Abstract: Disclosed are Synovial Sarcoma X breakpoint 2 binding molecules and methods for their use in the detection and treatment of cancer.

Abstract: A perfusion loop assembly for ex vivo liver perfusion includes a pump providing perfusion fluid through a line branching at a branching point into a first branch line and a second branch line. The first branch line provides a first portion of the perfusion fluid to the hepatic artery of the liver, the first branch line coupled with a gas exchanger, where the first branch line includes a flow rate sensor and/or a pressure sensor. The second branch line provides a second portion of the perfusion fluid to the portal vein of the liver; the second branch line includes a valve for controlling flow of perfusion fluid into the portal vein. The second branch line includes a flow rate sensor and/or a pressure sensor. A liver chamber assembly holds the liver ex vivo, and an outlet line for the perfusion fluid connects the liver chamber assembly and the pump.

Abstract: A length adjustment device for a finger motion rail of a therapeutic device, a finger motion rail having such a length adjustment device, a therapeutic device having such a finger motion rail, and a method for adjusting the length of a finger motion rail on a therapeutic device for carrying out a continuous, passive and/or actively assisted movement of a finger and/or a thumb of a hand. The length adjustment device and adjustment method having a finger motion rail that is automatically moved along an adjustment rail by a drive on a therapeutic device and allows the finger motion rail to be fixed on the adjustment rail and therefore on the therapeutic device at a desired position in order to then be able to carry out a continuous, passive and/or actively assisted movement of a finger and/or of a thumb of a hand in a stable position.

Abstract: The invention relates to an image-capturing device for the miniaturized near-field image capture of biological tissue, in particular for the imaging of genetic indicators. The image-capturing device comprises at least one digital image sensor and an objective lens in the form of a rod-shaped gradient index lens (GRIN), which objective lens is coupled to the digital image sensor for image capture. The objective lens is connected to the digital image sensor to from a monolithic, fixed assembly. There is no mechanical separating interface between the objective lens and the digital image sensor by means of which the digital image sensor can be separated from the objective lens by the user. The invention further relates to a system for the miniaturized near-field image capture of biological tissue, said system comprising an image-capturing device of this type and an evaluation device connected to the image-capturing device.

Abstract: A facility for the production of radionuclides based photonuclear irradiation, comprising: an electron accelerator (1), producing an electron beam (2); a converter target assembly (21) with a converter target (20) that converts the electron beam (2) to Bremsstrahlung photons (15); a production target (17), irradiated by the Bremsstrahlung photons (15) and thereby producing said radionuclides.

Abstract: It is provided a personal care product comprising two subproducts: a first subproduct which is a freeze-dried solid composition comprising a thickening agent and an humectant; and a second subproduct which is a dried solid film comprising a thickening agent and an humectant; wherein the second subproduct is adapted to contain the first product, thereby acting as a first enveloping element covering the first product, wherein the first product and the second product are adapted to be separately manipulated as two independent products, and each provide a different or equal personal care function by being water-soluble. The personal care product is suitable for cosmetic, oral care, dermatological and pharmaceutical use. Said product can further comprise a second enveloping element comprising a synthetic polymeric film and on the inner part a thickening agent. Furthermore, the present invention is directed to a method to prepare said product.

Abstract: The present invention pertains to a novel method for the generation of highly diverse RNA expressing vectors and vector libraries for use in targeted gene knock out, knock down and genome modification approaches. The invention pertains to a method for generating such higher order libraries without the need of classical cloning technologies. This is particularly useful for libraries based on large vectors wherein a sequence cannot be easily mutated with classical mutagenesis methods. The vectors and libraries generated according to the methods of the invention are in particular for RNA assisted silencing technologies such as RNA interference, and for targeted genome editing using the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas system or similar RNA/DNA-encoded gene perturbation systems which use small guide RNAs to target the CRISPR complex to a specific genomic sequence. The invention provides also kits comprising the materials for performing the methods of the invention.

Abstract: The invention relates to a measuring device for the non-invasive determination of a blood sugar concentration in the body of a mammal, comprising a housing (G), a measuring electronics (IC) in the housing (G), wherein the measuring electronics (IC) further comprises at least one transmitter (Tx) for emitting high-frequency signals with a frequency of more than 0.1 THz and less than 10 THz, at least one receiver (Rx) for receiving high-frequency signals with a frequency of more than 0.

Abstract: A method of stabilising a biological sample including glutathione (GSH) and glutathione disulfide (GSSG), including a) providing the biological sample having GSH and GSSG; b) contacting GSH and GSSG of the sample with a maleimide to obtain maleimide-alkylated GSH; c) separating excess maleimide from maleimide-alkylated GSH and GSSG; d) contacting maleimide-alkylated GSH and GSSG with a reducing agent such as TCEP under conditions which allow reduction of GSSG by the reducing agent such as TCEP to obtain further GSH; and e) contacting maleimide-alkylated GSH and GSH with a heavy isotopologue of the maleimide to obtain a heavy isotopologue of the maleimide-alkylated GSH. A stabilised biological sample is provide containing maleimide-alkylated GSH and a heavy isotopologue thereof, as well as a mass-spectrometric method for quantifying maleimide-alkylated GSH and a heavy isotopologue thereof in a sample and a kit for stabilising a biological sample including GSH and GSSG for mass spectrometric analysis.

Abstract: An optical system and an imaging method are disclosed, wherein the optical system comprises a multifilament conductor and an optical diffuser for imaging an intensity pattern onto the multifilament conductor, the intensity pattern representing phase information of light emitted from one or more three-dimensional objects; wherein the multifilament conductor is configured to transmit the intensity pattern in the form of a plurality of pixels to an evaluation system, and wherein the evaluation system is configured to generate an image based on the intensity pattern transmitted by the multifilament conductor, the image representing the one or more three-dimensional objects.

Abstract: A method of making a porous or non-porous three-dimensional structure is provided in which silicate-water solution is first formed and then contacted with a first alcohol, whereby a gel can be provided. Thereafter, the gel is transferred to an additive manufacturing apparatus and a build part is created Finally, drying and/or heat treatment takes place, in particular to obtain a desired porosity and/or phase composition. A structure so produced is also provided and the use thereof as a bone implant, in tissue engineering, for thermal insulation, fire prevention, heat protection, gas or blood filters, light weight parts and/or catalyst supports or other scenarios where the porosity is necessary. The non-porous parts can be used as packaging, construction parts or other scenarios where the pores should be avoided.

Abstract: A radiopeptide is provided which comprises (a) a radionuclide, wherein the radionuclide is terbium-161, (b) a chelator coordinating terbium-161, and (c) a peptide or peptide analogue, which is a somatostatin receptor (SSTR) antagonist. The radiopeptide is suitable for use in the treatment of tumor diseases.

Abstract: The invention relates to a method for solvent-free production of an electrode. By means of the method it is possible to produce an electrode which has high mechanical stability and which provides a high specific capacitance. The method also enables the production of an electrode which can be used as an anode in a lithium-ion battery, without giving rise to unstable operation with undesirable and irreversible degradation reactions. An electrode is also provided, which has the above-mentioned advantages. In addition, uses of the electrode according to the invention are proposed.

Abstract: A component for producing building parts has two outer parts arranged at a distance from one another and at least one inner part arranged between the outer parts. The inner part has at least one first part adjacent to an outer part and a second part adjacent to the upper outer part, which has at least one vibration-capable leg, which projects from a third part connecting the first part to the second part, is spaced from the first part by at least one slot and on its side facing away from the first part has at least one recess, which is bridged by the upper outer part and delimited at one end by a projection that has a contact surface, on which the upper outer part is mounted, so that an overall vibration-capable mounting results for the one outer part, leading to a decoupling of structure-borne sound.

Abstract: The present invention provides a new animal model for mucopolysaccharidosis type IVA or Morquio A syndrome and to methods of generating the animal model and uses thereof.

Abstract: A wafer includes a substrate and at least one intermediate layer formed on a surface of the substrate. The at least one intermediate layer covers the surface of the substrate at least partially. An outer surface of the at least one intermediate layer is directed away from the surface of the substrate. The wafer further includes nanostructures grown on the outer surface of the at least one intermediate layer. The at least one intermediate layer is formed in such a way that positions of growth of the nanostructures are predetermined on the outer surface of the at least one intermediate layer. At least one nanostructure material of the nanostructures is assembled at the positions of growth of the nanostructures.

Abstract: The present invention relates to polymeric particles comprising a biodegradable polymer, and at least one microorganism in a total concentration of at least 108 CFU/g dry weight that is stable for at least 35 weeks at 30° C. and optionally additional carriers and additives as well as to methods for producing polymeric particles and use thereof.

Abstract: Multi-component systems and methods for determining the proximity of surgical tools to key anatomical features are provided. The inventive systems and methods can be applied in any surgical procedure requiring precision to avoid damage to key anatomical features such as nerves, with a particular example being the robotic cochlear implantation minimally invasive approach to cochlear implantation. Use of purpose built surgical robots, electromyography and tissue impedance, stereotactic tracking and drilling force/bone density measurements are all key components, with inputs from these various modalities being dynamically weighted. In the example of robotic cochlear implantation, the inventive concepts are used to provide key surgical guidance so as to avoid damage to the facial nerve and the chorda tympani, among other anatomical features.

Abstract: The present invention relates to nanostructured conjugates, more specifically to nanostructured fusion proteins suitable for the selective delivery of their conjugated therapeutic agents to specific cell and tissue types. It also relates to nanoparticles comprising such nanostructured proteins and the therapeutic uses thereof.

Abstract: A method for obtaining mechanically recoverable recycled material from multilayer PET (polyethylene terephthalate) containers of post-consumer and/or post-industrial origin involves cleaning the containers, crushing them into pieces, mixing the pieces with a compatibilizing mixture and melting the mixed product to obtain a continuous filament. The compatibilising mixture is formed by at least: 10-45% thermoplastic polyolefin matrix; a reagent of plant origin in a percentage of less than 7.5% of the total mixture; and a rosin-based tackifier in a percentage of less than 7.5% of the total mixture.