Abstract: A cassette sequence for the transformation of a host cell includes at least: a first nucleotide sequence encoding a peptide or protein of interest to be produced by the host cell. The first sequence is linked to a second nucleotide sequence providing resistance to a toxin or encoding an antitoxin peptide to the toxin. The nucleotide sequences are organized in such a way that production of the peptide encoded by the second nucleotide sequence(s) is translationally coupled to production of the peptide encoded by the first nucleotide sequence.

Abstract: The present invention relates to methods for determining the concentration of a free beta-lactam antibiotic in a biological sample. In particular, the present invention relates to methods for measuring a free beta-lactam antibiotic in a biological sample, comprising the steps of: (a) providing at least one class C beta-lactamase, a functional fragment or variant thereof; (b) providing at least one biological sample; (c) contacting said at least one class C beta-lactamase with said at least one biological sample; and (d) determining the concentration of said free beta-lactam antibiotic in said at least one biological sample.

Abstract: A composite material, notably for seasonal storage of energy in a domestic heating system, comprises grains having at least one of the following pairings of hygroscopic salt arranged within a porous material (table) with the hygroscopic metal concentration in the central zone of the grain being at least 0.7 times that in the peripheral zone.

Abstract: The present invention relates to a p53-activating agent capable of transferring wild-type tumor protein p53 (p53) from an inactive conformation into an active conformation capable of inducing apoptosis, for use in the treatment of melanoma, wherein said p53-activating agent is administered simultaneously or sequentially with a BRAF-inhibiting agent capable of inhibiting activity of serine/threonine-protein kinase B-Raf (BRAF) comprising an activating mutation.

Abstract: A guide is used for the selective catheterism of anatomic structures and for placing therapeutic instruments.

Abstract: Systems, methods and kits monitor suspended matter loads concentration in a liquid. The systems, methods and kits collect environmental variables, comprising the pressure p at a depth L in said liquid and the liquid depth L at which said pressure p is collected to provide the value of the pressure p0 which is the aerial pressure. The systems, methods and kits further insert said environmental variables in an equation and calculate the suspended matter loads volumetric concentration in the liquid from the absolute pressure p measured at the depth L in the liquid.

Abstract: The present invention is related to an holographic probe device for recording a gabor hologram comprising: a coherent optical fiber bundle comprising a distal end and a proximal end; a recording medium optically coupled to the proximal end of the coherent optical fiber bundle; a light source producing in use a single light beam, illuminating the distal end of the coherent optical fiber bundle and the object to be observed.

Abstract: The present invention relates to a system for computer-aided intravenous delivery of anesthetics and/or other drugs to a patient, wherein said system comprises an Infusion Controller that delivers an amount of drug(s) to a patient; possibly a DataLogger Controller with one or more Sensors adapted so as to be coupled to a patient and to generate signals reflecting one or more health conditions or statuses of the patient; a Communication Controller connected with the infusion pumps and/or monitors; a Session Controller that carries out the modeling of anesthesia procedures and is arranged to run a first procedure and to dynamically adapt said first procedure and/or select and run a second procedure based upon one or more of said sensors' output and/or observation from a physician; a Graphic User Interface to display different views of the system and to accept user input; a set of interfaces used to link the Infusion, Datalogger and Session Controllers to views displayed by the Graphical User Interface; a Proces

Abstract: The present invention is related to a method for characterizing transparent objects (2, 3) in a transparent medium (1), said transparent objects (2, 3) presenting an optical focal area (5, 6) said method comprising the steps of: illuminating a sample comprising the objects (2, 3) to be characterized by means of a directional light (7) source, thereby inducing light intensity peaks (5, 6) at the focal area of said transparent objects; determining at least one characteristic of the light intensity peak (5, 6) induced by said object to be characterized, determining from said light intensity peak (5, 6) at least one property of said object.

Abstract: The present application provides a pharmaceutical formulation comprising a folate receptor (FR)-targeting antineoplastic substance or composition, wherein the pharmaceutical formulation is configured for administration by inhalation, wherein the FR-targeting antineoplastic substance or composition is comprised in a nanoparticle and wherein the nanoparticles are comprised in microparticles, and its use in the treatment of a proliferative disease affecting at least part of the respiratory tract. The present application further provides a pharmaceutical formulation comprising an antineoplastic agent and a FR-targeting excipient, for use in the treatment of a proliferative disease affecting at least part of the respiratory tract.

Abstract: The present invention is related to integrated method and tools to construct recombinant DNA molecules (to be used as DNA vaccine or gene therapy) without requiring the use of antibiotic(s) resistance gene(s) and without requiring the addition of one or more antibiotic(s) to the culture medium of cells submitted to this recombinant DNA method. The present invention allows to obtain the selection of recombinant host cell(s) transformed by a (exogenous) nucleic acid sequence of interest (extra-chromosomal vector containing the insert) and simultaneously stabilization (stable inheritance) of this (exogenous) nucleic acid sequence of interest into the transformed host cell(s) descendants (maintenance of the nucleic acid sequence of interest in the host cells population).

Abstract: A method is provided of generating and distributing secret random data. The method requires a plurality of participating parties each to own an identical private-key generation device and to request a random signal over a shared publication communication network. At each iteration of the method, the parties process the public random signal with the internal states of their secret-key generation devices using two functions, the output of the first function being generated secret random data and the output of the second function being a new internal state.

Abstract: Device for the selective detection of benzene gas, which comprises, on a base substrate, a combination of at least one functionalized multi- or single-wall carbon nanotube sensor decorated with rhodium clusters, and at least one functionalized multi- or single-wall carbon nanotube sensor decorated with metal clusters selected from gold, palladium, nickel and titanium, and/or undecorated, where said substrate additionally comprises means for measuring the variation in the resistance of said sensors. The device is useful at ambient temperature in the presence or absence of oxygen and easy to handle. It also relates to a method for the manufacturing thereof and for detecting the gas in the chemical industry, the petrochemical industry, petrol stations, or household, aeronautical or research applications.

Abstract: Described are lyophilized compositions comprising cidofovir, hydroxypropyl methylcellulose (HPMC) or hydroxyethylcellulose (HEC) and, optionally, a plasticizer. In particular, described are such compositions that form a sheet-shaped porous solid matrix. Also described are methods for producing such compositions and their use in treating human papillomavirus (HPV) infections and HPV-associated malignancies, in particular, HPV lesions and cervical cancer.

Abstract: An Interferometer for off-axis digital holographic microscopy includes a recording plane, and a grating located in a plane optically conjugated with the recording plane. The grating defining a first and a second optical path, the optical path corresponding to different diffraction order.

Abstract: The invention is related to an apparatus and method for charged hadron therapy verification by detecting and/or quantifying prompt gammas produced when irradiating a target (6) with a charged hadron beam. The apparatus comprises a collimator (1) provided with a slit-shaped portion (2) configured to be arranged perpendicularly to the beam line and facing the target, a detection means (3,4) suitable for detecting said prompt gammas and a calculation and representation means. In the apparatus and method of the invention, the slit is configured to allow the passage of prompt gammas emitted from a range of depths in said target (6), said depths being measured in the direction of the charged hadron beam.

Abstract: Novel phenazine derivatives of formula (I) are disclosed. In particular, substituted 2,3-dihydro-1H-benzo[a]pyrano[2,3-c]phenazines are disclosed. The compounds can be used as anti-angiogenic and/or anti-tumor agents.

Abstract: A wild-type human Apolipoprotein L-I is used in a method for the prevention and/or the treatment of renal disease.

Abstract: The present invention provides a synthetic peptide molecule that specifically binds an FXYD2-gamma isoform of pancreatic beta cells, said synthetic peptide molecule has 25 amino acids.

Abstract: A quantum random number generation system includes a source of light output as a plurality of coherent states such that each state has an indeterminate number of photons, a photodetector arranged to receive the light output from the light source and to generate a photocurrent dependent on the number of photons in each coherent state, and processing circuitry connected to receive the photocurrent and arranged to convert it to generate a sequence of random numbers.