Patents Assigned to Universite de Strasbourg
  • Acyl guanidine derivatives modulating the hedgehog protein signaling pathway
    Patent number: 8889678
    Abstract: The present invention relates to acyl guanidine derivatives modulating the hedgehog protein signaling pathway to be used as drugs, in particular for treating diseases involving a tissue dysfunction associated with a deregulation of the hedgehog protein signaling pathway, as well as to pharmaceutical compositions containing same. The present invention also relates to novel acyl guanidine derivatives as such.
    Type: Grant
    Filed: July 19, 2010
    Date of Patent: November 18, 2014
    Assignees: Centre National de la Recherche Scientifique, Universite de Strasbourg
    Inventors: Martial Ruat, Hélène Faure, Elisabeth Traiffort, Hermine Roudaut, André Mann, Angèle Schoenfelder, Maurizio Taddei, Fabrizio Manetti, Antonio Solinas
  • MULTIMODAL CONTRAST AND RADIOPHARMACEUTICAL AGENT FOR AN IMAGING AND A TARGETED THERAPY GUIDED BY IMAGING
    Publication number: 20140336368
    Abstract: A multimodal contrast and radiopharmaceutical agent for an imaging and a targeted therapy guided by imaging.
    Type: Application
    Filed: November 18, 2011
    Publication date: November 13, 2014
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE STRASBOURG, HOSPICES CIVILS DE LYON
    Inventors: Delphine Felder-Flesch, Claire Billotey, Giuseppe Lamanna, Marc Janier, David Kriza
  • METHODS AND PHARMACEUTICAL COMPOSITIONS FOR REDUCING AIRWAY HYPERRESPONSE
    Publication number: 20140328864
    Abstract: The present invention relates to agent selected from the group consisting of an anti-S100B antibody, an anti-S100B aptamer or an inhibitor of S100B gene expression for use in a method for reducing airway hyperresponse in a subject in need thereof. The present invention also relates to a method for determining whether a subject is at risk of having or developing an airway hyperresonse comprising determining the level of S100B protein in a biological sample obtained from said subject.
    Type: Application
    Filed: November 22, 2012
    Publication date: November 6, 2014
    Applicants: INSERM (INSTITUT NATIONAL DE LA SENTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE DE STRASBOURG, CNRS (CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE)
    Inventors: Yann Herault, Emilie Dalloneau
  • Device for supporting an elongated body and for the controlled translational movement of the same
    Patent number: 8840627
    Abstract: A device for supporting and controlling the translational movement of an elongated body, the body extending along the longitudinal axis thereof in the form of a rod, such as a needle intended for a percutaneous medical procedure. The device is designed to be mounted to a support that can be controlled in terms of position and orientation, and includes: (i) a first member for gripping the body, whose movement can be controlled in the translation direction with a pre-determined maximum stroke; and (ii) a second fixed member which can guide the elongated body when the body is moved by the first mobile gripping member and which can maintain the body in position when the body is not engaged with the first member.
    Type: Grant
    Filed: February 28, 2006
    Date of Patent: September 23, 2014
    Assignees: Institut National des Sciences Appliquees, Institut de la Recherche sur les Cancers de l'Appareil Digestif (IRCAD), Universite de Strasbourg, Centre National de la Recherche Scientifique
    Inventors: Michel De Mathelin, Benjamin Maurin, Bernard Bayle, Jacques Gangloff, Olivier Piccin
  • Methods for producing active scFv antibodies and libraries therefor
    Patent number: 8841238
    Abstract: The present disclosure describes scFv antibody libraries, antibodies isolated from the libraries, and methods of producing and using the same.
    Type: Grant
    Filed: March 17, 2008
    Date of Patent: September 23, 2014
    Assignees: Institut National de la Sante et de la Recherche Medicale (INSERM), Centre National de la Recherche Scientifique (C.N.R.S.), Universite de Strasbourg
    Inventors: Pierre Emile Ulysse Martineau, Etienne Weiss
  • PHOSPHOLIPID-DETERGENT CONJUGATES AND USES THEREOF
    Publication number: 20140243391
    Abstract: The invention relates to novel compounds, in particular novel O-substituted phospholipids that are useful for the in vitro and in vivo delivery of drugs as well as nucleic acids into cells. The invention also relates to pharmaceutical compositions and supramolecular complexes comprising said compounds and the use of these compounds in therapeutic treatment, in particular in gene therapy.
    Type: Application
    Filed: July 20, 2012
    Publication date: August 28, 2014
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE STRASBOURG
    Inventors: Luc Lebeau, Philippe Pierrat, Francoise Pons, Guy Zuber
  • FLUOROGENIC SUBSTRATES, METHODS OF MAKING THE SUBSTRATES, AND METHODS OF DETECTING GLYCOSIDASE ACTIVITIES
    Publication number: 20140234884
    Abstract: Fluorogenic substrates, methods of making the fluorogenic substrates, and methods of detecting glycosidase activities (EC3.2.1) are provided. The fluorogenic substrates are composed of a sugar covalently bonded to the 7-hydroxy position of a substituted coumarin sulfonated fluorophore is provided. The fluorogenic substrates include sodium ?-D-cellobioside 6,8-difluoro-7-hydroxycoumarin-4-methanesulfonate; sodium ?-D-glucoside 6,8-difluoro-7-hydroxycoumarin-4-methanesulfonate; sodium ?-D-xyloside 6,8-difluoro-7-hydroxycoumarin-4-methanesulfonate; sodium ?-D-xylobioside 6,8-difluoro-7-hydroxycoumarin-4-methanesulfonate; and sodium ?-D-xylopolyoside 6,8-difluoro-7-hydroxycoumarin-4-methanesulfonate. The fluorogenic substrates may be made by covalently bonding the sugar moiety to the 7-hydroxy position of the substituted coumarin sulfonated fluorophore by reaction in DMF.
    Type: Application
    Filed: March 14, 2014
    Publication date: August 21, 2014
    Applicants: UNIVERSITE DE STRASBOURG, ETS J. SOUFFLET
    Inventors: Antoine DREVELLE, Sylvain LADAME, Majdi NAJAH, Estelle MAYOT
  • Novel Compounds Modulating The Hedgehog Protein Signaling Pathway, Marked Forms Thereof, And Applications
    Publication number: 20140228441
    Abstract: The invention relates to compounds of formula (I), and the use thereof as a drug, particularly for the treatment of tumors associated with hyperactivation of the hedgehog protein signaling pathway, treatment of neurodegenerative diseases, treatment of diseases related to cerebral development (holoprosencephaly), for stem cell monitoring treatment of cerebrovascular accidents and cardiovascular accidents, treatment of diseases involving oligodendrocytes and diseases involving neurolemmocytes, for application thereof in vitro for modulating human or animal stem cell renewal, and for the treatment of diabetes. The invention also relates to pharmaceutical compositions having a compound of formula (I).
    Type: Application
    Filed: September 21, 2012
    Publication date: August 14, 2014
    Applicants: Centre National De La Recherche Scientifique, Universite De Strasbourg
    Inventors: Martial Ruat, Hélène Faure, Hermine Roudaut, Lucile Hoch, Angèle Schoenfelder, Maurizio Taddei, André Mann
  • Zeodration method for the preservation of blood platelets
    Patent number: 8802363
    Abstract: The present invention relates to a new method for the preservation of blood platelets. In particular, the present invention provides a method which includes submitting the platelets to zeodration carried out at temperatures between 18° C. and 24° C. The dried platelets thus obtained can be preserved at room temperature for long period of time. The invention also provides kits and compositions for using the preserved platelets.
    Type: Grant
    Filed: November 26, 2010
    Date of Patent: August 12, 2014
    Assignees: Inserm (Institut National de la Sante et de la Recherche Medicale), Universite de Strasbourg, Etablissement Francais du Sang
    Inventors: Francine Rendu, Thibault Donnet, Christian Gachet, Jean-Pierre Cazenave
  • METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CARDIOMYOPATHY DUE TO FRIEDREICH ATAXIA
    Publication number: 20140221462
    Abstract: A method for preventing or treating cardiomyopathy due to energy failure in a subject in need thereof is provided. The method comprises administering to the subject a therapeutically effective amount of a vector which comprises a nucleic acid sequence encoding a gene that can reverse energy failure. An exemplary cardiomyopathy is that which is associated with Friedreich ataxia and an exemplary nucleic acid sequence comprises a nucleic acid that encodes frataxin (FXN).
    Type: Application
    Filed: February 1, 2013
    Publication date: August 7, 2014
    Applicants: Institut National de la Sante et de la Recherche Medicale (INSERM), Cornell Center for Technology, Enterprise & Commercialization, Universite de Strasbourg, CNRS (Centre National de la Recherche Scientifique)
    Inventors: Helene Monique Puccio, Patrick Aubourg, Ronald G. Crystal
  • METHOD OF REDUCING MULTI-DRUG RESISTANCE USING INOSITOL TRIPYROPHOSPHATE
    Publication number: 20140199261
    Abstract: Inositol trisphosphate (ITPP) causes normalization of tumor vasculature and is a particularly effective cancer therapy when a second chemotherapeutic agent is administered following partial vascularization. ITPP also treats, alone or in combination, multi-drug resistant cancers. ITPP can also be used to reduce the amount of a second chemotherapeutic drug required for anticancer activity. In addition, ITPP enhances immune response and treats hyperproliferative disorders.
    Type: Application
    Filed: July 25, 2013
    Publication date: July 17, 2014
    Applicants: Universite de Strasbourg, NormOxys, Inc.
    Inventors: Yves Claude Nicolau, Jean-Marie Lehn, Claudine Kieda
  • METHOD OF PREPARING AN ADDUCT
    Publication number: 20140200161
    Abstract: A method for identifying one or several molecular structure(s) having a high-affinity for a target of interest, the molecular structure(s) each including one nucleotide chain onto which is hybridized at least one PNA-encoded molecule.
    Type: Application
    Filed: March 25, 2014
    Publication date: July 17, 2014
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE STRASBOURG
    Inventors: Nicolas WINSSINGER, Sofia BARLUENGA
  • CALCIUM/SODIUM SALT OF INOSITOL TRIPYROPHOSPHATE AS AN ALLOSTERIC EFFECTOR OF HEMOGLOBIN
    Publication number: 20140194391
    Abstract: The present invention relates to mixed calcium/sodium salt of inositol tripyrophosphate, methods of preparing and methods of use. The mixed calcium/sodium salt may be a monocalcium tetrasodium salt of inositol tripyrophosphate. Methods of use include administering the above salts in an effective amount to treat diseases caused by hypoxia or other conditions associated with inadequate function of the lungs or circulatory system, such as various types of cancer and Alzheimer's disease.
    Type: Application
    Filed: November 8, 2013
    Publication date: July 10, 2014
    Applicants: Universite de Strasbourg, NormOxys, Inc.
    Inventors: Yves Claude Nicolau, Jean-Marie Lehn, Konstantina C. Fylaktakidou, Ruth Greferath
  • BISACODYL AND ITS ANALOGUES AS DRUGS FOR USE IN THE TREATMENT OF CANCER
    Publication number: 20140186872
    Abstract: The present invention provides compounds having the formula A: (A) or pharmaceutically acceptable salt thereof, wherein W, R1, R2 and R5 are as defined in classes and subclasses herein, and pharmaceutical compositions thereof, as described generally and in subclasses herein, which compounds are useful as cytotoxic agents towards proliferating and/or quiescent cancer stem cells, and thus are useful, for example, for the treatment of cancer.
    Type: Application
    Filed: June 6, 2012
    Publication date: July 3, 2014
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE- CNRS, UNIVERSITE DE STRASBOURG
    Inventors: Marie Feve, Maria Zeniou-Meyer, Jacques Haiech, Herve Chneiweiss, Marie-Claude Kilhoffer, Samir Mameri, Marcel Hibert
  • CYCLITOLS AND THEIR DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS
    Publication number: 20140171394
    Abstract: The present invention is directed to polyphosphorylated and pyrophosphate derivatives of cyclitols. More particularly, the invention relates to polyphosphorylated and pyrophosphate derivatives of inositols. The invention also relates to compositions of the polyphosphorylated and pyrophosphate derivatives of inositol and other similar, more lipophilic derivatives, and their use as allosteric effectors, cell-signaling molecule analogs, and therapeutic agents.
    Type: Application
    Filed: December 9, 2013
    Publication date: June 19, 2014
    Applicants: Universite de Strasbourg, NormOxys, Inc.
    Inventors: Jean-Marie Lehn, Srinivasu Pothukanuri, Alexandros Koumbis, Carolina Duarte, Claude Nicolau
  • Diffractive signaling device for rear-view mirror with 2D/3D display
    Patent number: 8749371
    Abstract: Signaling device designed to be arranged on the reflective element forming a mirror of a rear-view device comprising at least an illumination unit and at least an optical device, characterized by the fact that the optical device includes a symbol generation unit which is provided with at least a diffraction grating designed to form an illuminated image corresponding to a first illuminated symbol, the symbol generation unit being generally transparent and the diffraction grating being formed on the surface of the symbol generation unit without affecting its transparency.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: June 10, 2014
    Assignees: Delphi Technologies, Inc., Universite de Strasbourg
    Inventors: Hassan Moussa, Idriss El Hafidi, Laurent Tupinier
  • POLYPHOSPHATE AND PYROPHOSPHATE DERIVATIVE OF SACCHARIDES
    Publication number: 20140155334
    Abstract: The present invention provides, among other things, phosphorylated and pyrophosphate derivatives of mono-, di- and oligosaccharides, as well as structural derivatives of these compounds. These compounds have a variety of uses including for pharmaceutical applications. Also provided are methods of use in the treatment of disease, including diseases related to oxygen delivery.
    Type: Application
    Filed: November 25, 2013
    Publication date: June 5, 2014
    Applicants: Université de Strasbourg, NormOxys, Inc.
    Inventors: Jean-Marie Lehn, Yves Claude Nicolau, Rajamalleswaramma Jogireddy, Adam H. Brockman, John Hey, Yongxin Yu
  • LINEAR DNA AMPLIFICATION
    Publication number: 20140141442
    Abstract: The present invention provides materials and methods for DNA amplification, in particular linear amplification methods using RNA polymerase. These methods permit high-throughput sequencing of pictogram amounts of DNA and are of use in a range of applications including genome-wide profiling of transcription factors and epigenetic DNA and histone modifications, global transcript profiling, mapping of chromatin conformations, as well as for forensic use and archaeological studies.
    Type: Application
    Filed: May 4, 2012
    Publication date: May 22, 2014
    Applicants: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S), STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK
    Inventors: Luisa Miguel Verdelho Trindade Van Gerven, Hinrich Gronemeyer, Shankara Narayanan Pattabhiraman
  • MACROCYCLIC PRODRUG COMPOUNDS USEFUL AS THERAPEUTICS
    Publication number: 20140135290
    Abstract: The present invention includes macrocyclic prodrug compounds, pharmaceutical compositions containing them. The present invention also includes use of these compounds in the treatment of various diseases including an autoimmune disease, an inflammatory disease, a neurological or neurodegenerative disease, cancer, a cardiovascular disease, allergy, asthma, a hormone-related disease, and tumors or symptoms resulting from neurofibromatosis.
    Type: Application
    Filed: November 4, 2013
    Publication date: May 15, 2014
    Applicants: ONCOSYNERGY, INC., LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE STRASBOURG
    Inventors: James HECK, Nicolas Winssinger, John C. Chabala, Sofia Barluenga, Ruihong Chen, Allan Rubenstein, Jin-Chen Yu
  • Head-up display system
    Patent number: 8724226
    Abstract: Independent optical unit for head-up display system for motor vehicle, intended for the display in the field of view of the driver of a virtual image obtained from an object image coming from a projector, including a first optical component reflecting the incident light rays emanating from the projector towards a second optical component placed in the field of view of the driver for the positioning of a final virtual image, means being provided for the adjustment of their relative position.
    Type: Grant
    Filed: May 10, 2011
    Date of Patent: May 13, 2014
    Assignees: Delphi Technologies, Inc., Universite de Strasbourg
    Inventors: Hassan Moussa, Idriss El Hafidi