Patents Assigned to Universitat
  • Patent number: 9069081
    Abstract: Radiation detector for measuring one or more characteristics of a radiation, comprising one or more detector pixels, a clock pulse generator, each detector pixel comprising a sensor producing an electrical signal in response to an event of a photon or charged particle of said radiation impinging on said sensor; a pixel electronics adapted for receiving and processing said electrical signal, comprising an analog processing unit for amplifying and shaping said electrical signal and producing a shaped pulse said pixel electronics comprises time determination unit for counting the TOT-count, the TOT-count being the number of clock pulses occurring during the time interval when said shaped pulse is above a threshold. Said pixel electronics comprises a plurality of event counters, each event counter counting the number of events having a TOT-count in a predefined ranges.
    Type: Grant
    Filed: August 11, 2008
    Date of Patent: June 30, 2015
    Assignees: European Organization For Nuclear Research (CERN), Friedrich-Alexander-Universitat Erlangen-Nurnberg, Ion Beam Applications S.A.
    Inventors: Michael Campbell, Xavier Llopart Cudie, Lukas Tlustos, Winnie Sze-Wing Wong, Rafael Ballabriga Suñe, Gisela Anton, Thilo Michel, Michael Böhnel, Karl L. Schwartz, Uwe Mollenhauer, Ernst Fritsch
  • Patent number: 9068002
    Abstract: The invention relates to the use of an antibody which can specifically bind to chemokine receptor CCR2 for producing a medicament utilized for the treatment of multiple sclerosis and/or rheumatoid arthritis in a subject that is preferably a primate or a human. In another embodiment, the invention relates to the use of an antibody which can specifically bind to chemokine receptor CCR2 for producing a medicament that is utilized for depleting monocytes in subjects suffering from multiple sclerosis and/or rheumatoid arthritis. The invention further relates to corresponding in vitro methods and therapeutic methods. And antibody which binds to CD 14, for example, can be used in addition to the antibody that can bind to CCR2.
    Type: Grant
    Filed: April 2, 2007
    Date of Patent: June 30, 2015
    Assignees: GEORG-AUGUST-UNIVERSITAT GOTTINGEN STIFTUNG OFFENTLICHEN RECHTS, UNIVERSITAT REGENSBURG
    Inventors: Marco Prinz, Wolfgang Bruck, Alexander Mildner, Matthias Mack
  • Patent number: 9067359
    Abstract: A method and a device for processing light-polymerizable material for the assembly of a mold, utilizing a lithography-based generative manufacturing technique wherein a layer of a light-polymerizable material, the material being located in at least one trough (4) having a particularly light-transmissive, horizontal bottom (6), is polymerized by illumination on at least one horizontal platform (12), the platform having a prespecified geometry and projecting into a trough (4), in an illumination field, wherein the platform (12) is displaced vertically to form a subsequent layer, light-polymerizable material is then added to the most recently formed layer, and repetition of the foregoing steps leads to the layered construction of the mold in the desired form, which arises from the succession of layer geometries.
    Type: Grant
    Filed: October 16, 2013
    Date of Patent: June 30, 2015
    Assignees: Ivoclar Vivadent AG, Technische Universitat Wien
    Inventors: Gottfried Rohner, Wolfgang Wachter, Christoph Appert, Johannes Patzer, Jürgen Stampfl
  • Patent number: 9067051
    Abstract: The invention relates to a valve device for controlling a flow of a fluid through a fluid channel, having a tube (2) made of a flexible material, in which a section of a fluid channel is formed, a valve component (1) assigned to the tube (2), a cantilevered arm (8), which is designed to be reversibly displaceable on the valve component (1) against a restoring force supplied at least partially by the cantilevered arm (8) itself, a squeeze element (10), which is arranged on a distal end of the cantilevered arm (8) for support of the cantilevered arm (8) on the valve component (1) and is configured to control a flow of a fluid through the fluid channel by pressing against an outside surface of the tube (2), optionally up to the closing of the fluid channel, and an actuator (11) which is configured to displace the squeeze element (10) in various control directions against the restoring force on the cantilevered arm (8), so that the pressure of the squeeze element (10) on the outside surface of the tube (2) and th
    Type: Grant
    Filed: June 1, 2011
    Date of Patent: June 30, 2015
    Assignee: Technische Universitat Berlin
    Inventors: Andreas Loth, Florian Buehs
  • Publication number: 20150174832
    Abstract: Method for the automated manufacturing of a spatial structure from fibre-reinforced plastic, and device for carrying out such a method The present invention relates in particular to methods for the automated manufacturing of a spatial structure from fibre-reinforced plastic, wherein the structure is constructed successively and in an automated manner from a multiplicity of individual fibre-texture blanks, in that the individual fibre-texture blanks are successively adjoined, and in that a plastic material which forms a matrix for the respective fibre-composite blank is consolidated in situ in a localized manner.
    Type: Application
    Filed: December 18, 2014
    Publication date: June 25, 2015
    Applicants: TECHNISCHE UNIVERSITÄT DRESDEN, APPARATEBAU GAUTING GMBH
    Inventors: Ulrich Wollenweber, Marco Zichner, Florian Lenz, Werner Hufenbach, Bernd Grüber
  • Patent number: 9062307
    Abstract: The present invention relates to antagonists of the expression and/or the function of the micro RNA miRNA-29 for use in the prevention and/or treatment of aortic aneurysms. Further disclosed is a method for the identification of miRNA-29 antagonists, a pharmaceutical composition comprising said miRNA-29 antagonists and a method for preventing and treating age-related aortic aneurysm formation in a subject in need of such a treatment.
    Type: Grant
    Filed: April 1, 2011
    Date of Patent: June 23, 2015
    Assignee: Johann Wolfgang Goethe-Universität Frankfurt am Main
    Inventors: Andreas Zeiher, Stefanie Dimmeler, Reinier Boon
  • Patent number: 9066108
    Abstract: Parametric Motion Vector Prediction (PMVP) methodologies and components and systems for performing those methodologies are provided to more effectively and efficiently encode video content that includes complex motion such as zoom or rotation. By substituting the PMVP for a collocated MVP used in HEVC in order to reduce the amount of bit rate increase required when including the PMVP analysis in the bit stream. Further, compression of the motion vectors is provided in a three stage approach based on transformation, quantization and difference coding.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: June 23, 2015
    Assignee: TECHNISCHE UNIVERSITAT BERLIN
    Inventors: Michael Tok, Alexander Glantz, Andreas Krutz, Thomas Sikora
  • Patent number: 9061007
    Abstract: The present invention relates to methods which make possible to assess and/or prognose a cancer disease, the metastatic behavior of a cancer disease and/or the occurrence of a relapse of cancer. In particular, the methods of the invention make possible to assess and/or prognose the occurrence of cancer metastasis, in particular distant metastasis. Preferably, the methods of the invention allow to discriminate malign from benign conditions.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: June 23, 2015
    Assignees: JOHANNES GUTENBERG-UNIVERSITAT MAINZ, BIONTECH AG
    Inventors: Ugur Sahin, Ozlem Tureci, Michael Koslowski
  • Patent number: 9062127
    Abstract: The invention relates to the rational mutagenesis of polypeptides of ?/? T-cell receptors that mediate an oncogen-specific T-cell response, nucleic acids encoding these and their use in the therapy, diagnosis and/or prevention of cancerous diseases. The invention further relates to a T-cell response-mediating MDM2-protein-specific ?/? T-cell receptor, which has been rationally mutated by means of the method according to the present invention, and the uses thereof.
    Type: Grant
    Filed: November 23, 2010
    Date of Patent: June 23, 2015
    Assignee: JOHANNES GUTENBERG-UNIVERSITAT MAINZ
    Inventors: Ralf-Holger Voss, Theobald Matthias
  • Publication number: 20150164567
    Abstract: The invention relates to a surgical tool for performing surgery on a bone, particularly for reinforcing the bone in a miniinvasive manner, comprising: a first and a second element (10, 20), wherein the two elements (10, 20) each comprise a shell (100, 200) defining a hollow space (101, 201) of the respective element (10, 20), wherein the second element (20) is designed to be inserted into the hollow space (101) of the first element (10), a guiding element (30), wherein the guiding element (30) comprises a first free end (31), and wherein the guiding element (30) is designed to be inserted into the hollow space (201) of the second element (20) with said first free end (31) of the guiding element (30) ahead, and wherein the guiding element (30) is designed to be drilled into said bone with its first free end (31) ahead so as to anchor said guiding element (31) in said bone, and a drill (40), which drill (40) is designed to be put over the guiding element (30) in a drilling state, in which drilling state the fir
    Type: Application
    Filed: January 23, 2013
    Publication date: June 18, 2015
    Applicant: UNIVERSITAT ZURICH
    Inventor: Bernhard Dimitris Ciritsis
  • Patent number: 9058661
    Abstract: The invention relates to a method for the real-time-capable, computer-assisted analysis of an image sequence of an object consisting of elements that can be moved relative to each other and are interconnected, said sequence containing a variable pose, wherein the individual images of the image sequence are recorded by way of a time-of-flight (TOF) camera such that said images can be processed by a computer, and contain brightness and distance data as functions of the pixel coordinates of the camera for each image of the sequence, comprising the following steps: a. Capturing the pixels of an individual image forming the object, b. calculating a three-dimensional (3D) point cloud in a virtual space, said point cloud representing the surface of the object that is visible to the camera, by a computational projection of object-depicting pixels in such a space, while taking captured distance data to the object into consideration, c.
    Type: Grant
    Filed: May 6, 2010
    Date of Patent: June 16, 2015
    Assignee: Universitat Zu Lubeck
    Inventors: Martin Haker, Erhardt Barth, Thomas Martinetz
  • Patent number: 9059503
    Abstract: An antenna arrangement for transmitting signals has improved directional characteristics and a higher antenna gain, is simple to produce, and is robust and cost-effective. The antenna arrangement has a plurality of planes, and a plurality of individual antennas are arranged in each plane.
    Type: Grant
    Filed: October 29, 2010
    Date of Patent: June 16, 2015
    Assignee: TECHNISCHE UNIVERSITAT DRESDEN
    Inventors: Dirk Plettemeier, Michael Jenning, Ting-Jung Liang
  • Patent number: 9056081
    Abstract: The invention relates to a HNK-I mimetic peptide or a polypeptide comprising such HNK-I mimetic peptide for treating or preventing a Pseudomonas infection, in particular an infection with Pseudomonas aeruginosa. The invention further relates to the use of a HNK-I mimetic peptide or a polypeptide comprising such HNK-I mimetic peptide for the preparation of a pharmaceutical composition for treating or preventing a Pseudomonas infection. The invention also relates to a pharmaceutical composition comprising a HNK-I mimetic peptide or a polypeptide comprising such HNK-I mimetic peptide, wherein the composition is for treating or preventing a Pseudomonas infection.
    Type: Grant
    Filed: May 10, 2010
    Date of Patent: June 16, 2015
    Assignees: Universitätsklinikum Hamburg-Eppendorf, Heinrich-Heine-Universität Düsseldorf
    Inventors: Melita Schachner, Heike Gustke, Udo Schumacher, Karl-Erich Jäger
  • Publication number: 20150157711
    Abstract: The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.
    Type: Application
    Filed: May 21, 2013
    Publication date: June 11, 2015
    Applicants: Ganymed Pharmaceuticals AG, TRONTRANSLATIONALE ONKOLOGIE AN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ GEMEINNÜTZIGE GMBH
    Inventors: Ugur Sahin, Özlem Türeci, Rita Mitnacht-Kraus, Stefan Denis Jacobs, Magdalena Jadwiga Utsch, Cornelia Adriana Maria Heinz, Christiane Regina Stadler
  • Patent number: 9052597
    Abstract: An embodiment of the present invention relates to a method of fabricating an optical device, the method comprising the steps of: depositing a photoresist layer on a carrier, said photoresist layer containing at least one optical component, determining the position of the at least one optical component inside the photoresist layer before exposing the photoresist layer to a first radiation, said first radiation being capable of transforming the photoresist layer from an unmodified state to a modified state, elaborating a device pattern based on the position of the at least one optical component, and fabricating the elaborated device pattern by locally exposing the photoresist layer to the first radiation and locally transforming the photoresist layer from the unmodified state to the modified state.
    Type: Grant
    Filed: April 4, 2013
    Date of Patent: June 9, 2015
    Assignees: HUMBOLDT-UNIVERSITÄT ZU BERLIN, KARLSRUHER INSTITUTE FÜR TECHNOLOGIE
    Inventors: Andreas Schell, Joachim Fischer, Johannes Kaschke, Oliver Benson, Martin Wegener
  • Patent number: 9051603
    Abstract: In invention relates to a method for the isolation of RNA from tissue pretreated with formaldehyde comprising homogenizing the sample in the presence of a guanidinium salt in aqueous solution, and incubating the sample in the presence of 0.1 M to 5 M ammonium salt at a temperature between 50° C. and 100° C. The heat treatment in the presence of an ammonium salts demodifies RNA by reverting methylol groups which are formed in the presence of formaldehyde between amino groups in nucleobases of RNA and in basic amino acids, and by cleavage of methylene bridges between amino groups in nucleobases of RNA and basic amino acids, to provide high RNA recoveries and consistently high quality of RNA for further reaction, e.g. for reverse transcriptase-polymerase chain reaction or microarray analysis.
    Type: Grant
    Filed: April 8, 2009
    Date of Patent: June 9, 2015
    Assignee: Universität Bern
    Inventors: Rolf Jaggi, Robert Häner
  • Publication number: 20150141637
    Abstract: The present invention provides novel tricyclic nucleosides and oligomeric compounds prepared therefrom. Incorporation of one or more of the tricyclic nucleosides into an oligomeric compound is expected to enhance one or more properties of the oligomeric compound. Such oligomeric compounds can also be included in double stranded compositions. In certain embodiments, the oligomeric compounds provided herein are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
    Type: Application
    Filed: March 15, 2013
    Publication date: May 21, 2015
    Applicant: UNIVERSITÄT BERN
    Inventors: Christian Leumann, Branislav Dugovic, Jory Liétard
  • Patent number: 9034599
    Abstract: DNA encoding a monomeric variant of red fluorescent protein eqFP611 comprising an amino acid sequence selected from the group consisting of SEQ ID No. 1, SEQ ID No. 3 and SEQ ID No. 5. DNA comprising a nucleotide sequence selected from the group consisting of SEQ ID No. 2, SEQ ID No. 4 and SEQ ID No. 6.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: May 19, 2015
    Assignee: Universitat Ulm
    Inventors: Jörg Wiedenmann, Simone Kredel, Franz Oswald, Gerd Ulrich Nienhaus
  • Publication number: 20150132253
    Abstract: The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.
    Type: Application
    Filed: May 21, 2013
    Publication date: May 14, 2015
    Applicants: GANYMED PHARMACEUTICALS AG, TRON - Translationale Onkologie an der Johannes Gutenberg-Universitat Mainz gemeinnuetzige GmbH
    Inventors: Ugur Sahin, Özlem Türeci, Rita Mitnacht-Kraus, Stefan Denis Jacobs, Magdalena Jadwiga Utsch, Cornelia Adriana Maria Heinz, Christiane Regina Stadler
  • Publication number: 20150135200
    Abstract: The invention relates to a method for the virtualization of a hardware resource associated with a computer system by an executable piece of code adapted for being injected into a process belonging to an application that is executed on an operating system comprising at least one API that is executed on the computer system. The method comprises: intercepting a call from the process to an API service related with the management of the data flow produced between the process and the hardware resource; and managing the data flow produced between the process and the hardware resource by the piece of code on the basis of the interception of the call from the process to the API service related with the management of the data flow produced between the process and the hardware resource.
    Type: Application
    Filed: April 18, 2013
    Publication date: May 14, 2015
    Applicant: UNIVERSITAT POLITÈCNICA DE CATALUNYA
    Inventors: Alejandro Pajuelo González, Javier Verdù Mulà