Abstract: The present invention relates to imidazolium salts, particularly imidazolium salts of the general formula I as well as the respective carbene metal complexes and their utilisation as bioanalytical tags for biomolecules.
Abstract: A process for the electrochemical deposition of nanoscale catalyst particles using a sacrificial hydrogen anode as counter electrode for the working electrode is disclosed, whereby a concurrent development of hydrogen at the working electrode is mostly or completely avoided.
Abstract: The invention relates to a method for heating and cooling a working fluid (2) using at least one thermochemical heat accumulator medium (3), wherein the working fluid (2) is guided through at least one thermochemical heat accumulator (6) comprising the heat accumulator medium (3), wherein the working fluid (2) is guided without contact to the heat accumulator medium (3), wherein upon charging of the heat accumulator medium (3) a heat flow (Q) is transferred from the working fluid (2) to the heat accumulator medium (3) and at least one substance (15) is released from the heat accumulator medium (3) and discharged from the heat accumulator (6), and wherein upon discharging of the heat accumulator medium (3) the substance (15) is fed with release of heat to the heat accumulator medium (3) or at least to a reaction product of the heat accumulator medium (3) that was produced during charging of the heat accumulator medium (3), and a heat flow (Q) is transferred to the working fluid (2).
Abstract: A device for combined optical and nuclear image comprises a nuclear image acquisition module and a reference image acquisition module. The reference image acquisition module has: an optical image sensor and an optical imaging system for deflecting the optical radiation from a reference field of view to the image sensor, wherein the optical imaging system comprises a mirror for the optical radiation, which mirror is arranged between the reference field of view and the optical image sensor. On the image sensor, a respective image area is assigned to at least one of nuclear partial fields of view. The optical imaging system is arranged such that the optical radiation coming from the at least one nuclear partial field of view is deflected substantially exactly to the respectively assigned of the image areas.
Abstract: The present invention is concerned with the provision of a polynucleotide encoding an AAV capsid polypeptide comprising an inserted peptide and a vector comprising said polynucleotide. Moreover, contemplated is a host cell comprising said polynucleotide or vector, a method for the manufacture of said capsid polypeptide as well as said polypeptide. Further included is an antibody specifically binding to said polypeptide and a medicament comprising said polynucleotide, vector, polypeptide, or antibody. Also contemplated are the use of said polynucleotide, vector, polypeptide, or antibody for the manufacture of a medicament for the treatment of vascular disease and a method for the identification of a compound binding to said polypeptide.
Abstract: The invention relates to a device for an atomic force microscope (AFM) for the study and/or modification of surface properties. The device comprises a cantilever (flexible bar) having an integrated, piezoresistive sensor, an integrated bimorphic actuator, and a measuring tip. The measuring tip carries at least two metal electrodes, which can be activated via electrical terminals. The measuring tip and/or the cantilever have at least one nanoscopic hole through which synchrotron radiation or laser light is directed onto the material surface to be studied. Furthermore, the invention relates to a method for the study and modification of surface properties and surface-proximal properties, which can be executed using such a device. To this end, atomic force microscopy (AFM), surface enhanced Raman scattering (SERS), photo emission spectroscopy (XPS, XAS), and material modification by local exposure are executed in sequence or simultaneously using the same device.
Type:
Grant
Filed:
December 10, 2008
Date of Patent:
July 2, 2013
Assignees:
Technische Universitat Ilmenau, Synchrotron Soleil, The Regents of the University of California
Inventors:
Stefan Kubsky, Deirdre Olynick, Peter Schuck, Jan Meijer, Ivo W. Rangelow
Abstract: The invention relates to a device and method for measuring the density of a plasma by determining an impulse response to a high-frequency signal coupled into a plasma. The density, electron temperature and/or collision frequency as a function of the impulse response can be determined. A probe having a probe head and a probe shaft can be introduced into the plasma, wherein the probe shaft is connected to a signal generator for electrically coupling a high-frequency signal into the probe head. The probe core is enclosed by the jacket and has at its surface mutually insulated electrode areas of opposite polarity. A balun is arranged at the transition between the probe head and an electrically unbalanced high-frequency signal feed to convert electrically unbalanced signals into balanced signals.
Type:
Application
Filed:
October 6, 2011
Publication date:
June 27, 2013
Applicant:
RUHR-UNIVERSITÄT BOCHUM
Inventors:
Ralf Peter Brinkmann, Jens Oberrath, Peter Awakowicz, Martin Lapke, Thomas Musch, Thomas Mussenbrock, Ilona Rolfes, Christian Schulz, Robert Storch, Tim Styrnoll, Christian Zietz
Abstract: The disclosed invention relates to peptides incorporating 3-aminoadamantane-1-carboxylic acids. These peptides are disclosed as surprisingly possessing neurogenic and neurotrophic properties. These pharmacological activities can advantageously be utilized for restoring or maintaining neuronal function in the CNS. In particular, the compounds can be used for treatment and prophylaxis of neurodegenerative diseases, e. g., Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, as well as in post-acute traumatic brain injury, or cerebral ischemia.
Abstract: A method is described for producing a radionuclide product B. A target is provided which includes an amount of a nuclide A. A gamma (?) beam from Compton back-scattering of laser light from an electron beam irradiates the target and thereby transmutes at least a portion of the amount of the nuclide A into the product B. Providing the target includes selecting a nuclide A which is transmutable into product B by a gamma (?) induced nuclear reaction.
Type:
Application
Filed:
February 19, 2013
Publication date:
June 27, 2013
Applicants:
Institut Max von Laue - Paul Langevin, Ludwig-Maximilians-Universitat Munchen
Inventors:
Ludwig-Maximilians-Universitat Munchen, Institut Max von Laue - Paul Langevin
Abstract: The present invention relates to methods for purification of Vaccinia viruses (VV) and/or Vaccinia virus (VV) particles, which can lead to highly pure and stable virus preparations of predominantly biologically active viruses. The invention encompasses purifying a virus preparation in a sterilized way with high efficiency and desirable yield in terms of purity, biological activity and stability, aspects advantageous for industrial production.
Abstract: The invention relates to a method for producing a solar cell and to a solar cell which can be produced accordingly. On a solar cell substrate, first a ridged texture, which may for example comprise pyramids produced by alkaline etching, is formed both on a front face and on a rear face of the solar cell substrate. Then an etching barrier layer is applied to the front face of the solar cell substrate. Next the texture on the rear face of, the solar cell substrate is smoothed by etching in an isotropically acting etching solution which for example contains acid, wherein the front face is protected by the etching barrier layer. Thus, ridged structures on the rear face can be avoided and in this way reflection can be increased and surface passivation can be improved, both of which can lead to an increased potential efficiency.
Abstract: The compounds of formula (I) substantially in exo form or salts thereof, wherein: X is a biradical selected from —(CH2)n—*, —(CH2CH2O)nCH2CH2—*, methylcyclohexyl and methylphenyl; n is an integer ranging between 1 and 30; Y is a radical selected from —COOH, a substituted phosphoramidite radical and N-hydroxysuccinimide ester (or other active ester) of carboxylic acid; and * represents the place through which X binds to Y, are useful in a general process for solid-phase preparation of maleimide-oligonucleotide derivatives.
Type:
Application
Filed:
May 2, 2011
Publication date:
June 20, 2013
Applicant:
UNIVERSITAT DE BARCELONA
Inventors:
Ana María Grandas Sagarra, Albert Sánchez González, Enrique Pedroso Muller
Abstract: The present invention relates to a cement based on magnesium sodium phosphate with clinical applications in bone surgery and odontology. This cement has an intrinsic antimicrobial effect as its main property. It also has a fast setting time, along with a high short-term compressive strength. Another property inherent to these cements is their adhesive character. Use of the cement is indicated for bone and dental applications, as well as filling bone defects or sealing dental cavities. The cement is especially indicated in cases in which an antimicrobial effect and/or adhesive properties are necessary.
Type:
Application
Filed:
March 11, 2011
Publication date:
June 20, 2013
Applicant:
Universitat Politecnica De Catalunya
Inventors:
Maria Pau Ginebra Molins, Gemma Mestres Beà
Abstract: A method for producing a component from a fibre composite. A number of layers of a dry fibrous material are stacked to form a pile, the pile is covered by a thermoplastic film in a gas-tight manner, the inner space occupied by the pile within the film is pumped dry and the layers are fixed to form a preform that is stable during transport, the preform is reshaped, a liquid thermosetting material is inserted into the inner space by infiltration of the fibrous material, and the preform is hardened with the infiltrated fibrous material to form the finished component, the film binding permanently as the surface. The invention also relates to a component produced in such a way, and to a corresponding preform. The production method provides a process-integrated surface finishing of the fibre composite. The surface properties are created by the bound thermoplastic film.
Abstract: The present invention is related to a method of determining a test compound's ability to modify the biological activity of a GPR17. Said method comprises, among others, the step of contacting the test compound with a GPR17, or a functional GPR17 fragment in the presence of a suitable amount of a GPR17 agonist of formula I.
Abstract: A method for producing a selective doping structure in a semiconductor substrate in order produce a photovoltaic solar cell. The method includes the following steps: A) applying a doping layer (2) to the emitter side of the semiconductor substrate, B) locally heating a melting region of the doping layer (2) and a melting region of the semiconductor substrate lying under the doping layer (2) in such a way that dopant diffuses from the doping layer (2) into the melted semiconductor substrate via liquid-liquid diffusion, so that a high doping region (3) is produced after the melt mixture solidifies, C) producing the planar low doping region by globally heating the semiconductor substrate, D) removing the doping layer (2) and E) removing or converting a layer of the semiconductor substrate on the doping side in such a way that part of the low doping region and of the high doping region close to the surface is removed or is converted into an electrically non-conducting layer.
Type:
Application
Filed:
June 16, 2011
Publication date:
June 20, 2013
Applicant:
ALBERT-LUDWIGS-UNIVERSITAT FREIBURG
Inventors:
Ulrich Jäger, Daniel Biro, Anne-Kristin Volk, Johannes Seiffe, Sebastian Mack, Andreas Wolf, Ralf Preu
Abstract: The present invention provides nano-, meso- and micro-polymer particles which are able to bind pathogenic proteins penetrating into the lining layer of the lung. Known pathogenic proteins in the pulmonary lining layer are negatively charged. These proteins damage the pulmonary surfactant system which is essential to maintain a low surface tension in the lung and thus a functional respiration. Polymer particles of this invention have a diameter between 20 nm and 10 ?m, are water-insoluble, have a positive surface charge and a low surface hydrophobicity. The isoelectric point of said particles is greater than 5 to that said particles are present in the lining layer of the lung as positively charged particles, and at the same time higher than the isoelectric point of the pathogenic protein to be bound. Polymer particles of this invention can for example be prepared using the precipitation or emulsion method.
Type:
Application
Filed:
July 18, 2011
Publication date:
June 13, 2013
Applicant:
Justus-Liebig-Universitat Giessen
Inventors:
Moritz Beck-Broichsitter, Thomas Schmehl, Tobias Gessler
Abstract: The invention relates to a method for establishing fundamental frequency curves of a plurality of signal sources from a single-channel audio recording of a mix signal, said method including the following steps: a) establishing the spectrogram properties of the pitch states of individual signal sources with use of training data; b) establishing the probabilities of the fundamental frequency combinations of the signal sources contained in the mix signal by a combination of the properties established in a) by means of an interaction model; and c) tracking the fundamental frequency curves of the individual signal sources.
Type:
Application
Filed:
February 22, 2011
Publication date:
June 13, 2013
Applicant:
TECHNISCHE UNIVERSITAT GRAZ
Inventors:
Michael Stark, Michael Wohlmayr, Franz Pernkopf
Abstract: A composition for the adhesive bonding and/or fixing of biological and/or synthetic tissues includes the components: a) a nitrogen-functionalized polysaccharide; and b) a terminally functionalized oligolactone.
Type:
Grant
Filed:
August 1, 2008
Date of Patent:
June 11, 2013
Assignees:
Aesculap AG, Universitat Rostock
Inventors:
Erich Odermatt, Jürgen Wegmann, Katrin Sternberg, Detlef Behrend
Abstract: A ferroic component is described, comprising a ferroic layer (10) arranged between two electrodes (12,13), a thin-film field-effect transistor (4) whose gate electrode (3) forms one of the two electrodes (12, 13) of the ferroic layer (10) which is joined to the gate electrode (3) via an intermediate layer (11) acting as a bonding agent, and a substrate that is used as a support. In order to obtain a flexible component it is proposed that the thin-film field-effect transistor (4) on the one hand and the ferroic layer (10) which consists of an internally charged cellular polymer on the other hand are applied to the substrate which is arranged as a flexible plastic film (1), optionally by interposing an insulating layer (2) therebetween.
Type:
Grant
Filed:
January 25, 2007
Date of Patent:
June 11, 2013
Assignee:
Universität Linz
Inventors:
Siegfried Bauer, Ingrid Graz, Reinhard Schwödiauer, Christoph Keplinger, Martin Kaltenbrunner, Stéphanie Perichon Lacour, Sigurd Wagner