Abstract: In a method and magnetic resonance (MR) apparatus for MR image reconstruction, an image reconstruction algorithm is used that operates on one calibration matrix that is formed by reorganizing a number of individual, undersampled k-space data sets respectively acquired by multiple reception coils in a parallel MR data acquisition from a subject exhibiting motion. The motion causes the k-space data sets to exhibit errors. In order to use the calibration matrix in the reconstruction algorithm, it is subjected to an iterative rank reduction procedure in which, in each iteration, a residual is calculated for each data point that represents how poorly, due to motion-induced corruptions, that data point satisfies the low rank constraint, and non-satisfying data points are removed from the data point for the next iteration. The resulting low rank matrix at the end of the iterations is then used to produce images with fewer motion-induced errors.

Abstract: The present invention relates to the general field of the treatment and prevention of diseases involving an inflammatory condition, namely sepsis or infectious or viral diseases as well as diseases requiring for the of treatment an immunosuppressive activity namely autoimmune diseases and graft rejection. In particular, the invention relates to an inhibitor of the activity or the formation of the PP1/GADD34 complex for the treatment of a condition requiring an immunosuppressive activity or an anti-inflammatory activity.

Abstract: A method for controlling the distribution of the RF magnetic field in a magnetic resonance imaging system, having steps of: placing a cage coil in a permanent magnet supplying a permanent magnetic field along a first axis, and supplying an RF signal to the cage coil in order for the coil to generate an RF magnetic field rotating in a plane that runs perpendicular to the first axis; and putting in place an electromagnetic resonator, the resonance mode of which is excited by the rotating magnetic field, the resonator being placed in a position inside or outside the cage coil and at a distance from a region to be analyzed of an object to be placed in the cage coil, the resonance mode and the position of the resonator in relation to the volumetric antenna being suitable for adjusting the intensity of the rotating magnetic field in an area of the region to be analyzed.

Abstract: A method for producing an MRI image includes the steps of acquiring lines of a volume under analysis using a steady-state gradient echo sequence in successive repetition times (TR); and applying an inhomogeneous magnetization transfer (ihMT) pre-saturation module (TMT) in each repetition time. The duration of the repetition times is greater than 20 milliseconds.

Abstract: The present invention relates to the field of human fertility treatment. The present invention more specifically relates to the identification of soluble CD146 (sCD146) as a biomarker which, when measured in an embryo culture medium, can be used to determine whether the embryo can be selected for implantation in the uterus of a mammal or not. The present invention thus provides a new tool and related kits to (pre)select embryo eligible for implantation. The invention also relates to methods for promoting pregnancy in a human who undergoes embryo transfer.

Abstract: An antenna array includes a plurality of linear electromagnetic resonators having longitudinal axes oriented parallel to one another and not aligned, and at least one decoupling device arranged between two the linear electromagnetic resonators, wherein the decoupling device comprises a plurality of open-loop electromagnetic resonators that are matched to a frequency located in the bandwidth of the two the adjacent linear electromagnetic resonators, that are electrically insulated and that are arranged in a plurality of planes that are not parallel to a plane containing the longitudinal axes of the two the linear electromagnetic resonators. Nuclear magnetic resonance imaging apparatus comprising such an antenna array is also provided.

Abstract: The present invention relates to compositions and methods for modulating angiogenesis in vivo, ex vivo or in vitro. More particularly, the invention relates to a soluble CD146 protein usable in the context of human therapy, as well as to corresponding antibodies. Particular forms of CD146, herein described, may be used to mobilize, in vivo or ex vivo, both mature and immature endothelial cells, as well as to increase their influence on angiogenesis. The invention also relates to compositions comprising such compounds, particularly pharmaceutical or diagnostic compositions, including kits and the like, as well as methods of therapy or diagnosis using said compounds, compositions and cells.

Abstract: A sample holder for the measurement of nuclear heating in a nuclear reactor, comprises: a body configured to contain a heat-sensitive sample along a longitudinal axis; and means for removing heat from the body to the exterior of the sample holder, wherein the means for removing heat from the body to the exterior of the sample holder comprise: a peripheral structure located on the periphery of the body; and a central structure mechanically linking the body and the peripheral structure, the central linking structure being configured to transfer heat radially, i.e. perpendicularly to the longitudinal axis, between the body and the peripheral structure. A calorimeter cell for the measurement of nuclear heating in a nuclear reactor, comprises: at least one sample holder; a seal-tight casing in which the sample holder is placed; and temperature-measuring means.

Abstract: The invention relates to a heated sensitive layer sensor comprising an insulating substrate bearing the sensitive layer; two complementary measurement electrodes in the form of two adjacent conductive tracks configured in electrical contact with the sensitive layer; and a heating element in the form of a resistive track arranged on the substrate for uniformly heating an active area of the sensitive layer. The resistive track comprises at least three power supply points regularly spaced over the length of the resistive track, and each point of even rank is supplied at a first supply voltage and each point of odd rank is supplied at a second supply voltage.

Abstract: The disclosure relates to a layer comprising at least one hydrophilic part and at least one hydrophobic part, the layer comprising self-assembled amphiphilic molecules polymerized with each other on both the hydrophilic part and the hydrophobic part of the layer; a detecting device comprising a substrate and the above-mentioned layer; and a liposome, a micelle, transport system for a substance and a biomimetic system comprising the above-mentioned layer. The disclosure also relates to a process for producing a layer, the process comprising: providing amphiphilic molecules; allowing sufficient time for the amphiphilic molecules to self-assemble and form at least one hydrophilic part and at least one hydrophobic part of the layer; polymerizing the self-assembled amphiphilic molecules with each other on both the hydrophilic part and the hydrophobic part of the layer.

Abstract: The present invention provides antibodies directed against ICOS or a derivative thereof which neutralize ICOS engagement on Treg by inhibiting the fixation between ICOS and ICOS-L and abrogate proliferation of Treg induced by plasmacytoid dendritic cells. The present invention further provides antibodies directed against ICOS or a derivative thereof which induce IL-10 and IFN? production, induce CD4? T cells proliferation, reduce Tconv proliferation, and increase the immunosuppressive function of Treg.

Abstract: A method for producing a device for detecting flux of neutrons with parameters in predetermined ranges, including: one phase of determining parameters, including: simulating penetration of a flux of incident neutrons with parameters in the predetermined ranges through a modelled stack including in succession and in order at least: one first electrode; one substrate including: a first layer; and a second layer; and one second electrode; and simulating at least one defect peak created in the first layer by vacancies and/or ionization of the particles generated by collisions between neutrons of the flux of incident neutrons and atoms of the second dopant species; and identifying depth of the defect peak closest the interface between the first and second layers of the modelled stack.

Abstract: A blood flow reducer (20) for insertion in a blood vessel, the reducer (20) being adapted to be deformed from a first configuration to an expanded configuration, wherein, in the expanded configuration, the reducer (20) defines an axial lumen (40) for allowing blood flow therethrough, the axial lumen (40) having a smallest cross-section, the reducer (20) has a largest cross-section, and the smallest cross-section is comprised between 20% and 90% of the largest cross-section. In particular, the smallest cross-section is strictly comprised between 70% and 90% of the largest cross-section. A method for preconditioning a liver of a living being before partial hepatectomy, wherein a 10 to 30% stenosis is created in a branch of a portal vein conducting blood to a first liver lobe.

Abstract: Described herein are anti-CD277 antibodies which: activates or inhibit the cytolytic function of V?9/V?2 T cells, and/or costimulates T cells together with CD3-TCR, and/or costimulates T cells in addition to CD28-B7 costimulation, and/or increases the activity and/or survival of monocytes and dendritic cells. The use of said antibodies in therapy is also described.

Abstract: A solid organic material comprising at least one amphiphilic block copolymer of the methacrylic type, the block copolymer being dispersed in a polymer matrix, the block copolymer having a number-average molar mass (Mn) greater than or equal to 20 000 g/mol; a method for preparing said solid organic material; use of said solid organic material for antibacterial, antimicrobial, antiviral, anti-inflammatory and/or antifungal applications; a medical device comprising said solid organic material.

Abstract: The invention relates to methods and compositions comprising a macrophage colony stimulating factor (M-CSF) polypeptide or an agonist of the M-CSF receptor for preventing or treating myeloid cytopenia and related complications (such as infections) in a patient in need thereof (such as a patient undergoing hematopoietic stem cell transplantation).

Abstract: The present invention relates generally to proteasome inhibiting ?-lactam compounds useful for the treatment of cancer and neurodegenerative disorders. The invention also provides pharmaceutical compositions and extended release formulations of said compounds, and medical uses of said compounds and/or pharmaceutical compositions to treat cancer and neurodegenerative disorders.

Abstract: An instrumented interface for quantifying at least one physiological parameter of the upper limbs of a person, capable of being secured to a gripping device, and including at least one gripping system which the person can hang from, the instrumented interface including at least one force sensor which measures a deformation of the interface when a person exerts a force on the interface via the one gripping device, and is capable of producing a value that translates a force value.

Abstract: The present invention relates to antibodies having specificity to nectin-4 and uses thereof.

Abstract: The present invention relates to a polyvalent culture medium for anaerobic bacteria under aerobic conditions in blood culture bottles. The present invention provides a polyvalent culture medium for culture in aerobic atmosphere of anaerobic bacteria or aerobic bacteria comprising a basal culture medium for bacteria characterized in that it further comprises a mixture of the following antioxidant compounds: sodium hydrosulphide (Na2S), L-cysteine, ascorbic acid, glutathione, catalase, ubiquinol and lipoic acid.