Abstract: TSG101 is a tumor susceptibility gene whose homozygous functional knock out in fibroblasts leads to transformation and the ability of these cells to form metastatic tumors in nude mice. The cellular transformation that results from inactivation of TSG101 is reversible by restoration of TSG101 function. Decreased expression of TSG101 is associated with the occurrence of certain human cancers, including breast carcinomas. The TSG101 nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like.

Abstract: Low temperature wafer bonding (temperature of 450° C. or less) is employed to fabricate CMUTs on a wafer that already includes active electrical devices. The resulting structures are CMUT arrays integrated with active electronics by a low-temperature wafer bonding process. The use of a low-temperature process preserves the electronics during CMUT fabrication. With this approach, it is not necessary to make compromises in the CMUT or electronics designs, as is typical of the sacrificial release fabrication approach. Various disadvantages of sacrificial release, such as low process control, poor design flexibility, low reproducibility, and reduced performance are avoided with the present approach. With this approach, a CMUT array can be provided with per-cell electrodes connected to the substrate integrated circuitry. This enables complete flexibility in electronically assigning the CMUT cells to CMUT array elements.

Abstract: Apparatus, systems, and methods can operate to provide efficient data clustering, data classification, and data compression. A method comprises training set of training instances can be processed to select a subset of size-1 patterns, initialize a weight of each size-1 pattern, include the size-1 patterns in classes in a model associated with the training set, and then include a set of top-k size-2 patterns in a way that provides an effective balance between local, class, and global significance patterns. A method comprises processing a dataset to compute an overall significance value of each size-2 pattern in each instance in the dataset, sort the size-2 patterns, and select the top-k size-2 patterns to be represented in clusters, which can be refined into a clustered hierarchy. A method comprises creating an uncompressed bitmap, reordering the bitmap, and compressing the bitmap. Additional apparatus, systems, and methods are disclosed.

Abstract: In accordance with some embodiments of the disclosed subject matter, systems, methods, and media for protecting a digital data processing device from attack are provided. For example, in some embodiments, a method for protecting a digital data processing device from attack is provided, that includes, within a virtual environment: receiving at least one attachment to an electronic mail; and executing the at least one attachment; and based on the execution of the at least one attachment, determining whether anomalous behavior occurs.

Abstract: Systems, methods, and media for generating sanitized data, sanitizing anomaly detection models, and generating anomaly detection models are provided. In some embodiments, methods for generating sanitized data are provided. The methods including: dividing a first training dataset comprised of a plurality of training data items into a plurality of data subsets each including at least one training data item of the plurality of training data items of the first training dataset; based on the plurality of data subsets, generating a plurality of distinct anomaly detection micro-models; testing at least one data item of the plurality of data items of a second training dataset of training data items against each of the plurality of micro-models to produce a score for the at least one tested data item; and generating at least one output dataset based on the score for the at least one tested data item.

Abstract: A device for measuring light scattering and absorption properties of a tissue, the device comprising: a probe comprising first and second optical fibers for irradiation and detection. The optical fibers are substantially parallel to each other at the distal end, and are separated by a distance of less than 2 mm, wherein said first and second optical fibers are arranged in said probe at an angle, 6=10 deg. to 45 deg., to the plane perpendicular to the distal end of said probe and wherein the tips of the optical fibers at the distal end are polished parallel to the plane perpendicular to the distal end of said probe.

Abstract: The present invention provides a new strategies for the synthesis of compounds of the rocaglamide family and related natural products. The synthetic approach generally involves photochemical generation of an oxidopyrylium species from a 3-hydroxychromone derivative followed by an enantioselective 1,3-dipolar cycloaddition of the oxidopyrylium species to a dipolarophile in the presence of a TADDOL derivative. This approach can be used for the formation of adducts containing an aglain core structure. Methods of the conversion of aglain core structures to aglain, rocaglamide and forbaglin ring systems are also provided. The present invention also relates to the use of rocaglamide/aglain/forbaglin derivatives for the manufacture of medicaments for use in the treatment of cancer or cancerous conditions, disorders associated with cellular hyperproliferation, or NF-?B-dependent conditions.

Abstract: Knee prostheses featuring components that more faithfully replicate the structure and function of the human knee joint in order to provide, among other benefits: greater flexion of the knee in a more natural way by promoting or at least accommodating internal tibial rotation in a controlled way, replication of the natural screw home mechanism, and controlled articulation of the tibia and femur respective to each other in a more natural way. In a preferred embodiment, such prostheses include an insert component disposed between a femoral component and a tibial component, the insert component preferably featuring among other things a reversely contoured posterolateral bearing surface that helps impart internal rotation to the tibia as the knee flexes.

Abstract: A method is disclosed for recognition of high-dimensional data in the presence of occlusion, including: receiving a target data that includes an occlusion and is of an unknown class, wherein the target data includes a known object; sampling a plurality of training data files comprising a plurality of distinct classes of the same object as that of the target data; and identifying the class of the target data through linear superposition of the sampled training data files using l1 minimization, wherein a linear superposition with a sparsest number of coefficients is used to identify the class of the target data.

Abstract: An icemaker and a refrigerator having an icemaker are discussed. The icemaker has pulse-electrothermal ice release and includes an ice-making tray having several ice forming portions in which water is stored and ice is formed; and a housing surrounding the ice-making tray provided with at least one cold air inlet and/or ice ejection port through which cold air is supplied and ice released along a bent channel. The cold air inlet and/or ice ejection ports are baffled to prevent contact with a user's fingers and thereby reduce the possibility of electric shock.

Abstract: A method and apparatus models one or more electromagnetic field modes of a waveguide. The method includes calculating a first matrix having a plurality of elements and having a first bandwidth using a refractive index profile of the waveguide. The plurality of elements of the first matrix represents an action of Maxwell's equations on a transverse magnetic field within the waveguide. The method further includes rearranging the plurality of elements of the first matrix to form a second matrix having a second bandwidth smaller than the first bandwidth. The method further includes shifting the second matrix and inverting the shifted second matrix to form a third matrix. The method further includes calculating one or more eigenvalues or eigenvectors of the third matrix corresponding to one or more modes of the waveguide.

Abstract: Double modulation of a magnetoresistive sensor entails modulating both an excitation (e.g., voltage or current) applied to the sensor and a tickling magnetic field applied to the sensor. The excitation and magnetic field are modulated at different frequencies fc and ff, respectively. As a result of the double modulation, the sensor output spectrum includes a carrier tone (CT) at frequency fc and side tones (STs) at frequencies fc±ff. A baseline relation between CT amplitude and ST amplitude is determined (e.g., by measuring CT and ST amplitude while drift occurs in the absence of a sample). During sensor operation, raw ST measurements are corrected using corresponding raw CT measurements to provide corrected ST measurements as the sensor output.

Abstract: The present invention relates to methods and compositions for testing individuals to determine whether they are at increased risk of developing anti-resorptive therapy-associated osteonecrosis of the jaw.

Abstract: A method of making capsules includes forming a mixture including a core liquid, a polyurethane precursor system, a first component of a two-component poly(urea-formaldehyde) precursor system, and a solvent. The method further includes emulsifying the mixture, adding a second component of the two-component poly(urea-formaldehyde) precursor system to the emulsified mixture, and maintaining the emulsified mixture at a temperature and for a time sufficient to form a plurality of capsules that encapsulate at least a portion of the core liquid. The capsules made by the method may include a polymerizer in the capsules, where the capsules have an inner capsule wall including a polyurethane, and an outer capsule wall including a poly(urea-formaldehyde). The capsules may include in the solid polymer matrix of a composite material.

Abstract: A method for forming decorative grass and packaging materials from renewable and/or biodegradable polymer materials is provided. Methods of utilizing the renewable and/or biodegradable decorative grasses and packaging materials are also provided.

Abstract: A wheat variety designated MSU Line E0028, the plants and seeds of MSU Line E0028, methods for producing a wheat plant produced by crossing the variety E0028 with another wheat plant, and hybrid wheat seeds and plants produced by crossing the variety E0028 with another wheat line or plant, and the creation of variants by mutagenesis or transformation of variety E0028. The present technology also relates to methods for producing other wheat varieties or breeding lines derived from MSU Line E0028 and to wheat varieties or breeding lines produced by those methods.

Abstract: Described herein are methods for implementing a calendaring system for managing flexible events. In an embodiment of the present invention, a method is disclosed where an individual's currently calendared events are considered when scheduling a new flexible event. For example, given an individual's many previously scheduled events, a method of the present invention considers the flexibility of the new event to be scheduled to find its appropriate time slots. From the appropriate time slots, the flexible event is then scheduled. In this way, the flexible event need not be scheduled at only one time but can be scheduled as its specified attributes allow. Moreover, as further events are entered the new or pre-existing events with flexible attributes can be re-scheduled toward resolving conflicts.

Abstract: The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human cancer. A variety of chromosomal regions (MCRs) and markers corresponding thereto, are provided, wherein alterations in the copy number of one or more of the MCRs and/or alterations in the amount, structure, and/or activity of one or more of the markers is correlated with the presence of cancer.

Abstract: In an embodiment of the present invention, three novel human reference genome sequences were developed based on the most common population-specific DNA sequence (“major allele”). Methods were developed for their integration into interpretation pipelines for highthroughput whole genome sequencing.

Abstract: Methods are disclosed for assessing the condition of a cartilage in a joint, particularly in a human knee. The methods include converting an image such as an MRI to a three dimensional map of the cartilage. The cartilage map can be correlated to a movement pattern of the joint to assess the effect of movement on cartilage wear. Changes in the thickness of cartilage over time can be determined so that therapies can be provided. Information on thickness of cartilage and curvature of cartilage or subchondral bone can be used to plan therapy. Information on movement pattern can be used to plan therapy. Planning therapy may include generating one or more physical models.