Abstract: The invention relates to a device comprising a body and a set of vibration absorbers mounted on the body, each absorber being movable relative to the body between a first position and a second position, each absorber being capable of oscillating relative to the body between its first and second positions, a first natural frequency being defined for each absorber, at least one absorber having a first natural frequency different from the first natural frequency of another absorber. Each absorber comprises at least one deformation part capable of deforming as the vibration absorber oscillates between its first position and its second position, the deformation part having at least two faces configured to rub against each other during the deformation of the deformation part.

Abstract: A biosensor assembly includes a plurality of biosensor units which are juxtaposed next to one another. Respective portions of a continuous piezoelectric monocrystal layer are dedicated to the biosensor units, and Bragg solid bulk structures are arranged on the piezoelectric layer between the portions thereof that pertain to neighboring biosensor units. Each Bragg structure has a pattern repetition direction that is parallel to the piezoelectric layer, and is designed for confinement of elastic vibrations and suppressing cross-talk between the biosensor units. The biosensor assembly can be manufactured from a piezoelectric wafer with low cost price.

Abstract: A method for manufacturing an ion sensor, especially a pH measurement sensor, based on optical fibre, including the following steps: cleaving the optical fibre, with free hydroxyl groups appearing on the cleavage surface, grafting a layer of trifunctional silane directly on free hydroxyl groups having appeared accordingly on the cleavage surface of the optical fibre, without a prior external activation step, grafting a layer of difunctional silane on the cleavage surface of the optical fibre, and grafting a fluorescent dye.

Abstract: The present invention is relative to an isolated nucleic acid molecule encoding a chimeric antigen receptor (CAR), wherein the CAR comprises an antibody or antibody fragment which includes a anti-IL-1RAP binding domain, polypeptides encoded by this nucleic acid molecule, isolated chimeric antigen receptor (CAR) molecule comprising such an antibody or antibody fragment, a vector comprising a nucleic acid molecule encoding a CAR, as well as a T cell comprising this vector. The present invention is also relative to the use of this T cell (autologous or allogeneic) expressing a CAR molecule to treat a proliferative disease in a mammal.

Abstract: Disclosed is a device and a method for storing and transporting at least one human or animal tissue with a view to transplantation or ex vivo experimentation. The device can store such tissue in a specific storage medium until the transplantation or the ex vivo experimentation, and in particular to storing a sample of human or animal cornea, such as a corneal graft. This device for storing at least one human or animal tissue comprises at least one chamber which is suitable for receiving and storing the tissue in a liquid storage medium and which comprises means for continuous renewal of the medium in said at least one chamber. The device additionally comprises means for adjusting at least one physicochemical parameter of said medium, including its pH, by continuous circulation of a buffer gas in said at least one chamber outside of and in contact with said medium.

Abstract: A composition including a supernatant obtained from co-culture of phagocytes with apoptotic cells. The composition is obtained by a) providing phagocytes, b) providing apoptotic cells, c) optionally washing the cells from step a) and b), d) co-culturing the cells of step a) and b), and e) separating the supernatant from the cells. The composition may be used in preventing or treating a pathological immune response.

Abstract: A process for fabricating a micro-electro-mechanical system, includes the following steps: production of a stack on the surface of a temporary substrate so as to produce a first assembly, comprising: at least depositing a piezoelectric material or a ferroelectric material to produce a layer of piezoelectric material or of ferroelectric material; producing a first bonding layer; production of a second assembly comprising at least producing a second bonding layer on the surface of a host substrate; production of at least one acoustic isolation structure in at least one of the two assemblies; production of at least one electrode level containing one or more electrodes in at least one of the two assemblies; bonding the two assemblies via the two bonding layers, before or after the production of the at least one electrode level in at least one of the two assemblies; removing the temporary substrate.

Abstract: A layered solid element includes a ferroelectric layer of a crystalline material Li1?x(Nb1?yTay)1+xO3+2x?z which has X- or 33° Y-orientation with respect to a substrate of the layered solid element. The ferroelectric layer is grown epitaxially from a buffer layer having of one of the chemical formulae LkNirO1.5·(k+r)+w or Ln+1NinO3n+1+?, where L is a lanthanide element. Such layered solid element may form a thin-film bulk acoustic resonator and be useful for integrated electronic circuits such as RF-filters, or guided optical devices such as integrated optical modulators.

Abstract: Disclosed is a device for mechanically characterizing an element of interest, for example an oocyte. The mechanical characterization device includes: a support receiving a container suitable for containing a liquid medium; a holder for holding the element of interest; an indenting member; a magnet for generating a magnetic field in which the indenting member is intended to move and which participates in suspending the indenting member with an unstable horizontal direction oriented coaxially to the longitudinal axis; a controller to control the magnet to maneuver the indenting member in translation along the unstable horizontal direction; and a component for determining the mechanical characteristics of the element of interest.

Abstract: A process for delaying a useful optical signal (P1) having a wavelength value ? between 0.2 ?m and 3 ?m, with respect to a reference optical signal (P2) having the same wavelength value ?. The process includes having the useful optical signal propagate along a tapered fiber portion. A length of the tapered fiber portion can be varied using stretching means that are light, less cumbersome and less expensive compared to those necessary for a standard optical fiber. In addition, the delay value which is effective for the useful optical signal can be varied over a wide range. Such process can be useful for interferometry measurements in particular.

Abstract: A detector of high-energy (higher than 100 eV) ionising radiation, including an optical fibre having an outside diameter, called the fibre diameter, smaller than 250 microns, including a fibre core, a first cladding, called the useful cladding, encircling the fibre core and a second cladding, called the protective cladding, encircling the useful cladding, and a scintillating layer provided to convert the ionising radiation into light; including a portion, called the detecting portion, arranged in a length of the fibre and having a void formed in the protective cladding, in the useful cladding, and possibly in the fibre core, the scintillating layer being arranged in the void in contact with the useful cladding and the fibre core.

Abstract: A method for diagnosing the operating state of an electrochemical system in real-time comprising a stack of cells, said method comprising steps for performing voltage measurements of said cells. Said method further comprises: real-time processing of the voltage measurements (61) thus performed, in order to extract specific waveforms (40) therefrom, converting said specific waveforms in order to generate specific points (65) therefrom of the real-time operation of the electrochemical system, and comparing these specific points of the real-time operation and specific points (75) of an off-line operation of the electrochemical system that originate from a conversion of specific waveforms (74) extracted from voltage measurements (78) performed off-line, while the electrochemical system is placed in known operating states including fault states, so as to produce information (69) relating to the real-time operating state of the electrochemical system.

Abstract: The invention is relative to monoclonal anti-CD123 antibodies, or fragments thereof that specifically bind to the alpha chain of the human interleukin 3 (IL3) receptor. Further, the invention is relative to an isolated nucleic acid molecule encoding a chimeric antigen receptor (CAR), wherein the CAR comprises an antibody or an antibody fragment which includes an anti-CD123 binding domain, a transmembrane domain, and an intracellular signaling domain comprising at least a stimulatory domain, polypeptides encoded by said nucleic acid molecule as well as an isolated chimeric antigen receptor (CAR) molecules comprising such an antibody or antibody fragment. The invention is also relative to a vector comprising a nucleic acid molecule encoding a CAR, as well as a T cell comprising said vector, and to the use of a T cell expressing a CAR molecule for a treatment of a proliferative disease in a mammal, such as cancer.

Abstract: A movement amplifying actuation device may include two piezoelectric beams, one beam being attached at a fixed point, and a hinge connecting a first beam and a second beam between them. Each hinge may include a first flexible portion connected to the first beam, a second flexible portion connected to the second beam, a first rigid portion connecting the first and second flexible portions, a second rigid portion capable of being positioned against a fixed point, and a third flexible portion connecting the second beam to the second rigid portion at a pivot point of the second beam such that the assembly formed by the second rigid portion and the second beam forms a lever around the pivot point. The flexible and rigid portions may form a single piece.

Abstract: A particulate structure that includes a/ a biodegradable polymer particle, b/ gold nanoparticles covered on their surface with macrocyclic chelators complexing at least one ion of interest and/or a radionuclide for medical imaging, c/ a polycation having a positive charge over a pH range from 5 to 11, the gold nanoparticles b/ being encapsulated in the polymer particle a/ and/or adsorbed at the surface of the polymer particle a/. Also, a method for preparing the particulate structures. Further, the use of the particulate structures for radiotherapy or chemotherapy in the context of cancer treatment.

Abstract: A device for diagnosing the ventilatory efficacy of a patient under respiratory assistance, said device being intended to cooperate with a system for ventilating the patient, the device having: a bidirectional thermal mass sensor for measuring, in real time, the air flows during insufflation and during exhalation, an electronic casing connected to said sensor and configured to receive and process data relating to the air flows measured by the sensor, the electronic casing having: i. a user interface comprising a display device and data input means, ii. a data-processing center, the data-processing center functioning according to programmed algorithms for acquiring, processing and displaying the data, for analyzing the efficacy of the ventilation in real time, and for managing alarms, and iii. means for supplying electricity.

Abstract: An H2S sensor includes at least one acoustic wave transducer and a film having a polymer matrix. The polymer matrix includes carboxylate functional groups and lead or zinc cations. The film may have a thickness of between a hundred nanometres and a 2 microns The H2S sensor optionally includes an antenna to remotely interrogate the H2S sensor.

Abstract: Disclosed is a device for measuring radiation doses absorbed by a gel dosimeter, including in particular a polarizer for a light beam according to at least two distinct polarization angles, the polarizer being positioned between a light source and an optical detector, a unit for measuring the value of the intensity of the light beam, which intensity is measured by the optical detector, and a unit for calculating the value of a ratio of intensities of the light beam, which intensities are measured by the optical detector, for two distinct polarization angles of the light beam that is selected by the polarizer.

Abstract: Some embodiments are directed to an elementary acoustic metamaterial cell, including a body made of solid material and at least one resonator defining a groove of width l and depth p, the groove being open on the surface of the body, wherein the depth p is set by a resonant frequency (f) of the cell according to a relationship x, c being the speed of sound in air and the width l is set by an energy density confined in the cell according to a logarithmic relationship Emax ?log (l) determined experimentally, the groove having an acoustic absorption controlled by a ratio between the depth p and the width l of the groove. Some embodiments are also directed to an acoustic screen including such an elementary cell.

Abstract: The invention relates to a haptic feedback device comprising: a body (10) able to form an interface with a user; contacting means (20) able to establish a contact with a surface (2) of a system (3) able to contain information; a first actuator (30) linked to the contacting means and able to apply a translational movement to said contacting means with respect to said body; braking means (40) able to apply a mechanical resistance to the relative movement between the contacting means (20) and the body (10); a second actuator (50) able to make the mechanical resistance applied by the braking means (40) vary.