Abstract: The present invention relates to specific analogs of combretastatin, in particular the compounds of formula (I) as described and defined herein, and pharmaceutical compositions comprising the compounds, as well as their medical use, in particular in the treatment or prevention of cancer, including multidrug-resistant cancer.

Abstract: The present invention relates to a process for the enzymatic production of a dipeptide composition from a cyanophycin (CGP) or CGP-like polymer preparation by degrading the polymer preparation with an CGPase, a CGPase particularly adapted for said process, and the use of cyanophycin (CGP) or CGP-like polymers or fragments thereof, notably a dipeptide composition obtained by the process as defined above, as pharmaceutical composition, medicament, or as food or feed substitute.

Abstract: The present invention relates to pre-catalysts for olefin metathesis and composition involving these pre-catalysts.

Abstract: The invention relates to a friction stir welding apparatus for joining workpieces 1, 2, having a welding pin 3, which is rotatable about its center axis 9 by means of a drive, and having at least one clamping apparatus for clamping the workpieces 1, 2 to be joined, characterized in that the clamping apparatus comprises at least two clamping elements 10, 11, which respectively have an undercut guideway 12, the guideways 12 being arranged parallel to one another and parallel to a joining region 8, in that between the clamping elements 10, 11 is arranged a sliding element 13, which is secured by the guideways 12 against the workpieces 1, 2 and is translatorily displaceable along the guideways 12, and in that the sliding element 12 is provided with an opening 14 for the lead-through of the welding pin 3, and further relates to a method for friction stir welding, using the above-stated apparatus.

Abstract: The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.

Abstract: An electronic unit is produced including at least one electronic component at least partially embedded in an insulating material. A film assembly is provided with at least one conductive layer and a carrier layer. The conductive layer includes openings in the form of holes for receiving bumps, which are connected to contact surfaces of the at least one electronic component. The at least one component is placed on the film assembly such that the bumps engage with the openings of the conductive layer. The at least one component is partially embedded from the side opposite of the bumps into a dielectric layer. The carrier layer of the film assembly is removed such that the surface of the bumps is exposed. A metallization layer is then deposited on the side of the remaining conductive layer having the exposed bumps and so as to produce conductor tracks that overlap with the bumps.

Abstract: A semiconductor component (1, 20, 30) comprising a semiconductor substrate (3) composed of silicon carbide and comprising separate electrodes (4, 5) applied thereto, said electrodes each comprising at least one monolayer of epitaxial graphene (11) on silicon carbide, in such a way that a current channel is formed between the electrodes (4, 5) through the semiconductor substrate (3).

Abstract: The invention relates to an enzyme that comprises or includes a sequence according to SEQ. ID No. 1 or SEQ. ID No. 2, to a method for the production thereof, and to the use thereof as a catalyst in the oxidative cleavage of vinyl aromatics.

Abstract: The invention relates to a method and corresponding devices for reducing mode instability in an optical waveguide (1), a light signal becoming unstable in the optical waveguide (1) beyond an output power threshold and energy being transformed from a basic mode into higher order modes. The invention proposes a reduction in temperature variation (2) along the optical waveguide (1) and/or a reduction in changes in the optical waveguide (1) that are caused by spatial temperature variation as a result of mode interference.

Abstract: The present invention relates to peptides comprising at least one antigenic determinant or epitope of an apicomplexan Ferlin, Ferlin-like protein and/or another C2-domain containing protein for use as malaria vaccines. It further relates to compositions comprising said peptides and to the use of such compositions as malaria vaccines.

Abstract: At least one embodiment of the method is designed to create a two-dimensional image of a three-dimensional sample.

Abstract: The invention is based on the finding of specific surface markers for M1-like (classically activated) and M2-like (alternatively activated) macrophages and provides for a method for the identification, characterization and isolation of M1-like and M2-like macrophages based on the abundance of said surface markers and for means for performing such method.

Abstract: The present invention relates to a novel polymeric material with enhanced hydrophilicity for medical use comprising a biocompatible polyester material selected from the group consisting of poly(hydroxyalkanoate)s, poly(lactic acid)s, poly(glycolic acid)s, poly(caprolactone)s and copolymers and blends thereof, wherein the biocompatible polyester material is crosslinked with a functionalized poly(alkylene oxide) having at least two functional groups independently selected from the group consisting of azido-formate and alkanoyl azide. The novel polymeric material with enhanced hydrophilicity is useful as a biocompatible material in a variety of medical applications, including medical implants, bioresorbable implants, tissue engineering, and controlled release.

Abstract: The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast cancer, lung cancer, gastric cancer, ovarian cancer, and hepatocellular cancer.

Abstract: The invention relates to a device for sensing a microwave magnetic field polarization component (B?, B?, B+,) of a microwave relative to a static magnetic field B0, comprising: a preparation means being designed to prepare an atomic vapor (10) comprising a plurality of thermal atoms in a first hyperfine state, particularly a dark state to applied laser light, which first hyperfine state is split from at least one other hyperfine state due to the zero-field hyperfine splitting and/or due to a static magnetic field (B0) generated by said preparation means, at least one cell (1) enclosing said plurality of thermal atoms (10), wherein said microwave is adapted to drive Rabi oscillations of said plurality of thermal atoms between said first hyperfine state and a second hyperfine state, the Rabi frequency of said Rabi oscillations being proportional to said magnetic field polarization component (B?, B?, B+) of said microwave, and an imaging means being designed to capture a state image of said plurality of atoms re

Abstract: The present invention relates to a method for the preparation of a strain-adapted vaccine specific for a bacterial strain, comprising the steps of: (a) genetically engineering a bacterial strain obtained from a subject, wherein said genetic engineering comprises introducing a nucleic acid molecule encoding a fusion protein, wherein the fusion protein comprises a bacterial membrane protein fused to at least one affinity tag, (b) growing the genetically engineered bacterial strain obtained in step (a) in solution, (c) isolating membrane vesicles from the growth culture of step (b) by affinity purification using the affinity tag, and (d) formulating the membrane vesicles isolated in step (c) into a strain-adapted vaccine. The present invention further relates to a nucleic acid molecule encoding a fusion protein comprising a bacterial membrane protein fused to at least one affinity tag and a kit comprising said fusion protein.

Abstract: Methods and apparatus are described for monocular 3D human pose estimation and tracking, which are able to recover poses of people in realistic street conditions captured using a monocular, potentially moving camera. Embodiments of the present invention provide a three-stage process involving estimating (10, 60, 110) a 3D pose of each of the multiple objects using an output of 2D tracking-by detection (50) and 2D viewpoint estimation (46). The present invention provides a sound Bayesian formulation to address the above problems. The present invention can provide articulated 3D tracking in realistic street conditions. The present invention provides methods and apparatus for people detection and 2D pose estimation combined with a dynamic motion prior. The present invention provides not only 2D pose estimation for people in side views, it goes beyond this by estimating poses in 3D from multiple viewpoints. The estimation of poses is done in monocular images, and does not require stereo images.

Abstract: The invention relates to the technical field of the histological preparation of biological tissue comprising a method and means for preparing transparent biological specimens for examination under a light microscope.

Abstract: The present invention relates to 3-(Indolyl)- and 3-(azaindolyl)-4-phenylmaleimide compounds of formula (I) wherein R1, R2 and R3 are as defined in the description, and the physiologically acceptable salts, solvates and solvates of the salts of the compounds of formula (I). The compounds of formula (I) are suitable for treating tumors.

Abstract: The invention relates to a thermo-pneumatic actuator having a cavity defined by walls and being hermetically sealed, which is inflated with a working medium that alters the gas pressure thereof when a temperature change occurs. A wall region of the cavity is constructed as a ductile membrane, which can be deflected in at least two working positions located on both sides of a neutral position, in which the membrane is curved in opposite directions to one another. In order to alter the gas pressure in the cavity, and to adjust the membrane from one working position to the other working position, a tempering device is heat-conductively connected to the working medium. In the neutral position, the membrane is compressively loaded such that respectively, it maintains its position in both working positions if no outside force impacts the membrane.