Abstract: A heat exchanger comprises a base, and a plurality of deformable fins connected to a surface of the base. Some deformable fins have a free end configured to move away from the surface of the base as a function of a local temperature increase of the base. The deformable fins are distributed on the surface of the base to be exposed to a coolant flowing over the surface of the base, wherein a distribution of the deformable fins on the surface of the base is non-uniform.

Abstract: The invention relates to methods for obtaining a fucoxanthin-crystal-containing precipitate, in particular fucoxanthin crystals, in particular fucoxanthin, and a fatty-acid-containing lipid fraction, in particular fatty acids, from the biomass of algae, in particular methods for the integrated extraction and separation of fucoxanthin and fatty acids from the biomass of algae, and to the products obtained from these methods, in particular fucoxanthin crystals and fatty acids.

Abstract: It is provided a method for manufacturing viruses in an in vitro cell culture. The method comprising the following steps: providing a cell culture of avian epithelial cells chosen from at least one of the cell cultures deposited under deposition numbers DSM ACC3345, DSM ACC3346, DSM ACC3347, DSM ACC3348, DSM ACC3349 at Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen and Zellkulturen GmbH on Dec. 12, 2018; infecting at least some of the cells in the cell culture with virus particles; incubating the cells for a first period of time; and recovering viruses produced by the cell culture from a supernatant of the cell culture.

Abstract: An extrusion-based additive manufacturing process for producing a 3D printed article, the process involving the steps of: (i) providing a build material in pellet form, containing a propylene polymer composition with specific weight percentages of heterophasic propylene copolymer, propylene homopolymer or copolymer, elastomeric block copolymer, elastomeric ethylene copolymer, glass material as filler, and a compatibilizer, the propylene polymer composition having MFR of at least 1.0 g/10 min; (ii) providing an additive-manufacturing system; (iii) at least partially fusing the build material within the system to create a fused build material; and (iv) extruding the fused build material to form the final 3D printed article.

Abstract: The present invention relates to novel specific small molecule inhibitors that block KMT9 methyltransferase activity. In particular, the present invention is concerned with a compound of formula (I) wherein X1, X2, X3, X4, R1, R2, R3, R5, R6 and L are as defined herein. Further, the present invention is concerned with a pharmaceutical composition comprising a pharmaceutically effective amount of the compound of formula (I). The present invention also relates to a compound of formula (I) and a pharmaceutical composition comprising a compound of formula (I) for use in medicine. Yet further, the present invention is concerned with a compound of formula (I) and a pharmaceutical composition comprising a compound of formula (I) for use as inhibitor of KMT9.

Abstract: The invention relates to a biologically produced nucleic acid sequence comprising two or three primary nucleic acid sequence parts of SARS-COV-2 and not more than three secondary nucleic acid sequence parts, wherein a secondary nucleic acid sequence part encodes an amino acid sequence having the function of a SARS-COV-2 amino acid sequence encoded by ORF3a, ORF6, ORF7a or ORF8. The invention further relates to a host cell or a kit for producing the nucleic acid of the invention, a vector encoding the nucleic acid of the invention and products that can be obtained by the expression of the nucleic acid of the invention such as virus envelopes. The invention further relates a pharmaceutical composition comprising the nucleic acid of the invention or products derived thereof, preferably for use in the prevention of SARS-COV-2.

Abstract: The present invention relates to an adhesive composition based on a lignin structure, wherein the lignin structure is a lignin functionalised by reaction with dimethylformamide and acrylic acid.

Abstract: A method for determining a property of at least one particle in a medium, wherein the method comprises: emitting a coherent light beam to irradiate a sample of the medium; recording an interference image of a first part of the light beam scattered by the at least one particle and a second part of the light beam not scattered by particles; computing, for positions within the sample, an electric field of the first part from the interference image; generating a representation comprising for each position, a phase value determined from the computed electric field and from an estimated electric field of the second part, and an intensity value determined from the intensity of the first part and from the phase value; and determining said property using the representation.

Abstract: Methods of providing neuromodulation therapy to a patient are disclosed herein. In particular, methods of applying deep brain stimulation (DB S) for the treatment of Parkinson's disease (PD) and related disorders are disclosed. Aspects of the methods involve using stimulation waveforms having a first polarity (e.g., cathodic stimulation) to determine an optimum arrangement of electrodes for providing the therapy (i.e., identifying a sweet-spot for stimulation). Therapy is then provided using the optimum arrangement of electrodes to deliver stimulation waveforms having the opposite polarity (e.g., anodic stimulation).

Abstract: In a multi-chip module and method, the multi-chip module includes a carrier; a multimode optical waveguide formed on and/or in the carrier; a first and second chip disposed on the carrier and coupled to the multimode optical waveguide; wherein the first chip is configured to transmit light beams into the multimode optical waveguide; the multimode optical waveguide is configured to generate mixed light beams that are an at least partial superposition of the light beams; the second chip is configured to receive the mixed light beams from the multimode optical waveguide; and the second chip is configured to store a representation of the received mixed light beams as a transmission signature and/or as a cryptographic key in a memory associated with the second chip, and/or compare the representation of the received mixed light beams with a target representation stored in the memory associated with the second chip.

Abstract: Provided is a process which allows uranium and molybdenum fluorides to be efficiently separated, said process comprising a step of providing a mixture containing MoF6 and UF6; a step of reducing the UF6 to UF5 in the gas phase or in a liquid phase; and a step of separating the UF5 and the MoF6 or a conversion product thereof which may be obtained by further converting the molybdenum fluoride to another molybdenum compound. In a further aspect, a process for the fluorination of metals or semimetals is provided.

Abstract: A computer-implemented method, computing device, system and computer program product for assisting positioning of a tool (5) with respect to a specific body part (202) of a patient (200) comprising: receiving intraoperative imaging data (ID) comprising 2D images capturing the specific body part (202) from a plurality of perspectives and 2D image(s) capturing at least a part of the tool (5) from at least one perspective; reconstructing an anatomical 3D shape (AS) of the specific body part (202) using an artificial-intelligence based algorithm corresponding to the specific body part (202) based on the intraoperative imaging data (ID) and data indicative of perspectives of 2D images; estimating a current position (5c) of the tool (5) with respect to the anatomical 3D shape (AS) based on the intraoperative imaging data (ID); and generating positioning guidance data (GD) comprising the estimated current position (5c) of the

Abstract: The present invention relates to a peptide comprising an amino acid sequence EX1EAX2SGSS according to SEQ ID No. 1, or a pharmaceutically acceptable salt thereof, wherein X1 and X2 independently represent a linker which links the adjoining amino acids or an amino acid deletion, and wherein the peptide has an overall length in the range of from 7 to 30 amino acids. The present invention further relates to a pharmaceutical composition comprising the peptide, and the peptide for use in the preventive treatment of acute lymphoblastic leukemia, myelodysplastic syndrome or acute myeloid leukemia, particularly therapy-related acute lymphoblastic leukemia, therapy-related myelodysplastic syndrome or therapy-related acute myeloid leukemia.

Abstract: The present invention relates to therapeutic proteins (therapeutic proteins) for use in the treatment of polyQ diseases by therapy, mRNAs, gene therapy vectors or viral particles coding for said therapeutic proteins and composition comprising them.

Abstract: The present invention relates to a QTL allele in maize associated with drought resistance and carbon isotope composition as well as specific marker alleles associated with the QTL allele. The present invention further relates methods for identifying maize plants based on screening for the presence of the QTL allele or marker alleles. The invention also relates to methods for modifying drought resistance and carbon isotope composition in maize plants.

Abstract: The present invention provides compounds, methods for their preparation, methods for their use and compositions containing them, which are suitable for industrial application in the pharmaceutical and diagnostic/prognostic field, particularly for the detection and diagnosis of Toxoplasma gondii infections, as well as for the treatment and prevention of said infections.

Abstract: A nanofluidic analysis device allowing for spontaneous flow of molecules and method for the analysis of DNA molecules, the device comprising a detection nanochannel, a supply channel in fluid communication with an inlet for the detection nanochannel and a discharge channel in fluid communication with an outlet for the detection nanochannel, so that a fluid comprising DNA molecules introduced into the supply channel may flow along a flow direction through the supply channel, via the inlet into the detection nanochannel, through the detection nanochannel, and out of the outlet into the discharge channel, wherein a laser detector system is provided for analyzing the DNA molecules in the detection nanochannel, wherein both a width and a depth of the inlet and thereby a cross section of the inlet decrease along the flow direction and wherein both a width and a depth of the outlet and thereby a cross section of the outlet increase along the flow direction, wherein the detection nanochannel has a length of not more

Abstract: The present invention relates to a method of identifying one or more T cells, as well as method of isolating one or more T cells. Further, the invention relates to a method of identifying one or more TCR, a nucleic acid molecule comprising a nucleic acid sequence encoding the TCR identified by the methods of the invention. The invention also relates to a method of generating one or more immune cells. The invention also relates to a host cell comprising a nucleic molecule encoding a TCR identified by the invention or generated by a method of the invention. The invention also relates to a pharmaceutical composition comprising a cell of the invention, or a cell of the invention for use in therapy. Finally, the invention also relates to a method of diagnosing cancer.

Abstract: A method for producing a catalyst-coated polymer membrane for an electrolyser and/or a fuel cell includes steps including providing a glass-ceramic substrate and synthesizing a mesoporous catalyst layer on the glass-ceramic substrate. The steps include pressing a polymer membrane onto the glass-ceramic substrate coated with the catalyst layer at a first temperature T1, thereby producing a sandwich structure. The steps further include separating the sandwich structure. The catalyst layer is separated from the glass-ceramic substrate and adheres to the polymer membrane.

Abstract: The present invention relates to a multi-domain polypeptide comprising (i) a first complement control protein repeat (CCP)-comprising domain being a convertase decay accelerating domain for convertases of the classical and alternative pathways of complement activation, (ii) a host cell recognition domain, and (iii) a second CCP-comprising domains with cofactor activity. The present invention further relates to a polynucleotide encoding said multi-domain polypeptide, to a vector comprising said polynucleotide, and to a host cell comprising said polynucleotide and/or said vector. Further, the present invention relates to the multi-domain polypeptide, the polypeptide, and the vector for use in medicine and for treating and/or preventing inappropriate complement activation and/or a disease having inappropriate complement activation as a symptom. Moreover, the present invention relates to methods and uses related to multi-domain polypeptide, the polypeptide, and the vector.