Abstract: The present invention relates to a compound of formula (1) or a pharmaceutically acceptable salt or solvate thereof, wherein Y3 is O or S, wherein s, t, u and w are, independently of each other, 0 or 1, wherein i is an integer of from 1 to 3, wherein j is an integer of from 3 to 5, and wherein Z1, Z2 and Z3 are independently of each other, selected from the group consisting of CO2H, —SO2H, —SO3H, —OSO3H, and —OPO3H2, R1 is —CH3 or H, preferably H, X is selected from the group consisting of alkylaryl, aryl, alkylheteroaryl and heteroaryl, Y1 and Y2 are independently, of each other, selected from the group consisting of aryl, alkylaryl, cycloalkyl, heterocycloalkyl, heteroaryl and alkylheteroaryl, and wherein A is a chelator residue having a structure selected from the group consisting of (Ia), (Ib) and (Ic) wherein R2, R3, R4 and R5 are, independently of each other, selected from the group consisting of H, —CH2—COOH and —CH2—C(?O)—NH2 or wherein R2 and R4 form a —(CH2)n— bridge with n being an integer

Abstract: Disclosed are Synovial Sarcoma X breakpoint 2 binding molecules and methods for their use in the detection and treatment of cancer.

Abstract: The invention relates to a computer-assisted tomography (CT) system having the following features: a) at least one X-ray source, b) at least one patient couch for supporting a patient, c) at least one collimator in the ray path of the X-rays from the X-ray source through the patient, wherein a targeted X-ray from among the total X-ray radiation of the X-ray source is radiated by the collimator onto the patient, d) at least one X-ray detector, provided permanently or at least temporarily in the ray path of the targeted X-ray radiated by the collimator through the patient, e) at least one automatically actuable drive mechanism, using which the collimator can be moved with respect to the radiation direction of the targeted X-ray passing through the collimator, relative to the patient and/or to the X-ray detector, f) at least one electronic control device that is configured to automatically actuate the drive mechanism.

Abstract: Method and system for executing a one-time program comprising at least one instruction operating on at least one input value (a, b) and returning at least one output value (O), wherein each instruction of the one-time program is encoded onto a state of an elementary quantum system, comprising: encoding the at least one input value (a, b) onto a quantum gate according to a pre-defined input-encoding scheme; applying the quantum gate to the at least one elementary quantum system; making a measurement of a resulting state of the at least one elementary quantum system after the quantum gate; and determining the at least one output value from a result of the measurement.

Abstract: The invention relates to an infectious arenavirus particle that is engineered to contain a genome with the ability to amplify and express its genetic information in infected cells but unable to produce further infectious progeny particles in normal, not genetically engineered cells. One or more of the four arenavirus open reading frames glycoprotein (GP), nucleoprotein (NP), matrix protein Z and RNA-dependent RNA polymerase L are removed or mutated to prevent replication in normal cells but still allowing gene expression in arenavirus vector-infected cells, and foreign genes coding for an antigen or other protein of interest or nucleic acids modulating host gene expression are expressed under control of the arenavirus promoters, internal ribosome entry sites or under control of regulatory elements that can be read by the viral RNA-dependent RNA polymerase, cellular RNA polymerase I, RNA polymerase II or RNA polymerase III.

Abstract: A perfusion loop assembly for ex vivo liver perfusion includes a pump providing perfusion fluid through a line branching at a branching point into a first branch line and a second branch line. The first branch line provides a first portion of the perfusion fluid to the hepatic artery of the liver, the first branch line coupled with a gas exchanger, where the first branch line includes a flow rate sensor and/or a pressure sensor. The second branch line provides a second portion of the perfusion fluid to the portal vein of the liver; the second branch line includes a valve for controlling flow of perfusion fluid into the portal vein. The second branch line includes a flow rate sensor and/or a pressure sensor. A liver chamber assembly holds the liver ex vivo, and an outlet line for the perfusion fluid connects the liver chamber assembly and the pump.

Abstract: The present invention relates to compositions, immunogenic or vaccine compositions and pharmaceutical compositions for the prevention or treatment of insect bite 5 hypersensitivity of equine mammals, preferably of horses. Furthermore, the invention provides methods for preventing or treating insect bite hypersensitivity of equine mammals, preferably of horses.

Abstract: The invention relates to an image-capturing device for the miniaturized near-field image capture of biological tissue, in particular for the imaging of genetic indicators. The image-capturing device comprises at least one digital image sensor and an objective lens in the form of a rod-shaped gradient index lens (GRIN), which objective lens is coupled to the digital image sensor for image capture. The objective lens is connected to the digital image sensor to from a monolithic, fixed assembly. There is no mechanical separating interface between the objective lens and the digital image sensor by means of which the digital image sensor can be separated from the objective lens by the user. The invention further relates to a system for the miniaturized near-field image capture of biological tissue, said system comprising an image-capturing device of this type and an evaluation device connected to the image-capturing device.

Abstract: A length adjustment device for a finger motion rail of a therapeutic device, a finger motion rail having such a length adjustment device, a therapeutic device having such a finger motion rail, and a method for adjusting the length of a finger motion rail on a therapeutic device for carrying out a continuous, passive and/or actively assisted movement of a finger and/or a thumb of a hand. The length adjustment device and adjustment method having a finger motion rail that is automatically moved along an adjustment rail by a drive on a therapeutic device and allows the finger motion rail to be fixed on the adjustment rail and therefore on the therapeutic device at a desired position in order to then be able to carry out a continuous, passive and/or actively assisted movement of a finger and/or of a thumb of a hand in a stable position.

Abstract: It is provided a personal care product comprising two subproducts: a first subproduct which is a freeze-dried solid composition comprising a thickening agent and an humectant; and a second subproduct which is a dried solid film comprising a thickening agent and an humectant; wherein the second subproduct is adapted to contain the first product, thereby acting as a first enveloping element covering the first product, wherein the first product and the second product are adapted to be separately manipulated as two independent products, and each provide a different or equal personal care function by being water-soluble. The personal care product is suitable for cosmetic, oral care, dermatological and pharmaceutical use. Said product can further comprise a second enveloping element comprising a synthetic polymeric film and on the inner part a thickening agent. Furthermore, the present invention is directed to a method to prepare said product.

Abstract: A facility for the production of radionuclides based photonuclear irradiation, comprising: an electron accelerator (1), producing an electron beam (2); a converter target assembly (21) with a converter target (20) that converts the electron beam (2) to Bremsstrahlung photons (15); a production target (17), irradiated by the Bremsstrahlung photons (15) and thereby producing said radionuclides.

Abstract: The invention relates to a measuring device for the non-invasive determination of a blood sugar concentration in the body of a mammal, comprising a housing (G), a measuring electronics (IC) in the housing (G), wherein the measuring electronics (IC) further comprises at least one transmitter (Tx) for emitting high-frequency signals with a frequency of more than 0.1 THz and less than 10 THz, at least one receiver (Rx) for receiving high-frequency signals with a frequency of more than 0.

Abstract: The present invention pertains to a novel method for the generation of highly diverse RNA expressing vectors and vector libraries for use in targeted gene knock out, knock down and genome modification approaches. The invention pertains to a method for generating such higher order libraries without the need of classical cloning technologies. This is particularly useful for libraries based on large vectors wherein a sequence cannot be easily mutated with classical mutagenesis methods. The vectors and libraries generated according to the methods of the invention are in particular for RNA assisted silencing technologies such as RNA interference, and for targeted genome editing using the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas system or similar RNA/DNA-encoded gene perturbation systems which use small guide RNAs to target the CRISPR complex to a specific genomic sequence. The invention provides also kits comprising the materials for performing the methods of the invention.

Abstract: A method of stabilising a biological sample including glutathione (GSH) and glutathione disulfide (GSSG), including a) providing the biological sample having GSH and GSSG; b) contacting GSH and GSSG of the sample with a maleimide to obtain maleimide-alkylated GSH; c) separating excess maleimide from maleimide-alkylated GSH and GSSG; d) contacting maleimide-alkylated GSH and GSSG with a reducing agent such as TCEP under conditions which allow reduction of GSSG by the reducing agent such as TCEP to obtain further GSH; and e) contacting maleimide-alkylated GSH and GSH with a heavy isotopologue of the maleimide to obtain a heavy isotopologue of the maleimide-alkylated GSH. A stabilised biological sample is provide containing maleimide-alkylated GSH and a heavy isotopologue thereof, as well as a mass-spectrometric method for quantifying maleimide-alkylated GSH and a heavy isotopologue thereof in a sample and a kit for stabilising a biological sample including GSH and GSSG for mass spectrometric analysis.

Abstract: An optical system and an imaging method are disclosed, wherein the optical system comprises a multifilament conductor and an optical diffuser for imaging an intensity pattern onto the multifilament conductor, the intensity pattern representing phase information of light emitted from one or more three-dimensional objects; wherein the multifilament conductor is configured to transmit the intensity pattern in the form of a plurality of pixels to an evaluation system, and wherein the evaluation system is configured to generate an image based on the intensity pattern transmitted by the multifilament conductor, the image representing the one or more three-dimensional objects.

Abstract: A method of making a porous or non-porous three-dimensional structure is provided in which silicate-water solution is first formed and then contacted with a first alcohol, whereby a gel can be provided. Thereafter, the gel is transferred to an additive manufacturing apparatus and a build part is created Finally, drying and/or heat treatment takes place, in particular to obtain a desired porosity and/or phase composition. A structure so produced is also provided and the use thereof as a bone implant, in tissue engineering, for thermal insulation, fire prevention, heat protection, gas or blood filters, light weight parts and/or catalyst supports or other scenarios where the porosity is necessary. The non-porous parts can be used as packaging, construction parts or other scenarios where the pores should be avoided.

Abstract: A radiopeptide is provided which comprises (a) a radionuclide, wherein the radionuclide is terbium-161, (b) a chelator coordinating terbium-161, and (c) a peptide or peptide analogue, which is a somatostatin receptor (SSTR) antagonist. The radiopeptide is suitable for use in the treatment of tumor diseases.

Abstract: A component for producing building parts has two outer parts arranged at a distance from one another and at least one inner part arranged between the outer parts. The inner part has at least one first part adjacent to an outer part and a second part adjacent to the upper outer part, which has at least one vibration-capable leg, which projects from a third part connecting the first part to the second part, is spaced from the first part by at least one slot and on its side facing away from the first part has at least one recess, which is bridged by the upper outer part and delimited at one end by a projection that has a contact surface, on which the upper outer part is mounted, so that an overall vibration-capable mounting results for the one outer part, leading to a decoupling of structure-borne sound.

Abstract: The invention relates to a method for solvent-free production of an electrode. By means of the method it is possible to produce an electrode which has high mechanical stability and which provides a high specific capacitance. The method also enables the production of an electrode which can be used as an anode in a lithium-ion battery, without giving rise to unstable operation with undesirable and irreversible degradation reactions. An electrode is also provided, which has the above-mentioned advantages. In addition, uses of the electrode according to the invention are proposed.

Abstract: The present invention provides a new animal model for mucopolysaccharidosis type IVA or Morquio A syndrome and to methods of generating the animal model and uses thereof.