Abstract: The present invention relates to a structured monolayer that is composed of low-molecular aromatics and fully cross-linked in the lateral direction, the monolayer having a pattern of functional groups on one of the two surfaces, and to a method for preparing such a structured monolayer, as well as to the use thereof.

Abstract: A method of synthesizing Pyrazoles by means of the oxidative conversion of Enamines with suitable N-containing carboxylic acid derivatives in the presence of copper ions and 2-picolinic acid derivatives is provided.

Abstract: Devices for the in vitro aggregation of cells. The devices are characterized by containing special ground cavities allowing cluster formation to take place when a cell suspension is seeded onto the device. Further, the present invention relates to a method for aggregating cells and the use of the devices of the present invention for the aggregation of cells.

Abstract: The present invention relates to the novel compound classes of dendritic polyglycerol sulfates and sulfonates as well as to their production and use for the treatment of diseases, particularly inflammatory diseases, and to their use as selectin inhibitors and selectin indicators. The dendritic polyglycerol sulfates and sulfonates are also suitable for imaging diagnostics, particularly with respect to inflammatory diseases.

Abstract: The invention provides a method for predicting a hemorrhagic disorder in a patient consisting determining amine oxidase and, particularly, VAP-1 in a sample from said patient. The invention also provides pharmaceutical compositions comprising an inhibitor of amine oxidase and an antithrombotic agent as well as the use of an inhibitor of amine oxidase for treatment of hemorrhagic disorders.

Abstract: A method includes introducing the examination object into an examination region of a combination device; recording emission computed tomography data over a measurement period and storing detection events and detection instants associated therewith; measuring magnetic resonance data of at least two subregions of the examination region at at least two instants during the recording period of the emission computed tomography data and storing the magnetic resonance data and the recording instants; determining motion information describing a motion of a region of the examination object at a first instant relative to the position at a second instant from the magnetic resonance data recorded at the first instant and the second instant, for each subregion; determining a motion model describing motion of the examination object, for the entire object, from information for the subregions; and calculating motion-corrected emission tomography data from detection events, detection instants and the motion model.

Abstract: The present invention relates to a method for providing a fluid flow to a compressor system of a first turbo machine, wherein the compressor system includes at least one compressor housing in which at least one impeller is arranged and through which a compressor flow flows. The method includes feeding a primary fluid flow to a mixing region of the compressor system. The method further includes feeding a secondary fluid flow from an outside region of the compressor housing to the mixing region so that the secondary fluid flow mixes at least in part with the primary fluid flow to form a resulting fluid flow so that between the primary fluid flow and the secondary fluid flow a momentum exchange takes place, and so that the secondary fluid flow is promoted by the primary fluid flow. The method further includes feeding the resulting fluid flow to the compressor flow upstream of the impeller in the direction of the impeller.

Abstract: The present invention relates to the field of vaccination or immunization, in particular therapeutic vaccination, and diagnosis. Pharmaceutical compositions and kits capable of eliciting a protective immune response against polyoma virus JC (JCV) are disclosed, which may be used e.g., for therapy or for prevention of progressive multifocal leukoencephalopathy (PML) and/or progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome (PML-IRIS). Individuals in danger of such PML or PML-IRIS may, e.g., be immuno-compromised or immunosuppressed patients or patients having an autoimmune disease eligible for immunosuppressive treatment. The invention also relates to compositions comprising at least one CD4+ epitope of a JCV protein and to therapeutic, prophylactic and diagnostic uses thereof.

Abstract: The use of opioids or opioid mimetics is suggested for the manufacture of a medicament for the treatment of resistant cancer patients.

Abstract: The invention relates to a method for local high-doping and contacting of a semiconductor structure which is a solar cell or a precursor of a solar cell and has a silicon semiconductor substrate (1) of a base doping type. The high-doping and contacting is effected by producing a plurality of local high-doping regions of the base doping type in the semiconductor substrate (1) on a contacting side (1a) of the semiconductor substrate and applying a metal contacting layer (7) to the contacting side (1a) or, if applicable, one or more intermediate layers wholly or partially covering the contacting side (1a), to form electrically conductive connections between the metal contacting layer (7) and the semiconductor substrate (1) at the high doping regions.

Abstract: The invention relates to a method for producing substantially two-dimensional flat coils (28), wherein at least two cover plates (2, 3) that each have a cover surface (20) and a former (4) having a former surface (21) that is smaller than the cover surfaces are provided, wherein the former is releasably clamped between the two cover plates, such that at least some sections of lateral support surfaces (10) are formed by projecting sections (9) of the cover plates, wherein a coil conductor (25) for the geometry of the flat coil (28) is wound along the circumference of the former between the cover plates, and wherein the wound coil conductors (25) are fixed locally relative to one another through cut-outs (16) in at least one of the cover plates. The invention further relates to a corresponding winding device (1, 11, 22).

Abstract: The invention relates to a fundus camera that incorporates an integral imaging system for capturing an integral photograph of the fundus. This integral photograph enables projecting a three-dimensional image and generating topographical maps of the fundus. The fundus camera can function plenoptically and thus zoom onto a two-dimensional image generated from the integral photograph. The proposed equipment consists of an optical system for illuminating the fundus and an optical system forming the integral image capture system. This capture system includes an ophthalmoscopic lens, a microlens array and a sensor, and it allows recording, in a single shot, multiple views of the fundus. To improve the resolution of the integral photograph, the capture system has a device that allows displacing the microlens array by a few microns.

Abstract: A circuit arrangement for controlling the masking of test and diagnosis data with X values of an electronic circuit with N scan paths, wherein the test data are provided on insertion into the N scan paths by a decompressor with m inputs and N outputs (m<N) and wherein the masked test data are compacted by a compactor with N data inputs and n data outputs and m<N applies is provided.

Abstract: ?-Hairpin peptidomimetics of the general formula Cyclo(-Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11-Xaa12-Xaa13-Xaa14-), enantiomers and pharmaceutically acceptable salts thereof, with Xaa1-Xaa14 being amino acid residues of certain types which are defined in the description and the claims, have anti-infective activity, e.g. to selectively inhibit the growth of or to kill microorganisms such as Bacillus subtilis and/or Shigella boydii. They can be used as medicaments to treat or prevent infections or as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.

Abstract: Template-fixed ?-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 12, 14 or 18 ?-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid), are Gly, NMeGly, Pro or Pip, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have CXCR4 antagonizing properties. These ?-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.

Abstract: The present invention relates to a system for automatically distinguishing atrial flutter from atrial fibrillation based on a sequence of R-R-intervals of ECG-data. The system of the invention comprises means adapted to calculate or simulate an R-R-pattern from a model which is based on a periodic or almost periodic signal representing peaks of an atrial flutter signal, a first AV block scheme blocking respective ones of the atrial excitations while transmitting the others with a predetermined transmittal delay and at least one more AV-block scheme blocking respective ones of the excitations transmitted by the previous AV-block scheme and transmitting the others with a predetermined transmittal delay. The excitations transmitted by the last AV-block scheme constitute the calculated R-R-pattern.

Abstract: Biomaterials containing a three-dimensional polymeric network formed from the reaction of a composition containing at least a first synthetic precursor molecule having n nucleophilic groups and a second precursor molecule having m electrophilic groups wherein the sum of n+m is at least five and wherein the sum of the weights of the first and second precursor molecules is in a range from about 8 to about 16% b weight of the composition, preferably from about 10 to about 15%, more preferably from about 12 to about 14.5% by weight of the composition. In one embodiment, the first and second precursor molecules are polyethylene glycols functionalized with nucleophilic and electrophilic groups, respectively. In a preferred embodiment, the nucleophilic groups are amino and/or thiol groups and the electrophilic groups are conjugated, unsaturated groups.

Abstract: The invention relates to an anti-HSV antibody as defined in the claims, a pharmaceutical composition comprising of an effective amount of the said antibody, an expression vector comprising of a nucleotide sequence which encodes the said antibody, a host cell comprising of the said nucleotide sequence, a hybridoma cell capable of producing the said antibody and the use of the said antibody as a drug, in particular to use for the manufacture of a drug for the prophylactical or therapeutical treatment of HSV-associated diseases in a subject; as defined in the claims.

Abstract: A method for scaling two-dimensional structures, which is especially usable for resizing digital 2D images with a rational scaling factor, is based on efficient implementation of a diamond-shaped filter. The conventional “1”-diamond matrices of variable size are replaced by a (m×n) coefficient matrix. For any given rational scaling factor, the computational load for calculating an output pixel is reduced to filtering (m×n) input pixels with a corresponding (m×n) filter matrix. The coefficients of this filter matrix depend from the phase of the output pixel to be calculated and the factor of interpolation, but are always integer numbers. The coefficients may be stored in lookup tables (LUT), which leads to a very efficient implementation of the inventive method. In one embodiment, a (3×3) coefficient matrix has been found to be advantageous.

Abstract: Described is a chimeric peptide, comprising, in order, (a) a first detectable label (b) a cAMP binding moiety having only one cAMP binding site and (c) a second detectable label least two detectable labels is describe. The chimeric peptide is useful for direct determination of cAMP concentration in vitro and/or in vivo. Also described are nucleic acids encoding the chimeric peptide, methods of making and modifying the chimeric peptide, a method for determining the cAMP concentration, and kits.