Abstract: A device for a nonlinear optical frequency-conversion of laser radiation comprises a multipass arrangement being arranged such that a laser radiation coupled into the multipass arrangement carries out multiple roundtrips in the multipass arrangement. The device further comprises a nonlinear optical medium-arranged at least partly within the multipass arrangement such that at least in several of the roundtrips the laser radiation coupled into the multipass arrangement passes through the nonlinear optical medium to carry out a nonlinear optical conversion of a part of the laser radiation propagating through the nonlinear optical medium into frequency-converted components based on a second order susceptibility ?(2) of the nonlinear optical medium. The device is configured such that the laser radiation- and the frequency-converted components propagate in the multipass arrangement-along a common beam path including at least five passes through the nonlinear optical medium.

Abstract: The invention discloses using secreted splicing variant of mammal Klotho (s-KL) as an agent for the prevention and/or treatment of cognitive and/or behaviour impairments. It also refers to gene constructs and expression vectors useful in gene therapy for the delivery of said s-KL variant to the central nervous system of a mammal, in particular a rodent or a human. Pharmaceutical compositions comprising either the protein s-KL or any gene construct for expressing the protein in the CNS are also disclosed.

Abstract: A process for the manufacture of a non-isocyanate polyurethane (NIPU) composition by transesterification of a condensed tannin with a carbonate or a carbonate precursor followed by the reaction with a hardener selected from diamines, triamines, polyamines and mixtures thereof and products and compositions obtained thereby.

Abstract: Provided herein is an inositol polyphosphate oligo alkyl ether compound, or its pharmaceutically acceptable salt, for use in treatment or prevention of a disease associated with formation of calcium salt crystals.

Abstract: The formation of compensation elements (7) on an at least partially transparent membrane (2) that provides the actuator elements (5) to compensate or neutralize unwanted deformations of the compartment (3), e.g. induced by gravity effects, and/or to generate positive (convex) deflections of a limiting membrane (14), where the plurality of actuator elements (5) and the at least one compensation element (7) are provided at a common electrode membrane (2).

Abstract: The present invention relates to methods for predicting peptides or polypeptides such as T cell epitopes useful for immunotherapy such as for vaccination. In particular, the present invention relates to methods for predicting whether peptides or polypeptides such as tumor-associated antigens or epitopes, in particular tumor-associated neoantigens or neoepitopes, are immunogenic and, in particular, useful for immunotherapy such as for vaccination. The methods of the invention may be used, in particular, for the provision of vaccines which are specific for a patient's tumor and, thus, in the context of personalized cancer vaccines.

Abstract: The present invention relates to a gene editing system for editing the arylsulfatase A (ARSA) gene, polynucleotides, sgRNA molecules and repair templates which may form parts of the gene editing system, vectors and host cells incorporating said nucleic acid molecules, a pharmaceutical composition, and kits. It also relates to a method of gene editing the arylsulfatase A (ARSA) gene in a cell or a subject, and to a method of treating a disease or disorder associated with functional deficiency of the ARSA enzyme in a subject.

Abstract: The present invention relates to compositions comprising polyplex formulations for delivery of RNA to a target organ or a target cell after parenteral administration, in particular after intramuscular administration. More precisely, the present invention relates to formulations for administration of RNA such as self-replicating RNA, in particular by intramuscular injection. In more detail, the formulations comprise polyplex particles from single stranded RNA and a polyalkyleneimine.

Abstract: The invention relates to dendritic cells, the NF?B signaling pathway of which has been manipulated by RNA transfection, to the manufacture thereof and to use thereof.

Abstract: The invention relates to a method and a device for producing an electrode-separator assembly for a battery cell. The method comprises the following: supplying a separator material (2) by means of a separator supply device; supplying an electrode (9; 10) by means of an electrode supply device; and producing an electrode-separator assembly by means of a joining device, the electrode (9; 10) being joined to the separator material (2) and an adhesive bond being formed between the electrode (9; 10) and the separator material (2).

Abstract: A method and an apparatus for producing a concrete component, comprising concrete and a textile reinforcement composed of a reinforcement fiber strand (28), wherein first a yarn (20) is saturated with a mineral suspension (35) and forms the at least one reinforcement fiber strand (28). According to the invention, the reinforcement fiber strand (28) is fed by means of a moving device, so that the reinforcement fiber strand (28) is placed in a concrete strand (4), placed on a concrete layer (2), or placed on a vertical side surface of a plurality of concrete layers placed on top of each other, so that a perpendicular reinforcement is produced when arranged on the outside, and wherein the reinforcement fiber strand (28) is further enclosed by the concrete immediately upon placement or subsequently before the mineral suspension (35) has cured. The invention also relates to a reinforced concrete component (1).

Abstract: A method for the mobilization of a transposable element is provided. The method comprises the steps of a) providing an inhibitor of DNA methylation, and/or an inhibitor of transcription, and b) contacting the inhibitor(s) with a cell comprising inactivated transposable elements, yielding a cell with mobilized transposable elements. In a second aspect of the invention a method for increasing the genetic and/or epigenetic variation in a plurality of eukaryotic organisms is provided. The method comprises the steps of i. providing an inhibitor of DNA methylation and/or an inhibitor of transcription, ii. contacting the organism with the inhibitor(s) and iii. propagating the organism.

Abstract: The present invention provides new polynucleotide sequences, adeno-associated virus-derived vectors and pharmaceutical compositions containing the same for the treatment of lysosomal storage disorders and specially, for the treatment of mucopolysaccharidosis type IVA or Morquio A syndrome.

Abstract: Compositions comprising aptamers, and methods of thereof as carrier molecules in cell-mediated immunotherapies, and activation of antigen-specific T-cell responses.

Abstract: The invention relates to a hybrid process and a hybrid device for the production or thermal treatment of inorganic raw substances or materials in combination with further organic additives with the use of at least one gas burner in combination with at least one plasma burner in a furnace facility.

Abstract: The present invention refers to a compound as defined in formula (I) or a salt thereof for use in a method of treating or preventing BEST1-related retinopathies such as autosomal dominant Best vitelliform macular dystrophy. The present invention also refers to a pharmaceutical composition comprising a compound as defined in formula (I) or a salt thereof and a pharmaceutical acceptable excipient and/or carrier for use in a method of treating or preventing BEST1-related retinopathies such as autosomal dominant Best vitelliform macular dystrophy. In addition, the present invention refers to a pharmaceutical pack comprising one or more compartments, wherein at least one compartment comprises a compound as defined in formula (I) or a salt thereof or the pharmaceutical composition of the present invention for use according to the present invention.

Abstract: A method for doping a silicon substrate, in particular for a solar cell, includes coating a surface of the silicon substrate with a layer stack composed of at least two glass layers such that the layer stack at least covers a first region to be doped and a second region to be doped of the silicon substrate. the layer stack includes a first glass layer containing boron as p-type dopant and a second glass layer containing phosphorus as n-type dopant; and irradiating the first region covered with the layer stack with laser radiation such that dopant predominantly from the glass layer of the two glass layers that is closer to the surface of the silicon substrate than the other of the two glass layers is introduced into the silicon substrate close to the surface.

Abstract: A method of contrast enhancement of a three-dimensional light sheet microscopy image formed from N individual images each corresponding to a light sheet plane and spaced apart from each other in the z-direction by at least a distance d, the x/y-plane being the light sheet plane and the x-direction being the propagation direction of the light sheet of the light sheet plane, comprising: Deconvolution of the three-dimensional image in the z-direction, comprising: For each intensity vector of N intensities (Ix,y,1, . . . , Ix,y,N) having the same x/y value, performing a multiplication with a tridiagonal N×N deconvolution matrix, which assigns to each voxel (x, y, n) a correction parameter f1, with which, by the multiplication of the deconvolution matrix with the intensity vector, for a component I(x, y, n) of the intensity vector the intensities Ix, y, n+1 and Ix, y, n?1 of the corresponding voxels of the neighboring image plane are multiplied, before they are subtracted from the intensity value I(x, y, n).

Abstract: Provided is a block copolymer comprising a polymer block (A) formed from repeating units of formula (I): wherein R1 is methyl or ethyl, and a polymer block (B) formed from repeating units of formula (II): as well as a hydrogel comprising the block copolymer.

Abstract: A plasma thruster comprises a cylindrical discharge channel (1), an injector (4), a RF antenna surrounding the discharge channel (1) and a device (3) for generating an axial static magnetic field in the discharge channel (1). The RF antenna is a cylindrical birdcage antenna (2) formed of several electrically conductive parallel legs (10) connected by two end rings (11) including capacitors (12) between adjacent legs (10) in each case. The two end rings (11) with the capacitors (12) are formed on two printed circuit boards (14) to which the legs (10) are attached, said printed circuit boards (14) having a through opening for the discharge channel (1). The antenna maximizes electrical coupling efficiency and provides resulting electromagnetic fields for quasi-neutral plasma acceleration along with the magnetic field effect provided by the externally applied magnetic field.