Abstract: Monatomic metal anions are generated in the gas phase by collision-induced dissociation of the anions [26] of a dicarboxylic acid salt of the metal. This method is applicable to a number of metals, including sodium, potassium, cesium, and silver. The metal anions produced in this way can subsequently be stored in an ion trap [88] or transmitted as a focused beam [52]. The metal anions of this invention undergo collisional cooling and have low kinetic energy, which distinguishes them from ions produced by other high energy processes (with kinetic energy in excess of 1 keV). Metal anions so produced can be used to pattern nanoscale features on surfaces [56], used as electron transfer agents or reducing agents in ion-molecule reactions, or used for surface [122] modification of biomaterials [124].
Type:
Application
Filed:
March 23, 2011
Publication date:
February 28, 2013
Applicant:
The Trustees of the Stevens Institute of Technology
Inventors:
Athula Buddhagosha Attygalle, Carl S. Weisbecker
Abstract: Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HA hemagglutinin, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an immune response against one or more Influenza A serotpyes using the vaccines that are provided.
Type:
Application
Filed:
October 26, 2012
Publication date:
February 28, 2013
Applicant:
The Trustees of the University of Pennsylvania
Inventor:
The Trustees of the University of Pennsylvania
Abstract: Compounds having the structures below that are TPH1 inhibitors are provided: The compounds are useful of, e.g., to increase bone mass. In preferred embodiments, the patient is known to have, or to be at risk for, a low bone mass disease such as osteoporosis.
Type:
Application
Filed:
November 2, 2010
Publication date:
February 28, 2013
Applicant:
The Trustees of Columbia University in th City of
Abstract: Embodiments of the present disclosure, in one aspect, relate to a nanoparticle, methods of imaging a tumor, method of imaging a disease, method of treating a condition, disease, or related biological event, or the like.
Type:
Application
Filed:
August 24, 2012
Publication date:
February 28, 2013
Applicant:
The Board of Trustees of the Leland Stanford Junior University
Abstract: An electrolytic cell system to convert carbon dioxide to a hydrocarbon that includes a first electrode including a substrate having a metal porous dendritic structure applied thereon; a second electrode, and an electrical input adapted for coupling to a source of electricity, for applying a voltage across the first electrode and the second electrode.
Type:
Application
Filed:
October 24, 2012
Publication date:
February 28, 2013
Applicant:
The Trustees of Columbia University in the City of New York
Inventor:
The Trustees of Columbia University in the City of
Abstract: A system that incorporates teachings of the present disclosure may include, for example, a method for applying a force to at least one of an inner stream, an outer stream or both of a combined stream to produce a plurality of capsules, receiving image data, processing the image data, detecting undesirable capsules from the processed image data, applying a bias charge only to the detected undesirable capsules, and segregating the biased undesirable capsules from the unbiased desirable capsules. Additional embodiments are disclosed.
Type:
Application
Filed:
September 24, 2012
Publication date:
February 28, 2013
Applicant:
The Board of Trustees of the University of Illinois
Inventor:
The Board of Trustees of The University of IL
Abstract: Microfabricated microvalves may be used with liquid-filled control channels and actuated using compact and battery-powered components, without the need for heavier or fixed infrastructure. The disclosed embodiments include microvalves with on-off fluid control with relatively fast response times, coordinated switching of multiple valves, and operation of a biological (enzyme-substrate) assay in a handheld configuration.
Type:
Application
Filed:
January 28, 2011
Publication date:
February 28, 2013
Applicant:
The Trustee of Columbia University in the City of New York
Inventors:
Kweku Addae-Mensah, Yuk Kee Cheung, Samuel K. Sia
Abstract: A method of adaptively positioning a scanner [10] within a three-dimensional scene identifies an optimal next position for the scanner [40] based on analysis of a data point cloud that mimics the scanned portion of the scene. Occluded areas [38] are delineated from scan data and scans made at different locations in the scene are registered to a reference four-coordinate system. The fourth coordinate corresponds to the hue observed by the scanner at each data point.
Type:
Application
Filed:
April 8, 2011
Publication date:
February 28, 2013
Applicant:
The Trustees of the Stevens Institute of Technology
Inventors:
Kishore V. Pochiraju, Hao Men, Biruk Assefa Gebre
Abstract: The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified.
Type:
Grant
Filed:
August 9, 2011
Date of Patent:
February 26, 2013
Assignee:
Board of Trustees of the Leland Stanford Junior University
Inventors:
Thomas D. Willis, Paul Hardenbol, Maneesh Jain, Viktor Stolc, Mostafa Ronaghi, Ronald W. Davis
Abstract: A variety of methods, devices and storage mediums are implemented for creating digital representations of figures. According to one such computer implemented method, a volumetric representation of a figure is correlated with an image of the figure. Reference points are found that are common to each of two temporally distinct images of the figure, the reference points representing movement of the figure between the two images. A volumetric deformation is applied to the digital representation of the figure as a function of the reference points and the correlation of the volumetric representation of the figure. A fine deformation is applied as a function of the coarse/volumetric deformation. Responsive to the applied deformations, an updated digital representation of the figure is generated.
Type:
Grant
Filed:
December 24, 2008
Date of Patent:
February 26, 2013
Assignees:
The Board of Trustees of the Leland Stanford Junior University, Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Inventors:
Edilson De Aguiar, Carsten Stoll, Christian Theobalt, Hans-Peter Seidel, Sebastian Thrun
Abstract: An isolated cell from the cell line identified as TnT4. This cell may be infected with a baculovirus expression vector which may carry a heterologous nucleotide that encodes a polypeptide, such as a membrane protein, e.g., human neurotensin receptor 1. Also included is a method for using this cell line to produce a polypeptide, such as a membrane protein; and a method for identifying a cell-of-interest which expresses a protein-of-interest.
Type:
Grant
Filed:
April 14, 2009
Date of Patent:
February 26, 2013
Assignee:
Board of Trustees of Michigan State University
Abstract: The present invention relates to the use of proteins that are differentially expressed in tumor associated stromal cells, as compared to normal stromal, as biomolecular targets for tumor treatment therapies. The present invention also provides compounds and pharmaceutically acceptable compositions for administration in the methods of the invention.
Type:
Grant
Filed:
March 13, 2008
Date of Patent:
February 26, 2013
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Hanson Zhen, Julie Sneddon, Patrick O. Brown, Anthony Oro
Abstract: The present invention relates to isolated nicotinamide riboside kinase (Nrk) nucleic acid sequences, vectors and cultured cells containing the same, and Nrk polypeptides encoded thereby. Methods for identifying individuals or tumors susceptible to nicotinamide riboside-related prodrug treatment and methods for treating cancer by administering an Nrk nucleic acid sequence or polypeptide in combination with a nicotinamide riboside-related prodrug are also provided. The present invention further provides screening methods for isolating a nicotinamide riboside-related prodrug and identifying a natural source of nicotinamide riboside.
Abstract: An optical fiber includes a cladding, a first core, and a second core. At least one of the first core and the second core is hollow and is substantially surrounded by the cladding. At least a portion of the first core is generally parallel to and spaced from at least a portion of the second core. The optical fiber includes a defect substantially surrounded by the cladding, the defect increasing a coupling coefficient between the first core and the second core.
Type:
Grant
Filed:
December 7, 2011
Date of Patent:
February 26, 2013
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Vinayak Dangui, Michel J. F. Digonnet, Gordon S. Kino
Abstract: This invention provides compositions and methods of inhibiting, suppressing, or treating a tendinous or musculoskeletal soft tissue injury. The invention further provides a method of ameliorating symptoms associated with a tendinous or musculoskeletal soft tissue injury. Additionally, the invention provides methods for evaluating the risk of developing a tendinous or musculoskeletal soft tissue injury.
Type:
Grant
Filed:
January 26, 2009
Date of Patent:
February 26, 2013
Assignee:
The Trustees of the University of Pennsylvania
Abstract: A method, apparatus, article of manufacture, and a memory structure for brokering information between a plurality of clients using identifiers defining a plurality of data constructs is disclosed. An exemplary method comprises accepting a new data construct from an authoring entity, assigning a globally unique identifier to the new data construct, storing the new data construct and the assigned globally unique identifier in a database, and brokering between the authoring entity and a second entity commercially distinct from the authoring entity to provide the second entity access to the new data construct by reference to the assigned globally unique identifier of the new data construct or to provide the authoring entity access to an at least one of a plurality of pre-existing data constructs for use with the new data construct by reference to a globally unique identifier of the existing data construct.
Type:
Grant
Filed:
March 22, 2012
Date of Patent:
February 26, 2013
Assignee:
Herbert Stettin, as Chapter 11 Trustee for Rothstein Rosenfeldt Alder
Abstract: The present disclosure invention relates to medical devices treated with a solution comprising one or more solvents and a combination of chlorhexidine free base and a water-soluble chlorhexidine salt in a weight/weight ratio of between about 1:1 to about 1:5, preferably about 1:1.
Type:
Grant
Filed:
November 28, 2007
Date of Patent:
February 26, 2013
Assignee:
The Trustees of Columbia University in the City of New York
Abstract: A nanofibrillar structure for cell culture and tissue engineering is disclosed. The nanofibrillar structure can be used in a variety of applications including methods for proliferating and/or differentiating cells and manufacturing a tissue. Also disclosed is an improved nanofiber comprising a lipid, lipophilic molecule, or chemically modified surface. The nanofibers can be used in a variety of applications including the formation of nanofibrillar structures for cell culture and tissue engineering.
Type:
Grant
Filed:
April 26, 2010
Date of Patent:
February 26, 2013
Assignee:
Board of Trustees of Michigan State University
Abstract: Certain embodiments relate to and involve producing broadband phase-locked frequency combs in the near-infrared and mid-infrared spectral ranges. One such embodiment is directed to a system, with a pump laser and an optical parametric oscillator (OPO) resonator, that is configured to produce broad-bandwidth frequency combs in the near-infrared and mid-infrared frequency ranges. The pump laser is configured to produce femtosecond pulses of light having a pulse repetition rate. The optical parametric oscillator (OPO) resonator that is coupled to the pump laser for facilitating synchronous OPO pumping by matching a roundtrip time of the pulses of light within the OPO resonator with the pulse repetition rate of the pump laser.
Type:
Grant
Filed:
August 12, 2010
Date of Patent:
February 26, 2013
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Konstantin L. Vodopyanov, Samuel T. Wong, Robert L. Byer
Abstract: Highly sensitive Surface Enhanced Raman Spectroscopy (SERS) sensors are described in the form of a optical resonator and a metal nanostructure deposited on surface of the optical resonator. In one embodiment the optical resonator is in the form of a photonic crystal, but other optical resonators are contemplated. Examples are described in which the resonant near-fields of a large-area replica molded photonic crystal efficiently couples light from a laser to dielectric-metal “post-cap” nanostructures deposited on the photonic crystal surface by a glancing angle evaporation technique, achieving a high SERS enhancement factor. Other constructions are also contemplated a metal nanostructure formed on a dielectric support deposited on the photonic crystal, including a metallic film deposited over close-packed surface of nanospheres, arrays of metallic nanotriangles, metallic nanorods, metallic nanohelices, arrays of metallic nanospheres, and roughened metal surfaces.
Type:
Grant
Filed:
September 22, 2009
Date of Patent:
February 26, 2013
Assignee:
Board of Trustees of the University of Illinois