Abstract: A method for depositing a fluorinated layer on a substrate includes the injection of a gas mixture including a fluorinated compound and a carrier gas in a discharge or post-discharge area of a cold atmospheric plasma at a pressure comprised between 0.8 and 1.2 bars. The fluorinated compound has a boiling temperature at a pressure of 1 bar above 25° C.

Abstract: An isolated and purified polypeptide is obtained from tick salivary glands and presents more than 75% sequence identity with at least a sequence selected from the group consisting of SEQ. ID. NO. 1.

Abstract: A method for differentiating or promoting or inducing differentiation of stem cells into pluripotent cardiovascular progenitors (MCPs) by transiently inducing the expression of a single gene, namely Mesp1, is disclosed. Cells obtained by the method and their uses in research and clinical settings are also disclosed. Using genome wide transcriptional analysis, the inventors found that Mesp1 rapidly activates and represses a discrete set of genes, which form potential new targets for both therapy and for the identification of MCPs. Insights into the molecular mechanisms underlying the earliest step of cardiovascular specification and potential methods for dramatically increasing the number of cardiovascular cells for cellular therapy in humans are provided.

Abstract: A device for exercise rehabilitation and evaluation of a joint between bone elements of the hand, of the arm or of the leg of a user includes: a portable housing (1), and magnetically controllable resistance devices (10,11,13). A rotable output shaft (9) is directly connected to the controllable resistance devices. Controllers (18) control for controlling at least the supply of current to the controllable resistance devices. Tools (40, 41) mount on the output shaft (9) and are gripable by or attached to the user during the rotation of the output shaft (9). The tools (40, 41) are in direct connection with the rotable output shaft (9) extending out of the housing (1). Mechanical positioners (20, 21, 22) are adapted to user's morphology that enable positioning the joint at a pre-determined position (x,y,z) in a three dimensional reference system attached to the housing (1).

Abstract: A gene or protein set includes at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95 possibly 100, 105, 110 genes or proteins or the entire set or antibodies (or hypervariable portion thereof) directed against the proteins encoded by these genes.

Abstract: The present invention concerns methods for in vitro detection of an infection by Mycobacterium tuberculosis in mammals, and methods for in vitro distinction between mammals infected with Mycobacterium tuberculosis in which the disease is declared (active form) and mammals which are infected but asymptomatic for tuberculosis (latent form), and a method for in vitro distinction between mammals presenting an active form of tuberculosis and mammals not infected by M. tuberculosis or presenting a latent form of tuberculosis. The present invention also pertains to kits for detection and distinction between infected mammals presenting tuberculosis symptoms and infected mammals with no disease development, and a kit for distinguishing between mammals presenting an active form of tuberculosis and mammals not infected by M. tuberculosis or presenting a latent form of tuberculosis.

Abstract: The present invention is related to a deformable mirror comprising individual units (1), each unit including a continuous reflective substrate (2) having a front and back surface, on the back surface of the substrate: a continuous mass electrode (3) and a plurality of in-plane actuators (4) of electrostrictive or piezo-electric material, arranged between the mass electrode (3) and individual addressing electrodes (5).

Abstract: An energetic or nutritive composition includes at least one compound having laxative properties, mineral salts (or electrolytes) such as sodium, potassium, chlorine, calcium, magnesium, phosphor. The composition may also include carbohydrates that may be assimilated by the human digestive system such as glucose, galactose, fructose, maltose, saccharose, polysaccharides.

Abstract: The invention relates to in vitro methods for differentiating mammalian pluripotent stem cells into cells displaying a neuronal phenotype, more particularly into cortical-type neurons including inter alia pyramidal neurons and cortical inhibitory interneurons. The invention further encompasses so-obtained neuronal cells and cell population, compositions comprising such, and further uses of said neuronal cells and cell population.

Abstract: The invention relates to the use of sirtuin inhibitors for reducing TNF-alpha production by cells and organisms. The invention also concerns prophylactic and therapeutic applications of sirtuin inhibitors in TNF-alpha mediated pathologies, such as various inflammatory and autoimmune disorders.

Abstract: A method for evaluating the in vivo presence of a factor that prevents the biological effect of a type I (IFN) in an individual that is under treatment with type I interferon is described. The in vivo presence of antibodies directed against a type I interferon (IFN) is evaluated in an individual that is under treatment with type I interferon. The method includes incubating a blood sample of the individual in vitro with a suitable amount of the type I interferon for a suitable period of time, and determining mRNA levels of a biological marker of IFN activity, preferably M×A, in the blood sample. The treatment may involve a treatment of multiple sclerosis, HCV or HBV using a type I interferon.

Abstract: The present invention relates to an RNAi molecule suitable for reducing the expression of galectin-1 containing any of the sequences of SEQ ID NOs: 1-33, and preferably the sequences of SEQ ID NO: 2, 3, or 4, and to the use thereof as a medicament, or for the manufacture of a medicament for treating and/or for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma.

Abstract: The present invention relates to new compositions of (active) solid lipidic particles (SLP), e.g. for inhalation, and their use as carriers or as fillers in pharmaceutical compositions. It also relates new formulations obtained by mixing a SLP composition of the invention and a (micronized) active compound. It further relates to a method for fabricating said compositions of (active) solid lipidic particles.

Abstract: The present invention is related to a device, kit and method for pulsing a biological sample with a pulsing agent and subsequently stabilizing the biological sample so pulsed. The invention has application in the fields of medical diagnostics, particularly relating to immunity.

Abstract: The invention provides prophylactic and therapeutic applications of select aminoalkyl glucosamine phosphate (AGP) compounds in autoimmune diseases.

Abstract: Method of conditionally controlling the survivability of a recombinant cell population and of containing such cells to an environment or containing replicons to a host cell is based on the use of proteic killer systems including E. coli relBE locus and similar systems found in Gram-negative and Gram-positive bacteria and Archae. Such systems are generally based on a cytotoxin polypeptide and an antitoxin or antidote polypeptide that in contrast to the cytotoxin is degradable by proteases. The recombinant cells are useful as vaccines, pollutant degrading organisms or as biological pest control organism e.g. expressing B. thuringiensis crystalline proteins.

Abstract: Method of conditionally controlling the survivability of a recombinant cell population and of containing such cells to an environment or containing replicons to a host cell is based on the use of proteic killer systems including the E. coli relBE locus and similar systems found in Gram-negative and Gram-positive bacteria and Archae. Such system are generally based on a cytotoxin polypeptide and an antitoxin or antidote polypeptide that in contrast to the cytotoxin is degradable by proteases. The recombinant cells are useful as vaccines, pollutant degrading organisms or as biological pest control organisms e.g. expressing B. thuringiensis crystalline proteins.

Abstract: A surgical device (1) is disclosed for making a bore in a tissue or a joint. The device includes an external trephine (2) having an open distal end (6) provided with a cutting rim (9), an open proximal end (7) and a hollow tubular portion (8). An internal trephine (3) is disclosed which is adapted to be positioned and to slide inside the external trephine (2), which has an open distal end (10) which is provided with a cutting rim (13), an open proximal end (11), and a hollow tubular portion (12). A guiding rod (4) is adapted to be positioned and to slide inside the internal trephine (3). The surgical device may also include an awl (5) which slides inside the external trephine (2) and has a distal end (18) provided with a cutting blade (38), and a proximal end (19) provided with a handle (21) and a solid tubular portion (20). A syringe (32) may be coupled to the internal (3) and/or external (2) trephine so that the surgical device can be also operated as an injection device.

Abstract: The present invention is related to a composition comprising apolipoprotein L-l, the use of apolipoprotein L-l or a derivated polypeptide for the diagnostic, the treatment and/or the prevention of diseases induced in mammals by Trypanosoma. Another aspect is related to a transgenic non-human mammal comprising a polynucleotide expressing the apolipoprotein L-l or a derivated polypeptide and which is tolerant or resistant to the Trypanosoma infection.

Abstract: The present invention provides a method for reducing spreading of a pulse in a transmission line, said spreading being as a result of polarization mode dispersion, comprising inducing predetermined polarization rotations of particle or wave components of the pulse in the transmission line.