Patents Assigned to Universite de Strasbourg
  • INDUCED PRESOMITIC MESODERM (IPSM) CELLS AND THEIR USE
    Publication number: 20140127169
    Abstract: The invention relates to a method for reprogramming target cells to multipotent progenitor cells capable of differentiating into muscular, skeletal or dermal cell lines. In particular, the invention relates to an ex vivo method for preparing induced presomitic mesoderm (iPSM) cells, said method comprising the steps of: a) providing target cells to be reprogrammed, and, b) culturing said target cells under appropriate conditions for reprogramming said target cells into iPSM cells, wherein said appropriate conditions comprises increasing expression of at least one T-Box transcription factor in said target cells. The invention further relates to the use of said iPSM cells, for example, for regenerating skeletal, muscle, dermal and cartilage tissues.
    Type: Application
    Filed: January 24, 2012
    Publication date: May 8, 2014
    Applicants: UNIVERSITE DE STRASBOURG, STOWERS INSTITUTE FOR MEDICAL RESEARCH, ASSOCIATION FRANCAISE CONTRE LES MYOPATHIES
    Inventors: Olivier Pourquie, Matthias Wahl, Jerome Chal
  • Sulfonated coumarins, their synthesis, fluorogenic substrates resulting from grafting of these coumarins on sugars, method for obtaining these substrates, and their applications
    Patent number: 8716496
    Abstract: Substituted sulfonated coumarins are expressed in the general formula (I), where: R1 is H, OH, or a substituted or unsubstituted, straight or branched C1-C6 alkyl radical, or —COR4, or —COOR4, or —CONHR4, R2 is H or a halogen, in particular fluorine, or a substituted or unsubstituted, straight or branched C1-C6 alkyl radical, or —COR4, or —COOR4, or —CONHR4, R1 and R2 being capable of together forming a ring, such as a substituted or unsubstituted aryl or furane, R3 is H or a halogen, in particular fluorine, or a substituted or unsubstituted, straight or branched C1-C6 alkyl radical, or —COR4, or —COOR4, or —CONHR4, where R4 is H, or a substituted or unsubstituted, straight or branched C1-C6 alkyl radical, or a substituted or unsubstituted aryl, and M is Na or K.
    Type: Grant
    Filed: September 16, 2011
    Date of Patent: May 6, 2014
    Assignees: Universite de Strasbourg
    Inventors: Antoine Drevelle, Sylvain Ladame, Majdi Najah, Estelle Mayot
  • Method of preparing an adduct
    Patent number: 8716191
    Abstract: A method for identifying one or several molecular structure(s) having a high-affinity for a target of interest, the molecular structure(s) each including one nucleotide chain onto which is hybridized at least one PNA-encoded molecule.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: May 6, 2014
    Assignees: Universite de Strasbourg, Centre National de la Recherche Scientifique
    Inventors: Nicolas Winssinger, Sofia Barluenga
  • METHOD AND DEVICE TO MODIFY PROPERTIES OF MOLECULES OR MATERIALS
    Publication number: 20140102876
    Abstract: A method and a device to modify the properties of molecules or materials. A method to modify the chemical properties, the work function, the electrochemical potential and/or the NMR frequency of one or more molecules, biomolecules or materials, method includes the steps of: providing a reflective or photonic structure (1) which has an electromagnetic mode which is resonant with a transition in the molecules, biomolecules or material (2); and placing the molecule(s), biomolecule(s) or material (2) in or on a structure of the previous type.
    Type: Application
    Filed: May 7, 2012
    Publication date: April 17, 2014
    Applicant: UNIVERSITE DE STRASBOURG (Etablissement Public National a Caractere Scientifique, Culturel et P..
    Inventors: James A. Hutchison, Tal Schwartz, Cyriaque Genet, Eloise Devaux, Thomas W. Ebbesen, Paolo Samori
  • Process for Identifying Novel Anti-Inflammatory Molecules with Reduced Direct Transrepression of Genes Induced by Glucocorticoids
    Publication number: 20140093884
    Abstract: The present invention relates to a new process for identifying novel anti-inflammatory molecules with reduced direct transrepression of genes induced by glucocorticoids. The inventors have discovered that GCs-mediated transrepression can be mediated not only via the tethering indirect pathway, but also through direct binding of GR to “simple” negative GREs (nGRE), which belongs to a novel family of evolutionary-conserved cis-acting negative response elements (IR nGREs), and are found in numerous GC-repressed genes.
    Type: Application
    Filed: April 13, 2012
    Publication date: April 3, 2014
    Applicants: UNIVERSITE DE STRASBOURG, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Pierre Chambon, Daniel Metzger, Milan Surjit
  • POLYPHOSPHATE AND PYROPHOSPHATE DERIVATIVE OF SACCHARIDES
    Publication number: 20140088036
    Abstract: The present invention provides, among other things, phosphorylated and pyrophosphate derivatives of mono-, di- and oligosaccharides, as well as structural derivatives of these compounds. These compounds have a variety of uses including for pharmaceutical applications. Also provided are methods of use in the treatment of disease, including diseases related to oxygen delivery.
    Type: Application
    Filed: September 30, 2011
    Publication date: March 27, 2014
    Applicants: UNIVERSITE DE STRASBOURG, NORMOXYS, INC.
    Inventors: Jean Marie Lehn, Yves Claude Nicolau, Rajamalleswaramma Jogireddy, Adam H. Brockman, John Hey, Yongxin Yu
  • RADIOPAQUE IODINATED PRODUCTS INTENDED FOR USE MEDICAL IMAGING AND THEIR METHODS
    Publication number: 20140065067
    Abstract: Iodinated amphiphilic compound of formula (I): AG1-X—R??(I) wherein AG1 represents an unsaturated (C8-C52) aliphatic hydrocarbon chain found in fatty acids having specific location of double bonds, the chain including at least one iodine atom directly linked to a carbon atom of a non-conjugated double bond by a covalent link, the second carbon atom of the double bond bearing a halogen atom different from a iodine atom, X represents a polyethylene glycol including 1 to 50 ethylene glycol groups, R represents a hydrogen atom or a group AG2 being identical to or different from AG1, AG1, X, R and AG2 being selected so that the amphiphilic compound has a hydrophilic/lipohilic balance included between 4 and 30.
    Type: Application
    Filed: December 13, 2011
    Publication date: March 6, 2014
    Applicant: UNIVERSITE DE STRASBOURG
    Inventors: François Hallouard, Nicolas Anton, Guy Zuber, Thierry Vandamme, André Constantinesco, Philippe Choquet
  • DERIVATIVES OF ALLOPREGNANOLONE AND OF EPIALLOPREGNANOLONE AND USES THEREOF FOR TREATING A NEUROPATHOLOGICAL CONDITION
    Publication number: 20140058079
    Abstract: The présent invention relates to novel neurosteroids, especially derivatives of allopregnanolone and of epiallopregnanolone of formula (I) and the uses thereof as médicament for the treatment of neuropathologies, in particular neuropathies induced by the chemotherapy of a cancer. Thèse molécules according to the invention have both preventative and curative effects. The neurosteroids according to the invention may also be of use in the treatment of neurodegenerative disorders, in particular for preventing neuronal cell death. They may thus be used as neuroprotectants and/or as an agent that stimulâtes neuronal prolifération.
    Type: Application
    Filed: March 23, 2012
    Publication date: February 27, 2014
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS, UNIVERSITE DE STRASBOURG
    Inventors: Ayikoe Guy Mensah-Nyagan, Laurence Meyer, Christine Patte-Mensah, Omar Taleb, Michel Miesch, Philippe Geoffroy, Blandine Ressault
  • COMPOUND COMPRISING ALPHA-MSH FOR USE IN ENDODONTIC REGENERATION
    Publication number: 20140050773
    Abstract: The present invention concerns a compound comprising an ?-MSH peptide, coupled to a polypeptide consisting of a chain of about 15 to about 400 amino acids, for use in endodontic regeneration and/or for the treatment of dental inflammatory diseases. The invention further concerns pharmaceutical compositions, in particular nanostructured compositions, comprising such a compound.
    Type: Application
    Filed: November 26, 2010
    Publication date: February 20, 2014
    Applicant: Universite De Strasbourg
    Inventors: Nadia Benkirane-Jessel, Carlos Mendoza Palomares, Florence Fioretti
  • COMPOUNDS HAVING CHROMOPHORE AND PHOTOREACTIVE GROUPS
    Publication number: 20140045173
    Abstract: The invention relates to the field of hydrophobic photoaffinity marking by element of probes that are multifunctional lipid compounds. The compounds include at least one chromophore group and two lipid chains, one of which includes a photoreactive group. The compounds can be used for the study and identification of hydrophobic regions or domains within proteins, particularly within viruses.
    Type: Application
    Filed: March 23, 2012
    Publication date: February 13, 2014
    Applicant: UNIVERSITE DE STRASBOURG
    Inventors: Eve-Isabelle Pecheur, Line Bourel-Bonnet, Benoit Hilbold
  • NOVEL AMINO-PYRROLINE DERIVATIVES, AND USE THEREOF IN THE PREVENTION AND/OR TREATMENT OF METABOLIC SYNDROME
    Publication number: 20140045910
    Abstract: Novel amino-pyrrolinic derivatives, their pharmacologically acceptable salts and use thereof in the prevention and/or treatment of metabolic syndrome.
    Type: Application
    Filed: April 17, 2012
    Publication date: February 13, 2014
    Applicant: UNIVERSITE DE STRASBOURG
    Inventors: Pascal Bousquet, Jean Daniel Ehrhardt, Lyne Fellmann, Vincent Gasparik, Hugues Greney, Mohamed Hadjeri, Andre Mann, Nathalie Niederhoffer, Stephan Schann
  • DEPLETED ANTI-STAPHYLOCOCCAL ENTEROTOXINS POLYCLONAL ANTIBODIES, PREPARATION AND USES THEREOF
    Publication number: 20140037651
    Abstract: The present invention relates to the preparation of a set of depleted polyclonal antibodies, each depleted polyclonal antibody being raised against one specific staphylococcal enterotoxin, and its use for multiplex detection.
    Type: Application
    Filed: February 28, 2012
    Publication date: February 6, 2014
    Applicant: UNIVERSITÉ DE STRASBOURG
    Inventors: Gilles Prévost, Charline Barasino, Daniel Keller, Khaldoun Masoud
  • POCHOXIME CONJUGATES USEFUL FOR THE TREATMENT OF HSP90 RELATED PATHOLOGIES
    Publication number: 20140031302
    Abstract: The present invention includes novel derivatives, analogs, and intermediates of the natural products radicicol, pochonins, pochoximes, and their syntheses. The present invention also provides a pharmaceutical composition comprising the present compound and the use of the compound as inhibitors of kinases and of the enzyme family known as heat shock protein 90 (HSP90).
    Type: Application
    Filed: October 24, 2011
    Publication date: January 30, 2014
    Applicant: UNIVERSITE DE STRASBOURG
    Inventors: Nicolas Winssinger, Sofia Barluenga
  • Photocatalysts based on structured three-dimensional carbide, in particular ?-SiC, foams
    Patent number: 8628726
    Abstract: The invention relates to a photocatalyst comprising a ?-SiC cellular foam and a photocatalytically active phase, deposited directly on said cellular foam or on an intermediate phase deposited on said cellular foam. The average size of the cells is between 2500 ?m and 5000 ?m. The foam can comprise nanotubes or nanofibers (particularly of carbon, SiC, and TiO2) that consist of, or carry as an intermediate phase, a photocatalytically active phase.
    Type: Grant
    Filed: September 14, 2009
    Date of Patent: January 14, 2014
    Assignees: Centre National de la Recherche Scientifique, Universite de Strasbourg
    Inventors: Cuong Pham-Huu, Nicolas Keller, Marc-Jacques Ledoux, Valérie Keller-Spitzer, Dominique Begin, Mathieu Grandcolas, Izabela Janowska, Shabnam Hajesmaili
  • NANO-RESERVOIRS TECHNOLOGY FOR USE IN BONE AND/OR CARTILAGE REGENERATION
    Publication number: 20130325144
    Abstract: The present invention concerns a biomaterial comprising a nanofibrous scaffold made of polymers, such as poly(?-caprolactone) or collagen, coated with at least one layer pair consisting of a layer of polyanions and a layer of polycations, wherein said at least one layer pair incorporates a therapeutic molecule such as a growth factor. The biomaterial may optionally comprise living cells such as osteoblasts and/or chondrocytes.
    Type: Application
    Filed: February 22, 2012
    Publication date: December 5, 2013
    Applicant: UNIVERSITÉ DE STRASBOURG
    Inventors: Nadia Benkirane-Jessel, Didier Mainard, Carlos Mendoza Palomares
  • Chemical reactor with nanometric superstructure
    Patent number: 8574419
    Abstract: The invention relates to a chemical reactor with a nanometric superstructure, comprising at least one member wherein at least one reaction chamber is arranged, and said reaction chamber being filled at least partially with a high specific surface area material having a specific surface area greater than 5 m2/g, and characterized in that said high specific surface area material is selected from nanotubes or nanofibers. These nanotubes or nanofibers are preferably selected in the group consisting of carbon nanofibers or nanotubes, ?-SiC nanofibers or nanotubes, TiO2 nanofibers or nanotubes. They may be deposited on an intermediate structure selected in the group consisting of glass fibers, carbon fibers, SiC foams, carbon foams, alveolar ?-SiC foams, said intermediate structure filling the reaction chamber of said reactor at least partially.
    Type: Grant
    Filed: November 26, 2008
    Date of Patent: November 5, 2013
    Assignees: Centre National de la Recherche Scientifique, Universite de Strasbourg
    Inventors: Cuong Phamhuu, Nicolas Keller, Jacques M. Ledoux, Izabella Janowska, David Edouard, Valérie Keller-Spitzer, Thierry Romero, Liu Yu
  • DISEASE-ASSOCIATED PROTEIN
    Publication number: 20130287738
    Abstract: Disclosed are methods and compositions for early diagnosis, monitoring and treatment of retinal dystrophy, age-related macular degeneration, Bardet-Biedel syndrome, Bassen-kornzweig syndrome, best disease, choroidema, gyrate atrophy, congenital amourosis, refsun syndrome, stargardt disease and Usher syndrome. In particular, the invention relates to a protein, termed “Rdcvf1,” that is differentially transcribed and expressed in subjects suffering from retinal dystrophies and the like, such as retinal dystrophy and age-related macular degeneration compared with nonsufferers, antibodies which recognize this protein, and methods for diagnosing such conditions.
    Type: Application
    Filed: June 4, 2013
    Publication date: October 31, 2013
    Applicants: UNIVERSITE DE STRASBOURG, NOVARTIS AG
    Inventors: Thierry LEVEILLARD, Jose Alain SAHEL, Saddek MOHAND-SAID, David HICKS
  • INSTRUMENT CLUSTER FOR A MOTOR VEHICLE
    Publication number: 20130258431
    Abstract: An instrument cluster, in particular for a motor vehicle comprises a display screen to display information to the driver of the vehicle, a holographic memory containing the information stored in the form of holograms, and a light source to generate one or more reading light beams to extract the information to be displayed from the holographic memory and display the information extracted from the holographic memory on the display screen. A head-up display device is integrated in the instrument cluster and comprises a combiner that projects information extracted from the holographic memory into the head-up field of view of the driver.
    Type: Application
    Filed: May 23, 2011
    Publication date: October 3, 2013
    Applicants: UNIVERSITE DE STRASBOURG, DELPHI TECNOLOGIES, INC.
    Inventors: Alain Guidi, Claude Simon, Hassan Moussa, Idriss El Hafidi, Thibaud Barillot
  • Compositions comprising polynucleotides encoding RDCVF1 or RDCVF2
    Patent number: 8518695
    Abstract: Disclosed are methods and compositions for early diagnosis, monitoring and treatment of retinal dystrophy, age-related macular degeneration, Bardet-Biedel syndrome, Bassen-kornzweig syndrome, best disease, choroidema, gyrate atrophy, congenital amourosis, refsun syndrome, stargardt disease and Usher syndrome. In particular, the invention relates to a protein, termed “Rdcvf1,” that is differentially transcribed and expressed in subjects suffering from retinal dystrophies and the like, such as retinal dystrophy and age-related macular degeneration compared with nonsufferers, antibodies which recognize this protein, and methods for diagnosing such conditions.
    Type: Grant
    Filed: January 11, 2012
    Date of Patent: August 27, 2013
    Assignees: Novartis AG, Universite de Strasbourg
    Inventors: Thierry Leveillard, Jose Alain Sahel, Saddek Mohand-Said, David Hicks
  • Compositions and methods comprising analogues of radicicol A
    Patent number: 8513440
    Abstract: Disclosed are novel analogues of the natural product radicicol A of formulae I, .Ia, pi, Ha, lib and HI, pharmaceutical compositions comprising the compounds. The compounds of the invention are kinase and phosphatase inhibitors and find utility in the treatment or prevention of kinase and phosphatase-mediated disorders. Also provided are uses and methods for the treatment or prevention of kinase- and phosphatase-mediated disorders and synthetic processes for the preparation of the compounds.
    Type: Grant
    Filed: June 5, 2008
    Date of Patent: August 20, 2013
    Assignees: Universite de Strasbourg, Centre National de la Recherche Scientifique
    Inventors: Nicolas Winssinger, Sofia Barluenga