Patents Assigned to Universitat
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Patent number: 12383602Abstract: The invention relates to a HLA-B57 open conformer or a HLA-B57 Fc fusion protein for use in the treatment or prevention of cancer. The Fc open conformer comprises or consists of a first and a second monomer, and each monomer comprises a HLA-B57 chain. The Fc fusion protein further comprises a protein stabilizing polypeptide sequence and optionally an amino acid linker. Further aspects of the invention provide combination medicaments comprising the HLA-B57 Fc open conformer and immune checkpoint inhibitors and/or checkpoint agonist agents. Furthermore, the invention relates to the use of HLA-B57 open conformer as an immunomodulator, particularly in diseases where modulation of diverse immune cell components (e.g. cytotoxic CD8+ T cells, Tregs) is a therapeutic strategy, e.g. infectious diseases.Type: GrantFiled: June 26, 2022Date of Patent: August 12, 2025Assignees: UNIVERSITAT ZURICH, UNIVERSITAT BASELInventors: Osiris Marroquin Belaunzaran, Ulf Petrausch, Christoph Renner
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Patent number: 12384839Abstract: Described herein is the use of a non-agonist ligand, particularly an antibody, specifically binding to GM-CSF or one of CD116, CD131 and the GM-CSF receptor composed of CD116 and CD131 for use in treatment of leukemia in a patient having undergone allo-HCT or in treatment of other complications arising as a consequence of hematopoietic cell transplantation from an immunologically non-identical donor.Type: GrantFiled: May 18, 2023Date of Patent: August 12, 2025Assignee: UNIVERSITAT ZURICHInventors: Burkhard Becher, Sonia Tugues
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Patent number: 12389725Abstract: The invention refers to a composite wavelength converter (1) for an LED (100), comprising a substrate (10) and an epitaxial film (20) formed by liquid phase epitaxy on the top and bottom of the substrate (10). Furthermore, the invention refers to a method of preparation of a composite wavelength converter (1) for an LED (100). Furthermore, the invention refers to a white LED light source comprising an LED (100) and an inventive composite wavelength converter (1) mounted on a light emitting surface of the LED (100).Type: GrantFiled: December 1, 2020Date of Patent: August 12, 2025Assignee: Friedrich-Alexander-Universität Erlangen-NürnbergInventors: Yuriy Zorenko, Miroslaw Batentschuk, Christoph Brabec, Andres Osvet, Vitalii Gorbenko, Ievgen Levchuk, Tetiana Zorenko, Liudmyla Chepyga, Anton Markovskyi, Sandra Witkiewicz-Lukaszek
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Patent number: 12378323Abstract: The present invention provides a polypeptides comprising a heavy chain domain 2 (HD2) from IgM or IgE and at least one pharmaceutically active moiety, complexes thereof and their use for therapy and prophylaxis.Type: GrantFiled: November 9, 2020Date of Patent: August 5, 2025Assignee: UNIVERSITAT STUTTGARTInventors: Roland Kontermann, Oliver Seifert, Aline Plappert
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Patent number: 12378570Abstract: The present invention relates to transgenic plants with altered photorespiration and improved CO2 fixation as well as a method of producing said transgenic plants. Particularly, the transgenic plants show an improved growth rate, productivity and energy conversion efficiency. This method can be successfully applied to many agricultural crop plants with nutritional and medicinal uses.Type: GrantFiled: August 5, 2020Date of Patent: August 5, 2025Assignees: Max-Planck-Gesellschaft zur F6rderung der Wissenschaften e.V., Heinrich-Heine-Universitat DusseldorfInventors: Lennart Schada Von Borzyskowski, Tobias Jürgen Erb, Andreas Paul Michael Weber, Marc-Sven Roll
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Patent number: 12370237Abstract: The present invention relates to lipopeptide-based compounds for use in the diagnosis, prevention and/or treatment of a liver disease or condition, preferably liver involved metabolic diseases, as well as in the control or modification of the cholesterol level or cholesterol uptake and, thus, diagnosis, prevention and/or treatment of a cardiovascular disease. The present invention furthermore relates to an in vitro or in vivo assay or method for testing or measuring the NTCP-mediated transport of test compound(s). The present invention furthermore relates to a method for the diagnosis, prevention and/or treatment of a liver disease or condition, comprising administering a therapeutically effective amount of a lipopeptide-based compound to a patient. The present invention furthermore relates to a method for the diagnosis, prevention and/or treatment of a cardiovascular disease.Type: GrantFiled: June 6, 2023Date of Patent: July 29, 2025Assignee: RUPRECHT - KARLS - UNIVERSITÄT HEIDELBERGInventors: Volker Cleeves, Stephan Urban, Ralf Kubitz
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Patent number: 12370221Abstract: The present invention concerns a method of generating a population of skeletal muscle derived human muscle precursor cells. For this purpose, a specialized FBS-free cell growth medium is used. The invention further concerns a composition comprising such a population of hMPCs for use as a medicament, especially in the treatment of skeletal muscle dysfunction.Type: GrantFiled: May 6, 2019Date of Patent: July 29, 2025Assignee: UNIVERSITÄT ZÜRICHInventors: Daniel Eberli, Deana Mohr, Souzan Salemi, Fahd Azzabi Zouraq
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Publication number: 20250236493Abstract: The present disclosure relates to a system for transmitting power. The system comprises a first component which includes a first cable winch configured to rotate to at least partially wind and unwind a first cable on the first cable winch. The system comprises a second component which includes a second cable winch configured to rotate to at least partially wind and unwind a second cable on the second cable winch. The first component comprises a first engagement device and the second component comprises a second engagement device configured to selectively engage with the first engagement device to couple and decouple the first cable winch and the second cable winch to and from each other, respectively. The present disclosure further relates to an assisting device and a method of operating a system.Type: ApplicationFiled: January 17, 2025Publication date: July 24, 2025Applicant: FRIEDRICH-ALEXANDER-UNIVERSITÄT ERLANGEN-NÜRNBERGInventors: Jonas WALTER, Dominik BRAUN, Jörg FRANKE, Alessandro DEL VECCHIO, Raul SIMPETRU, Nico WEBER
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Patent number: 12365922Abstract: The invention relates to a method to determine a homology directed repair (HDR) event within a eukaryotic cell, wherein the cell expresses a first isoform of a surface protein, which is different from a second isoform of said surface protein with regard to an amino acid marker. The method comprises the steps of inducing a DNA double strand break, providing a HDR template DNA construct comprising the amino acid marker corresponding to the second isoform of the surface protein and subsequently determining the expression of the first or second isoform of said surface protein on said cell, wherein expression of the second isoform indicates a successful HDR event. The invention also relates to a method for editing a genomic location of interest within a eukaryotic cell, and to a method of selectively depleting or enriching an edited cell in a composition of non-edited and edited cells.Type: GrantFiled: September 20, 2022Date of Patent: July 22, 2025Assignee: UNIVERSITÄT BASELInventors: Mara Kornete, Lukas Jeker
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Patent number: 12364957Abstract: The present invention relates to a tubular mixing device (6) with reversed coiled configuration (also referred to as “coiled flow reverser” CFR)) wherein after a number n of turns (2) with n=1; 2 the flow path is reverted to the opposite direction, and wherein the device (6) has an overall straight coil axis.Type: GrantFiled: May 20, 2020Date of Patent: July 22, 2025Assignee: OTTO-VON-GUERICKE-UNIVERSITAT MAGDEBURGInventors: Michael Mansour, Dominique Thevenin
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Patent number: 12364759Abstract: The present invention generally relates to the formation, chemistry and application of biologically active compositions. More particularly, the present invention relates to certain dyes, specifically porphyrin and chlorin derivatives, in combination with inventive polymers, i.e. light-cleavable polymers, that can be used as photosensitizer compositions for a wide range of light irradiation treatments such as photodynamic therapy of cancer, infections and other diseases. The dye derivatives may either be adsorbed on, or incorporated in, or attached to specific polymers, which as well form part of the invention.Type: GrantFiled: September 24, 2019Date of Patent: July 22, 2025Assignees: WESTFÄLISCHE WILHELMS-UNIVERSITÄT MÜNSTER, UNIVERSITÄT PADERBORN, BIOLITEC RESEARCH GMBHInventors: Klaus Langer, Juliane Anderski, Laura Mahlert, Dennis Mulac, Dirk Kuckling, Jingjiang Sun, Wolfgang Birnbaum, Arno Wiehe, Gerhard Dieter Wieland, Volker Albrecht
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Patent number: 12366002Abstract: The invention relates to a process for the oxidation of carbon-containing organic compounds where the said compounds have at least one bond with a bond order >1, wherein an oxidizing of these carbon-containing organic compounds to be oxidized is performed with electrochemically generated C—O—O oxidizing agents, in particular peroxodicarbonate. Also described is the use of C—O—O oxidizing agents generated electrochemically from carbonate, in particular peroxodicarbonate, as oxidizing agents for the oxidation of carbon-containing organic compounds, in particular carbon-containing organic compounds where the said compounds have at least one bond with a bond order >1.Type: GrantFiled: November 12, 2019Date of Patent: July 22, 2025Assignees: Condas, GMBH, Johannes Gutenberg-Universität MainzInventors: Siegfried Waldvogel, Michael Zirbes, Rieke Neuber, Thorsten Matthée
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Publication number: 20250233512Abstract: A DC-DC converter includes a converter circuit including a switchable first circuit path that is in a conductive state in a first time interval and that has at least a first and a second switchable element interconnected in series, and including a second circuit path that is coupled to the first circuit path by way of an inductive element and that is in a conductive state in second time interval disjunct from the first time interval, wherein there is a time lag between the first time interval and the second time interval. A control device is configured to switch the first circuit path. A switchable freewheeling path is coupled in parallel with the inductive element, wherein the control device is configured to switch the switchable freewheeling path temporarily to a conductive state in a freewheeling interval during the time lag.Type: ApplicationFiled: January 13, 2025Publication date: July 17, 2025Applicants: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., Friedrich-Alexander-Universität Erlangen-Nürnberg, in Vertretung des Freistaates BayernInventors: Yan ZHOU, Kilian DREXLER
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Patent number: 12360036Abstract: An imaging device and method for imaging an object, such as for multispectral or hyperspectral imaging, are disclosed. The imaging device includes an image sensor located in an image plane of the imaging device. The image sensor includes photosensitive elements. A first imaging system is configured to generate an intermediate image of the object in an intermediate image plane. A second imaging system is configured to generate an image of the intermediate image on the image sensor in the image plane. A diffractive optical element is arranged in the intermediate image plane. An aperture is arranged in a beam path of the second imaging system between the intermediate image plane and the image sensor. The diffractive optical element, the second imaging system, and the aperture are arranged such that different images for different wavelengths of the intermediate image are generated on different groups of the photosensitive elements.Type: GrantFiled: October 27, 2022Date of Patent: July 15, 2025Assignee: Universität StuttgartInventors: Tobias Haist, Robin Hahn, Kristina Michel
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Patent number: 12358826Abstract: A method of joining glass elements with material continuity, to a glass component, to a housing, and to a vacuum insulating panel. The method includes (A) providing first and second glass elements, with each of the glass elements having at least one joining region having an outer edge to be joined, (B) introducing a metallic material into the first glass element in the region of the joining region of the first glass element, (C) placing the first and second glass elements onto one another such that the first and second glass elements contact one another at least at one outer edge of the respective joining region; and (D) heating the metallic material in the first glass element so that the glass element at least partially melts in the region of the joining region of the first glass element so that a connection with material continuity is produced between the first and second glass elements.Type: GrantFiled: July 28, 2022Date of Patent: July 15, 2025Assignees: Fraunhofer-Gesellschaft zur Förderund der angewandten Forschung e.V., Technische Universität BerlinInventors: Philipp Wachholz, Norbert Arndt-Staufenbiel, Michael Töpper, Julian Schwietering
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Patent number: 12359153Abstract: A culturing membrane comprising a support provided by a mesh with holes filled with extracellular matrix proteins, as well as a method of producing a culturing membrane made of components found in a basal membrane, comprising the steps of using a mesh having holes; and providing a solution with the components found in the basal membrane on the mesh.Type: GrantFiled: April 21, 2023Date of Patent: July 15, 2025Assignees: AlveoliX Technologies AG, UNIVERSITÄT BERNInventors: Olivier Thierry Guenat, Janick Daniel Stucki, Marcel Aeschlimann, Christophe Léchot
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Patent number: 12357680Abstract: The present invention is inter alia concerned with an inhibitor selected from the group consisting of a selective KMT9-inhibitor, a selective METTL21A-inhibitor and a selective METTL21B-inhibitor for use in the treatment of cancer. KMT9, METTL21A and METTL21B are characterized herein for the first time as histone methyl transferases, and inhibitors of the same can be used for treating cancer.Type: GrantFiled: September 18, 2019Date of Patent: July 15, 2025Assignee: Albert-Ludwigs-Universitat FreiburgInventors: Roland Schüle, Eric Metzger, Sheng Wang, Manfred Jung, Nicolas Barthes, Bernhard Breit, Daad Sarraf, Tabea Pappert
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Patent number: 12357711Abstract: The present invention relates to a compound according to formula (V): or a pharmaceutically acceptable salt thereof, optionally containing a chelated radioactive cation and wherein F is optionally 18F.Type: GrantFiled: January 30, 2020Date of Patent: July 15, 2025Assignees: Technische Universität München, TECHNISCHE UNIVERSITÄT MÜNCHEN— KLINIKUM RECHTS DER ISARInventors: Alexander Josef Wurzer, Hans-Jürgen Wester, Matthias Johannes Eiber
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Patent number: 12362126Abstract: The invention relates to an X-ray source (10) comprising at least one waveguide (30) for X-ray radiation, wherein the at least one waveguide (30) has a core (32) and a casing (40) surrounding the core (32), and wherein at least one part of the waveguide (30) is designed to emit X-ray radiation (50), if the part of the waveguide (30) is bombarded with electrons (52). The invention also relates to a system for generating X-ray radiation comprising an X-ray source of this type, and a method for generating X-ray radiation by means of an X-ray source of this type or a system of this type.Type: GrantFiled: April 7, 2021Date of Patent: July 15, 2025Assignee: GEORG-AUGUST-UNIVERSITÄT GÖTTINGEN STIFTUNG ÖFFENTLICHEN RECHTSInventors: Malte Vassholz, Tim Salditt
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Patent number: 12358802Abstract: The present invention relates to a microporous material of the zeolite type, known as IDM-1, the method for preparing same, and applications thereof. Said material may be entirely silicon-based or may include different elements at either the reticular or non-reticular positions. The present invention falls within the fields of crystalline silicas, zeolites and catalysts.Type: GrantFiled: February 15, 2021Date of Patent: July 15, 2025Assignee: UNIVERSITAT POLITECNICA DE VALENCIAInventor: Luis Angel Villaescusa Alonso