Abstract: Movement amplifying actuation device (100) comprising at least two piezoelectric beams (101, 102, 103), one beam (101) being attached at a fixed point (111), and at least one hinge (131, 132) connecting a first beam (101, 102) and a second beam (102, 103) between them. Each hinge comprises: a first flexible portion connected to the first beam, a second flexible portion connected to the second beam, a first rigid portion connecting the first and second flexible portions, a second rigid portion capable of being positioned against a fixed point (112, 113), and third flexible portion connecting the second beam to the second rigid portion at a pivot point of said second beam such that the assembly formed by the second rigid portion and the second beam forms a lever around said pivot point. Said flexible and rigid portions form a single piece.

Abstract: The invention relates to a haptic feedback device comprising: a body (10) able to form an interface with a user; contacting means (20) able to establish a contact with a surface (2) of a system (3) able to contain information; a first actuator (30) linked to the contacting means and able to apply a translational movement to said contacting means with respect to said body; braking means (40) able to apply a mechanical resistance to the relative movement between the contacting means (20) and the body (10); a second actuator (50) able to make the mechanical resistance applied by the braking means (40) vary.

Abstract: The invention relates to a gas cell for an atomic sensor, comprising an optical cavity provided with at least one optical window (9) and fillable with a gas. The cell also comprises a sealing cup comprising a cavity mouth, a channel mouth, and a sealing access, as well as a membrane which hermetically closes the sealing access of the sealing cup. The membrane can be plastically deformed by heating so as to hermetically close the cavity mouth and/or the channel mouth, in such a way as to hermetically separate the optical cavity from the gas inflow channel.

Abstract: A composition including a supernatant obtained from co-culture of phagocytes with apoptotic cells. The composition is obtained by a) providing phagocytes, b) providing apoptotic cells, c) optionally washing the cells from step a) and b), d) co-culturing the cells of step a) and b), and e) separating the supernatant from the cells. The composition may be used in preventing or treating a pathological immune response.

Abstract: The invention relates to a peptide of 15 to 20 amino acids deriving from TERT protein, which peptide is capable of (i) binding to HLA class II and (ii) stimulating a CD4 Th response. These universal cancer peptides are especially useful in anti-tumor immunotherapy and immunomonitoring.

Abstract: Provided herein is a method for treating or preventing a pathological immune response comprising administering a supernatant obtainable from co-culture of phagocytes with apoptotic cells.

Abstract: Some embodiments are directed to a parallel robotic structure with six degrees of freedom, comprising movable bases that can be rotated or translated. A platform coupled with the movable bases by moving elements, wherein the platform is made up of two rigid elements connected to one another by a single articulation. This parallel robotic structure makes it possible to perform cutting, gripping and manipulating operations simultaneously with six degrees of without requiring an additional tool. The gripping functionality is provided due to the articulated platform, which is an integral part of the mechanical architecture and can be entirely controlled by the offset actuators located in the stationary base.

Abstract: Some embodiments are directed to a method for manufacturing photonic waveguides and to photonic waveguides manufactured by this method.

Abstract: A process for surface treatment of metal substrates, including the steps of: providing a metal substrate including hydroxyl groups at its surface; bringing the metal substrate into contact with a solution of at least one organophosphorus compound to enable the reaction of the hydroxyl groups at the surface of the metal substrate with the organophosphorus compound to form a monomolecular layer over the surface and a second layer of physisorbed organophosphorus molecules at least preponderantly crystallized, the obtained treated substrate being coated with the organophosphorus compound in the form of a first monomolecular layer coating at least 15% of the surface of the substrate and in the form of a physisorbed second layer at least preponderantly crystallized. A treated metal substrate which may be obtained by the process thereof, corresponding solution and its use for treating metallic substrates to improve their tribological properties during their shaping, in particular their stamping.

Abstract: According to one aspect, the invention relates to a device (1, 2, 3) for laser nanomachining a sample made of a material having a given transparency band, the device comprising: a focusing module (203, 703) allowing a nondiffracting beam (210, 710) to be generated, along a focusing line generally oriented along the optical axis of the focusing module, from a given incident beam; first means (202, 702) for emitting a first light pulse (I1) of spectral band comprised in the transparency band of said material, able to generate in said material, after focusing by said focusing module, a plasma of free charges along said focusing line via multi-photon absorption, thus forming a “plasma channel”; and second means (202, 702) for emitting at least one second electromagnetic wave (I2) of spectral band comprised in the transparency band of said material, which wave(s) is/are intended to be spatially superposed on said plasma channel in order to heat said material via absorption by the free charges of the plasma.

Abstract: Device for shaping a laser beam for an atomic sensor, comprising a retroreflector prism with an entrance area, an exit area and two reflection surfaces forming a right angle therebetween. The device for shaping includes a linear polarizer disposed upstream from the entrance area of the retroreflector prism for linearly polarizing a laser beam entering into the retroreflector prism by the entrance area, and a form birefringence plate disposed downstream from the exit area of the retroreflector prism to circularly polarize a laser beam exiting from the retroreflector prism by the exit area.

Abstract: The invention relates to a gas cell for an atomic sensor, comprising an optical cavity provided with at least one optical window (9) and fillable with a gas. The cell also comprises a sealing cup comprising a cavity mouth, a channel mouth, and a sealing access, as well as a membrane which hermetically closes the sealing access of the sealing cup. The membrane can be plastically deformed by heating so as to hermetically close the cavity mouth and/or the channel mouth, in such a way as to hermetically separate the optical cavity from the gas inflow channel.

Abstract: A process for surface treatment of metal substrates, including the steps of: providing a metal substrate including hydroxyl groups at its surface; bringing the metal substrate into contact with a solution of at least one organophosphorus compound to enable the reaction of the hydroxyl groups at the surface of the metal substrate with the organophosphorus compound to form a monomolecular layer over the surface and a second layer of physisorbed organophosphorus molecules at least preponderantly crystallized, the obtained treated substrate being coated with the organophosphorus compound in the form of a first monomolecular layer coating at least 15% of the surface of the substrate and in the form of a physisorbed second layer at least preponderantly crystallized. A treated metal substrate which may be obtained by the process thereof, corresponding solution and its use for treating metallic substrates to improve their tribological properties during their shaping, in particular their stamping.

Abstract: The invention relates to a peptide of 15 to 20 amino acids deriving from TERT protein, which peptide is capable of (i) binding to HLA class II and (ii) stimulating a CD4 Th response. These universal cancer peptides are especially useful in anti-tumor immunotherapy and immunomonitoring.

Abstract: A method for producing a ridge optical waveguide having low coupling losses between the ridge optical waveguide and an optical fiber includes forming on the surface of a dielectric substrate an optical waveguide having a first end and a second end opposite the first end; cutting out two parallel recesses spaced apart by a distance wr on the surface of the dielectric substrate to form a rigid optical waveguide with an increased width (wr) between the two recesses. The recesses are cut such that the depth of each recess changes continuously and gradually between a zero depth at the height of the first end of the optical waveguide and a maximum depth (Hm) at a pre-determined distance (Ip) from the first end.

Abstract: Some embodiments are directed to a method for manufacturing photonic waveguides and to photonic waveguides manufactured by this method.

Abstract: A micropositioning device for a piezoelectric actuator includes a means for controlling an electric field applied to the piezoelectric actuator so as to deform the piezoelectric material, and means for simultaneous measurement of a variation of electric charge accumulated on the piezoelectric actuator resulting from the deformation; and means for acquiring measurements of the variation of electric charge, for processing these acquisitions and for estimating a displacement (x, y, z) of the piezoelectric actuator and/or an applied force.

Abstract: The invention relates to a secure system for the perfusion of a body liquid, enabling a final control of compatibility of a treatment with the patient and/or the medical situation previously diagnosed by a doctor, in a simple, efficient and energy-saving manner. To this end, the system includes a fluidic circuit of a perfusion having a perfusion catheter, a perfusion tubing and a container for the determined perfusion product to be perfused to a patient. The system is also configured to take a body liquid sample from a patient and to analyze and compare the body liquid sample to the determined perfusion product so as to control the flow of the perfusion product.

Abstract: An actuation device (1) which includes an actuation element (3) with a fixed 10 portion (31) and a driving portion (32); wherein the fixed portion (31) includes a crawling surface (311). The driving portion (32) includes a flexible moveable blade (321) positioned in parallel and at a distance from the crawling surface (311). When a power supply voltage is applied between the moveable blade (321) and the crawling surface (311), the free end (3211) comes into contact with the crawling surface (311), and a contact area, between the moveable blade (321) and the crawling surface (311), increases by propagation of the crawling front (3213) along the moveable blade (321). The propagation of the crawling front displaces the moveable blade (321) according to a first orientation.

Abstract: A method for producing a ridge optical waveguide having low coupling losses between the ridge optical waveguide and an optical fibre includes forming on the surface of a dielectric substrate an optical waveguide having a first end and a second end opposite the first end; cutting out two parallel recesses spaced apart by a distance wr on the surface of the dielectric substrate to form a rigid optical waveguide with an increased width (wr) between the two recesses. The recesses are cut such that the depth of each recess changes continuously and gradually between a zero depth at the height of the first end of the optical waveguide and a maximum depth (Hm) at a pre-determined distance (Ip) from the first end.