Patents Assigned to Trustee
  • ADENO-ASSOCIATED VIRUS SEROTYPE I NUCLEIC ACID SEQUENCES, VECTORS AND HOST CELLS CONTAINING SAME
    Publication number: 20130059289
    Abstract: The nucleic acid sequences of adeno-associated virus (AAV) serotype 1 are provided, as are vectors and host cells containing these sequences and functional fragments thereof. Also provided are methods of delivering genes via AAV-1 derived vectors.
    Type: Application
    Filed: March 16, 2011
    Publication date: March 7, 2013
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: JAMES M. WILSON, Weidong Xiao
  • FUSION PROTEINS FOR INHIBITION AND DISSOLUTION OF COAGULATION OF THROMBI
    Publication number: 20130058929
    Abstract: Fusion proteins containing a ligand which specifically binds to a selected vascular bed linked to an anti-thrombotic molecule are provided. Also provided are methods for use of these fusion proteins to prevent coagulation, to dissolve blood clots and to protect against the risk of iatrogenic side effects including those arising from cancer therapy and specific vascular occluding agents.
    Type: Application
    Filed: June 20, 2012
    Publication date: March 7, 2013
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: VLADIMIR R. MUZYKANTOV, Claudia Gottstein, Bi-Sen Ding, Douglas B. Cines
  • Relaxin analogs
    Patent number: 8389475
    Abstract: Human relaxin analogs, polypeptide compositions related thereto, as well as nucleotide compositions encoding the same, are provided.
    Type: Grant
    Filed: August 6, 2010
    Date of Patent: March 5, 2013
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jae-II Park, Sheau Yu Hsu
  • Inhibiting infections
    Patent number: 8389682
    Abstract: The invention relates to Staphylococcus epidermidis peptides, antibodies and nucleic acids that can inhibit Staphylococcus epidermidis infection of a mammalian subject and colonization of a medical device in the mammal.
    Type: Grant
    Filed: January 16, 2008
    Date of Patent: March 5, 2013
    Assignee: Trustees of Columbia University in the City of New York
    Inventors: Carlos Arrecubieta, Mei-Ho Lee, Franklin D. Lowy
  • Systems, methods and devices for adaptive steering control of automotive vehicles
    Patent number: 8392064
    Abstract: A variety of methods, systems, devices and arrangements are implemented for automated assistance for a driver. One such method relates to a synergistic combination of automation and human control for a motor vehicle traveling on a lane, thereby allowing human-based decisions to be supplement (or be supplemented by) automated decisions. Specific aspects facilitate maintenance of the vehicle on the lane. The vehicle is automatically steered towards a lateral offset within the vehicle lane. Steering input from the driver results in changes to this lateral offset. This modification of the lateral offset can be used to allow the driver to follow any trajectory parallel to the road, including trajectories where the vehicle is not centered within the lane.
    Type: Grant
    Filed: May 27, 2008
    Date of Patent: March 5, 2013
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Sebastian Thrun, Jesse S. Levinson
  • Vaccines for human papilloma virus and methods for using the same
    Patent number: 8389706
    Abstract: Improved anti-HPV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus HPV 18 E6 and E7. Pharmaceutical composition, recombinant vaccines comprising and live attenuated vaccines are disclosed as well methods of inducing an immune response in an individual against HPV are disclosed.
    Type: Grant
    Filed: January 21, 2010
    Date of Patent: March 5, 2013
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: David B Weiner, Jian Yan
  • Microcantilever with reduced second harmonic while in contact with a surface and nano scale infrared spectrometer
    Patent number: 8387443
    Abstract: Described herein are devices and methods for sensing pulsed forces. Some of the described devices and methods are also useful for measuring infrared absorbances and compiling spectral and chemical maps of surfaces. Also described are microcantilever having reduced harmonic frequencies when operating in contact mode. Some of the described microcantilevers comprise an internal resonator configured to vibrate substantially independent of friction between the microcantilever tip and a surface when the microcantilever operates in contact mode. A number of the described devices and methods are useful for monitoring pulsed forces with enhanced sensitivity.
    Type: Grant
    Filed: September 11, 2009
    Date of Patent: March 5, 2013
    Assignees: The Board of Trustees of The University of Illinois, Anasys Instruments
    Inventors: William P. King, Jonathan R. Felts, Craig Prater, Kevin Kjoller
  • Method forming a one-piece articulating spacing device for a knee joint
    Patent number: 8388881
    Abstract: The present invention provides molds and methods for producing articulating spacers that are custom-fit to the bone and can be used in two-stage revision knee arthroplasty and other orthopaedic surgery.
    Type: Grant
    Filed: May 17, 2010
    Date of Patent: March 5, 2013
    Assignees: The Board of Trustees of the Leland Stanford Junior University, The United States of America, as represented by the Department of Veterans Affairs
    Inventor: Nicholas John Giori
  • Controllable dexterous endoscopic device
    Patent number: 8388519
    Abstract: A selectively rigidizable endoscopic device is described. In one aspect, an endoscopic medical device is described that includes a flexible inner tube having a first lumen, a flexible outer tube that receives the inner tube, and a multiplicity of overlapping, rigidizable scale-like strips. Each scale-like strip is coupled with the inner tube and positioned between the inner and outer tubes. Of particular note, the overlapping strips are actuatable between a non-rigidized state in which overlapping strips are slideable relative to one another and a rigidized state in which overlapping strips are not slideable relative to one another.
    Type: Grant
    Filed: July 25, 2008
    Date of Patent: March 5, 2013
    Assignees: SRI International, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Pablo Garcia, Thomas Low, Bryan Chavez, Harsha Prahlad, Natalia Isaza, Sanjeev Dutta
  • Modulators of aldehyde dehydrogenase and methods of use thereof
    Patent number: 8389522
    Abstract: The present disclosure provides compounds that function as modulators of aldehyde dehydrogenase (ALDH) enzymatic activity, as well as compositions and formulations comprising the compounds. The present disclosure provides therapeutic methods involving administering a subject compound, or a subject pharmaceutical composition.
    Type: Grant
    Filed: October 19, 2009
    Date of Patent: March 5, 2013
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Daria Mochly-Rosen, Che-Hong Chen, Wenjin Yang
  • Composite thermal interface material including aligned nanofiber with low melting temperature binder
    Patent number: 8389119
    Abstract: A thermal interface material includes a mechanically compliant vertically aligned nanofiber film and a binder material for joining the nanofibers of the film to the surfaces of two substrates. Preferably, the binder material comprises a non-hydrocarbon-based material such as a metallic eutectic with a melting temperature below a nanofiber thermal damage threshold temperature of the film. The film is grown on a substrate which is then bonded to another substrate by the binder material in an adhesion process that may include pressure and heat. Alternatively, the film may be released from the substrate to produce a stand-alone thermal tape which may later be placed between two substrates and bonded.
    Type: Grant
    Filed: July 26, 2007
    Date of Patent: March 5, 2013
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Matthew Panzer, Kenneth E. Goodson, Xuejiao Hu, David Mann
  • Therapeutic system and method for altering the gait of a patient
    Patent number: 8387277
    Abstract: The therapeutic system of the preferred embodiments includes a foot platform having a lateral segment and a medial segment. The foot platform is coupled to the foot of the patient and supports the body force of the patient. The foot platform functions to move the foot from an equilibrium position to an activated position. The transition of the foot between equilibrium position and activated position, preferably occurs substantially instantaneously once the foot platform supports greater than substantially half of the body force.
    Type: Grant
    Filed: June 23, 2008
    Date of Patent: March 5, 2013
    Assignee: Board of Trustees of the Leland Stanford Junior University
    Inventors: Thomas Andriacchi, David Scott Fisher
  • Treatment devices and methods with extending elements
    Patent number: 8389791
    Abstract: Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.
    Type: Grant
    Filed: April 18, 2011
    Date of Patent: March 5, 2013
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Geoffrey C. Gurtner, Reinhold H. Dauskardt, Michael T. Longaker, Paul Yock
  • System and method of determining nitrogen levels from a digital image
    Patent number: 8391565
    Abstract: A system and method of determining nitrogen levels from a digital image. In particular, a method of determining leaf nitrogen concentration and yield from a digital photograph of a fully developed leaf (collared leaf) of a crop of nonlegumes, such as corn, rice, wheat, cotton, potatoes or sugarcane. The digital image is processed to determine a dark green color index (“DGCI”), which is closely related to leaf nitrogen concentration and yield. Standardized color disks having known DGCI values are included in the digital photograph and serve as an internal standard. The internal standard allows correction of DGCI of samples when using different cameras and/or when lighting conditions change.
    Type: Grant
    Filed: May 24, 2010
    Date of Patent: March 5, 2013
    Assignee: Board of Trustees of the University of Arkansas
    Inventors: Larry C Purcell, Robert L. Rorie, Douglas E Karcher
  • Assays, method and compositions that exploit a mycobacterial iron acquistion pathway in cells
    Patent number: 8389231
    Abstract: Assays for the identification of antibacterial agents that inhibit mycobacterial growth by interfering with the iron acquisition pathway in host cells are disclosed. Also disclosed are methods of inhibiting mycobacterial growth by interfering with iron uptake or by delivering antibacterial agents to mycobacteria in host cells through the iron uptake pathway, as well as certain compounds that are useful in the assay methods, and also as antibacterial agents.
    Type: Grant
    Filed: August 23, 2006
    Date of Patent: March 5, 2013
    Assignee: The Trustees of Princeton University
    Inventor: John T. Groves
  • Apparatus for managing a neurological disorder
    Patent number: 8391986
    Abstract: A system that incorporates teachings of the present disclosure may include, for example, a Neuro Sensing and Stimulation Device having a conductive lead for implanting in a brain of a living entity, a sensor coupled to the conductive lead for collecting data associated with one or more electrical signals detected in the conductive lead, a stimulator coupled to the conductive lead to apply one or more electrical signals thereto, and a controller. The controller can be operable to collect data associated with one or more electrical signals detected in the conductive lead, determine a stimulation sequence from the collected data, and direct the stimulator to apply on the conductive lead one or more electrical signals determined from the stimulation sequence. Additional embodiments are disclosed.
    Type: Grant
    Filed: May 12, 2009
    Date of Patent: March 5, 2013
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Daniel Graupe, Daniela Tuninetti, Ishita Basu
  • Method and device for online dynamic semantic video compression and video indexing
    Patent number: 8391355
    Abstract: A technique for semantic video compression is shown in block (120). Uncompressed video data (210), including a plurality of video data segments (S1, S2, . . . Sn), are organized into two or more buffer slots (220), such that each of the two or more buffer slots is filled with one or more of the received video data segments, thereby forming two or more buffered video portions corresponding to the two or more buffer slots. The buffered video data is then processed by a leaking rule, to extract one or more buffered video portions, while outputting one or more non-extracted buffered video portions, as compressed video data (230). The leaking rule data is stored in a histogram (240) and later used to organize and index data according to a users request.
    Type: Grant
    Filed: January 7, 2009
    Date of Patent: March 5, 2013
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Tiecheng Liu, John R. Kender
  • Method and system for distributed audio transcoding in peer-to-peer systems
    Patent number: 8392201
    Abstract: A method for streaming audio data in a network, the audio data having a sequence of samples, includes encoding the sequence of samples into a plurality of coded base bitstreams, generating a plurality of enhancement streams, and transmitting the coded base bitstreams and the enhancement bitstreams to a receiver for decoding. Each of the enhancement bitstreams is generated from one of a plurality of non-overlapping portions of the sequence of samples.
    Type: Grant
    Filed: July 30, 2010
    Date of Patent: March 5, 2013
    Assignees: Deutsche Telekom AG, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jeonghun Noh, Bernd Girod, Peter Pogrzeba, Sachin Kumar Agarwal, Jatinder Pal Singh, Kyu-Han Kim
  • Maintenance and propagation of mesenchymal stem cells
    Patent number: 8388947
    Abstract: Various embodiments of the present invention include compositions, materials and methods for maintaining and propagating mammalian mesenchymal stem cells in an undifferentiated state in the absence of feeder cells and applications of the same.
    Type: Grant
    Filed: November 16, 2011
    Date of Patent: March 5, 2013
    Assignees: The Board of Trustees of the University of Arkansas, The United States of America as Represented by the Department of Veterans Affairs
    Inventors: Xiao-Dong Chen, Robert L. Jilka
  • Immortalized mouse fibroblast cell lines deficient in Bax and/or Bak
    Patent number: 8389276
    Abstract: The present invention relates to a composition comprising an immortalized cell line which is deficient in the expression of one or more gene(s) of the intrinsic apoptotic pathway, selected from the group consisting of Bax, Bak, and mixtures thereof. The present invention further relates to the product of a process for producing an immortalized mouse fibroblast cell line which is deficient in the expression of Bax, Bak, and mixtures thereof. Finally, the present invention relates to a method and a kit for identifying a compound or composition which induces or blocks the extrinsic apoptotic pathway.
    Type: Grant
    Filed: November 12, 2002
    Date of Patent: March 5, 2013
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Wei-Xing Zong, Craig B. Thompson, Tullia Lindsten