Abstract: A device for particle isolation includes a reservoir to contain a liquid including particles and a channel with an inlet and an outlet. The inlet is configured to be fluidically coupled to the reservoir containing the liquid including particles. The device includes further a pressure generator configured to generate a pressure gradient in the channel by which liquid including a single particle is aspirated from the reservoir through the inlet of the channel against the force of gravity and to cause liquid to be output through the outlet of the channel. Additionally, the device includes an actuator configured to cause a relative movement between the particles and the inlet of the channel so as to bring a single particle in a vicinity of the inlet to be aspirated through the inlet.

Abstract: The invention refers to an electronic component, in particular an organic electrochemical transistor (OECT) which comprises at least one gate electrode, a source electrode, a drain electrode, a channel and an electrolyte. The electrolyte is a solid electrolyte comprising a polymer, and the channel comprises an organic semiconductor as channel material. The electrolyte has a low water content and/or a low C1-C3-alcohol content as well as a low maximum halogen alkaline salt or alkaline earth or acetate salt content. The invention further refers to the use of this electronic component as a Schmitt-Trigger or a Muller-C-element or a flip-flop or a 1-bit memory. Further, the invention provides a method for forming such an electronic component.

Abstract: The present invention relates to chitosan oligomers obtainable by enzymatic hydrolysis of chitosan polymers, compositions containing them, and uses thereof.

Abstract: A method of encryption for quantum-secured communication includes structuring a pair of quantum-enabled hardware security modules to include an interface to a temporarily common quantum channel and an interface to a communication channel. A secret key is shared with the pair of quantum-enabled hardware security modules for a symmetrical encryption between the pair of quantum-enabled hardware security module. The secret key is obtained using quantum key distribution via the temporarily common quantum channel. The temporarily common quantum channel is disconnected from at least one of the pair of quantum-enabled hardware security modules and a communication network is structured to include at least two nodes configured to communicate using symmetrical encryption between the pair of quantum-enabled hardware security modules sharing a same secret key.

Abstract: An absorber device for absorbing a force acting thereon includes an absorber housing which encloses an interior space and a hydraulic medium arranged in the interior space. An absorber piston rod has an absorber piston arranged thereon. The absorber piston divides the interior space into a first chamber and a second chamber. The absorber piston rod has a spring device for resiliently supporting the absorber piston relative to a quasi-static component. The absorber piston is mounted axially movably on the absorber piston rod. A first spring and a second spring of the spring device are arranged in each case on both sides of the absorber piston and resiliently connect the absorber piston rod to the absorber piston and counteract a movement of the absorber piston in the axial direction, relative to the absorber piston rod. The absorber device can be arranged in a hollow damper piston rod of a damper.

Abstract: An apparatus for promoting a mass transfer reaction having a flow distributor and a drive unit. The flow distributor has a top end surface, a bottom end surface and a peripheral surface that are axisymmetric with respect to a rotation axis. The flow distributor is configured to submerge in a fluid medium and to generate a flow of the fluid medium through at least one of the top end surface and the bottom end surface and through the peripheral surface by rotating around the rotation axis. The drive unit is configured to move the flow distributor perpendicular to the rotation axis.

Abstract: The invention relates to an electrolyte arrangement for a cell having at least one anode (1) and at least one cathode (3) comprising at least three superposed layers (2.1, 2.2, 2.3), wherein the middle layer (2.2) comprises a porous electrically nonconductive structure, and wherein a layer of a polymer-based electrolyte (2.1, 2.3) is arranged on both opposite sides of the porous electrically nonconductive structure, wherein at least one of the superposed layers (2.1, 2.2, 2.3) contains a ceramic material, wherein the ceramic material of the middle layer (2.2) is selected from metal ion-conductive ceramic material, a ceramic material which does not conduct metal ions, and/or mixtures thereof, and the ceramic material of the polymer-based electrolyte layer(s) (2.1, 2.3) is a metal ion-conductive ceramic material.

Abstract: A system and method for monitoring personal mobility vehicles in urban environments, comprising a double magnetic coil (1), disposed at an area of personal mobility vehicle traffic, and connected to an oscillator circuit (2), a phase-locked loop (3), a signal conditioning circuit (4) and a signal processor (5); where the signal processor (5) is configured to calculate the temporal variation in voltage (V(t), V?(t)) produced in the phase-locked loop (3) and due to a variation in the oscillation frequency of the double magnetic coil (1) when at least one personal mobility vehicle passes said double magnetic coil (1); and to establish the type, speed, direction of travel and length of the personal mobility vehicle that has generated the variation in the oscillation frequency of the double magnetic coil (1).

Abstract: The present invention relates to the field of in vitro 3D modeling of neural tissues, particularly of the brain. There is the need of developing cell culture models of neural tissue that reflect physiological aspects of neural tissues. The present invention provides bioengineered neuronal organoid (BENOs) compositions capable of organizing as a functional neuronal network and methods for modeling a disease of neural tissue and/or for drug design based on phenotypic tissue screening or phenotypic drug screening using the disclosed BENO compositions. The present invention also relates to kits for making the instant BENO compositions.

Abstract: The present invention relates to the field of assessment of the health status, particular with regard to prostate cancer risk, by measurement of certain proteins in human samples, in particular in human urine.

Abstract: Device for performing an interferometric measurement having a source for generating at least two coherent waves, an overlap apparatus for overlapping the at least two coherent waves and for generating an interference pattern, a measuring apparatus for measuring the interference pattern so as to form measured interference values, a disturbance apparatus for disturbing the interference pattern and an analyzer for analyzing the measured interference values, wherein the overlap apparatus comprises a passage region that is delimited at its edge by an edge element and is passed through by the at least two overlapping coherent waves, and comprises a beam-splitting element in the center region of the passage region.

Abstract: In one aspect, a method of treating a subject having or at risk of having graft-versus-host disease (GvHD) generally includes administering to the subject a plurality of myeloid-derived suppressor cells (MDSCs) effective to ameliorate at least one symptom or clinical sign of graft-versus-host disease compared to a suitable control subject. In another aspect, a method of treating a tumor in a subject generally includes administering to the subject an anti-tumor therapy and co-administering to the subject an inflammasome inciting agent in an amount effective to increase inflammasome activation of MDSCs sufficiently to reduce suppressor function of the MDSCs.

Abstract: Provided is a method and an apparatus of manufacturing nano-structures by cutting out portions of a material layer and removing the cut-out portions.

Abstract: An apparatus for determining a response of a device under test to an electrical pulse generated by a pulse generator. The apparatus can include a conductor for coupling the electrical pulse generator to the device under test and at least two sensing probes connected to the conductor. Each of the at least two sensing probes can be positioned at one of at least two measurement points and can be configured to generate a signal in direct proportion to a current flowing in or a voltage applied to the conductor at the corresponding measurement point. A determination device can be configured to determine the response of the device under test to the electrical pulse based on the signals generated by the at least two sensing probes nd the transit times of the electrical pulse between these different measurement points.

Abstract: Methods for gradually exposing a subject to a fear comprising: adapting a virtual reality scenario to expose the subject to the fear by gradually transforming one or more of objects from a first state to a second state, the second state of the object provoking an increase of the fear, and wherein the transforming one or more of the objects take place only if the following two conditions are fulfilled: a time condition specifying an amount of time from the previous increase of fear, and the object is in a peripheral field of vision of the subject as derived from the orientation of the head mounted device. A computer program and computing systems for gradually exposing a subject to a fear are also disclosed.

Abstract: The present invention relates to a compound of formula (1) or a pharmaceutically acceptable salt or solvate thereof, wherein Y3 is O or S, wherein s, t, u and w are, independently of each other, 0 or 1, wherein i is an integer of from 1 to 3, wherein j is an integer of from 3 to 5, and wherein Z1, Z2 and Z3 are independently of each other, selected from the group consisting of CO2H, —SO2H, —SO3H, —OSO3H, and —OPO3H2, R1 is —CH3 or H, preferably H, X is selected from the group consisting of alkylaryl, aryl, alkylheteroaryl and heteroaryl, Y1 and Y2 are independently, of each other, selected from the group consisting of aryl, alkylaryl, cycloalkyl, heterocycloalkyl, heteroaryl and alkylheteroaryl, and wherein A is a chelator residue having a structure selected from the group consisting of (Ia), (Ib) and (Ic) wherein R2, R3, R4 and R5 are, independently of each other, selected from the group consisting of H, —CH2—COOH and —CH2—C(?O)—NH2 or wherein R2 and R4 form a —(CH2)n— bridge with n being an integer

Abstract: The invention relates to an infectious arenavirus particle that is engineered to contain a genome with the ability to amplify and express its genetic information in infected cells but unable to produce further infectious progeny particles in normal, not genetically engineered cells. One or more of the four arenavirus open reading frames glycoprotein (GP), nucleoprotein (NP), matrix protein Z and RNA-dependent RNA polymerase L are removed or mutated to prevent replication in normal cells but still allowing gene expression in arenavirus vector-infected cells, and foreign genes coding for an antigen or other protein of interest or nucleic acids modulating host gene expression are expressed under control of the arenavirus promoters, internal ribosome entry sites or under control of regulatory elements that can be read by the viral RNA-dependent RNA polymerase, cellular RNA polymerase I, RNA polymerase II or RNA polymerase III.

Abstract: The invention relates to a computer-assisted tomography (CT) system having the following features: a) at least one X-ray source, b) at least one patient couch for supporting a patient, c) at least one collimator in the ray path of the X-rays from the X-ray source through the patient, wherein a targeted X-ray from among the total X-ray radiation of the X-ray source is radiated by the collimator onto the patient, d) at least one X-ray detector, provided permanently or at least temporarily in the ray path of the targeted X-ray radiated by the collimator through the patient, e) at least one automatically actuable drive mechanism, using which the collimator can be moved with respect to the radiation direction of the targeted X-ray passing through the collimator, relative to the patient and/or to the X-ray detector, f) at least one electronic control device that is configured to automatically actuate the drive mechanism.

Abstract: Method and system for executing a one-time program comprising at least one instruction operating on at least one input value (a, b) and returning at least one output value (O), wherein each instruction of the one-time program is encoded onto a state of an elementary quantum system, comprising: encoding the at least one input value (a, b) onto a quantum gate according to a pre-defined input-encoding scheme; applying the quantum gate to the at least one elementary quantum system; making a measurement of a resulting state of the at least one elementary quantum system after the quantum gate; and determining the at least one output value from a result of the measurement.

Abstract: The present invention relates to compositions, immunogenic or vaccine compositions and pharmaceutical compositions for the prevention or treatment of insect bite 5 hypersensitivity of equine mammals, preferably of horses. Furthermore, the invention provides methods for preventing or treating insect bite hypersensitivity of equine mammals, preferably of horses.