. Williamson, Brett Tingley
  • Methods of Treatment and Devices for Repair of Inflammatory, Neurotransmitter, Endocrine or Metabolic Issues
    Publication number: 20240024664
    Abstract: Various methods and devices for treatment or assessment of structures or nerves accessible via the nasal cavity utilizing electrical stimulation or signal recording are provided. Devices can include one or more electrodes to provide electrical stimulation or signal recording. Electrodes can be disposed upon an inflatable balloon or a flat-surfaced tool or a precision tip.
    Type: Application
    Filed: September 10, 2021
    Publication date: January 25, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventor: Zara Marzban Patel
  • METABOLIC AUGMENTATION TO PROMOTE AND ENHANCE IMMUNE RESPONSE BY TCF1+ T CELL REPOPULATION
    Publication number: 20240027465
    Abstract: A method of treating a condition in a subject by improving the immune response of the subject comprising first determining the level of TCF1 in the subject to identify the subject as having an anti-PD-1 responder phenotype or an anti-PD-1 non-responder phenotype, then administering an anti-PD-1 treatment to a subject having an anti-PD-1 responder phenotype or a metabolic inhibitor prior to ant-PD-1 treatment to a subject having an anti-PD-1 non-responder phenotype.
    Type: Application
    Filed: September 23, 2021
    Publication date: January 25, 2024
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Steven L Reiner, Brian S Henick, Naiyer A Rizvi, Rohan Maniar
  • SPLIT PRIME EDITING PLATFORMS
    Publication number: 20240026381
    Abstract: The present disclosure provides prime editors, editor systems and methods of uses thereof. Specifically, the disclosure provides methods of use of split prime editors for editing genomic DNA.
    Type: Application
    Filed: November 3, 2021
    Publication date: January 25, 2024
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: Pablo Perez-Pinera, Wendy Woods, Jackson Winter, Michael Gapinske
  • GENE THERAPY FOR TREATING MUCOPOLYSACCHARIDOSIS TYPE I
    Publication number: 20240024510
    Abstract: A suspension useful for AAV9-mediated intrathecal/intracisternal and/or systemic delivery of an expression cassette containing a hIDUA gene is provided herein. Also provided are methods and kits containing these vectors and compositions useful for treating MPSI and the symptoms associated with Hurler, Hurler-Scheie and Scheie syndromes.
    Type: Application
    Filed: September 27, 2023
    Publication date: January 25, 2024
    Applicant: The Trustees of the University of Pennsylania
    Inventors: Christian Hinderer, James M. Wilson