Patents Assigned to Universite de Strasbourg
  • Antiviral agent
    Patent number: 9492501
    Abstract: The present invention describes the use of a composition including or constituted by at least one element chosen from: a specific protein including or consisting of the amino acid sequence SEQ ID NO: 5, and a protein homologous to the specific protein, for the preparation of a medicament intended for the prevention or treatment of pathologies associated with a viral infection or an inflammation.
    Type: Grant
    Filed: March 4, 2010
    Date of Patent: November 15, 2016
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE STRASBOURG, UNIVERSITE DE LA MEDITERRANEE
    Inventors: Eric Chabriere, Mikael Elias, Olivier Rohr, Christian Schwartz
  • PYRIDAZINE COMPOUNDS, COMPOSITIONS AND METHODS
    Publication number: 20160326139
    Abstract: The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.
    Type: Application
    Filed: June 29, 2016
    Publication date: November 10, 2016
    Applicants: NORTHWESTERN UNIVERSITY, UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: D. Martin WATTERSON, Linda VAN ELDIK, Jacques HAIECH, Marcel HIBERT, Jean-Jacques BOURGUIGNON, Anastasia VELENTZA, Wenhui HU, Magdalena ZASADZKI
  • Nanoparticles containing a peptide, vectors containing said nanoparticles, and pharmaceutical uses of said nanoparticles and vectors
    Patent number: 9458212
    Abstract: The present invention relates to nanoparticles containing a P140 peptide and to carriers, with or without dispersant, containing the nanoparticles. The present invention also relates to pharmaceutical and therapeutic uses of the nanoparticles, in particular for the treatment of systemic lupus erythematosus.
    Type: Grant
    Filed: May 20, 2009
    Date of Patent: October 4, 2016
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), UNIVERSITE DE STRASBOURG
    Inventors: Louis Danicher, Yves Frere, Sylviane Muller, Anne Wawrezinieck
  • Microfluidic system and methods for highly selective droplet fusion
    Patent number: 9446360
    Abstract: A method and chip for fusing droplets in a chip comprising (i) providing a first set of droplets which are partially or not stabilized by surfactant, (ii) providing a second set of droplets which are stabilized by surfactant, (iii) contacting each droplet of the first set with single or multiple droplets of the second set in a pairing module and (iv) fusing droplets of the first set with droplets of the second set through a droplet fusion module in which the droplets experience at least one acceleration and/or deceleration and/or reorientation and/or rearrangement in space and time.
    Type: Grant
    Filed: May 7, 2010
    Date of Patent: September 20, 2016
    Assignees: UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFQUE
    Inventor: Linas Mazutis
  • Catalyst supports made from silicon carbide covered with TiOfor Fischer-Tropsch synthesis
    Patent number: 9416066
    Abstract: Catalysts supports and catalysts capable of being used in heterogeneous catalysis. The catalyst support belongs to the porous supports based on silicon carbide (SiC), in particular, based on ?-SiC, modified by a surface deposit of TiO2.
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: August 16, 2016
    Assignees: Sicat Catalysts, Inc., Centre National de la Recherche Scientifique, Universite de Strasbourg
    Inventors: Yuefeng Liu, Cuong Pham-Huu, Patrick Nguyen, Charlotte Pham
  • Luminescent probes for biological labeling and imaging, method for preparing same
    Patent number: 9388202
    Abstract: The present invention relates to organic compounds that are usable as ligands for preparing complexes of lanthanides or of certain transition metals which are water-soluble, to a method for preparing same, and also to the use thereof as a fluorescent probe.
    Type: Grant
    Filed: October 11, 2012
    Date of Patent: July 12, 2016
    Assignees: CENTRE NATIONAL DE LA RECHRCHE SCIENTIFIQUE, UNIVERSITE DE STRASBOURG
    Inventors: Raymond Ziessel, Mathieu Starck, Alexandra Sutter
  • Spin-polarised current source
    Patent number: 9379317
    Abstract: Method of filtering electrons to obtain spin-polarization of a current conducting at least 75% of electrons at the Fermi level, used with a spin-polarized current source comprising: a polarized spin injection device comprising an electrically conducting substrate of which a first face has magnetic properties and an organic layer in contact with the first face of the substrate; an electrically conducting material called the ground, the organic layer being arranged between the ground and the substrate; a current source electrically connected to the first face of the substrate and the ground; the method comprising circulation of the electron conduction current by means of the current source, between the first face of the substrate and the ground, at a temperature higher than ?220° C.
    Type: Grant
    Filed: April 15, 2013
    Date of Patent: June 28, 2016
    Assignees: Centre National de la Recherche Scientifique, Universite de Strasbourg
    Inventors: Martin Bowen, Wolfgang Weber, Loïc Joly, Eric Beaurepaire, Fabrice Scheurer, Samy Boukari, Mébarek Alouani
  • Spin injector device comprising a protection layer at the centre thereof
    Patent number: 9362488
    Abstract: A method for manufacturing a spin injector device, comprising the following steps of: a) forming a metal protection layer on a face of a substrate, so as to restrict or prevent oxidation and/or contamination of said face by its environment, the face being magnetic and electrically conductive, the protection layer being of a diamagnetic or paramagnetic nature; b) forming an upper layer onto the protection layer, able to promote a spin bias of electronics sates in the vicinity of the Fermi level of the interface between the protection layer and the upper layer according to an amplitude and a spin referential frame which are defined by the magnetism of the substrate and/or of the face of the substrate, the upper layer being an organic layer of which one or more molecular sites have, in contact with the protection layer, a paramagnetic moment.
    Type: Grant
    Filed: April 15, 2013
    Date of Patent: June 7, 2016
    Assignees: Centre National de la Recherche Scientifique, Universite de Strasbourg
    Inventors: Martin Bowen, Mébarek Alouani, Samy Boukari, Eric Beaurepaire, Wolfgang Weber, Fabrice Scheurer, Loïc Joly
  • Use of zwitterionic molecules for forming a hole or electron transport layer
    Patent number: 9349958
    Abstract: The invention relates to the use of zwitterionic molecules for forming a hole or electron transport layer. The preferred zwitterionic molecules of the invention are derivatives of p-benzoquinonemonoimines. The invention is useful in the field of electronic devices in particular.
    Type: Grant
    Filed: August 23, 2011
    Date of Patent: May 24, 2016
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE STRASBOURG, UNIVERSITY OF NEBRASKA LINCOLN
    Inventors: Bernard Doudin, Pierre Braunstein, Lucie Routaboul, Guillaume Dalmas, Zhengzheng Zhang, Peter Dowben
  • Nanosphere-histone acetyltransferase (HAT) activator composition, process and methods thereof
    Patent number: 9314539
    Abstract: The present invention is in relation to a composition including nanosphere and histone acetyltransferase (HAT) activator. The nanosphere is carbon nanosphere (CSP) which is intrinsically fluorescent and the HAT activator is N-(4-Chloro-3-trifluoromethyl-phenyl)-2-n-propoxy-benzamide. The N-(4-Chloro-3-trifluoromethyl-phenyl)-2-n-propoxy-benzamide is covalently conjugated with the carbon nanosphere. The present invention further relates to a process for obtaining a composition including carbon nanosphere and Histone acetyltransferase (HAT) activator [N-(4-Chloro-3-trifluoromethyl-phenyl)-2-n-propoxy-benzamide]. The composition is capable of crossing blood brain barrier and inducing histone acetylation in brain. Further, the composition is capable of increasing neurogenesis, as well as improving long-term memory formation.
    Type: Grant
    Filed: April 27, 2013
    Date of Patent: April 19, 2016
    Assignees: JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH, UNIVERSITE DE STRASBOURG
    Inventors: Tapas Kumar Kundu, Anne-Laurence Boutillier, Snehajyoti Chatterjee, Muthusamy Eswaramoorthy, Pushpak Mizar, Chantal Mathis, Jean-Christophe Cassel, Romain Neidl, Mohankrishna Dalvoy Vasudevarao, Vedamurthy Bhusainahalli Maheshwarappa
  • Preparation of graphene by mechanically thinning graphite materials
    Patent number: 9309122
    Abstract: The preparation of graphene, mono-, bi- and multi-layers from graphite-based precursor materials, for example, pencil lead or graphite, by a method of mechanical thinning on the surface of a planar substrate with controlled roughness, followed by sonication in order to collect the graphene deposited on the substrate in a liquid medium. The bearing force during thinning by mechanical friction enables the number of graphene sheets deposited on the surface of the substrate to be controlled.
    Type: Grant
    Filed: November 3, 2010
    Date of Patent: April 12, 2016
    Assignees: Centre National de la Recherche Scientifique, Universite de Strasbourg
    Inventors: Izabela Janowska, Dominique Begin, Kambiz Chizari, Ovidiu Ersen, Pierre Bernhardt, Thierry Romero, Marc Ledoux, Cuong Pham-Huu
  • Amino-pyrroline derivatives, and use thereof in the prevention and/or treatment of metabolic syndrome
    Patent number: 9303019
    Abstract: Novel amino-pyrrolinic derivatives, their pharmacologically acceptable salts and use thereof in the prevention and/or treatment of metabolic syndrome.
    Type: Grant
    Filed: April 17, 2012
    Date of Patent: April 5, 2016
    Assignee: UNIVERSITE DE STRASBOURG
    Inventors: Pascal Bousquet, Jean Daniel Ehrhardt, Lyne Fellmann, Vincent Gasparik, Hugues Greney, Mohamed Hadjeri, Andre Mann, Nathalie Niederhoffer, Stephan Schann
  • SYNTHESIS OF RESORCYLIC ACID LACTONES USEFUL AS THERAPEUTIC AGENTS
    Publication number: 20160075677
    Abstract: Disclosed are macrocyclic compounds of formulae I, I?, II, II?, III, III?, IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.
    Type: Application
    Filed: April 21, 2015
    Publication date: March 17, 2016
    Applicant: UNIVERSITE DE STRASBOURG
    Inventors: Nicolas Winssinger, Sofia Barluenga, Martin Karplus
  • Method for controlling the biological activity of a protein in a vertebrate cell
    Patent number: 9273115
    Abstract: The present invention relates to a method for tightly temporally controlling the biological activity of a protein of interest in a vertebrate, upon induction of the activity of a fusion protein comprising said protein of interest and an ERM polypeptide containing a mutated ligand binding domain of the human oestrogen receptor ?, with a synthetic ligand that does not interfere with oestrogen signalling. In particular, the present invention concerns a method for generating tightly temporally-controlled targeted somatic mutations in a vertebrate, preferably a mouse, by inducing the activity of a fusion protein comprising a site-specific recombinase protein and an ERM polypeptide, with a synthetic ligand devoid of oestrogenic and anti-oestrogenic activities.
    Type: Grant
    Filed: January 22, 2010
    Date of Patent: March 1, 2016
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, UNIVERSITE DE STRASBOURG
    Inventors: Daniel Metzger, Pierre Chambon, Huimin Zhao, John Katzenellenbogen
  • Labelling reagents having a pyridine nucleus bearing a diazomethyl function, process for synthesis of such reagents and processes for detection of biological molecules
    Patent number: 9266902
    Abstract: A process for synthesis of a labelling reagent, a process for the labelling of a biological molecule, a labelled biological molecule obtained by the process, a process for labelling and fragmentation of a single or double strand nucleic acid, a labelled nucleic acid capable of being obtained by the process, a kit for detection of a target nucleic acid containing a labelled nucleic acid, a solid support onto which is attached a reagent and a process for capture of nucleic acids.
    Type: Grant
    Filed: July 28, 2009
    Date of Patent: February 23, 2016
    Assignees: BIOMERIEUX, UNIVERSITE DE STRASBOURG, CNRS
    Inventors: Alain Laurent, Ali Laayoun, Mitsuhara Kotera
  • Method for determining the irradiation dose deposited in a scintillator by ionising radiation and associated device
    Patent number: 9244178
    Abstract: Method of determination of an irradiation dose deposited in a scintillator (5) by ionising radiation, comprising the steps of: irradiating the scintillator (5) during a predetermined time; detecting a moment of excitation of the scintillator (5) with a first photodetector (11); then detecting a moment of reception of a scintillation photon with a second photodetector (14), functioning in single photon counting mode; identifying each sequence consisting of the detection of a moment of excitation by the first photodetector (11), and the detection of a moment of reception by the second photodetector (14) with a coincidence event; counting the number of coincidence events; obtaining the irradiation dose deposited during the irradiation time as a function of the number of coincidence events counted and of a predetermined proportionality factor.
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: January 26, 2016
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S), UNIVERSITÉ DE STRASBOURG
    Inventors: Jean-Marc Jung, Till Sohier, Mélodie Munier, Rémi Barillon, Mauricio Torres
  • Compounds having chromophore and photoreactive groups
    Patent number: 9234848
    Abstract: The invention relates to the field of hydrophobic photoaffinity marking by element of probes that are multifunctional lipid compounds. The compounds include at least one chromophore group and two lipid chains, one of which includes a photoreactive group. The compounds can be used for the study and identification of hydrophobic regions or domains within proteins, particularly within viruses.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: January 12, 2016
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), UNIVERSITE CLAUDE BERNARD LYON 1, UNIVERSITE DE STRASBOURG
    Inventors: Eve-Isabelle Pecheur, Line Bourel-Bonnet, Benoit Hilbold
  • Catalyst for reforming tar used in the steam gasification of biomass
    Patent number: 9221033
    Abstract: A catalyst includes an olivine substrate on which an iron compound layer is deposited, produced by impregnating the olivine substrate with a solution including an iron salt, and then heat-treating. The catalyst is useful for steam-reforming tar, in particular in gaseous media from the steam gasification of biomass. Further, the catalyst can be used alone for catalyzing the steam gasification of organic compounds from biomass while limiting the amount of tar produced in the synthesized gases.
    Type: Grant
    Filed: May 19, 2010
    Date of Patent: December 29, 2015
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), UNIVERSITE DE STRASBOURG
    Inventors: Alain Kiennemann, Claire Courson, Mirella Virginie
  • P-chirogenic organophosphorus compounds
    Patent number: 9186661
    Abstract: Novel P-chirogenic organophosphorus compounds of general formula (I), a process for the synthesis of the compounds of formula (I), and intermediate products of general formulae (II), (III) and (IV), as shown below, are involved in the synthesis of compounds (I). Metal complexes including compounds (I) as ligands are also described. The novel compounds and complexes are useful in asymmetric catalysis by transition metal complexes or organocatalysis, especially for asymmetric hydrogenation or allylation. Compounds of general formula (I) may be useful as agrochemical and therapeutic substances, or as reagents or intermediates for fine chemistry.
    Type: Grant
    Filed: July 10, 2012
    Date of Patent: November 17, 2015
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE BOURGOGNE, UNIVERSITE DE STRASBOURG, SYNTHELOR SAS
    Inventors: Sylvain Juge, Jerome Bayardon, Emmanuelle Remond, Hugo Laureano, Jean-Christophe Henry, Frederic Leroux, Francoise Colobert
  • PEPTIDIC ANTAGONISTS OF CLASS III SEMAPHORINS/NEUROPILINS COMPLEXES
    Publication number: 20150307589
    Abstract: The present invention concern a peptidic antagonist of class III semaphorins/neuropilins complexes comprising an amino acid sequence, which is derived from the transmembrane domain of a protein selected in the group consisting of neuropilin-1, neuropilin-2, plexin-A1, plexin-A2, plexin-A3, plexin-A4, Nr-CAM, L1-CAM, integrin Beta 1 and integrin beta 2, and including at least a GxxxG motif, eventually fused to an heterologous sequence; a nucleic acid encoding for said peptidic antagonist, a pharmaceutical composition comprising such a peptidic antagonist or a nucleic acid encoding thereof and uses thereof.
    Type: Application
    Filed: January 16, 2015
    Publication date: October 29, 2015
    Applicants: INSERM - INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, Universite De Strasbourg
    Inventors: Dominique BAGNARD, Lise Roth, Cecile Nasarre, Pierre Hubert, Sylvie Dirrig-Grosch, Gerard Cremel, Dominique Aunis