Abstract: Systems, methods, and media for outputting a dataset based upon anomaly detection are provided. In some embodiments, methods for outputting a dataset based upon anomaly detection: receive a training dataset having a plurality of n-grams, which plurality includes a first plurality of distinct training n-grams each being a first size; compute a first plurality of appearance frequencies, each for a corresponding one of the first plurality of distinct training n-grams; receive an input dataset including first input n-grams each being the first size; define a first window in the input dataset; identify as being first matching n-grams, the first input n-grams in the first window that correspond to the first plurality of distinct training n-grams; compute a first anomaly detection score for the input dataset using the first matching n-grams and the first plurality of appearance frequencies; and output the input dataset based on the first anomaly detection score.

Abstract: Systems and methods determining amplitude and phase versus frequency of an incoming beam of pulsed laser light. The incoming beam is split into two beams of substantially equal intensity, one of which is delayed for a delay period t. The two split beams are recombined to shine onto a thick SHG crystal at rotation angle ? and light emitted from the thick SHG crystal is detected as data and stored with reference to the delay period t and the angle ?. The thick SHG crystal is rotated by an angle ??, and light is detected as data and stored until the thick SHG crystal has completed 360° of rotation. This is repeated for ?t increases in the delay period until a selected beam delay period range has been completed. The stored data is processed to determine amplitude and phase versus frequency of the incoming beam of pulsed laser light.

Abstract: This invention is directed to mutated Activin A type I receptor proteins (ACVR1) and isolated nucleic acids encoding same. The invention also relates to compositions and methods for siRNA-based regulation of mutated ACVR1 expression in the treatment of Fibrodysplasia Ossificans Progressiva (FOP).

Abstract: The present invention relates to the discovery that two pore K+ channel (2PK) gene expression is increased in tumors and tumor cell lines, especially prostate tumor cells. The present invention encompasses methods for disease diagnosis, drug screening and the treatment of cancer.

Abstract: The present invention comprises peptide compositions and methods for specifically inhibiting signaling through G? subunits.

Abstract: The methods and compositions described herein are based, in part, on the discovery of a polypeptide of soluble CD23 (sCD23) that binds and sequesters IgE. Thus, the sCD23 peptides, polypeptides and derivatives described herein are useful for treating conditions or disorders involving increased IgE levels such as e.g., allergy, anaphylaxis, inflammation, lymphoma, and certain cancers.

Abstract: The present invention is a nanotechnology-based personal sensor device composed of molecularly imprinted polymers that are interrogated using radio frequency identification (RFID) technology for use in simultaneously monitoring airborne contaminants, e.g., of second-hand cigarette smoke.

Abstract: Injectable or implantable drug delivery systems providing on-demand ultrasound-triggered drug release and methods for controlling the release of drug in a patient are provided herein. The on-demand drug delivery systems contain a drug depot and a drug encapsulated in an encapsulating material, where the encapsulating material is different from the depot. In the preferred embodiment, the depot also contains microbubbles that encapsulate one or more gases. The microbubbles enhance the drug release when ultrasound is applied compared to the same system in the absence of microbubbles. In a preferred embodiment, the drug delivery system, contains an encapsulating material, preferably liposomes, a drug to be delivered, microbubbles, and at least two hydrogel-forming precursor components. Following injection or implantation, the patient can control the time, location and dosage released by administering ultrasound.

Abstract: The present invention relates to biomarkers which constitute a metastasis associated fibroblast (“MAF”) signature and their use in diagnosing and staging a variety of cancers. It is based, at least in part, on the discovery that identifying the differential expression of certain genes indicates a diagnosis and/or stage of a variety of cancers with a high degree of specificity. In particular, the presence of the signature implies that the cancer has already become invasive. Accordingly, in various embodiments, the present invention provides for methods of diagnosis, diagnostic kits, as well as methods of treatment that include an assessment of biomarker status in a subject. Further, because the differential expression of certain genes can function as marker for the acquisition of metastatic potential, such expression profiles can be used to predict the appropriateness of certain therapeutic interventions, such as the appropriateness of neoadjuvant therapies.

Abstract: Provided are methods of diagnosis, prognosis, and monitoring of aging using biomarkers that have been discovered to be linked to biological aging process. Methods for increasing neural cell regeneration and cognitive function are also provided. The methods are, at least in part, based on a discovery that altered expression patterns of certain biological markers are associated with biological aging processes. These markers comprise at least Eotaxin/CCL11, 2-microglobulin, MCP-1 and Hap-toglobulin, increased expression of which has been shown to be associated with increase in biological aging process.

Abstract: Compositions and methods of using compositions that induce UBE1L or a ubiquitin-like protein ISG15, or inhibit a deconjugase UBP43 to degrade oncogenic proteins and enhance apoptosis of cancer (neoplastic) or pre-cancerous (pre-neoplastic) cells are provided. Methods for the prevention or treatment of cancer via administration of these compositions are also provided.

Abstract: This invention relates to a detection system for particles suspended in a gas. The detection system includes an electrostatic precipitator constructed to collect the particles from the gas onto a collection surface using the force of an induced electrostatic charge on the particles. The detection system also includes an optical probe coupled with the electrostatic precipitator and constructed to probe the particles with a beam in order to detect the particles. The body of the electrostatic precipitator has a geometry that allows the beam to travel from the optical probe to the collection surface.

Abstract: The present invention relates to compositions comprising cupredoxins, and their use to inhibit angiogenesis in mammalian cells, tissues, and animals, and particularly the angiogenesis that accompanies tumor development and particularly in humans. Specifically, the present invention relates to compositions comprising the cupredoxin(s), and or peptides that are variants, derivatives or structural equivalents of cupredoxins, which retain the ability to inhibit angiogenesis in mammalian cells, tissues or animals. These compositions may be peptides or pharmaceutical compositions, among others. The compositions of the invention may be used to treat any pathological condition that has as a symptom or cause, inappropriate angiogenesis, and particularly inappropriate angiogenesis related to tumor development.

Abstract: A low cost and lightweight interchangeable lens system is provided. The lens system includes two aspheric elements that is usable both for page-based and bit-based data storage systems. The lens system has a large field of view up to ±50 degrees and a high numerical aperture up to 0.8. The invention reduces cost and weight of the objective lenses and is usable with the servoing technology. The invention provides a long working distance of 20% of the focal length and provides sufficient physical space to accommodate media and aberration corrections, which enable a media interchangeable and compatible system among the both optical recording formats.

Abstract: The invention relates to a method of making alkali metal silicide compositions, and the compositions resulting from the method, comprising mixing an alkali metal with silicon and heating the resulting mixture to a temperature below about 475° C. The resulting compositions do not react with dry O2. Also, the invention relates to sodium silicide compositions having a powder X-ray diffraction pattern comprising at least three peaks with 2Theta angles selected from about 18.2, 28.5, 29.5, 33.7, 41.2, 47.4, and 56.2 and a solid state 23Na MAS NMR spectra peak at about 18 ppm. Moreover, the invention relates to methods of removing a volatile or flammable substance in a controlled manner. Furthermore, the alkali metal silicide compositions of the invention react with water to produce hydrogen gas.

Abstract: The invention concerns a method for making an article having a tunable adhesive, said method comprising applying strain to mechanically deform a substrate in at least one direction; applying a rigid coating layer on the substrate; and releasing the strain to form an article having a rippled surface. Ripple characteristics can be altered by mechanical strain in real time which further changes the adhesion properties.

Abstract: An improved technique is provided for compressing a packet classifier for a computer network system. A set of packet classification rules is first partitioned into one or more partitions. For each partition, columns of bits in each of the ternary strings of a given partition are reordered, the ternary strings within each partition are consolidated into one or more replacement strings and then the columns of bits of the replacement strings are rearranged back to the starting order. The rearranged replacement strings from each of the partitions are appended together to form a compressed packet classifier which may be instantiated in a content-addressable memory device.

Abstract: A method of producing dried cellulose nanofibrils includes atomizing an aqueous suspension of cellulose nanofibrils and introducing the atomized aqueous suspension into a drying chamber of a drying apparatus. The aqueous suspension is then dried, thereby forming substantially non-agglomerated dried cellulose nanofibrils.

Abstract: A method detects a topology of a reflective surface. The method includes providing an optical fiber positioned such that light emitted from the optical fiber is reflected by at least a portion of the reflective surface. The optical fiber and the portion of the reflective surface form an optical resonator having an optical resonance with a resonance lineshape. The method further includes emitting light from the optical fiber while the optical fiber is at a plurality of positions along the reflective surface. The light emitted from the optical fiber irradiates a corresponding plurality of portions of the reflective surface. The method further includes measuring a change of the resonance lineshape due to the irradiation of the plurality of portions of the reflective surface.

Abstract: Compounds that are inhibitors of the unfolded protein response and endonuclease IRE1 are provided, together with compositions comprising such compounds, and methods for their use in the treatment of various disorders, such as cancer, autoimmune disorders, and diabetes. Also provided are packaged pharmaceuticals comprising these compositions. The compositions may be administered in combination with another therapeutic agent.