Patents Assigned to Universitat
  • Publication number: 20250222083
    Abstract: The present invention relates to therapeutical uses of non-classical human major histocompatibility complex (MHC) molecules (also named MHC class Ib molecules) in combination with myelin-associated peptide antigens for the treatment of multiple sclerosis (MS), MOG antibody disease and MOG antibody positive neuromyelitis optica. The invention more specifically relates to recombinant polypeptides comprising peptide antigens and one or more domains of a non-classical MHC class Ib molecule. The invention also relates to methods of producing such recombinant polypeptides, pharmaceutical compositions comprising the same, as well as their uses for treating multiple sclerosis (MS), MOG antibody disease and MOG antibody positive neuromyelitis optica.
    Type: Application
    Filed: March 24, 2023
    Publication date: July 10, 2025
    Applicant: Julius-Maximilians-Universität Würzburg
    Inventors: Valentin BRUTTEL, Jörg WISCHHUSEN, Daniela BRÜNNERT, Fadhil AHSAN
  • Patent number: 12350882
    Abstract: In a first aspect, the invention refers to a printhead for the additive manufacturing of a fibre reinforced material, comprising a fibre reinforcement in a polymer matrix, comprising an infiltration unit for mixing and/or infiltrating a fibre roving with a molten polymer; at least one feeder for a polymer and/or a fibre roving to the infiltration unit; a heating element, at least for partially melting the polymer within the infiltration unit; at least one deflecting element within the infiltration unit and an outlet for the resulting fibre reinforced material from the infiltration unit, wherein the molten polymer can be guided within the infiltration unit with a polymer flow direction, from the feeder to the outlet, along a channel between the feeder and the outlet, and the fibre roving can be guided within the channel, by means of deflection, around the deflecting element, area by area, transversely to the polymer flow direction, from the feeder to the outlet.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: July 8, 2025
    Assignee: TECHNISCHE UNIVERSITÄT BERLIN
    Inventors: Mathias Czasny, Aleksander Gurlo, Oliver Görke, Franziska Schmidt
  • Patent number: 12351955
    Abstract: This disclosure relates to a stimulus-responsive mesh made from hydrogel fibers that provide varying degrees of ventilation depending on environmental conditions. The hydrogel fibers may be arranged into a mesh with openings that change size depending on the degree of swelling of the hydrogel fibers. As the hydrogel fibers of the mesh change (e.g., from a contracted state to/from a swollen state), fluids may flow through the mesh at a variable flow rate that depends on the degree of swelling. The swelling of the hydrogel fibers may be responsive to changes in the ambient environment experienced by the mesh, including, for example, the moisture level at the mesh, the temperature level of the mesh, the chemical composition of the moisture incident the mesh, the presence of magnetic/electric fields near the mesh, and/or the light level at the mesh.
    Type: Grant
    Filed: May 25, 2021
    Date of Patent: July 8, 2025
    Assignee: TECHNISCHE UNIVERSITAT DRESDEN
    Inventors: Simon Binder, Adrian Ehrenhofer, Alice Mieting
  • Patent number: 12350283
    Abstract: Provided herein are methods and compositions related to treating motor neuron diseases, such as ALS, in a subject by administering to the subject (e.g., orally administering to the subject) a composition comprising nicotinamide riboside, pterostilbene and a phosphodiesterase (PDE) inhibitor, including a PDE4 inhibitor such as ibudilast, and also including a thiol/cysteine donor, such as acetylcysteine.
    Type: Grant
    Filed: February 25, 2020
    Date of Patent: July 8, 2025
    Assignees: UNIVERSITAT DE VALENCIA-ESTUDI GENERAL, ELYSIUM HEALTH, INC.
    Inventors: José María Estrela Arigüel, Maria Elena Obrador Pla, Rosario Salvador, Ryan W. Dellinger
  • Publication number: 20250215503
    Abstract: The present invention is concerned with (i) an in vitro method of diagnosing prostate cancer (PCa) and/or a stage thereof in a subject suspected to or known to suffer from PCa, comprising the steps as disclosed herein; (ii) the use of a characteristic of extracellular vesicles (EVs) in a method of diagnosing cancer and/or a stage thereof, wherein the characteristic of the EVs is selected from the group consisting of the size, the density, the origin and combinations thereof; and (iii) a method of establishing a method of diagnosing cancer and/or a stage thereof, wherein the method of establishing comprises a step of analyzing a characteristic of extracellular vesicles (EVs), wherein the characteristic of the EVs is selected from the group consisting of the size, the density, the origin, and combinations thereof.
    Type: Application
    Filed: March 31, 2023
    Publication date: July 3, 2025
    Applicant: ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG
    Inventors: Irina NAZARENKO, Konrad WILHELM, Wolfgang SCHULTZE-SEEMANN, Liliia PANIUSHKINA
  • Publication number: 20250216054
    Abstract: An optical beam former for generating an emerging light beam from an incident light beam includes a condenser lens array for receiving the incident light beam, wherein the condenser lens array includes a plurality of condenser lenses. The optical beam former includes a projection lens array arranged parallel to the condenser lens array for emitting the incident light beam, wherein the projection lens array comprises a plurality of projection lenses. The condenser lens array comprises at least one cluster of condenser lenses, wherein each condenser lens of the cluster comprises an aperture adapted to a subarea of an overall pattern projected by the optical beam former to provide, for the projection lens array, part of the incident light beam associated with the subarea of the overall pattern. A combination of the apertures of the condenser lenses is adapted to the overall pattern.
    Type: Application
    Filed: March 23, 2025
    Publication date: July 3, 2025
    Applicants: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., Friedrich-Schiller-Universität Jena
    Inventors: Peter SCHREIBER, Rohan KUNDU, Dirk MICHAELIS
  • Publication number: 20250216045
    Abstract: A low-beam headlight includes a light source arrangement for generating a light cone consisting of light that is less divergent in a first transverse direction than in a second transverse direction perpendicular to the first transverse direction. The low-beam headlight includes beamforming optics for generating, on the basis of light, a light/dark distribution comprising a light/dark edge extending obliquely at least in portions with respect to the first transverse direction and the second transverse direction, wherein the beamforming optics comprises a condenser lens array for receiving incident light, and a projection lens array with a multitude of projection lenses for outputting light received by the condenser lens array.
    Type: Application
    Filed: March 23, 2025
    Publication date: July 3, 2025
    Applicants: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., Friedrich-Schiller-Universität Jena
    Inventors: Leo Maximilian WILHELM, Peter SCHREIBER, Dmitrii STEFANIDI
  • Publication number: 20250205322
    Abstract: The present invention relates to therapeutical uses of non-classical human major histocompatibility complex (MHC) molecules (also named MHC class Ib molecules) in combination with peptide antigens for the treatment of neuromyelitis optica (NMO). The invention more specifically relates to recombinant polypeptides comprising peptide antigens and one or more domains of a non-classical MHC class Ib molecule. The invention also relates to methods of producing such recombinant polypeptides, pharmaceutical compositions comprising the same, as well as their uses for treating neuromyelitis optica (NMO).
    Type: Application
    Filed: March 24, 2023
    Publication date: June 26, 2025
    Applicant: Julius-Maximilians-Universität Würzburg
    Inventors: Valentin BRUTTEL, Jörg WISCHHUSEN, Shriya Mamatha JAYARAM, Fadhil AHSAN
  • Publication number: 20250208411
    Abstract: The invention relates to a method and to a device for simultaneously compensating for the phase distortion of multiple wavelengths of an arrangement of electromagnetic waveguides and/or for implementing functions which change the propagation directions of electromagnetic radiation upon entrance into and/or exit from the arrangement, wherein these functions can be designed, for example, as focusing the electromagnetic radiation on a focal point, implementing a doughnut mode, and/or tilting the propagation direction of the electromagnetic radiation.
    Type: Application
    Filed: October 30, 2024
    Publication date: June 26, 2025
    Applicant: Technische Universität Dresden
    Inventors: Robert Kuschmierz, Jürgen Czarske, Elias Scharf, Jakob Dremel
  • Publication number: 20250206719
    Abstract: Please cancel the abstract of this application and replace it with the following amended abstract presented in clean form according to the procedures outlines in MPEP 714(II)(B): It is provided a chemical compound according to general formula (1)
    Type: Application
    Filed: March 23, 2023
    Publication date: June 26, 2025
    Applicant: TECHNISCHE UNIVERSITÄT BERLIN
    Inventors: Roderich SÜSSMUTH, John WESTON, Kay HOMMERNICK, Marcel KULIKE-KOCZULA, Lieby ZBOROVSKY, Leonardo KLEEBAUER
  • Publication number: 20250205323
    Abstract: The present invention relates to therapeutical uses of non-classical human major histocompatibility complex (MHC) molecules (also named MHC class Ib molecules) in combination with peptide antigens for the treatment of type 1 diabetes (T1D). The invention more specifically relates to recombinant polypeptides comprising peptide antigens and one or more domains of a non-classical MHC class Ib molecule. The invention also relates to methods of producing such recombinant polypeptides, pharmaceutical compositions comprising the same, as well as their uses for treating type 1 diabetes (T1D).
    Type: Application
    Filed: March 24, 2023
    Publication date: June 26, 2025
    Applicant: Julius-Maximilians-Universität Würzburg
    Inventors: Valentin BRUTTEL, Jörg WISCHHUSEN, Daniela BRÜNNERT, Fadhil AHSAN
  • Publication number: 20250205321
    Abstract: The present invention relates to therapeutical uses of non-classical human major histocompatibility complex (MHC) molecules (also named MHC class Ib molecules) in combination with peptide antigens for the treatment of Parkinson's disease. The invention more specifically relates to recombinant polypeptides comprising peptide antigens and one or more domains of a non-classical MHC class Ib molecule. The invention also relates to methods of producing such recombinant polypeptides, pharmaceutical compositions comprising the same, as well as their uses for treating Parkinson's disease.
    Type: Application
    Filed: March 24, 2023
    Publication date: June 26, 2025
    Applicant: Julius-Maximilians-Universitat Wurzburg
    Inventors: Jörg WISCHHUSEN, Valentin BRUTTEL, Chi Wang IP
  • Patent number: 12339297
    Abstract: A method for measurement of a sequence of recurring electronic signals (10) is proposed, wherein the sequence to be measured consists of n recurring electronic signals, wherein a time-to-digital converter (2) and a memory (5) are provided.
    Type: Grant
    Filed: December 15, 2021
    Date of Patent: June 24, 2025
    Assignees: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., Friedrich-Schiller-Universitat Jena
    Inventors: Falk Eilenberger, Tobias Vogl
  • Patent number: 12341970
    Abstract: The present disclosure relates to an apparatus and a method for providing a plurality of motion vectors related to an image coded in a bitstream. The method includes obtaining a set of sample positions within the image, obtaining respective motion vectors associated with the set of sample positions, deriving an additional motion vector based on information coded in the bitstream, determining an additional sample position located within a triangle, which is formed by three sample positions of the set of sample positions, based on the respective motion vectors associated with the three sample positions, the triangle not including the rest of the sample positions of the set of sample positions, adding the additional sample position to the set of sample positions, and associating the derived additional motion vector with the additional sample position.
    Type: Grant
    Filed: October 28, 2022
    Date of Patent: June 24, 2025
    Assignees: Huawei Technologies Co., Ltd., Friedrich-Alexander-Universität Erlangen-Nürnberg
    Inventors: Fabian Brand, Jürgen Seiler, André Kaup, Elena Alexandrovna Alshina, Semih Esenlik
  • Patent number: 12338448
    Abstract: The present invention relates to systems and methods suitable for high-level protein production. In particular, a system comprising two separate RNA molecules is foreseen, each comprising a nucleotide sequence derived from an alphavirus: one RNA molecule comprises a RNA construct for expressing alphavirus replicase, and one RNA molecule comprises a RNA replicon that can be replicated by the replicase in trans. The system of the present invention enables expression of a protein of interest in a cell or organism, but is not associated with undesired virus-particle formation. The present invention is suitable for efficiently and safely producing a protein of interest in a target organism. Respective methods of protein production in vitro and in vivo as well as medical uses are provided herein. The present invention also provides DNA encoding the RNA molecules of the invention, and cells comprising the RNA molecules of the invention.
    Type: Grant
    Filed: March 13, 2017
    Date of Patent: June 24, 2025
    Assignees: TRON-Translationale Onkologie an der Universitatsmedizin der Johannes Gutenberg-Universitat Mainz, BIONTECH SE
    Inventors: Tim Beissert, Ugur Sahin, Mario Perkovic
  • Patent number: 12339203
    Abstract: A semi-volatile particulate matter detection device is disclosed for detecting semi-volatile particulate matter in a gas flow. The device has a first filter stage for receiving the gas flow, the first filter stage being configured to capture particulate matter and to be heated to a temperature of at least 150° C. to volatilise semi-volatile particulate matter to produce semi-volatile vapour for passing through the first filter stage with the gas flow. The device also has a conveyance section downstream of the first filter stage to convey the gas flow and the semi-volatile vapour. A second filter stage is configured to receive the flow from the conveyance section. The temperature of the conveyance section and/or of the second filter stage is controllable so as to cause condensation of at least some of the semi-volatile vapour and collect it on the second filter stage. A detector is provided for detecting at least one characteristic of the condensed semi-volatile vapour on the second filter stage.
    Type: Grant
    Filed: November 11, 2020
    Date of Patent: June 24, 2025
    Assignees: Cambridge Enterprise Limited, Technische Universität Graz
    Inventors: Adam Boies, George Giannopoulos, Alexander Bergmann, Markus Bainschab
  • Publication number: 20250197816
    Abstract: The present invention relates to a method for in vitro amplification of a linear virus genome, in particular a bacteriophage, expression and self-assembling of the virus, in particular the bacteriophage, in a cell-free expression system as well as a virus 5 or bacteriophage provided by such methods. Further aspects of the invention relate to a synthetic bacteriophage and the use thereof.
    Type: Application
    Filed: March 7, 2023
    Publication date: June 19, 2025
    Applicants: Technische Universität München
    Inventors: Sophie VON SCHÖNBERG, Kilian VOGELE, Friedrich SIMMEL
  • Publication number: 20250203011
    Abstract: An apparatus for forming a computerized communication environment for a technical working environment, comprising: A mixing device to which a plurality of devices are connected, the plurality of devices comprising: a plurality of intercom devices with a microphone and an audio output, each of which is assigned to a person in the technical working environment, preferably a surgical operating room; wherein the mixing device with the plurality of intercoms controls, for each pair of two intercoms connected to the mixing device, whether and in which direction a flow of information is enabled between the two connected intercoms; wherein a control matrix is provided for controlling the flow of information, the matrix having a matrix entry defining the flow of information for each pair of devices connected to the mixing device, the device further comprising: a measuring microphone for measuring the ambient sound, which measures the sound level in the room; and wherein the mixing device comprises: a computer-implemen
    Type: Application
    Filed: December 9, 2021
    Publication date: June 19, 2025
    Applicant: Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Universitätsmedizin
    Inventor: Martin FRIEDRICH
  • Patent number: 12329990
    Abstract: A method and an apparatus for determining information regarding the location of energy deposition of an ion beam, in particular a proton beam, in an absorptive medium, such as in the tissue of a patient undergoing radiation therapy.
    Type: Grant
    Filed: February 28, 2023
    Date of Patent: June 17, 2025
    Assignees: Universität der Bundeswehr München, Technische Universität München, Ludwig-Maximilians-Universität München
    Inventors: Jannis Schauer, Günther Dollinger, Heinrich Ruser, Yuanhui Huang, Vasilis Ntziachristos, Hans Peter Wieser, Katia Parodi
  • Patent number: 12335415
    Abstract: The present disclosure refers to a method for decorrelating input signals from a physical identifier. In a system having one or more processors, the method comprises: providing input signals from a physical identifier: providing a decorrelation matrix; generating output signals, comprising decorrelating the input signals by applying the decorrelation matrix to the input signals; and providing the output signals at an output. The providing of the decorrelation matrix comprises: providing an initial matrix, the initial matrix being an orthogonal matrix; and determining the decorrelation matrix from the initial matrix by at least once selecting and applying at least one of a plurality of matrix extensions on the initial matrix, wherein each of the plurality of matrix extensions generates, from an input orthogonal matrix, a further orthogonal matrix with higher matrix dimension than the input orthogonal matrix. Furthermore, a system for decorrelating input signals from a physical identifier is provided.
    Type: Grant
    Filed: March 22, 2021
    Date of Patent: June 17, 2025
    Assignee: TECHNISCHE UNIVERSITÄT BERLIN
    Inventors: Onur Günlü, Rafael F. Schaefer