Abstract: A device for determining a dose deposited in a scintillator by an ionizing radiation, comprises: a scintillator configured to be irradiated by the ionizing radiation and capable of emitting scintillation photons during interaction with the ionizing radiation; a measurement device comprising a single photodetector, the photodetector being a low-noise photodetector, the determination device being configured in such a way that the photodetector functions in single photon counting mode, the photodetector supplying, at the output of same, a measurement of the total intensity of light received by the photodetector from the scintillator; and an analyzer configured to determine a dose deposited in the scintillator by the ionizing radiation from the total intensity alone of light measured by the photodetector and a predetermined constant dependent only on the scintillator, the light output of the determination device and the type of ionizing radiation.

Abstract: The invention pertains to novel FLT3 receptor antagonists of general formula (1). The compounds are useful for the treatment or the prevention of pain disorders, cancer and autoimmune diseases.

Abstract: Some embodiments are directed to a method for controlling the viscosity of orthopedic bone cement during its curing in percutaneous vertebroplasty by allowing a controlled heating and/or cooling of the cement during the injection that leads to a dynamic and full control of the viscosity of the cement during the injection.

Abstract: The kit includes: a first implant (16) defining a window (26), and a second implant (18) including a second tubular body (42) designed to be positioned in the window (26). The second implant (18) includes a retaining member for retaining the second implant (18) relative to the first implant. The kit further includes a retaining ring (20) for retaining the second implant (18) attached on the first tubular body (22) in the window (26) and delimiting an insertion passage (60) for the second implant (18). The retaining ring (20) is elastically deformable in the window (26) to allow a reversible increase of at least 20%, advantageously at least 30%, of the outer contour of the insertion passage (60).

Abstract: The present disclosure relates to an inhibitor of Dynamin 2 or composition comprising the same for use in the treatment of Duchenne's muscular dystrophy.

Abstract: A method is provided for modifying a surface of a solid conducting material, which includes applying a potential difference between this surface and a surface of another conducting solid material positioned facing it, and wherein, simultaneously, the surface (S) is put into contact with a liquid medium comprising in solution triarylamines (I): while subjecting these triarylamines (I) to electromagnetic radiation, at least partly converting them at into triarylammonium radicals. Also provided is a conducting device which includes two conducting metal materials, the surfaces of which, (S) and (S?) respectively, are electrically interconnected through an organic material comprising conducting fibrillar organic supramolecular species comprising an association of triarylamines of formula (I).

Abstract: The invention relates to markers for Crohn's disease and to specific compounds for detecting said markers. The invention also relates to methods for detecting, diagnosing and monitoring the progression of Crohn's disease as well as to methods for evaluating the efficacy of a treatment for said disease, and to compositions and kits that can be used for implementing said methods.

Abstract: A device for selectively grasping a part of a separate elongated body extending through the device, includes at least three partially mobile jaw members defining between them a through hole of variable diameter depending on their mutual relative positioning, supporting and driving elements to which the jaw members are mounted and which are adapted to provide a coordinated motion to the members around the elongated body situated in the variable through hole, resulting in a closing or opening of the through hole. The jaw members have an elongated shape with two opposed ends and the supporting and driving elements include a circular or annular support body to which a first end of each jaw member is connected and a mobile annular driving body to which a second opposed end of each jaw member is connected.

Abstract: Disclosed is a method to modify the electrical conductivity of an organic and/or molecular material including the steps of providing a reflective or photonic structure and of placing the organic and/or molecular material in or on the structure. The method also includes providing a structure (1) which has an electromagnetic mode which is by design, or can be made by way of adjustment or tuning, resonant with a transition in the organic and/or molecular material (2) and controlling, in particular enhancing, the mobility of the charge carriers, and thus the electrical current, in the organic and/or molecular material (2), by way of strongly coupling the material (2) to the local electromagnetic vacuum field and exploiting the formation of extended macroscopic states in the material.

Abstract: P-chirogenic organophosphorus compounds of general formula (I), a process for the synthesis of the compounds of formula (I), and intermediate products of general formulae (II), (III) and (IV), as shown below, are involved in the synthesis of compounds (I). Metal complexes comprising compounds (I) as ligands are also described. The compounds and complexes are useful in asymmetric catalysis by transition metal complexes or organocatalysis, especially for asymmetric hydrogenation or allylation. Compounds of general formula (I) may be useful as agrochemical and therapeutic substances, or as reagents or intermediates for fine chemistry.

Abstract: The invention relates to oligonucleotide-oligocation molecules AiBjH that can be synthetized via automated phosphoramidite chemistry having oligonucleotides moieties Ai and oligocations moieties Bj, wherein .Ai is an i-mer oligonucleotide residue, with i=5 to 50, where nucleotide A is an oligomer with naturally or non naturally occurring nucleobases and/or pentafuranosyl groups and/or native phosphodiester bonds, for example selected from the group comprising deoxyribo, ribo, locked (LNA) nucleotides as well as their chemical modifications or substitutions such as phosphorothioate, 2?-fluoro, 2?-O-alkyl, or a marker group such as a fluorescent agent, .Bj is a j-mer organic oligocation moiety, with j=1 to 50, where B is selected from the group comprising .—HPO3—R1—(X—R2n)n1—X—R3—O—, where R1, R2n and R3, identical or different, are lower alkylene, X is NH or NC(NH2)2, n varies from 1 to 5 and n1=2 to 20, .

Abstract: The present invention relates to a process for labeling compounds comprising thiol moieties with 3-arylpropiolonitrile compounds, to 3-arylpropiolonitrile compounds substituted with tag moieties and to specific 3-arylpropiolonitrile linkers.

Abstract: The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.

Abstract: The present invention relates to disintegratable core/shell silica particles encapsulating a bioactive macromolecule or bioactive macromolecule cluster in an active conformation, a method for producing the same, and uses thereof.

Abstract: The present invention relates to a pharmaceutical composition comprising an inhibitor of eIF2?, a compound increasing the expression and/or activity of protein BiP and/or an inhibitor of Caspase-12, preferably an inhibitor of eIF2? and a compound increasing the expression and/or activity of protein BiP. The present invention also relates to pharmaceutical compositions and methods for treating retinal degeneration related to ciliary dysfunction.

Abstract: A multimodal contrast and radiopharmaceutical agent for an imaging and a targeted therapy guided by imaging.

Abstract: The subject matter of the present invention concerns the preparation of a coated solid surface wherein the coating contains at least one in-plane oriented layer of anisotropic shaped objects through a specific spraying method, and the device enabling this method.

Abstract: The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.

Abstract: The present invention relates to new anti-infectious compounds consisting of (i) a polar head having from one to three mannose, dimannose or trimannose moieties, which is coupled through an appropriate linker to (ii) a single lipid chain of at least 17 carbon atoms in length. Pharmaceutical compositions and therapeutic uses thereof are also provided.

Abstract: Catalytic process for the partial conversion of a gaseous mixture containing carbon monoxide and hydrogen into a mixture of hydrocarbons, including bringing the said gaseous mixture into contact with a solid catalyst, the solid catalyst having a porous support with a composite material including SiC and a titanium carbide and/or a titanium oxide, and an active phase. The support is prepared in the form of grains, beads, or extrudates, or in the form of cylinders or sheets of cellular foam.