Abstract: The invention relates to a novel use of ultrafine nanoparticles, of use as a diagnostic, therapeutic or theranostic agent, characterized by their mode of administration via the airways. The invention is also directed toward the applications which follow from this novel mode of administration, in particular for imaging the lungs, and the diagnosis or prognosis of pathological pulmonary conditions. In the therapeutic field, the applications envisioned are those of radiosensitizing or radioactive agents for radiotherapy (and optionally curietherapy), or for neutron therapy, or of agents for PDT (photodynamic therapy), in particular for the treatment of lung tumors.

Abstract: A system for determining a set of at least one cardio-respiratory descriptor of an individual during sleep comprises a memory device having a first accelerometer for a thoracic position, a second accelerometer synchronized with the first and for an abdominal position, and an optional sensor (e.g., a photoplethysmorgraphic sensor). The system also includes memory for recording accelerometer and optional sensor data; memory with a reference model; and a device for filtering accelerometer data and configured to extract low-, medium-, and high-frequency ranges. A computer is configured for determining, within the extracted frequency ranges, at least one characteristic representative of a cardio-respiratory and physiological state and the time of the extraction thereof; comparing the determined characteristic(s) with similar characteristics from the reference model; and deducing therefrom a set of at least one probable corresponding event the individual experienced during a predetermined period of time.

Abstract: The disclosure provides a new method for the specific metabolic labeling of bacterial teichoic acids cell wall by modified choline and click chemistry, and its use in various applications such as bio-imaging, diagnostic, vaccination or bio-materials engineering.

Abstract: The invention relates to anti-Tau nanobodies.

Abstract: A method for measuring, monitoring, controlling, evaluating and correcting proprioceptive and/or postural and/or locomotor and/or motor and/or spatial orientation abilities of a user, includes measuring and processing in order to detect an effective movement or an effective posture of the user; comparing the effective movement or the effective posture to a theoretical movement or a theoretical posture; providing biological feedback in order to allow the user to correct his effective movement or his effective posture with respect to the theoretical movement or the theoretical posture; calculating and storing a score; transmitting the score to a third party in order to allow the latter to monitor the performances of the user; and automatically or non-automatically updating a level of difficulty.

Abstract: The invention relates to a device for measuring the speed of blood in a blood vessel of the eye. Said device includes: a light source (5), two detectors provided with input diaphragms (36, 46) for receiving two light beams backscattered by a blood vessel, an optical system including a Dove prism (70) through which the source beam and backscattered beams pass and which is rotatably adjustable about an axis parallel to the source beam passing therethrough, and a focusing system (62) capable of forming the image of a blood vessel on the input diaphragms, a processor capable of processing the signals from the detectors, and an opitcal element (52) that can be inserted during the device adjustment phase so as to convert the light spot, provided by the light source, into a line coplanar with the source beam and the backscattered beams.

Abstract: The present disclosure is related to a live-attenuated strain of Pseudomonas for its use as a vaccine, and for use in a method for preventive immunizing and for treating Pseudomonas infection, in particular in patients suffering from cystic fibrosis. Preferably, the live-attenuated strain of Pseudomonas is furthermore treated to become ‘killed but metabolically active’.

Abstract: The invention is a method for determining a stress level of an individual, depending on a physiological parameter of the individual, the method comprising: a) measuring a physiological-parameter value in various calibration periods during a calibration time period; b) defining a range of variation in the physiological-parameter values measured in the various calibration periods; c) depending on the range of variation, establishing a membership function defining a stress level of the individual depending on the physiological-parameter value, the stress level defined by the membership function being able to vary between: a rest level, corresponding to a rest state of the individual; a stressed level, corresponding to a stressed state of the individual; and at least one intermediate level, comprised between the rest level and the stressed level; d) following c), measuring a physiological-parameter value during a measurement period, and determining the stress level of the individual by applying the membersh

Abstract: A mechanical structure comprising a stack including an active substrate and at least one actuator designed to generate vibrations at the active substrate, the stack comprises an elementary structure for amplifying the vibrations: positioned between the actuator and the active substrate, the structure designed to transmit and amplify the vibrations; and comprising at least one trench, located between the actuator and the active substrate. A method for manufacturing the structure comprising the use of a temporary substrate is provided.

Abstract: A NADPH oxidase (Nox) protein includes a domain including 3 to 7 transmembrane helices, and an amino acid sequence including at least 2 bis-histidyl motifs, wherein each of the bis-histidyl motifs consists of 2 histidine residues separated by 12, 13 or 14 amino acid residues. The Nox protein may be produced by a method that includes solubilizing a solution of cells expressing the Nox protein using a detergent from the maltoside family to suspend the Nox protein in the solution.

Abstract: An antibody or a fragment thereof directed against an epitope including or being constituted by at least six contiguous amino acids in the SEQ ID NO: 1 or a conformational epitope comprising or being constituted by at least six amino acids of SEQ ID NO: 1 which are always in the order of the sequence, and its use for the prognosis and/or the diagnosis of a cancer.

Abstract: An electrochemical reactor block including at least two pellets cut out of a flexible conductive film including chains of a linear polymer, carbon nanotubes being bound to each of the chains by pi-pi interaction, a catalyst agent selected from the group including enzymes, metal catalysts, macrocyclic catalysts, and redox mediators being trapped between the pellets.

Abstract: The invention relates to a novel use of ultrafine nanoparticles, of use as a diagnostic, therapeutic or theranostic agent, characterized by their mode of administration via the airways. The invention is also directed toward the applications which follow from this novel mode of administration, in particular for imaging the lungs, and the diagnosis or prognosis of pathological pulmonary conditions. In the therapeutic field, the applications envisioned are those of radiosensitizing or radioactive agents for radiotherapy (and optionally curietherapy), or for neutron therapy, or of agents for PDT (photodynamic therapy), in particular for the treatment of lung tumors.

Abstract: An item of interconnection equipment for a high-voltage DC grid includes first and second terminals for connection to first and second lines of a high-voltage DC grid, a third terminal for connection to a local station or a line of the high-voltage grid, a node connected to the first to third terminals, a first superconductor current limiter and a first controlled switch connected in series between the first terminal and the node, a second superconductor current limiter and a second controlled switch connected in series between the second terminal and the node, a third superconductor current limiter and a third controlled switch connected in series between the third terminal and the node, and a current injector configured to inject an electrical current into the node.

Abstract: A device for performing a mechanical four-point bending test on a test piece and to a method for using one such device. The device comprises: a) structure for holding a first end of the test piece (27; 127; 28; 128) and structure for holding a second end of the test piece (30, 31); b) traction wire (25) and converting structure (16, 116) for converting a translational movement of said traction means into a rotational movement; c) conversion structure (26; 27; 126; 127) for converting said rotational movement into bending deformation of the test piece. Said conversion structure comprises at least one first Cardan joint (26; 126), connected to the structure for holding the first end of the test piece.

Abstract: The invention relates to a method for manufacturing an optoelectronic device (50) including wire-like, conical, or frustoconical semiconductor elements (20) predominantly comprising a III-V compound. Each semiconductor element extends along an axis and includes a portion (54), the side surfaces (55) of which are covered with a shell (56) including at least one active region (31), wherein the portions are created by continuous growth in a reactor, and wherein the temperature in the reactor varies in an uninterrupted manner from a first temperature value that favors growth of first crystallographic planes perpendicular to said axis, to a second temperature value that is strictly lower than the first temperature value and favors growth of second crystallographic planes parallel to said axis.

Abstract: Disclosed are dihydropyrene derivatives, processes for preparing the same and their uses.

Abstract: A pharmaceutical composition in which the active substance includes or is: (i) a protein including the sequence SEQ ID NO: 1, representing the APRIL protein, (ii) any derived protein, which is derived from protein of sequence SEQ ID NO: 1 by substitution, removal or addition of one or more amino-acids, provided it allows the binding of the derived protein to an astrocyte and/or CSPG, (iii) any homologous protein, the sequence of which has a percentage of identity of at least approximately 70%, and in particular 85% with the sequence SEQ ID NO: 1, provided it allows the binding of the homologous protein to an astrocyte and/or CSPG, or (iv) any fragment of the protein of sequence SEQ ID NO: 1, provided it allows the binding of the fragment to an astrocyte and/or CSPG. The active substance is in association with an acceptable pharmaceutical vehicle.

Abstract: A capsule configured for collecting samples in the intestine, comprising a body delimiting at least one compartment for receiving samples and comprising at least one opening for samples intake, and a mobile mechanism for opening and/or closing the opening controlled by the dissolution of a material which is dissolvable in the intestine.

Abstract: A method is described to regenerate an oxygen trap, comprising at least the following steps: circulating a current in the trap material (2) to reduce this material; measuring the value Im of the current and estimating its derivative dIm/dt in relation to time; estimating the length (?) of material reduced by the current as a function of the value of the current and its derivative; stopping circulation of the current when the length of reduced material is at least equal to a threshold value (?s).