Abstract: An assaying kit is for pre-transfusion blood group matching between two blood samples. The kit includes at least two assemblies (101,201) corresponding to the first and the second blood sample, each assembly has at least two test units (1). Each test unit (1) includes a reagent containing an antigen present on erythrocytes or an antibody able to bind to an antigen present on erythrocytes. Each test unit (1) also includes a membrane (2) permeable to free erythrocytes (6) and impermeable to hemagglutinated erythrocytes. The antibody contained in the first test unit for both the first assembly (101) and the second assembly (201) corresponds to a first blood group and the antibody contained in the second test units for both the first assembly (101) and the second assembly (201) corresponds to a second blood group.

Abstract: The present invention provides a method and a kit for detecting a S. pneumoniae nucleic acid in a sample. The method comprises the steps of isolating said nucleic acid and detecting hybridization between the S. pneumoniae nucleic acid and a labeled probe, wherein the detection of hybridization comprises detecting a change in signal from the labeled probe during or after hybridization relative to the labeled probe signal before hybridization. The method of the present invention is characterized in that said nucleic acid is a ribonucleic acid, which isolation comprises the addition of acidic phenol to said sample and the purification of said ribonucleic acid.

Abstract: The present invention is related to a method for the selection of recombinant clones having integrated a gene of interest and a nucleotide sequence encoding a functional antidote protein to a toxic molecule, wherein said recombinant clones are the ones which survive following their integration into a host cell comprising in its genome a nucleotide sequence encoding said toxic molecule. The present invention is also related to a nucleic acid construct, a vector comprising said nucleic acid construct, a host cell and a cloning and/or sequencing kit for performing said method.

Abstract: The invention relates to a glass having SiO2, Na2O and CaO as main components, which comprises two amorphous phases having different compositions, one of the two phases being in the form of inclusions dispersed in the volume of the other phase and comprising crystalline particles. Such a glass has good mechanical strength, in particular good resistance to scratch propagation and allows improved tempering. This glass furthermore has a pleasant aesthetic appearance.

Abstract: The invention relates to a glass-ceramic material having SiO2, Na2O and CaO as main components and comprising crystalline particles of SiO2 dispersed homogeneously in the volume of an amorphous matrix. Such a material has good mechanical strength, in particular good resistance to scratch propagation and allows improved tempering. This material furthermore has a pleasant aesthetic appearance.

Abstract: The present invention relates to methods for determining the concentration of a free beta-lactam antibiotic in a biological sample. In particular, the present invention relates to methods for measuring a free beta-lactam antibiotic in a biological sample, comprising the steps of: (a) providing at least one class C beta-lactamase, a functional fragment or variant thereof; (b) providing at least one biological sample; (c) contacting said at least one class C beta-lactamase with said at least one biological sample; and (d) determining the concentration of said free beta-lactam antibiotic in said at least one biological sample.

Abstract: The present invention relates to compositions, comprising (a) a compound of the formula (I), and (b) a polymeric material, to specific oligomers of the formula I, and their use as organic semiconductor in organic devices, especially in organic photovoltaics (solar cells) and photodiodes, or in a device containing a diode and/or an organic field effect transistor. High efficiency of energy conversion, excellent field-effect mobility, good on/off current ratios and/or excellent stability can be observed, when the compositions, or oligomers according to the invention are used in organic field effect transistors, organic photovoltaics (solar cells) and photodiodes.

Abstract: A method is provided of generating and distributing secret random data. The method requires a plurality of participating parties each to own an identical private-key generation device and to request a random signal over a shared publication communication network. At each iteration of the method, the parties process the public random signal with the internal states of their secret-key generation devices using two functions, the output of the first function being generated secret random data and the output of the second function being a new internal state.

Abstract: The application teaches a composition comprising one or more pharmaceutical active ingredients selected from the group consisting of interleukin-8 (IL-8 or CXCL8), a functional fragment of IL-8, a functional variant of IL-8, and an agonist of IL-8 receptor, for therapeutic and/orprophylactic interventions in impaired bone fracture healing, such as but not limited to non-union fractures, mal-union fractures, or delayed union fractures.

Abstract: The present invention relates to the medical field. In a first aspect the present invention relates to novel water soluble cyclodextrin-curcumin complexes having a pharmacological activity, in particular an anti-tumor and/or anti-inflammatory activity, and improved physico-chemical properties. In a second aspect, the present invention relates to a method for preparation of said water soluble curcumin derivatives. The invention further relates in a third aspect to a pharmaceutical composition comprising an effective amount of said water soluble curcumin derivatives. In a fourth aspect, the present invention concerns the use of said water soluble cucumin derivatives as a medicament and the use of said water soluble curcumin derivatives for the preparation of a medicament for the treatment of cancer and inflammatory diseases.

Abstract: The invention relates to in vitro methods for differentiating mammalian pluripotent stem cells into cells displaying a neuronal phenotype, more particularly into cortical-type neurons including inter alia pyramidal neurons and cortical inhibitory interneurons. The invention further encompasses so-obtained neuronal cells and cell population, compositions comprising such, and further uses of said neuronal cells and cell population.

Abstract: Described are lyophilized compositions comprising cidofovir, hydroxypropyl methylcellulose (HPMC) or hydroxyethylcellulose (HEC) and, optionally, a plasticizer. In particular, described are such compositions that form a sheet-shaped porous solid matrix. Also described are methods for producing such compositions and their use in treating human papillomavirus (HPV) infections and HPV-associated malignancies, in particular, HPV lesions and cervical cancer.

Abstract: The present invention provides a synthetic peptide molecule that specifically binds an FXYD2-gamma isoform of pancreatic beta cells, said synthetic peptide molecule has 25 amino acids.

Abstract: A method for detecting a three dimensional object smaller than 300 nm includes providing a light source producing a first light beam (1), the light source being at least partially coherent; and splitting the first light beam (1) into an object beam (2) and a reference beam (6) by a first beam splitter (BS1). An image of the light source is produced in a light source image plane by a first microscope objective (L1), in the optical path of the object beam (2). The three dimensional object to be detected in an object cell (3) is positioned in the optical path of the object beam (2), between the first beam splitter (BS1) and the first microscope objective (L1). The object beam (2) and the reference beam (6) are recombined into a recombined beam (8) by use of optical devices. An optical stop (4) is placed in the light source image plane of the microscope objective (L1) on the optical axis of the microscope objective (L1).

Abstract: The present application discloses particularly interleukin-8 (IL-8) as a novel biomarker for the prediction, diagnosis, prognosis and/or monitoring of impaired bone fracture healing; and related methods, uses and kits.

Abstract: An endoscopic support device configured to support an endoscope during a surgical procedure is disclosed. The endoscopic support device has a connection ring with a height smaller than its diameter and configured to be in an open or deployed position and in a closed or non-deployed position. The support device also has at least two guiding elements, an orientation component, and extension means for manipulating the ring between the deployed and non-deployed positions.

Abstract: A wild-type human Apolipoprotein L-I is used in a method for the prevention and/or the treatment of renal disease.

Abstract: A method to determine the clinical outcome of breast tumour affecting a patient if treated with an antitumoural agent against breast tumour, the said method comprising the step of assaying a sample of a breast tumour from said patient for an expression level of selected genes, by contacting mRNA sequences from the cells of this breast tumour with a set of more than 3 nucleotide sequences related to human mutated PIK3CA.

Abstract: Device for puncturing a membrane of a human or animal body so as to introduce a liquid formulation thereinto, provided with a patch (10) made of a polymeric material, includes a base surface (12) having a distal side and a proximal side, and a plurality of projections (11), each projection projecting from the distal side of the base surface to end in a tip (13) arranged for puncturing the membrane. Each projection (11) has a cavity (14) and a shell (111) enveloping the cavity at the distal side. The cavity is open towards the proximal side of the base surface. The shells (111) have substantially constant thicknesses. The projections (11) include fluid channels (150) emanating from the cavities (14), running through the shells to end at orifices (15) provided in the shells, offset from the tips (13), the fluid channels being oriented obliquely relative to the proximal-distal axis (16, 160). A method provides for manufacturing the patch.

Abstract: The invention relates to in vitro methods for differentiating mammalian pluripotent stem cells into cells displaying a neuronal phenotype, more particularly into cortical-type neurons including inter alia pyramidal neurons and cortical inhibitory interneurons. The invention further encompasses so-obtained neuronal cells and cell population, compositions comprising such, and further uses of said neuronal cells and cell population.